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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for ZEB2

check button Gene summary
Gene informationGene symbol

ZEB2

Gene ID

9839

Gene namezinc finger E-box binding homeobox 2
SynonymsHSPC082|SIP-1|SIP1|SMADIP1|ZFHX1B
Cytomap

2q22.3

Type of geneprotein-coding
Descriptionzinc finger E-box-binding homeobox 2SMAD interacting protein 1Smad-interacting protein 1zinc finger homeobox 1b
Modification date20180519
UniProtAcc

O60315

ContextPubMed: ZEB2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
ZEB2

GO:0000122

negative regulation of transcription by RNA polymerase II

12837246|20516212


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Exon skipping events across known transcript of Ensembl for ZEB2 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for ZEB2

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for ZEB2

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3438552145145583:145147595:145153978:145154159:145155867:145157837145153978:145154159ENSG00000169554.12ENST00000539609.3,ENST00000303660.4,ENST00000409487.3,ENST00000558170.2
exon_skip_3438582145153978:145154159:145155867:145157837:145158765:145158874145155867:145157837ENSG00000169554.12ENST00000539609.3,ENST00000303660.4,ENST00000409487.3,ENST00000558170.2
exon_skip_3438592145161561:145161697:145162402:145162591:145182362:145182434145162402:145162591ENSG00000169554.12ENST00000303660.4,ENST00000409487.3,ENST00000392861.2,ENST00000558170.2,ENST00000427902.1
exon_skip_3438602145161561:145161697:145162402:145162591:145187335:145187593145162402:145162591ENSG00000169554.12ENST00000539609.3
exon_skip_3438622145162435:145162591:145182362:145182434:145187335:145187593145182362:145182434ENSG00000169554.12ENST00000303660.4,ENST00000409487.3,ENST00000392861.2,ENST00000558170.2,ENST00000440875.1,ENST00000427902.1
exon_skip_3438642145187477:145187593:145255274:145255331:145274844:145274986145255274:145255331ENSG00000169554.12ENST00000434448.1,ENST00000453352.1
exon_skip_3438652145187477:145187593:145274844:145274986:145277505:145277569145274844:145274986ENSG00000169554.12ENST00000539609.3,ENST00000303660.4,ENST00000444559.1,ENST00000472146.1
exon_skip_3438672145274917:145274986:145275859:145276013:145277505:145277569145275859:145276013ENSG00000169554.12ENST00000465308.1
exon_skip_3438682145274917:145274986:145277505:145277775:145277918:145277953145277505:145277775ENSG00000169554.12ENST00000444559.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for ZEB2

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3438552145145583:145147595:145153978:145154159:145155867:145157837145153978:145154159ENSG00000169554.12ENST00000558170.2,ENST00000409487.3,ENST00000303660.4,ENST00000539609.3
exon_skip_3438582145153978:145154159:145155867:145157837:145158765:145158874145155867:145157837ENSG00000169554.12ENST00000558170.2,ENST00000409487.3,ENST00000303660.4,ENST00000539609.3
exon_skip_3438592145161561:145161697:145162402:145162591:145182362:145182434145162402:145162591ENSG00000169554.12ENST00000558170.2,ENST00000409487.3,ENST00000303660.4,ENST00000427902.1,ENST00000392861.2
exon_skip_3438602145161561:145161697:145162402:145162591:145187335:145187593145162402:145162591ENSG00000169554.12ENST00000539609.3
exon_skip_3438622145162435:145162591:145182362:145182434:145187335:145187593145182362:145182434ENSG00000169554.12ENST00000558170.2,ENST00000409487.3,ENST00000303660.4,ENST00000427902.1,ENST00000392861.2,ENST00000440875.1
exon_skip_3438642145187477:145187593:145255274:145255331:145274844:145274986145255274:145255331ENSG00000169554.12ENST00000434448.1,ENST00000453352.1
exon_skip_3438652145187477:145187593:145274844:145274986:145277505:145277569145274844:145274986ENSG00000169554.12ENST00000303660.4,ENST00000539609.3,ENST00000472146.1,ENST00000444559.1
exon_skip_3438662145219749:145219904:145221732:145221909:145274844:145274986145221732:145221909ENSG00000169554.12ENST00000484313.1
exon_skip_3438672145274917:145274986:145275859:145276013:145277505:145277569145275859:145276013ENSG00000169554.12ENST00000465308.1
exon_skip_3438682145274917:145274986:145277505:145277775:145277918:145277953145277505:145277775ENSG00000169554.12ENST00000444559.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for ZEB2

