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Fusion gene ID: 10001 |
FusionGeneSummary for DIP2B_PRELID1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DIP2B_PRELID1 | Fusion gene ID: 10001 | Hgene | Tgene | Gene symbol | DIP2B | PRELID1 | Gene ID | 57609 | 27166 |
| Gene name | disco interacting protein 2 homolog B | PRELI domain containing 1 | |
| Synonyms | - | CGI-106|PRELI|PX19|SBBI12 | |
| Cytomap | 12q13.12 | 5q35.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | disco-interacting protein 2 homolog BDIP2 disco-interacting protein 2 homolog B | PRELI domain-containing protein 1, mitochondrial25 kDa protein of relevant evolutionary and lymphoid interestpx19-like protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9P265 | Q9Y255 | |
| Ensembl transtripts involved in fusion gene | ENST00000301180, | ENST00000303204, ENST00000503216, ENST00000502670, | |
| Fusion gene scores | * DoF score | 11 X 8 X 9=792 | 3 X 3 X 3=27 |
| # samples | 13 | 3 | |
| ** MAII score | log2(13/792*10)=-2.60698880705116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DIP2B [Title/Abstract] AND PRELID1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PRELID1 | GO:0010917 | negative regulation of mitochondrial membrane potential | 18945965 |
| Tgene | PRELID1 | GO:0010950 | positive regulation of endopeptidase activity | 18945965 |
| Tgene | PRELID1 | GO:0043066 | negative regulation of apoptotic process | 21364629 |
| Tgene | PRELID1 | GO:0045580 | regulation of T cell differentiation | 18945965 |
| Tgene | PRELID1 | GO:0051881 | regulation of mitochondrial membrane potential | 21364629 |
| Tgene | PRELID1 | GO:0070234 | positive regulation of T cell apoptotic process | 18945965 |
| Tgene | PRELID1 | GO:0090201 | negative regulation of release of cytochrome c from mitochondria | 23931759 |
| Tgene | PRELID1 | GO:0097035 | regulation of membrane lipid distribution | 23931759 |
| Tgene | PRELID1 | GO:1901857 | positive regulation of cellular respiration | 21364629|23931759 |
| Tgene | PRELID1 | GO:2001140 | positive regulation of phospholipid transport | 23931759 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-CD-8531-01A | DIP2B | chr12 | 50898807 | + | PRELID1 | chr5 | 176730833 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000301180 | ENST00000303204 | DIP2B | chr12 | 50898807 | + | PRELID1 | chr5 | 176730833 | + |
| intron-5UTR | ENST00000301180 | ENST00000503216 | DIP2B | chr12 | 50898807 | + | PRELID1 | chr5 | 176730833 | + |
| intron-intron | ENST00000301180 | ENST00000502670 | DIP2B | chr12 | 50898807 | + | PRELID1 | chr5 | 176730833 | + |
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FusionProtFeatures for DIP2B_PRELID1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DIP2B | PRELID1 |