ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for PPIG

Gene summary

Gene information	Gene symbol	PPIG
	Gene ID	9360
	Gene name	peptidylprolyl isomerase G
	Synonyms	CARS-Cyp\|CYP\|SCAF10\|SRCyp
	Cytomap	2q31.1
	Type of gene	protein-coding
	Description	peptidyl-prolyl cis-trans isomerase GCARS-cyclophilinCASP10Clk-associating RS-cyclophilinPPIase GSR-cyclophilinSR-cypSR-related CTD-associated factor 10cyclophilin Gpeptidyl-prolyl isomerase G (cyclophilin G)rotamase G
	Modification date	20180523
	UniProtAcc	Q13427
	Context	PubMed: PPIG [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
PPIG	GO:0000413	protein peptidyl-prolyl isomerization	20676357

Top

Exon skipping events across known transcript of Ensembl for PPIG from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Gene isoform structures and expression levels for PPIG

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

Top

Exon skipping events with PSIs in TCGA for PPIG

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_330898	2	170440867:170441000:170460151:170460204:170460535:170460612	170460151:170460204	ENSG00000138398.11	ENST00000530152.1,ENST00000409714.3
exon_skip_330901	2	170441156:170441409:170460151:170460204:170460535:170460612	170460151:170460204	ENSG00000138398.11	ENST00000414307.1
exon_skip_330903	2	170460549:170460612:170460696:170460771:170462548:170462589	170460696:170460771	ENSG00000138398.11	ENST00000418888.1,ENST00000260970.3,ENST00000530152.1,ENST00000409714.3,ENST00000462903.1,ENST00000414307.1,ENST00000448752.2
exon_skip_330904	2	170460696:170460771:170462548:170462656:170463613:170463658	170462548:170462656	ENSG00000138398.11	ENST00000260970.3,ENST00000530152.1,ENST00000462903.1,ENST00000414307.1,ENST00000448752.2
exon_skip_330905	2	170460696:170460771:170462612:170462656:170463613:170463658	170462612:170462656	ENSG00000138398.11	ENST00000417938.2
exon_skip_330906	2	170462612:170462656:170463613:170463658:170465180:170465268	170463613:170463658	ENSG00000138398.11	ENST00000417938.2,ENST00000260970.3,ENST00000530152.1,ENST00000433207.1,ENST00000462903.1,ENST00000414307.1,ENST00000448752.2
exon_skip_330907	2	170463613:170463658:170465180:170465268:170470973:170471003	170465180:170465268	ENSG00000138398.11	ENST00000417938.2,ENST00000260970.3,ENST00000433207.1,ENST00000462903.1,ENST00000414307.1,ENST00000448752.2
exon_skip_330908	2	170487359:170487497:170488108:170488157:170488275:170488443	170488108:170488157	ENSG00000138398.11	ENST00000482772.1
exon_skip_330910	2	170487359:170487497:170488275:170488443:170489669:170489757	170488275:170488443	ENSG00000138398.11	ENST00000260970.3,ENST00000409714.3,ENST00000462903.1,ENST00000448752.2
exon_skip_330911	2	170487359:170487497:170488284:170488443:170489669:170489757	170488284:170488443	ENSG00000138398.11	ENST00000433207.1
exon_skip_330912	2	170488284:170488443:170489669:170489757:170492601:170492738	170489669:170489757	ENSG00000138398.11	ENST00000466142.1,ENST00000260970.3,ENST00000433207.1,ENST00000409714.3,ENST00000482772.1,ENST00000448752.2
exon_skip_330915	2	170489669:170489757:170492601:170492738:170492922:170493251	170492601:170492738	ENSG00000138398.11	ENST00000260970.3,ENST00000433207.1,ENST00000409714.3,ENST00000482772.1,ENST00000448752.2

PSI values of skipped exons in TCGA.

Top

Exon skipping events with PSIs in GTEx for PPIG

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_330898	2	170440867:170441000:170460151:170460204:170460535:170460612	170460151:170460204	ENSG00000138398.11	ENST00000409714.3,ENST00000530152.1
exon_skip_330901	2	170441156:170441409:170460151:170460204:170460535:170460612	170460151:170460204	ENSG00000138398.11	ENST00000414307.1
exon_skip_330903	2	170460549:170460612:170460696:170460771:170462548:170462589	170460696:170460771	ENSG00000138398.11	ENST00000260970.3,ENST00000409714.3,ENST00000530152.1,ENST00000462903.1,ENST00000448752.2,ENST00000418888.1,ENST00000414307.1
exon_skip_330904	2	170460696:170460771:170462548:170462656:170463613:170463658	170462548:170462656	ENSG00000138398.11	ENST00000260970.3,ENST00000530152.1,ENST00000462903.1,ENST00000448752.2,ENST00000414307.1
exon_skip_330905	2	170460696:170460771:170462612:170462656:170463613:170463658	170462612:170462656	ENSG00000138398.11	ENST00000417938.2
exon_skip_330906	2	170462612:170462656:170463613:170463658:170465180:170465268	170463613:170463658	ENSG00000138398.11	ENST00000260970.3,ENST00000433207.1,ENST00000530152.1,ENST00000462903.1,ENST00000448752.2,ENST00000414307.1,ENST00000417938.2
exon_skip_330907	2	170463613:170463658:170465180:170465268:170470973:170471003	170465180:170465268	ENSG00000138398.11	ENST00000260970.3,ENST00000433207.1,ENST00000462903.1,ENST00000448752.2,ENST00000414307.1,ENST00000417938.2
exon_skip_330908	2	170487359:170487497:170488108:170488157:170488275:170488443	170488108:170488157	ENSG00000138398.11	ENST00000482772.1
exon_skip_330910	2	170487359:170487497:170488275:170488443:170489669:170489757	170488275:170488443	ENSG00000138398.11	ENST00000260970.3,ENST00000409714.3,ENST00000462903.1,ENST00000448752.2
exon_skip_330911	2	170487359:170487497:170488284:170488443:170489669:170489757	170488284:170488443	ENSG00000138398.11	ENST00000433207.1
exon_skip_330912	2	170488284:170488443:170489669:170489757:170492601:170492738	170489669:170489757	ENSG00000138398.11	ENST00000260970.3,ENST00000433207.1,ENST00000409714.3,ENST00000448752.2,ENST00000482772.1,ENST00000466142.1
exon_skip_330915	2	170489669:170489757:170492601:170492738:170492922:170493251	170492601:170492738	ENSG00000138398.11	ENST00000260970.3,ENST00000433207.1,ENST00000409714.3,ENST00000448752.2,ENST00000482772.1