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000409487145153978145154159Frame-shift
ENST00000558170145153978145154159Frame-shift
ENST00000409487145155867145157837Frame-shift
ENST00000558170145155867145157837Frame-shift
ENST00000409487145162402145162591In-frame
ENST00000558170145162402145162591In-frame
ENST00000409487145182362145182434In-frame
ENST00000558170145182362145182434In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000409487145153978145154159Frame-shift
ENST00000558170145153978145154159Frame-shift
ENST00000409487145155867145157837Frame-shift
ENST00000558170145155867145157837Frame-shift
ENST00000409487145162402145162591In-frame
ENST00000558170145162402145162591In-frame
ENST00000409487145182362145182434In-frame
ENST00000558170145182362145182434In-frame

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Infer the effects of exon skipping event on protein functional features for ZEB2

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000040948753001214145182362145182434520591110134
ENST0000055817010217121414518236214518243415171588110134
ENST0000040948753001214145162402145162591592780134197
ENST0000055817010217121414516240214516259115891777134197

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000040948753001214145182362145182434520591110134
ENST0000055817010217121414518236214518243415171588110134
ENST0000040948753001214145162402145162591592780134197
ENST0000055817010217121414516240214516259115891777134197

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
O60315110134111134Alternative sequenceID=VSP_044797;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O60315110134111134Alternative sequenceID=VSP_044797;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O6031511013411214ChainID=PRO_0000047236;Note=Zinc finger E-box-binding homeobox 2
O6031511013411214ChainID=PRO_0000047236;Note=Zinc finger E-box-binding homeobox 2
O60315134197111134Alternative sequenceID=VSP_044797;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O60315134197111134Alternative sequenceID=VSP_044797;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O6031513419711214ChainID=PRO_0000047236;Note=Zinc finger E-box-binding homeobox 2
O6031513419711214ChainID=PRO_0000047236;Note=Zinc finger E-box-binding homeobox 2
O60315134197142142Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
O60315134197142142Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
O60315110134111134Alternative sequenceID=VSP_044797;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O60315110134111134Alternative sequenceID=VSP_044797;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O6031511013411214ChainID=PRO_0000047236;Note=Zinc finger E-box-binding homeobox 2
O6031511013411214ChainID=PRO_0000047236;Note=Zinc finger E-box-binding homeobox 2
O60315134197111134Alternative sequenceID=VSP_044797;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O60315134197111134Alternative sequenceID=VSP_044797;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O6031513419711214ChainID=PRO_0000047236;Note=Zinc finger E-box-binding homeobox 2
O6031513419711214ChainID=PRO_0000047236;Note=Zinc finger E-box-binding homeobox 2
O60315134197142142Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
O60315134197142142Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163


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SNVs in the skipped exons for ZEB2

