|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 10029 |
FusionGeneSummary for DIS3L2_FAM124B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DIS3L2_FAM124B | Fusion gene ID: 10029 | Hgene | Tgene | Gene symbol | DIS3L2 | FAM124B | Gene ID | 129563 | 79843 |
| Gene name | DIS3 like 3'-5' exoribonuclease 2 | family with sequence similarity 124 member B | |
| Synonyms | FAM6A|PRLMNS|hDIS3L2 | - | |
| Cytomap | 2q37.1 | 2q36.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DIS3-like exonuclease 2DIS3 mitotic control homolog-like 2family with sequence similarity 6, member A | protein FAM124Bfamily with sequence similarity 124B | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8IYB7 | Q9H5Z6 | |
| Ensembl transtripts involved in fusion gene | ENST00000273009, ENST00000360410, ENST00000325385, ENST00000409401, ENST00000409307, ENST00000470087, | ENST00000389874, ENST00000409685, ENST00000243806, | |
| Fusion gene scores | * DoF score | 8 X 7 X 8=448 | 1 X 1 X 1=1 |
| # samples | 9 | 1 | |
| ** MAII score | log2(9/448*10)=-2.31550182572793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: DIS3L2 [Title/Abstract] AND FAM124B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DIS3L2 | GO:0010587 | miRNA catabolic process | 24141620 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-18-3411-01A | DIS3L2 | chr2 | 232952431 | + | FAM124B | chr2 | 225244925 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000273009 | ENST00000389874 | DIS3L2 | chr2 | 232952431 | + | FAM124B | chr2 | 225244925 | - |
| 5CDS-3UTR | ENST00000273009 | ENST00000409685 | DIS3L2 | chr2 | 232952431 | + | FAM124B | chr2 | 225244925 | - |
| 5CDS-intron | ENST00000273009 | ENST00000243806 | DIS3L2 | chr2 | 232952431 | + | FAM124B | chr2 | 225244925 | - |
| 5CDS-3UTR | ENST00000360410 | ENST00000389874 | DIS3L2 | chr2 | 232952431 | + | FAM124B | chr2 | 225244925 | - |
| 5CDS-3UTR | ENST00000360410 | ENST00000409685 | DIS3L2 | chr2 | 232952431 | + | FAM124B | chr2 | 225244925 | - |
| 5CDS-intron | ENST00000360410 | ENST00000243806 | DIS3L2 | chr2 | 232952431 | + | FAM124B | chr2 | 225244925 | - |
| 5CDS-3UTR | ENST00000325385 | ENST00000389874 | DIS3L2 | chr2 | 232952431 | + | FAM124B | chr2 | 225244925 | - |
| 5CDS-3UTR | ENST00000325385 | ENST00000409685 | DIS3L2 | chr2 | 232952431 | + | FAM124B | chr2 | 225244925 | - |
| 5CDS-intron | ENST00000325385 | ENST00000243806 | DIS3L2 | chr2 | 232952431 | + | FAM124B | chr2 | 225244925 | - |
| 5CDS-3UTR | ENST00000409401 | ENST00000389874 | DIS3L2 | chr2 | 232952431 | + | FAM124B | chr2 | 225244925 | - |
| 5CDS-3UTR | ENST00000409401 | ENST00000409685 | DIS3L2 | chr2 | 232952431 | + | FAM124B | chr2 | 225244925 | - |
| 5CDS-intron | ENST00000409401 | ENST00000243806 | DIS3L2 | chr2 | 232952431 | + | FAM124B | chr2 | 225244925 | - |
| 5CDS-3UTR | ENST00000409307 | ENST00000389874 | DIS3L2 | chr2 | 232952431 | + | FAM124B | chr2 | 225244925 | - |
| 5CDS-3UTR | ENST00000409307 | ENST00000409685 | DIS3L2 | chr2 | 232952431 | + | FAM124B | chr2 | 225244925 | - |
| 5CDS-intron | ENST00000409307 | ENST00000243806 | DIS3L2 | chr2 | 232952431 | + | FAM124B | chr2 | 225244925 | - |
| 3UTR-3UTR | ENST00000470087 | ENST00000389874 | DIS3L2 | chr2 | 232952431 | + | FAM124B | chr2 | 225244925 | - |
| 3UTR-3UTR | ENST00000470087 | ENST00000409685 | DIS3L2 | chr2 | 232952431 | + | FAM124B | chr2 | 225244925 | - |
| 3UTR-intron | ENST00000470087 | ENST00000243806 | DIS3L2 | chr2 | 232952431 | + | FAM124B | chr2 | 225244925 | - |
Top |
FusionProtFeatures for DIS3L2_FAM124B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DIS3L2 | FAM124B |