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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for WTAP |
 Gene summary |
| Gene information | Gene symbol | WTAP | Gene ID | 9589 |
| Gene name | WT1 associated protein | |
| Synonyms | Mum2 | |
| Cytomap | 6q25.3 | |
| Type of gene | protein-coding | |
| Description | pre-mRNA-splicing regulator WTAPPNAS-132Wilms tumor 1 associated proteinWilms' tumour 1-associating proteinfemale-lethal(2)D homologhFL(2)Dputative pre-mRNA splicing regulator female-lethal(2D)wilms tumor 1-associating protein | |
| Modification date | 20180523 | |
| UniProtAcc | Q15007 | |
| Context | PubMed: WTAP [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for WTAP from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for WTAP |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for WTAP |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_455153 | 6 | 160148619:160148735:160157289:160157327:160160021:160160077 | 160157289:160157327 | ENSG00000146457.10 | ENST00000337387.4 |
| exon_skip_455154 | 6 | 160157289:160157327:160160021:160160077:160163119:160163178 | 160160021:160160077 | ENSG00000146457.10 | ENST00000337387.4,ENST00000358372.4 |
| exon_skip_455159 | 6 | 160160021:160160077:160163119:160163178:160164696:160164726 | 160163119:160163178 | ENSG00000146457.10 | ENST00000337387.4,ENST00000358372.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for WTAP |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_455153 | 6 | 160148619:160148735:160157289:160157327:160160021:160160077 | 160157289:160157327 | ENSG00000146457.10 | ENST00000337387.4 |
| exon_skip_455154 | 6 | 160157289:160157327:160160021:160160077:160163119:160163178 | 160160021:160160077 | ENSG00000146457.10 | ENST00000358372.4,ENST00000337387.4 |
| exon_skip_455159 | 6 | 160160021:160160077:160163119:160163178:160164696:160164726 | 160163119:160163178 | ENSG00000146457.10 | ENST00000358372.4,ENST00000337387.4 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for WTAP |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000358372 | 160160021 | 160160077 | Frame-shift |
| ENST00000358372 | 160163119 | 160163178 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000358372 | 160160021 | 160160077 | Frame-shift |
| ENST00000358372 | 160163119 | 160163178 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for WTAP |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for WTAP |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
WTAP_PAAD_exon_skip_455159_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BRCA | TCGA-A8-A07F-01 | exon_skip_455159 | 160163120 | 160163178 | 160163165 | 160163165 | Nonsense_Mutation | C | A | p.Y44* |
| PAAD | TCGA-HZ-A9TJ-01 | exon_skip_455159 | 160163120 | 160163178 | 160163179 | 160163180 | Splice_Site | - | T | . |
| PAAD | TCGA-HZ-A9TJ-06 | exon_skip_455159 | 160163120 | 160163178 | 160163179 | 160163180 | Splice_Site | - | T | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-HZ-A9TJ-06 |
| Cancer type: PAAD | |
| ESID: exon_skip_455159 | |
| Skipped exon start: 160163120 | |
| Skipped exon end: 160163178 | |
| Mutation start: 160163179 | |
| Mutation end: 160163180 | |
| Mutation type: Splice_Site | |
| Reference seq: - | |
| Mutation seq: T | |
| AAchange: . | |
exon_skip_455159_PAAD_TCGA-HZ-A9TJ-06.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NCIH2342_LUNG | 160157290 | 160157327 | 160157316 | 160157316 | Missense_Mutation | C | G | p.L7V |
| NCIH1770_LUNG | 160160022 | 160160077 | 160160067 | 160160067 | Missense_Mutation | T | A | p.L26I |
| NCIH2106_LUNG | 160160022 | 160160077 | 160160067 | 160160067 | Missense_Mutation | T | A | p.L26I |
| HT115_LARGE_INTESTINE | 160160022 | 160160077 | 160160025 | 160160025 | Nonsense_Mutation | C | T | p.R12* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for WTAP |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for WTAP |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for WTAP |
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RelatedDrugs for WTAP |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WTAP |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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