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Fusion gene ID: 10010 |
FusionGeneSummary for DIP2C_GDI2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DIP2C_GDI2 | Fusion gene ID: 10010 | Hgene | Tgene | Gene symbol | DIP2C | GDI2 | Gene ID | 22982 | 2665 |
| Gene name | disco interacting protein 2 homolog C | GDP dissociation inhibitor 2 | |
| Synonyms | KIAA0934 | HEL-S-46e|RABGDIB | |
| Cytomap | 10p15.3 | 10p15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | disco-interacting protein 2 homolog CDIP2 disco-interacting protein 2 homolog CDIP2 homolog C | rab GDP dissociation inhibitor betaGDI-2epididymis secretory sperm binding protein Li 46eguanosine diphosphate dissociation inhibitor 2rab GDI betarab GDP-dissociation inhibitor, beta | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9Y2E4 | P50395 | |
| Ensembl transtripts involved in fusion gene | ENST00000280886, ENST00000381496, ENST00000540204, | ENST00000380191, ENST00000479928, ENST00000380132, ENST00000380181, | |
| Fusion gene scores | * DoF score | 13 X 7 X 11=1001 | 8 X 6 X 4=192 |
| # samples | 14 | 8 | |
| ** MAII score | log2(14/1001*10)=-2.83794324189103 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DIP2C [Title/Abstract] AND GDI2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-FD-A3SP-01A | DIP2C | chr10 | 486811 | - | GDI2 | chr10 | 5842668 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000280886 | ENST00000380191 | DIP2C | chr10 | 486811 | - | GDI2 | chr10 | 5842668 | - |
| 5CDS-intron | ENST00000280886 | ENST00000479928 | DIP2C | chr10 | 486811 | - | GDI2 | chr10 | 5842668 | - |
| 5CDS-intron | ENST00000280886 | ENST00000380132 | DIP2C | chr10 | 486811 | - | GDI2 | chr10 | 5842668 | - |
| 5CDS-intron | ENST00000280886 | ENST00000380181 | DIP2C | chr10 | 486811 | - | GDI2 | chr10 | 5842668 | - |
| In-frame | ENST00000381496 | ENST00000380191 | DIP2C | chr10 | 486811 | - | GDI2 | chr10 | 5842668 | - |
| 5CDS-intron | ENST00000381496 | ENST00000479928 | DIP2C | chr10 | 486811 | - | GDI2 | chr10 | 5842668 | - |
| 5CDS-intron | ENST00000381496 | ENST00000380132 | DIP2C | chr10 | 486811 | - | GDI2 | chr10 | 5842668 | - |
| 5CDS-intron | ENST00000381496 | ENST00000380181 | DIP2C | chr10 | 486811 | - | GDI2 | chr10 | 5842668 | - |
| intron-3CDS | ENST00000540204 | ENST00000380191 | DIP2C | chr10 | 486811 | - | GDI2 | chr10 | 5842668 | - |
| intron-intron | ENST00000540204 | ENST00000479928 | DIP2C | chr10 | 486811 | - | GDI2 | chr10 | 5842668 | - |
| intron-intron | ENST00000540204 | ENST00000380132 | DIP2C | chr10 | 486811 | - | GDI2 | chr10 | 5842668 | - |
| intron-intron | ENST00000540204 | ENST00000380181 | DIP2C | chr10 | 486811 | - | GDI2 | chr10 | 5842668 | - |
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FusionProtFeatures for DIP2C_GDI2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DIP2C | GDI2 |