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.
ZEB2_LUAD_exon_skip_343858_psi_boxplot.png
boxplot
ZEB2_PAAD_exon_skip_343858_psi_boxplot.png
boxplot
ZEB2_SKCM_exon_skip_343858_psi_boxplot.png
boxplot
ZEB2_STAD_exon_skip_343858_psi_boxplot.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LUADTCGA-55-8620-01exon_skip_343858
145155868145157837145156076145156076Frame_Shift_DelG-p.P893fs
LIHCTCGA-DD-A1EG-01exon_skip_343858
145155868145157837145156109145156109Frame_Shift_DelG-p.P882fs
LIHCTCGA-G3-A3CJ-01exon_skip_343858
145155868145157837145156725145156725Frame_Shift_DelT-p.I677fs
LIHCTCGA-DD-A1EG-01exon_skip_343858
145155868145157837145156810145156810Frame_Shift_DelG-p.P648fs
LIHCTCGA-DD-A3A0-01exon_skip_343858
145155868145157837145156870145156870Frame_Shift_DelA-p.F628fs
LIHCTCGA-DD-A1EG-01exon_skip_343858
145155868145157837145156970145156970Frame_Shift_DelG-p.P595fs
LIHCTCGA-DD-A1EG-01exon_skip_343858
145155868145157837145156984145156984Frame_Shift_DelA-p.F590fs
LIHCTCGA-DD-A3A0-01exon_skip_343858
145155868145157837145157069145157069Frame_Shift_DelA-p.L562fs
LUADTCGA-64-5815-01exon_skip_343858
145155868145157837145157069145157069Frame_Shift_DelA-p.L562fs
LUADTCGA-49-4487-01exon_skip_343858
145155868145157837145157401145157401Frame_Shift_DelG-p.P451fs
LIHCTCGA-DD-A1EG-01exon_skip_343858
145155868145157837145157586145157586Frame_Shift_DelT-p.I390fs
CESCTCGA-JW-A5VH-01exon_skip_343858
145155868145157837145157710145157710Frame_Shift_DelG-p.K349fs
SARCTCGA-X6-A8C2-01exon_skip_343858
145155868145157837145157714145157715Frame_Shift_DelTT-p.N347fs
LIHCTCGA-BC-A112-01exon_skip_343858
145155868145157837145156665145156666Frame_Shift_Ins-Tp.NL696fs
LUADTCGA-50-5941-01exon_skip_343858
145155868145157837145156965145156966Frame_Shift_Ins-Ap.L596fs
LUADTCGA-50-5941-01exon_skip_343858
145155868145157837145156965145156966Frame_Shift_Ins-Ap.LS596fs
LIHCTCGA-BC-A112-01exon_skip_343858
145155868145157837145157651145157652Frame_Shift_Ins-Gp.V368fs
ACCTCGA-OR-A5JB-01exon_skip_343855
145153979145154159145153988145153988Nonsense_MutationCAp.E1020*
ACCTCGA-OR-A5JB-01exon_skip_343855
145153979145154159145153988145153988Nonsense_MutationCAp.E1020X
ACCTCGA-OR-A5JB-01exon_skip_343855
145153979145154159145153988145153988Nonsense_MutationCAp.E996X
UCECTCGA-BS-A0UF-01exon_skip_343855
145153979145154159145154156145154156Nonsense_MutationCAp.E964*
PAADTCGA-IB-7651-01exon_skip_343858
145155868145157837145155993145155993Nonsense_MutationGAp.R921*
PAADTCGA-IB-7651-01exon_skip_343858
145155868145157837145155993145155993Nonsense_MutationGAp.R921X
UCECTCGA-AP-A051-01exon_skip_343858
145155868145157837145155993145155993Nonsense_MutationGAp.R921*
SKCMTCGA-BF-AAOU-01exon_skip_343858
145155868145157837145156014145156014Nonsense_MutationGAp.Q914*
STADTCGA-BR-8059-01exon_skip_343858
145155868145157837145156152145156152Nonsense_MutationCAp.E868X
LUADTCGA-17-Z026-01exon_skip_343858
145155868145157837145156752145156752Nonsense_MutationCAp.E668*
LUADTCGA-67-3771-01exon_skip_343858
145155868145157837145156847145156847Nonsense_MutationATp.L636*
PAADTCGA-IB-7651-01exon_skip_343858
145155868145157837145156911145156911Nonsense_MutationGAp.Q615*
PAADTCGA-IB-7651-01exon_skip_343858
145155868145157837145156911145156911Nonsense_MutationGAp.Q615X
SKCMTCGA-ER-A198-06exon_skip_343858
145155868145157837145157133145157133Nonsense_MutationGAp.Q517X
SKCMTCGA-ER-A198-06exon_skip_343858
145155868145157837145157133145157133Nonsense_MutationGAp.Q541*
LUADTCGA-78-7155-01exon_skip_343858
145155868145157837145157187145157187Nonsense_MutationTAp.K523*
LUADTCGA-55-8301-01exon_skip_343858
145155868145157837145157607145157607Nonsense_MutationCAp.E383*
HNSCTCGA-CV-A465-01exon_skip_343858
145155868145157837145157727145157727Nonsense_MutationGAp.R343*
READTCGA-F5-6814-01exon_skip_343859
exon_skip_343860
145162403145162591145162409145162409Nonsense_MutationCAp.E172X
LIHCTCGA-CC-A7IE-01exon_skip_343862
145182363145182434145182399145182399Nonsense_MutationCAp.E123X
DLBCTCGA-GR-7351-01exon_skip_343865
145274845145274986145274844145274844Splice_SiteCT.

