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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for ULK2

check button Gene summary
Gene informationGene symbol

ULK2

Gene ID

9706

Gene nameunc-51 like autophagy activating kinase 2
SynonymsATG1B|Unc51.2
Cytomap

17p11.2

Type of geneprotein-coding
Descriptionserine/threonine-protein kinase ULK2
Modification date20180523
UniProtAcc

Q8IYT8

ContextPubMed: ULK2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
ULK2

GO:0006914

autophagy

18936157

ULK2

GO:0046777

protein autophosphorylation

18936157


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Exon skipping events across known transcript of Ensembl for ULK2 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for ULK2

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for ULK2

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_2873601719674142:19674380:19679621:19679720:19680893:1968102919679621:19679720ENSG00000083290.15ENST00000361658.2
exon_skip_2873621719683784:19683942:19684298:19684417:19685201:1968538019684298:19684417ENSG00000083290.15ENST00000361658.2,ENST00000395544.4
exon_skip_2873631719684398:19684417:19685201:19685380:19687009:1968721819685201:19685380ENSG00000083290.15ENST00000361658.2,ENST00000395544.4,ENST00000571454.2
exon_skip_2873641719685273:19685380:19687009:19687218:19689249:1968931819687009:19687218ENSG00000083290.15ENST00000575432.1,ENST00000361658.2,ENST00000395544.4
exon_skip_2873651719687009:19687218:19689249:19689318:19698934:1969903819689249:19689318ENSG00000083290.15ENST00000575432.1
exon_skip_2873671719687009:19687218:19689249:19689399:19698934:1969903819689249:19689399ENSG00000083290.15ENST00000361658.2,ENST00000395544.4
exon_skip_2873691719698934:19699038:19699407:19699595:19700708:1970099519699407:19699595ENSG00000083290.15ENST00000361658.2,ENST00000395544.4
exon_skip_2873721719713690:19713751:19720061:19720233:19728406:1972849519720061:19720233ENSG00000083290.15ENST00000361658.2,ENST00000395544.4
exon_skip_2873731719728406:19728495:19729451:19729499:19741813:1974181719729451:19729499ENSG00000083290.15ENST00000361658.2,ENST00000395544.4,ENST00000571177.1
exon_skip_2873781719729451:19729499:19741813:19741896:19744801:1974486019741813:19741896ENSG00000083290.15ENST00000361658.2,ENST00000395544.4,ENST00000571177.1
exon_skip_2873831719741842:19741896:19744801:19744860:19746433:1974645119744801:19744860ENSG00000083290.15ENST00000574732.2,ENST00000361658.2,ENST00000395544.4,ENST00000571177.1
exon_skip_2873851719750049:19750223:19751567:19751657:19752681:1975269219751567:19751657ENSG00000083290.15ENST00000574732.2
exon_skip_2873861719753054:19753087:19764253:19764368:19768115:1976814919764253:19764368ENSG00000083290.15ENST00000580118.2

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for ULK2

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_2873621719683784:19683942:19684298:19684417:19685201:1968538019684298:19684417ENSG00000083290.15ENST00000361658.2,ENST00000395544.4
exon_skip_2873631719684398:19684417:19685201:19685380:19687009:1968721819685201:19685380ENSG00000083290.15ENST00000361658.2,ENST00000395544.4,ENST00000571454.2
exon_skip_2873641719685273:19685380:19687009:19687218:19689249:1968931819687009:19687218ENSG00000083290.15ENST00000361658.2,ENST00000395544.4,ENST00000575432.1
exon_skip_2873651719687009:19687218:19689249:19689318:19698934:1969903819689249:19689318ENSG00000083290.15ENST00000575432.1
exon_skip_2873671719687009:19687218:19689249:19689399:19698934:1969903819689249:19689399ENSG00000083290.15ENST00000361658.2,ENST00000395544.4
exon_skip_2873691719698934:19699038:19699407:19699595:19700708:1970099519699407:19699595ENSG00000083290.15ENST00000361658.2,ENST00000395544.4
exon_skip_2873721719713690:19713751:19720061:19720233:19728406:1972849519720061:19720233ENSG00000083290.15ENST00000361658.2,ENST00000395544.4
exon_skip_2873731719728406:19728495:19729451:19729499:19741813:1974181719729451:19729499ENSG00000083290.15ENST00000361658.2,ENST00000395544.4,ENST00000571177.1
exon_skip_2873781719729451:19729499:19741813:19741896:19744801:1974486019741813:19741896ENSG00000083290.15ENST00000361658.2,ENST00000395544.4,ENST00000571177.1
exon_skip_2873831719741842:19741896:19744801:19744860:19746433:1974645119744801:19744860ENSG00000083290.15ENST00000361658.2,ENST00000395544.4,ENST00000571177.1,ENST00000574732.2
exon_skip_2873851719750049:19750223:19751567:19751657:19752681:1975269219751567:19751657ENSG00000083290.15ENST00000574732.2

