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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for TP53I3

check button Gene summary
Gene informationGene symbol

TP53I3

Gene ID

9540

Gene nametumor protein p53 inducible protein 3
SynonymsPIG3
Cytomap

2p23.3

Type of geneprotein-coding
Descriptionquinone oxidoreductase PIG3p53-induced gene 3 proteinquinone oxidoreductase homolog
Modification date20180519
UniProtAcc

Q53FA7

ContextPubMed: TP53I3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
TP53I3

GO:0006739

NADP metabolic process

19349281


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Exon skipping events across known transcript of Ensembl for TP53I3 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for TP53I3

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for TP53I3

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_337345224300503:24300631:24302313:24302510:24303688:2430390124302313:24302510ENSG00000115129.9ENST00000238721.4,ENST00000335934.4
exon_skip_337348224300503:24300631:24303688:24303901:24305754:2430602224303688:24303901ENSG00000115129.9ENST00000407482.1,ENST00000313482.4
exon_skip_337352224302371:24302510:24303688:24303901:24305754:2430602224303688:24303901ENSG00000115129.9ENST00000238721.4,ENST00000335934.4
exon_skip_337354224303688:24303901:24305754:24306022:24307058:2430718124305754:24306022ENSG00000115129.9ENST00000238721.4,ENST00000335934.4,ENST00000407482.1,ENST00000313482.4,ENST00000413037.1
exon_skip_337357224303688:24303901:24305870:24306022:24307058:2430718124305870:24306022ENSG00000115129.9ENST00000417886.1
exon_skip_337362224305870:24306022:24307058:24307201:24307600:2430765524307058:24307201ENSG00000115129.9ENST00000313482.4

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for TP53I3

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_337345224300503:24300631:24302313:24302510:24303688:2430390124302313:24302510ENSG00000115129.9ENST00000335934.4,ENST00000238721.4
exon_skip_337348224300503:24300631:24303688:24303901:24305754:2430602224303688:24303901ENSG00000115129.9ENST00000313482.4,ENST00000407482.1
exon_skip_337352224302371:24302510:24303688:24303901:24305754:2430602224303688:24303901ENSG00000115129.9ENST00000335934.4,ENST00000238721.4
exon_skip_337354224303688:24303901:24305754:24306022:24307058:2430718124305754:24306022ENSG00000115129.9ENST00000335934.4,ENST00000238721.4,ENST00000313482.4,ENST00000407482.1,ENST00000413037.1
exon_skip_337357224303688:24303901:24305870:24306022:24307058:2430718124305870:24306022ENSG00000115129.9ENST00000417886.1
exon_skip_337362224305870:24306022:24307058:24307201:24307600:2430765524307058:24307201ENSG00000115129.9ENST00000313482.4

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for TP53I3

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000002387212430231324302510Frame-shift
ENST000003359342430231324302510Frame-shift
ENST000002387212430575424306022Frame-shift
ENST000003359342430575424306022Frame-shift
ENST000002387212430368824303901In-frame
ENST000003359342430368824303901In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000002387212430231324302510Frame-shift
ENST000003359342430231324302510Frame-shift
ENST000002387212430575424306022Frame-shift
ENST000003359342430575424306022Frame-shift
ENST000002387212430368824303901In-frame
ENST000003359342430368824303901In-frame

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Infer the effects of exon skipping event on protein functional features for TP53I3

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000002387212015332243036882430390112621474135206
ENST00000335934165233224303688243039018971109135206

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000002387212015332243036882430390112621474135206
ENST00000335934165233224303688243039018971109135206

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q53FA7135206143148Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206143148Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206167173Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206167173Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206187191Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206187191Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206192192Binding siteNote=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
Q53FA7135206192192Binding siteNote=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
Q53FA71352061332ChainID=PRO_0000160917;Note=Quinone oxidoreductase PIG3
Q53FA71352061332ChainID=PRO_0000160917;Note=Quinone oxidoreductase PIG3
Q53FA7135206152163HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206152163HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206175184HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206175184HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206197204HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206197204HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206151151MutagenesisNote=Loss of enzyme activity. S->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
Q53FA7135206151151MutagenesisNote=Loss of enzyme activity. S->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
Q53FA7135206180180Natural variantID=VAR_033032;Note=In a breast cancer sample%3B somatic mutation. M->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17224074;Dbxref=dbSNP:rs899619458,PMID:17224074
Q53FA7135206180180Natural variantID=VAR_033032;Note=In a breast cancer sample%3B somatic mutation. M->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17224074;Dbxref=dbSNP:rs899619458,PMID:17224074
Q53FA7135206148154Nucleotide bindingNote=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
Q53FA7135206148154Nucleotide bindingNote=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
Q53FA7135206173177Nucleotide bindingNote=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
Q53FA7135206173177Nucleotide bindingNote=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
Q53FA7135206133135TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206133135TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206192194TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206192194TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206205207TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206205207TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q53FA7135206143148Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206143148Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206167173Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206167173Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206187191Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206187191Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206192192Binding siteNote=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
Q53FA7135206192192Binding siteNote=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
Q53FA71352061332ChainID=PRO_0000160917;Note=Quinone oxidoreductase PIG3
Q53FA71352061332ChainID=PRO_0000160917;Note=Quinone oxidoreductase PIG3
Q53FA7135206152163HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206152163HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206175184HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206175184HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206197204HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206197204HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206151151MutagenesisNote=Loss of enzyme activity. S->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
Q53FA7135206151151MutagenesisNote=Loss of enzyme activity. S->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
Q53FA7135206180180Natural variantID=VAR_033032;Note=In a breast cancer sample%3B somatic mutation. M->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17224074;Dbxref=dbSNP:rs899619458,PMID:17224074
Q53FA7135206180180Natural variantID=VAR_033032;Note=In a breast cancer sample%3B somatic mutation. M->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17224074;Dbxref=dbSNP:rs899619458,PMID:17224074
Q53FA7135206148154Nucleotide bindingNote=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
Q53FA7135206148154Nucleotide bindingNote=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
Q53FA7135206173177Nucleotide bindingNote=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
Q53FA7135206173177Nucleotide bindingNote=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349281;Dbxref=PMID:19349281
Q53FA7135206133135TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206133135TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206192194TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206192194TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206205207TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z
Q53FA7135206205207TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J8Z