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description
ZEB2_145153978_145154159_145155867_145157837_145158765_145158874_TCGA-ER-A198-06Sample: TCGA-ER-A198-06
Cancer type: SKCM
ESID: exon_skip_343858
Skipped exon start: 145155868
Skipped exon end: 145157837
Mutation start: 145157133
Mutation end: 145157133
Mutation type: Nonsense_Mutation
Reference seq: G
Mutation seq: A
AAchange: p.Q517X
ZEB2_145153978_145154159_145155867_145157837_145158765_145158874_TCGA-ER-A198-06Sample: TCGA-ER-A198-06
Cancer type: SKCM
ESID: exon_skip_343858
Skipped exon start: 145155868
Skipped exon end: 145157837
Mutation start: 145157133
Mutation end: 145157133
Mutation type: Nonsense_Mutation
Reference seq: G
Mutation seq: A
AAchange: p.Q541*
exon_skip_343858_SKCM_TCGA-ER-A198-06.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
BICR18_UPPER_AERODIGESTIVE_TRACT145155868145157837145156967145156968Frame_Shift_DelAA-p.L596fs
HEC59_ENDOMETRIUM145155868145157837145157328145157328Frame_Shift_DelT-p.M476fs
CCRFCEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145155868145157837145157328145157328Frame_Shift_DelT-p.M476fs
BICR18_UPPER_AERODIGESTIVE_TRACT145182363145182434145182409145182410Frame_Shift_DelAG-p.T119fs
GB1_CENTRAL_NERVOUS_SYSTEM145182363145182434145182420145182423Frame_Shift_DelCTTC-p.ED115fs
COLO792_SKIN145182363145182434145182421145182421Frame_Shift_DelT-p.E115fs
BICR18_UPPER_AERODIGESTIVE_TRACT145155868145157837145156972145156973Frame_Shift_Ins-GAp.I594fs
L428_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145155868145157837145157327145157328Frame_Shift_Ins-Tp.M476fs
ESS1_ENDOMETRIUM145155868145157837145157327145157328Frame_Shift_Ins-Tp.M476fs
HDLM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145155868145157837145157327145157328Frame_Shift_Ins-Tp.M476fs
J82_URINARY_TRACT145155868145157837145157327145157328Frame_Shift_Ins-Tp.M476fs
KMRC20_KIDNEY145155868145157837145157327145157328Frame_Shift_Ins-Tp.M476fs
KPNSI9S_AUTONOMIC_GANGLIA145155868145157837145157327145157328Frame_Shift_Ins-Tp.M476fs
NCIH1792_LUNG145155868145157837145157327145157328Frame_Shift_Ins-Tp.M476fs
NCIH2452_PLEURA145155868145157837145157327145157328Frame_Shift_Ins-Tp.M476fs
NCIH647_LUNG145155868145157837145157327145157328Frame_Shift_Ins-Tp.M476fs
NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145155868145157837145157327145157328Frame_Shift_Ins-Tp.M476fs
OCIM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145155868145157837145157327145157328Frame_Shift_Ins-Tp.M476fs
RDES_BONE145155868145157837145157327145157328Frame_Shift_Ins-Tp.M476fs
RS5_FIBROBLAST145155868145157837145157327145157328Frame_Shift_Ins-Tp.M476fs
SLR25_KIDNEY145155868145157837145157327145157328Frame_Shift_Ins-Tp.M476fs
SAT_UPPER_AERODIGESTIVE_TRACT145162403145162591145162510145162511Frame_Shift_Ins-Tp.S162fs
BICR18_UPPER_AERODIGESTIVE_TRACT145182363145182434145182412145182413Frame_Shift_Ins-CAp.D118fs
SNU520_STOMACH145155868145157837145157236145157238In_Frame_DelAGG-p.P506del
CCRFCEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145153979145154159145154036145154036Missense_MutationAGp.C1004R
TUR_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145153979145154159145154071145154071Missense_MutationTCp.K992R
22RV1_PROSTATE145153979145154159145154084145154084Missense_MutationGAp.R988C
SKMEL28_SKIN145153979145154159145154100145154101Missense_MutationGGAAp.S982F
SKMEL28_SKIN145153979145154159145154101145154101Missense_MutationGAp.S982F
SKCO1_LARGE_INTESTINE145153979145154159145154120145154120Missense_MutationGTp.L976I
BICR18_UPPER_AERODIGESTIVE_TRACT145153979145154159145154154145154154Missense_MutationTGp.E964D
S117_SOFT_TISSUE145153979145154159145154154145154154Missense_MutationTGp.E964D
KM12_LARGE_INTESTINE145155868145157837145155892145155892Missense_MutationCAp.K954N
NCIH69_LUNG145155868145157837145155906145155906Missense_MutationGTp.Q950K
KYSE410_OESOPHAGUS145155868145157837145155912145155912Missense_MutationCAp.D948Y
HEC6_ENDOMETRIUM145155868145157837145155966145155966Missense_MutationTCp.S930G