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for ULK2

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000036165819679621196797205CDS-5UTR
ENST000003616581968429819684417Frame-shift
ENST000003955441968429819684417Frame-shift
ENST000003616581968520119685380Frame-shift
ENST000003955441968520119685380Frame-shift
ENST000003616581968700919687218Frame-shift
ENST000003955441968700919687218Frame-shift
ENST000003616581969940719699595Frame-shift
ENST000003955441969940719699595Frame-shift
ENST000003616581972006119720233Frame-shift
ENST000003955441972006119720233Frame-shift
ENST000003616581974181319741896Frame-shift
ENST000003955441974181319741896Frame-shift
ENST000003616581974480119744860Frame-shift
ENST000003955441974480119744860Frame-shift
ENST000003616581968924919689399In-frame
ENST000003955441968924919689399In-frame
ENST000003616581972945119729499In-frame
ENST000003955441972945119729499In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003616581968429819684417Frame-shift
ENST000003955441968429819684417Frame-shift
ENST000003616581968520119685380Frame-shift
ENST000003955441968520119685380Frame-shift
ENST000003616581968700919687218Frame-shift
ENST000003955441968700919687218Frame-shift
ENST000003616581969940719699595Frame-shift
ENST000003955441969940719699595Frame-shift
ENST000003616581972006119720233Frame-shift
ENST000003955441972006119720233Frame-shift
ENST000003616581974181319741896Frame-shift
ENST000003955441974181319741896Frame-shift
ENST000003616581974480119744860Frame-shift
ENST000003955441974480119744860Frame-shift
ENST000003616581968924919689399In-frame
ENST000003955441968924919689399In-frame
ENST000003616581972945119729499In-frame
ENST000003955441972945119729499In-frame

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Infer the effects of exon skipping event on protein functional features for ULK2

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000036165839251036197294511972949913071354262278
ENST0000039554460271036197294511972949912881335262278
ENST0000036165839251036196892491968939926212770700750
ENST0000039554460271036196892491968939926022751700750

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000036165839251036197294511972949913071354262278
ENST0000039554460271036197294511972949912881335262278
ENST0000036165839251036196892491968939926212770700750
ENST0000039554460271036196892491968939926022751700750

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q8IYT826227811036ChainID=PRO_0000086782;Note=Serine/threonine-protein kinase ULK2
Q8IYT826227811036ChainID=PRO_0000086782;Note=Serine/threonine-protein kinase ULK2
Q8IYT82622789271DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q8IYT82622789271DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q8IYT870075011036ChainID=PRO_0000086782;Note=Serine/threonine-protein kinase ULK2
Q8IYT870075011036ChainID=PRO_0000086782;Note=Serine/threonine-protein kinase ULK2


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q8IYT826227811036ChainID=PRO_0000086782;Note=Serine/threonine-protein kinase ULK2
Q8IYT826227811036ChainID=PRO_0000086782;Note=Serine/threonine-protein kinase ULK2
Q8IYT82622789271DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q8IYT82622789271DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q8IYT870075011036ChainID=PRO_0000086782;Note=Serine/threonine-protein kinase ULK2
Q8IYT870075011036ChainID=PRO_0000086782;Note=Serine/threonine-protein kinase ULK2


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SNVs in the skipped exons for ULK2

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
STADTCGA-BR-8591-01exon_skip_287373
19729452197294991972945319729453Frame_Shift_DelT-p.S279fs
STADTCGA-HU-A4GX-01exon_skip_287373
19729452197294991972945319729453Frame_Shift_DelT-p.S279fs
STADTCGA-HU-A4H4-01exon_skip_287373
19729452197294991972945319729453Frame_Shift_DelT-p.S279fs
STADTCGA-CG-5728-01exon_skip_287373
19729452197294991972948919729489Frame_Shift_DelA-p.S267fs
STADTCGA-HU-A4GN-01exon_skip_287373
19729452197294991972948919729489Frame_Shift_DelA-p.S267fs
THYMTCGA-X7-A8DI-01exon_skip_287373
19729452197294991972948919729489Frame_Shift_DelA-p.F266fs
THYMTCGA-X7-A8DI-01exon_skip_287373
19729452197294991972948919729489Frame_Shift_DelA-p.S267fs
LIHCTCGA-G3-A3CJ-01exon_skip_287373
19729452197294991972949519729495Frame_Shift_DelT-p.A264fs
LIHCTCGA-G3-A3CJ-01exon_skip_287378
19741814197418961974183019741830Frame_Shift_DelT-p.K257fs
LUSCTCGA-66-2742-01exon_skip_287383
19744802197448601974482019744820Frame_Shift_DelT-p.N229fs
STADTCGA-CG-4306-01exon_skip_287364
19687010196872181968707019687071Frame_Shift_Ins-Gp.P800fs
COADTCGA-AA-3492-01exon_skip_287373
19729452197294991972945219729453Frame_Shift_Ins-Tp.S279fs
COADTCGA-CM-5861-01exon_skip_287373
19729452197294991972945219729453Frame_Shift_Ins-Tp.S279fs
STADTCGA-BR-8591-01exon_skip_287383
19744802197448601974481919744820Frame_Shift_Ins-Tp.N229fs
STADTCGA-BR-8591-01exon_skip_287383
19744802197448601974482019744821Frame_Shift_Ins-Tp.N229fs
BLCATCGA-UY-A9PA-01exon_skip_287378
19741814197418961974184419741844Nonsense_MutationGAp.Q253*

