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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ST18 |
 Gene summary |
| Gene information | Gene symbol | ST18 | Gene ID | 9705 |
| Gene name | ST18, C2H2C-type zinc finger | |
| Synonyms | NZF3|ZC2H2C3|ZC2HC10|ZNF387 | |
| Cytomap | 8q11.23 | |
| Type of gene | protein-coding | |
| Description | suppression of tumorigenicity 18 proteinneural zinc finger transcription factor 3suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)suppression of tumorigenicity 18, zinc fingerzinc finger protein 387 | |
| Modification date | 20180523 | |
| UniProtAcc | O60284 | |
| Context | PubMed: ST18 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ST18 | GO:0008285 | negative regulation of cell proliferation | 15489893 |
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Exon skipping events across known transcript of Ensembl for ST18 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ST18 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ST18 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_489648 | 8 | 53055489:53055605:53062291:53062537:53071457:53071669 | 53062291:53062537 | ENSG00000147488.7 | ENST00000521824.1,ENST00000276480.7,ENST00000522251.1,ENST00000521582.1 |
| exon_skip_489649 | 8 | 53079411:53079546:53084128:53084183:53084351:53084674 | 53084128:53084183 | ENSG00000147488.7 | ENST00000521582.1 |
| exon_skip_489650 | 8 | 53092853:53092872:53113621:53113936:53124638:53124669 | 53113621:53113936 | ENSG00000147488.7 | ENST00000520257.1 |
| exon_skip_489652 | 8 | 53092853:53092872:53122589:53122677:53124638:53124669 | 53122589:53122677 | ENSG00000147488.7 | ENST00000522251.1 |
| exon_skip_489653 | 8 | 53119142:53119310:53122589:53122677:53124638:53124669 | 53122589:53122677 | ENSG00000147488.7 | ENST00000517456.1 |
| exon_skip_489654 | 8 | 53126779:53126817:53130301:53130461:53133300:53133408 | 53130301:53130461 | ENSG00000147488.7 | ENST00000517580.1,ENST00000521549.1 |
| exon_skip_489655 | 8 | 53126779:53126817:53130305:53130461:53133300:53133408 | 53130305:53130461 | ENSG00000147488.7 | ENST00000519118.1 |
| exon_skip_489656 | 8 | 53126779:53126817:53130372:53130461:53133300:53133408 | 53130372:53130461 | ENSG00000147488.7 | ENST00000517456.1 |
| exon_skip_489658 | 8 | 53142591:53142637:53159145:53159224:53161917:53161972 | 53159145:53159224 | ENSG00000147488.7 | ENST00000518545.1 |
| exon_skip_489660 | 8 | 53142591:53142637:53159145:53159224:53321887:53322012 | 53159145:53159224 | ENSG00000147488.7 | ENST00000520279.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ST18 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_489648 | 8 | 53055489:53055605:53062291:53062537:53071457:53071669 | 53062291:53062537 | ENSG00000147488.7 | ENST00000276480.7,ENST00000521824.1,ENST00000522251.1,ENST00000521582.1 |
| exon_skip_489649 | 8 | 53079411:53079546:53084128:53084183:53084351:53084674 | 53084128:53084183 | ENSG00000147488.7 | ENST00000521582.1 |
| exon_skip_489650 | 8 | 53092853:53092872:53113621:53113936:53124638:53124669 | 53113621:53113936 | ENSG00000147488.7 | ENST00000520257.1 |
| exon_skip_489652 | 8 | 53092853:53092872:53122589:53122677:53124638:53124669 | 53122589:53122677 | ENSG00000147488.7 | ENST00000522251.1 |
| exon_skip_489653 | 8 | 53119142:53119310:53122589:53122677:53124638:53124669 | 53122589:53122677 | ENSG00000147488.7 | ENST00000517456.1 |
| exon_skip_489654 | 8 | 53126779:53126817:53130301:53130461:53133300:53133408 | 53130301:53130461 | ENSG00000147488.7 | ENST00000517580.1,ENST00000521549.1 |
| exon_skip_489655 | 8 | 53126779:53126817:53130305:53130461:53133300:53133408 | 53130305:53130461 | ENSG00000147488.7 | ENST00000519118.1 |
| exon_skip_489656 | 8 | 53126779:53126817:53130372:53130461:53133300:53133408 | 53130372:53130461 | ENSG00000147488.7 | ENST00000517456.1 |