CAL72_BONE145155868145157837145155975145155975Missense_MutationCAp.D927Y
A253_SALIVARY_GLAND145155868145157837145156047145156047Missense_MutationCTp.A903T
SNU175_LARGE_INTESTINE145155868145157837145156047145156047Missense_MutationCTp.A903T
LXF289_LUNG145155868145157837145156048145156048Missense_MutationGTp.S902R
NCIH650_LUNG145155868145157837145156077145156077Missense_MutationGTp.P893T
FU97_STOMACH145155868145157837145156160145156160Missense_MutationATp.I865N
HCC515_LUNG145155868145157837145156168145156168Missense_MutationCGp.L862F
EN_ENDOMETRIUM145155868145157837145156184145156184Missense_MutationTCp.D857G
SNU520_STOMACH145155868145157837145156202145156202Missense_MutationGAp.S851F
HEC251_ENDOMETRIUM145155868145157837145156238145156238Missense_MutationGAp.A839V
RH30_SOFT_TISSUE145155868145157837145156241145156241Missense_MutationTAp.K838I
MN60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145155868145157837145156260145156260Missense_MutationCTp.A832T
BICR18_UPPER_AERODIGESTIVE_TRACT145155868145157837145156467145156467Missense_MutationGAp.P763S
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145155868145157837145156467145156467Missense_MutationGAp.P763S
BICR18_UPPER_AERODIGESTIVE_TRACT145155868145157837145156496145156496Missense_MutationTCp.N753S
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145155868145157837145156496145156496Missense_MutationTCp.N753S
HS895T_FIBROBLAST145155868145157837145156499145156499Missense_MutationGAp.T752M
ES3_BONE145155868145157837145156499145156499Missense_MutationGAp.T752M
SNUC1_LARGE_INTESTINE145155868145157837145156508145156508Missense_MutationTGp.N749T
RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145155868145157837145156548145156549Missense_MutationTACGp.M736V
NCIH526_LUNG145155868145157837145156562145156562Missense_MutationGTp.S731Y
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145155868145157837145156590145156591Missense_MutationGATGp.P722T
HT55_LARGE_INTESTINE145155868145157837145156641145156641Missense_MutationATp.S705T
HEC151_ENDOMETRIUM145155868145157837145156699145156699Missense_MutationCAp.Q685H
2313287_STOMACH145155868145157837145156724145156724Missense_MutationATp.I677N
LS411N_LARGE_INTESTINE145155868145157837145156814145156814Missense_MutationCTp.S647N
BICR18_UPPER_AERODIGESTIVE_TRACT145155868145157837145156821145156821Missense_MutationTGp.M645L
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145155868145157837145156821145156821Missense_MutationTGp.M645L
KMS11_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145155868145157837145156825145156825Missense_MutationTAp.K643N
HCT15_LARGE_INTESTINE145155868145157837145156841145156841Missense_MutationGAp.S638F
KNS81FD_CENTRAL_NERVOUS_SYSTEM145155868145157837145156865145156865Missense_MutationTAp.D630V
SKN3_UPPER_AERODIGESTIVE_TRACT145155868145157837145156869145156869Missense_MutationCTp.V629I
HS870T_FIBROBLAST145155868145157837145156875145156875Missense_MutationCTp.V627I
SW480_LARGE_INTESTINE145155868145157837145156957145156957Missense_MutationATp.H599Q
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145155868145157837145157027145157027Missense_MutationTCp.N576S
HEC6_ENDOMETRIUM145155868145157837145157033145157033Missense_MutationTAp.N574I
KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145155868145157837145157075145157075Missense_MutationCTp.R560H
NCIH1836_LUNG145155868145157837145157080145157080Missense_MutationCAp.K558N
AN3CA_ENDOMETRIUM145155868145157837145157111145157111Missense_MutationCAp.R548M
HEC251_ENDOMETRIUM145155868145157837145157168145157168Missense_MutationGAp.T529M
HEC6_ENDOMETRIUM145155868145157837145157168145157168Missense_MutationGAp.T529M
RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145155868145157837145157183145157183Missense_MutationCAp.S524I
MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145155868145157837145157220145157220Missense_MutationCTp.G512S
NCIH526_LUNG145155868145157837145157303145157303Missense_MutationGAp.S484L
HUNS1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145155868145157837145157328145157328Missense_MutationTCp.M476V
