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Open reading frame (ORF) annotation in the exon skipping event | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon | |
Gene summary for IKBKE |
Gene summary |
Gene information | Gene symbol | IKBKE | Gene ID | 9641 |
Gene name | inhibitor of nuclear factor kappa B kinase subunit epsilon | |
Synonyms | IKK-E|IKK-i|IKKE|IKKI | |
Cytomap | 1q32.1 | |
Type of gene | protein-coding | |
Description | inhibitor of nuclear factor kappa-B kinase subunit epsilonI-kappa-B kinase epsilonIKK-epsilonIKK-related kinase epsiloninducible I kappa-B kinaseinducible IkappaB kinaseinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | |
Modification date | 20180523 | |
UniProtAcc | Q14164 | |
Context | PubMed: IKBKE [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
IKBKE | GO:0006468 | protein phosphorylation | 10882136|20188669|24882218 |
IKBKE | GO:0051260 | protein homooligomerization | 24882218 |
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Exon skipping events across known transcript of Ensembl for IKBKE from UCSC genome browser |
Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for IKBKE |
Expression levels of gene isoforms across TCGA. |
Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for IKBKE |
Information of exkip skipping event in TCGA. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
exon_skip_17209 | 1 | 206643840:206644041:206644498:206644588:206647673:206647814 | 206644498:206644588 | ENSG00000143466.9 | ENST00000463979.1,ENST00000537984.1 |
exon_skip_17211 | 1 | 206644503:206644588:206646538:206646657:206647673:206647814 | 206646538:206646657 | ENSG00000143466.9 | ENST00000367120.3 |
exon_skip_17213 | 1 | 206651091:206651202:206651502:206651682:206652285:206652476 | 206651502:206651682 | ENSG00000143466.9 | ENST00000537984.1,ENST00000367120.3 |
exon_skip_17221 | 1 | 206666355:206666452:206666598:206666711:206667252:206667324 | 206666598:206666711 | ENSG00000143466.9 | ENST00000537984.1,ENST00000367120.3 |
exon_skip_17224 | 1 | 206666598:206666711:206667252:206667324:206669444:206669607 | 206667252:206667324 | ENSG00000143466.9 | ENST00000537984.1,ENST00000367120.3 |
PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for IKBKE |
Information of exkip skipping event in GTEx |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
exon_skip_17209 | 1 | 206643840:206644041:206644498:206644588:206647673:206647814 | 206644498:206644588 | ENSG00000143466.9 | ENST00000537984.1,ENST00000463979.1 |
exon_skip_17211 | 1 | 206644503:206644588:206646538:206646657:206647673:206647814 | 206646538:206646657 | ENSG00000143466.9 | ENST00000367120.3 |
exon_skip_17213 | 1 | 206651091:206651202:206651502:206651682:206652285:206652476 | 206651502:206651682 | ENSG00000143466.9 | ENST00000367120.3,ENST00000537984.1 |
exon_skip_17221 | 1 | 206666355:206666452:206666598:206666711:206667252:206667324 | 206666598:206666711 | ENSG00000143466.9 | ENST00000367120.3,ENST00000537984.1 |
exon_skip_17224 | 1 | 206666598:206666711:206667252:206667324:206669444:206669607 | 206667252:206667324 | ENSG00000143466.9 | ENST00000367120.3,ENST00000537984.1 |
PSI values of skipped exons in GTEx. |
* Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for IKBKE |
Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for IKBKE |
Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in TCGA. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in GTEx. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for IKBKE |
- Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
- Differential PSIs between mutated versus non-mutated samples. |
- Non-synonymous mutations located in the skipped exons in TCGA. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Depth of coverage in the three exons composing exon skipping event |
Depth of coverage in three exons | Mutation description |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for IKBKE |
sQTL information located at the skipped exons. |
Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for IKBKE |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for IKBKE |
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RelatedDrugs for IKBKE |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Q14164 | DB12010 | Fostamatinib | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | small molecule | approved|investigational |
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RelatedDiseases for IKBKE |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
IKBKE | C0041696 | Unipolar Depression | 1 | PSYGENET |
IKBKE | C1269683 | Major Depressive Disorder | 1 | PSYGENET |