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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SLK |
 Gene summary |
| Gene information | Gene symbol | SLK | Gene ID | 9748 |
| Gene name | STE20 like kinase | |
| Synonyms | LOSK|STK2|bA16H23.1|se20-9 | |
| Cytomap | 10q24.33-q25.1 | |
| Type of gene | protein-coding | |
| Description | STE20-like serine/threonine-protein kinaseCTCL tumor antigen se20-9Long Ste20-like KinaseSNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinaseSNF1 sucrose nonfermenting like kinaseSTE20-related kinaseSTE20- | |
| Modification date | 20180523 | |
| UniProtAcc | Q9H2G2 | |
| Context | PubMed: SLK [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| SLK | GO:0042981 | regulation of apoptotic process | 22203681 |
| SLK | GO:0046777 | protein autophosphorylation | 18239682 |
| SLK | GO:0051893 | regulation of focal adhesion assembly | 23128389 |
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Exon skipping events across known transcript of Ensembl for SLK from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SLK |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SLK |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_44846 | 10 | 105750432:105750597:105752355:105752404:105752741:105752891 | 105752355:105752404 | ENSG00000065613.9 | ENST00000369755.3,ENST00000335753.4 |
| exon_skip_44847 | 10 | 105759624:105759706:105761201:105761330:105761929:105763285 | 105761201:105761330 | ENSG00000065613.9 | ENST00000369755.3,ENST00000335753.4 |
| exon_skip_44848 | 10 | 105761201:105761330:105761929:105763285:105765318:105765449 | 105761929:105763285 | ENSG00000065613.9 | ENST00000369755.3,ENST00000335753.4 |
| exon_skip_44853 | 10 | 105767955:105768114:105770573:105770666:105777917:105778047 | 105770573:105770666 | ENSG00000065613.9 | ENST00000369755.3 |
| exon_skip_44859 | 10 | 105777917:105778047:105778541:105778666:105779491:105779680 | 105778541:105778666 | ENSG00000065613.9 | ENST00000369755.3,ENST00000335753.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SLK |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_44846 | 10 | 105750432:105750597:105752355:105752404:105752741:105752891 | 105752355:105752404 | ENSG00000065613.9 | ENST00000335753.4,ENST00000369755.3 |
| exon_skip_44847 | 10 | 105759624:105759706:105761201:105761330:105761929:105763285 | 105761201:105761330 | ENSG00000065613.9 | ENST00000335753.4,ENST00000369755.3 |
| exon_skip_44848 | 10 | 105761201:105761330:105761929:105763285:105765318:105765449 | 105761929:105763285 | ENSG00000065613.9 | ENST00000335753.4,ENST00000369755.3 |
| exon_skip_44853 | 10 | 105767955:105768114:105770573:105770666:105777917:105778047 | 105770573:105770666 | ENSG00000065613.9 | ENST00000369755.3 |
| exon_skip_44859 | 10 | 105777917:105778047:105778541:105778666:105779491:105779680 | 105778541:105778666 | ENSG00000065613.9 | ENST00000335753.4,ENST00000369755.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SLK |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000369755 | 105752355 | 105752404 | Frame-shift |
| ENST00000369755 | 105778541 | 105778666 | Frame-shift |
| ENST00000369755 | 105761201 | 105761330 | In-frame |
| ENST00000369755 | 105761929 | 105763285 | In-frame |
| ENST00000369755 | 105770573 | 105770666 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000369755 | 105752355 | 105752404 | Frame-shift |
| ENST00000369755 | 105778541 | 105778666 | Frame-shift |
| ENST00000369755 | 105761201 | 105761330 | In-frame |
| ENST00000369755 | 105761929 | 105763285 | In-frame |
| ENST00000369755 | 105770573 | 105770666 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SLK |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000369755 | 7783 | 1235 | 105761201 | 105761330 | 1410 | 1538 | 288 | 331 |
| ENST00000369755 | 7783 | 1235 | 105761929 | 105763285 | 1539 | 2894 | 331 | 783 |
| ENST00000369755 | 7783 | 1235 | 105770573 | 105770666 | 3330 | 3422 | 928 | 959 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000369755 | 7783 | 1235 | 105761201 | 105761330 | 1410 | 1538 | 288 | 331 |
| ENST00000369755 | 7783 | 1235 | 105761929 | 105763285 | 1539 | 2894 | 331 | 783 |