NCIN87_STOMACH145155868145157837145157411145157411Missense_MutationACp.L448R
NCIH358_LUNG145155868145157837145157418145157418Missense_MutationGTp.P446T
DL40_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145155868145157837145157476145157476Missense_MutationTGp.L426F
SW684_SOFT_TISSUE145155868145157837145157480145157480Missense_MutationGAp.P425L
JHU022_UPPER_AERODIGESTIVE_TRACT145155868145157837145157592145157592Missense_MutationGTp.L388I
5637_URINARY_TRACT145155868145157837145157607145157607Missense_MutationCGp.E383Q
NUGC4_STOMACH145155868145157837145157632145157632Missense_MutationCGp.E374D
SNU1040_LARGE_INTESTINE145155868145157837145157643145157643Missense_MutationTGp.N371H
SNU81_LARGE_INTESTINE145155868145157837145157675145157675Missense_MutationGTp.S360Y
SNU81_LARGE_INTESTINE145155868145157837145157758145157758Missense_MutationCAp.K332N
SNU81_LARGE_INTESTINE145155868145157837145157774145157774Missense_MutationGAp.S327L
CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145155868145157837145157820145157820Missense_MutationAGp.C312R
SNUC2A_LARGE_INTESTINE145162403145162591145162442145162442Missense_MutationGAp.R185C
SNUC2B_LARGE_INTESTINE145162403145162591145162442145162442Missense_MutationGAp.R185C
HS944T_SKIN145162403145162591145162490145162490Missense_MutationGAp.R169C
SNU1040_LARGE_INTESTINE145162403145162591145162523145162523Missense_MutationCTp.G158S
22RV1_PROSTATE145162403145162591145162528145162528Missense_MutationCTp.R156H
JHUEM7_ENDOMETRIUM145162403145162591145162538145162538Missense_MutationGTp.L153M
SNU407_LARGE_INTESTINE145182363145182434145182380145182380Missense_MutationGAp.A129V
BICR18_UPPER_AERODIGESTIVE_TRACT145182363145182434145182381145182381Missense_MutationCTp.A129T
SNU1040_LARGE_INTESTINE145182363145182434145182392145182392Missense_MutationGAp.T125M
NB17_AUTONOMIC_GANGLIA145182363145182434145182396145182396Missense_MutationCAp.A124S
NCIH2286_LUNG145182363145182434145182401145182402Missense_MutationGGCTp.P122R
NCIH2286_LUNG145182363145182434145182401145182401Missense_MutationGCp.P122R
NCIH2286_LUNG145182363145182434145182402145182402Missense_MutationGTp.P122T
PC9_LUNG145182363145182434145182413145182413Missense_MutationTCp.D118G
NCIH810_LUNG145274845145274986145274886145274886Missense_MutationCTp.R11Q
SNU1040_LARGE_INTESTINE145274845145274986145274899145274899Missense_MutationCTp.A7T
SNU1040_LARGE_INTESTINE145153979145154159145154000145154000Nonsense_MutationGAp.R1016*
TFK1_BILIARY_TRACT145155868145157837145155870145155870Nonsense_MutationGAp.Q962*
HCC515_LUNG145155868145157837145156187145156187Nonsense_MutationGTp.S856*
SH10TC_STOMACH145155868145157837145156320145156320Nonsense_MutationGAp.Q812*
NCIH510_LUNG145155868145157837145156437145156437Nonsense_MutationCAp.E773*
KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE145155868145157837145156682145156682Nonsense_MutationCTp.W691*
JHUEM7_ENDOMETRIUM145162403145162591145162409145162409Nonsense_MutationCAp.E196*
RKO_LARGE_INTESTINE145182363145182434145182387145182387Nonsense_MutationGAp.Q127*
TE5_OESOPHAGUS145153979145154159145154159145154159Splice_SiteCTp.G963R
NCIH2110_LUNG145162403145162591145162403145162403Splice_SiteCAp.D198Y
BICR18_UPPER_AERODIGESTIVE_TRACT145162403145162591145162590145162590Splice_SiteCAp.V135V
S117_SOFT_TISSUE145162403145162591145162590145162590Splice_SiteCAp.V135V

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZEB2

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZEB2


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZEB2


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RelatedDrugs for ZEB2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZEB2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
ZEB2C1856113Mowat-Wilson syndrome5CTD_human;UNIPROT
ZEB2C0007621Neoplastic Cell Transformation1CTD_human
ZEB2C0018798Congenital Heart Defects1CTD_human
ZEB2C0023893Liver Cirrhosis, Experimental1CTD_human
ZEB2C0027626Neoplasm Invasiveness1CTD_human
ZEB2C1458155Mammary Neoplasms1CTD_human