FGBPmap

FGBPmap is a reference FGBP score map to be searched the tendency of breakage across the human genome. The users can search the tendency of fragility across the 3 billion human genome sequence. We will implement two-way searching approaches using BP information based or sequence based strategies.

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Browse by ORF of fusion protein

In-frame	Frame-shift	3UTR-CDS	3UTR-5UTR	3UTR-3UTR	CDS-5UTR
5UTR-CDS	CDS-3UTR	5UTR-5UTR	5UTR-3UTR	3UTR-intron	CDS-intron
5UTR-intron	intron-CDS	intron-3UTR	intron-5UTR
intron-intron

FGs that might involve in oncogenic mechanisms.

- Inframe FGs retaining kinase domain (331)
- Inframe FGs retaining oncogene domain (840)

FGs that might involve in loss-of-function mechanisms.

    - Inframe FGs, but not retained Tumor suppressor gene (TSG) domains (896)
    - Inframe FGs, but not retained DNA damage repair (DDR) gene domains (118)
    - Inframe FGs, but lost protein-protein interaction (PPI) (976)
    - FGs lost TSG domain due to frame-shift (813)
    - FGs lost DDR gene domain due to frame-shift (166)
    - FGs lost PPIs due to frame-shift (761)

FGs that might alter downstream gene expression.

    - Kept target gene expression regulation
            - Inframe FGs retaining DNA-binding domain (DBD) (303)
            - Inframe FGs retaining epigenetic factors' (epifactors) domain (667)
    - Lost target gene expression regulation
            - Infrmae FGs, but not retained DBD (343)
            - Inframe FGs, but not retained epifactors' domain (766)
            - FGs lost DBD due to frame-shift (324)
            - FGs lost epifactors' domain due to frame-shift (713)

Browse by chromosome

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FGBPmap