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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for CDC25A |
 Gene summary |
| Gene information | Gene symbol | CDC25A | Gene ID | 993 |
| Gene name | cell division cycle 25A | |
| Synonyms | CDC25A2 | |
| Cytomap | 3p21.31 | |
| Type of gene | protein-coding | |
| Description | M-phase inducer phosphatase 1CDC25 isoform A1-CAGCDC25A2-CAG isoformdual specificity phosphatase CDC25A | |
| Modification date | 20180523 | |
| UniProtAcc | P30304 | |
| Context | PubMed: CDC25A [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CDC25A | GO:0009314 | response to radiation | 21376736 |
| CDC25A | GO:0034644 | cellular response to UV | 19966869 |
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Exon skipping events across known transcript of Ensembl for CDC25A from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for CDC25A |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for CDC25A |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_383393 | 3 | 48215773:48215947:48218860:48218932:48219343:48219478 | 48218860:48218932 | ENSG00000164045.7 | ENST00000302506.3,ENST00000351231.3 |
| exon_skip_383394 | 3 | 48219343:48219478:48222210:48222330:48224418:48224517 | 48222210:48222330 | ENSG00000164045.7 | ENST00000443342.1,ENST00000302506.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for CDC25A |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_383394 | 3 | 48219343:48219478:48222210:48222330:48224418:48224517 | 48222210:48222330 | ENSG00000164045.7 | ENST00000302506.3,ENST00000443342.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for CDC25A |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000302506 | 48218860 | 48218932 | In-frame |
| ENST00000302506 | 48222210 | 48222330 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000302506 | 48222210 | 48222330 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CDC25A |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000302506 | 3800 | 524 | 48222210 | 48222330 | 839 | 958 | 143 | 183 |
| ENST00000302506 | 3800 | 524 | 48218860 | 48218932 | 1094 | 1165 | 228 | 252 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000302506 | 3800 | 524 | 48222210 | 48222330 | 839 | 958 | 143 | 183 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P30304 | 143 | 183 | 144 | 183 | Alternative sequence | ID=VSP_000860;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11139144,ECO:0000303|Ref.2;Dbxref=PMID:11139144 |
| P30304 | 143 | 183 | 1 | 524 | Chain | ID=PRO_0000198641;Note=M-phase inducer phosphatase 1 |
| P30304 | 143 | 183 | 178 | 178 | Modified residue | Note=Phosphoserine%3B by CHEK1;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12676583,ECO:0000269|PubMed:12759351,ECO:0000269|PubMed:14559997;Dbxref=PMID:12676583,PMID:12759351,PMID:14559997 |
| P30304 | 143 | 183 | 141 | 143 | Motif | Note=KEN box |
| P30304 | 143 | 183 | 141 | 143 | Mutagenesis | Note=Prevents ubiquitination and subsequent degradation by the APC/C ubiquitin ligase complex. KEN->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12234927;Dbxref=PMID:12234927 |
| P30304 | 143 | 183 | 178 | 178 | Mutagenesis | Note=Increases basal stability and impairs CHEK1-dependent degradation following checkpoint activation%3B when associated with A-124%3B A-279 and A-293. Abrogates 14-3-3 protein binding. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO: |
| P30304 | 143 | 183 | 182 | 182 | Natural variant | ID=VAR_023532;Note=R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1836978;Dbxref=dbSNP:rs6771386,PMID:1836978 |
| P30304 | 143 | 183 | 182 | 182 | Natural variant | ID=VAR_023533;Note=R->W;Dbxref=dbSNP:rs6771386 |
| P30304 | 143 | 183 | 180 | 181 | Sequence conflict | Note=PA->QL;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P30304 | 228 | 252 | 1 | 524 | Chain | ID=PRO_0000198641;Note=M-phase inducer phosphatase 1 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P30304 | 143 | 183 | 144 | 183 | Alternative sequence | ID=VSP_000860;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11139144,ECO:0000303|Ref.2;Dbxref=PMID:11139144 |
| P30304 | 143 | 183 | 1 | 524 | Chain | ID=PRO_0000198641;Note=M-phase inducer phosphatase 1 |
| P30304 | 143 | 183 | 178 | 178 | Modified residue | Note=Phosphoserine%3B by CHEK1;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12676583,ECO:0000269|PubMed:12759351,ECO:0000269|PubMed:14559997;Dbxref=PMID:12676583,PMID:12759351,PMID:14559997 |
| P30304 | 143 | 183 | 141 | 143 | Motif | Note=KEN box |
| P30304 | 143 | 183 | 141 | 143 | Mutagenesis | Note=Prevents ubiquitination and subsequent degradation by the APC/C ubiquitin ligase complex. KEN->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12234927;Dbxref=PMID:12234927 |
| P30304 | 143 | 183 | 178 | 178 | Mutagenesis | Note=Increases basal stability and impairs CHEK1-dependent degradation following checkpoint activation%3B when associated with A-124%3B A-279 and A-293. Abrogates 14-3-3 protein binding. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO: |
| P30304 | 143 | 183 | 182 | 182 | Natural variant | ID=VAR_023532;Note=R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1836978;Dbxref=dbSNP:rs6771386,PMID:1836978 |
| P30304 | 143 | 183 | 182 | 182 | Natural variant | ID=VAR_023533;Note=R->W;Dbxref=dbSNP:rs6771386 |
| P30304 | 143 | 183 | 180 | 181 | Sequence conflict | Note=PA->QL;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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SNVs in the skipped exons for CDC25A |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_383393 | 48218861 | 48218932 | 48218915 | 48218915 | Frame_Shift_Del | G | - | p.P234fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CDC25A |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CDC25A |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CDC25A |
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RelatedDrugs for CDC25A |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDC25A |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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