| ENST00000369755 | 7783 | 1235 | 105770573 | 105770666 | 3330 | 3422 | 928 | 959 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for SLK |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_44859 | 105778542 | 105778666 | 105778616 | 105778616 | Frame_Shift_Del | A | - | p.K1028fs |
| KICH | TCGA-KN-8433-01 | exon_skip_44848 | 105761930 | 105763285 | 105762029 | 105762030 | Frame_Shift_Ins | - | A | p.E365fs |
| UCEC | TCGA-D1-A103-01 | exon_skip_44847 | 105761202 | 105761330 | 105761241 | 105761241 | Nonsense_Mutation | G | T | p.E302* |
| UCEC | TCGA-D1-A16X-01 | exon_skip_44848 | 105761930 | 105763285 | 105762314 | 105762314 | Nonsense_Mutation | G | T | p.E460* |
| UCEC | TCGA-AX-A05Z-01 | exon_skip_44848 | 105761930 | 105763285 | 105763002 | 105763002 | Nonsense_Mutation | C | A | p.S689* |
| COAD | TCGA-AA-3510-01 | exon_skip_44848 | 105761930 | 105763285 | 105763109 | 105763109 | Nonsense_Mutation | G | T | p.E725X |
| SKCM | TCGA-ER-A19Q-06 | exon_skip_44859 | 105778542 | 105778666 | 105778643 | 105778643 | Nonsense_Mutation | C | T | p.Q1037* |
| LUAD | TCGA-05-4432-01 | exon_skip_44848 | 105761930 | 105763285 | 105763286 | 105763286 | Splice_Site | G | A | p.Q783_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HCT116_LARGE_INTESTINE | 105761930 | 105763285 | 105762529 | 105762529 | Frame_Shift_Del | G | - | p.L531fs |
| CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 105761930 | 105763285 | 105762994 | 105762996 | In_Frame_Del | TCC | - | p.P687del |
| OC316_OVARY | 105761930 | 105763285 | 105761972 | 105761972 | Missense_Mutation | G | A | p.A346T |
| OC314_OVARY | 105761930 | 105763285 | 105761972 | 105761972 | Missense_Mutation | G | A | p.A346T |
| ABC1_LUNG | 105761930 | 105763285 | 105761983 | 105761983 | Missense_Mutation | A | T | p.E349D |
| AGS_STOMACH | 105761930 | 105763285 | 105762033 | 105762033 | Missense_Mutation | A | C | p.K366T |
| KLE_ENDOMETRIUM | 105761930 | 105763285 | 105762144 | 105762144 | Missense_Mutation | A | T | p.D403V |
| NCIH2087_LUNG | 105761930 | 105763285 | 105762149 | 105762149 | Missense_Mutation | C | A | p.Q405K |
| OMC1_CERVIX | 105761930 | 105763285 | 105762342 | 105762342 | Missense_Mutation | C | G | p.S469C |
| SNU520_STOMACH | 105761930 | 105763285 | 105762414 | 105762414 | Missense_Mutation | A | G | p.D493G |
| JHUEM7_ENDOMETRIUM | 105761930 | 105763285 | 105762523 | 105762523 | Missense_Mutation | G | T | p.E529D |
| KMM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 105761930 | 105763285 | 105762783 | 105762783 | Missense_Mutation | A | G | p.N616S |
| SH4_SKIN | 105761930 | 105763285 | 105762807 | 105762807 | Missense_Mutation | C | T | p.S624L |
| SNU1040_LARGE_INTESTINE | 105761930 | 105763285 | 105762817 | 105762817 | Missense_Mutation | A | G | p.I627M |
| HEC251_ENDOMETRIUM | 105761930 | 105763285 | 105763119 | 105763119 | Missense_Mutation | C | A | p.S728Y |
| HEC151_ENDOMETRIUM | 105778542 | 105778666 | 105778638 | 105778638 | Missense_Mutation | G | T | p.R1035I |
| KLE_ENDOMETRIUM | 105761930 | 105763285 | 105762149 | 105762149 | Nonsense_Mutation | C | T | p.Q405* |
| HT115_LARGE_INTESTINE | 105761930 | 105763285 | 105762404 | 105762404 | Nonsense_Mutation | G | T | p.E490* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SLK |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_44848 | 10 | 105761201:105761330:105761929:105763285:105765318:105765449 | 105761929:105763285 | ENST00000369755.3,ENST00000335753.4 | STAD | rs805657 | chr10:105762591 | G/A | 2.03e-03 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SLK |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SLK |
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RelatedDrugs for SLK |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q9H2G2 | DB12010 | Fostamatinib | STE20-like serine/threonine-protein kinase | small molecule | approved|investigational |
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RelatedDiseases for SLK |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| SLK | C0236969 | Substance-Related Disorders | 1 | CTD_human |
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