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SNVs in the skipped exons for TP53I3

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A39Y-01exon_skip_337345
24302314243025102430236224302362Frame_Shift_DelA-p.F256fs
LIHCTCGA-DD-A3A0-01exon_skip_337348
exon_skip_337352
24303689243039012430372624303726Frame_Shift_DelT-p.K194fs
LIHCTCGA-DD-A1EG-01exon_skip_337348
exon_skip_337352
24303689243039012430376024303760Frame_Shift_DelT-p.K183fs
LIHCTCGA-DD-A39Y-01exon_skip_337354
24305755243060222430597924305979Frame_Shift_DelA-p.L61fs
LIHCTCGA-DD-A39Y-01exon_skip_337357
24305871243060222430597924305979Frame_Shift_DelA-p.L61fs
LIHCTCGA-DD-A39Y-01exon_skip_337354
24305755243060222430600324306003Frame_Shift_DelG-p.P55fs
LIHCTCGA-DD-A39Y-01exon_skip_337357
24305871243060222430600324306003Frame_Shift_DelG-p.P55fs
LIHCTCGA-DD-A39Y-01exon_skip_337362
24307059243072012430711824307118Frame_Shift_DelC-p.E27fs
UCECTCGA-D1-A101-01exon_skip_337345
24302314243025102430235824302358Nonsense_MutationGAp.R258*
BRCATCGA-AO-A129-01exon_skip_337348
exon_skip_337352
24303689243039012430381424303814Nonsense_MutationCTp.W126*
SKCMTCGA-EE-A29M-06exon_skip_337354
24305755243060222430577324305773Nonsense_MutationGAp.Q130*
SKCMTCGA-EE-A29M-06exon_skip_337354
24305755243060222430577324305773Nonsense_MutationGAp.Q130X
KIRCTCGA-B0-5098-01exon_skip_337354
24305755243060222430587224305872Nonsense_MutationGAp.Q97*
KIRCTCGA-B0-5098-01exon_skip_337357
24305871243060222430587224305872Nonsense_MutationGAp.Q97*
KIRCTCGA-CJ-4902-01exon_skip_337362
24307059243072012430710024307100Nonsense_MutationTAp.K33*
KIRCTCGA-CJ-4902-01exon_skip_337362
24307059243072012430710024307100Nonsense_MutationTAp.K33X

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
SF268_CENTRAL_NERVOUS_SYSTEM24303689243039012430372524303726Frame_Shift_Ins-Tp.E195fs
MFE319_ENDOMETRIUM24303689243039012430372524303726Frame_Shift_Ins-Tp.E195fs
HEC6_ENDOMETRIUM24303689243039012430375124303751Missense_MutationGAp.A186V
NBTU110_AUTONOMIC_GANGLIA24303689243039012430378024303780Missense_MutationCAp.K176N
SNU1_STOMACH24303689243039012430382324303823Missense_MutationCTp.R162Q
HS742T_FIBROBLAST24303689243039012430385524303855Missense_MutationACp.S151R
EB2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE24303689243039012430385924303859Missense_MutationACp.L150R
EB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE24303689243039012430385924303859Missense_MutationACp.L150R
SISO_CERVIX24307059243072012430709324307093Missense_MutationGAp.A35V
GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE24307059243072012430709324307093Missense_MutationGAp.A35V
NCIH1623_LUNG24302314243025102430231524302315Splice_SiteTGp.K272T

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TP53I3

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TP53I3


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TP53I3


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RelatedDrugs for TP53I3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TP53I3

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
TP53I3C0024667Animal Mammary Neoplasms1CTD_human