| exon_skip_489658 | 8 | 53142591:53142637:53159145:53159224:53161917:53161972 | 53159145:53159224 | ENSG00000147488.7 | ENST00000518545.1 |
| exon_skip_489660 | 8 | 53142591:53142637:53159145:53159224:53321887:53322012 | 53159145:53159224 | ENSG00000147488.7 | ENST00000520279.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ST18 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000276480 | 53062291 | 53062537 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000276480 | 53062291 | 53062537 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ST18 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000276480 | 6204 | 1047 | 53062291 | 53062537 | 2491 | 2736 | 602 | 684 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000276480 | 6204 | 1047 | 53062291 | 53062537 | 2491 | 2736 | 602 | 684 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O60284 | 602 | 684 | 1 | 1047 | Chain | ID=PRO_0000234030;Note=Suppression of tumorigenicity 18 protein |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O60284 | 602 | 684 | 1 | 1047 | Chain | ID=PRO_0000234030;Note=Suppression of tumorigenicity 18 protein |
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SNVs in the skipped exons for ST18 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| ACC | TCGA-OR-A5LB-01 | exon_skip_489648 | 53062292 | 53062537 | 53062482 | 53062482 | Frame_Shift_Del | T | - | p.N621fs |
| STAD | TCGA-CD-A4MG-01 | exon_skip_489648 | 53062292 | 53062537 | 53062481 | 53062482 | Frame_Shift_Ins | - | T | p.N621fs |
| THCA | TCGA-DJ-A2Q6-01 | exon_skip_489648 | 53062292 | 53062537 | 53062481 | 53062482 | Frame_Shift_Ins | - | T | p.N621fs |
| STAD | TCGA-CD-A4MG-01 | exon_skip_489648 | 53062292 | 53062537 | 53062482 | 53062483 | Frame_Shift_Ins | - | T | p.N621fs |
| HNSC | TCGA-CR-7383-01 | exon_skip_489648 | 53062292 | 53062537 | 53062328 | 53062328 | Nonsense_Mutation | A | T | p.Y672* |
| BLCA | TCGA-DK-A3X1-01 | exon_skip_489648 | 53062292 | 53062537 | 53062372 | 53062372 | Nonsense_Mutation | G | A | p.Q658* |
| SKCM | TCGA-EE-A29R-06 | exon_skip_489648 | 53062292 | 53062537 | 53062480 | 53062480 | Nonsense_Mutation | G | A | p.R622* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC151_ENDOMETRIUM | 53062292 | 53062537 | 53062482 | 53062482 | Frame_Shift_Del | T | - | p.N621fs |
| SNGM_ENDOMETRIUM | 53062292 | 53062537 | 53062482 | 53062482 | Frame_Shift_Del | T | - | p.N621fs |
| SNU520_STOMACH | 53062292 | 53062537 | 53062482 | 53062482 | Frame_Shift_Del | T | - | p.N621fs |
| CTB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 53062292 | 53062537 | 53062481 | 53062482 | Frame_Shift_Ins | - | T | p.N621fs |
| HCC1419_BREAST | 53062292 | 53062537 | 53062298 | 53062300 | In_Frame_Del | CTC | - | p.E682del |
| SBC5_LUNG | 53062292 | 53062537 | 53062315 | 53062315 | Missense_Mutation | C | T | p.G677R |
| CORL321_PLEURA | 53062292 | 53062537 | 53062370 | 53062370 | Missense_Mutation | C | A | p.Q658H |
| BT474_BREAST | 53062292 | 53062537 | 53062419 | 53062419 | Missense_Mutation | G | A | p.S642F |
| MORCPR_LUNG | 53062292 | 53062537 | 53062490 | 53062490 | Missense_Mutation | C | T | p.M618I |
| HCT15_LARGE_INTESTINE | 53062292 | 53062537 | 53062537 | 53062537 | Splice_Site | C | A | p.G603* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ST18 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ST18 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ST18 |
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RelatedDrugs for ST18 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ST18 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| ST18 | C0001956 | alcohol use disorder | 1 | PSYGENET |
| ST18 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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