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
CW2_LARGE_INTESTINE19687010196872181968707019687070Frame_Shift_DelG-p.P800fs
CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE19744802197448601974481919744820Frame_Shift_Ins-Tp.N229fs
SNU175_LARGE_INTESTINE19679622196797201967967319679673Missense_MutationCTp.A1034T
MFE319_ENDOMETRIUM19679622196797201967967319679673Missense_MutationCTp.A1034T
BICR18_UPPER_AERODIGESTIVE_TRACT19684299196844171968431319684313Missense_MutationGAp.T915I
NCIH2803_PLEURA19684299196844171968434019684340Missense_MutationAGp.I906T
VMRCRCZ_KIDNEY19684299196844171968440019684400Missense_MutationACp.V886G
MOLT16_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE19685202196853801968535219685352Missense_MutationAGp.L830P
NCIH716_LARGE_INTESTINE19687010196872181968711019687110Missense_MutationGCp.A787G
CHLA266_SOFT_TISSUE19687010196872181968717119687171Missense_MutationCTp.V767M
JHUEM1_ENDOMETRIUM19689250196893991968930019689300Missense_MutationGAp.A734V
JHUEM1_ENDOMETRIUM19689250196893181968930019689300Missense_MutationGAp.A734V
HCT15_LARGE_INTESTINE19689250196893991968933719689337Missense_MutationCTp.A722T
MZ7MEL_SKIN19699408196995951969942019699420Missense_MutationGAp.A662V
PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE19699408196995951969944219699442Missense_MutationGAp.R655W
SLR21_KIDNEY19699408196995951969946819699468Missense_MutationACp.L646R
MZ7MEL_SKIN19699408196995951969952519699525Missense_MutationCTp.G627E
JHOM2B_OVARY19699408196995951969955119699551Missense_MutationGTp.N618K
RERFLCAD1_LUNG19699408196995951969955119699551Missense_MutationGTp.N618K
OVCAR4_OVARY19699408196995951969957319699573Missense_MutationGTp.P611H
DOV13_OVARY19699408196995951969959119699591Missense_MutationGAp.T605I
HS294T_SKIN19699408196995951969959119699591Missense_MutationGAp.T605I
SNGM_ENDOMETRIUM19720062197202331972010919720109Missense_MutationGAp.T350M
HEC108_ENDOMETRIUM19720062197202331972019919720199Missense_MutationTCp.N320S
BALL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE19729452197294991972948119729481Missense_MutationGCp.P269R
CW2_LARGE_INTESTINE19741814197418961974184719741847Missense_MutationGAp.L252F
NCIH1436_LUNG19741814197418961974186919741869Missense_MutationCGp.L244F
KPNYN_AUTONOMIC_GANGLIA19744802197448601974481719744817Missense_MutationCTp.R230K
DERL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE19689250196893991968926819689268Nonsense_MutationGAp.R745*
DERL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE19689250196893181968926819689268Nonsense_MutationGAp.R745*
OC316_OVARY19729452197294991972945319729453Splice_SiteT-p.K278fs
SW48_LARGE_INTESTINE19729452197294991972945319729453Splice_SiteT-p.K278fs
MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE19729452197294991972945319729453Splice_SiteT-p.K278fs
OC314_OVARY19729452197294991972945319729453Splice_SiteT-p.K278fs

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ULK2

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ULK2


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ULK2


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RelatedDrugs for ULK2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
Q8IYT8DB12010FostamatinibSerine/threonine-protein kinase ULK2small moleculeapproved|investigational

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RelatedDiseases for ULK2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
ULK2C0345967Malignant mesothelioma1CTD_human