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

Top

Open reading frame (ORF) annotation in the exon skipping event for PPIG

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000260970	170465180	170465268	Frame-shift
ENST00000448752	170465180	170465268	Frame-shift
ENST00000260970	170489669	170489757	Frame-shift
ENST00000448752	170489669	170489757	Frame-shift
ENST00000260970	170492601	170492738	Frame-shift
ENST00000448752	170492601	170492738	Frame-shift
ENST00000260970	170460696	170460771	In-frame
ENST00000448752	170460696	170460771	In-frame
ENST00000260970	170462548	170462656	In-frame
ENST00000448752	170462548	170462656	In-frame
ENST00000260970	170463613	170463658	In-frame
ENST00000448752	170463613	170463658	In-frame
ENST00000260970	170488275	170488443	In-frame
ENST00000448752	170488275	170488443	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000260970	170465180	170465268	Frame-shift
ENST00000448752	170465180	170465268	Frame-shift
ENST00000260970	170489669	170489757	Frame-shift
ENST00000448752	170489669	170489757	Frame-shift
ENST00000260970	170492601	170492738	Frame-shift
ENST00000448752	170492601	170492738	Frame-shift
ENST00000260970	170460696	170460771	In-frame
ENST00000448752	170460696	170460771	In-frame
ENST00000260970	170462548	170462656	In-frame
ENST00000448752	170462548	170462656	In-frame
ENST00000260970	170463613	170463658	In-frame
ENST00000448752	170463613	170463658	In-frame
ENST00000260970	170488275	170488443	In-frame
ENST00000448752	170488275	170488443	In-frame

Top

Infer the effects of exon skipping event on protein functional features for PPIG

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000260970	6385	754	170460696	170460771	282	356	20	45
ENST00000448752	2515	754	170460696	170460771	197	271	20	45
ENST00000260970	6385	754	170462548	170462656	357	464	45	81
ENST00000448752	2515	754	170462548	170462656	272	379	45	81
ENST00000260970	6385	754	170463613	170463658	465	509	81	96
ENST00000448752	2515	754	170463613	170463658	380	424	81	96
ENST00000260970	6385	754	170488275	170488443	982	1149	254	309
ENST00000448752	2515	754	170488275	170488443	897	1064	254	309

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000260970	6385	754	170460696	170460771	282	356	20	45
ENST00000448752	2515	754	170460696	170460771	197	271	20	45
ENST00000260970	6385	754	170462548	170462656	357	464	45	81
ENST00000448752	2515	754	170462548	170462656	272	379	45	81
ENST00000260970	6385	754	170463613	170463658	465	509	81	96
ENST00000448752	2515	754	170463613	170463658	380	424	81	96
ENST00000260970	6385	754	170488275	170488443	982	1149	254	309
ENST00000448752	2515	754	170488275	170488443	897	1064	254	309

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q13427	20	45	19	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	20	45	19	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	20	45	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
Q13427	20	45	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
Q13427	20	45	11	176	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00156
Q13427	20	45	11	176	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00156
Q13427	20	45	34	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	20	45	34	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	20	45	30	32	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	20	45	30	32	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	56	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	56	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	64	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	64	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	73	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	73	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
Q13427	45	81	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
Q13427	45	81	11	176	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00156
Q13427	45	81	11	176	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00156
Q13427	45	81	34	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	34	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	46	48	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFJ
Q13427	45	81	46	48	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFJ
Q13427	45	81	52	54	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	52	54	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	70	72	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	70	72	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	81	96	82	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	81	96	82	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	81	96	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
Q13427	81	96	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
Q13427	81	96	11	176	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00156
Q13427	81	96	11	176	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00156
Q13427	81	96	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	81	96	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	254	309	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
Q13427	254	309	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
Q13427	254	309	254	254	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
Q13427	254	309	254	254	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
Q13427	254	309	256	256	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
Q13427	254	309	256	256	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
Q13427	254	309	257	257	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
Q13427	254	309	257	257	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
Q13427	254	309	259	259	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
Q13427	254	309	259	259	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
Q13427	254	309	290	290	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
Q13427	254	309	290	290	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q13427	20	45	19	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	20	45	19	28	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	20	45	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
Q13427	20	45	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
Q13427	20	45	11	176	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00156
Q13427	20	45	11	176	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00156
Q13427	20	45	34	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	20	45	34	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	20	45	30	32	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	20	45	30	32	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	56	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	56	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	64	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	64	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	73	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	73	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
Q13427	45	81	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
Q13427	45	81	11	176	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00156
Q13427	45	81	11	176	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00156
Q13427	45	81	34	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	34	45	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	46	48	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFJ
Q13427	45	81	46	48	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFJ
Q13427	45	81	52	54	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	52	54	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	70	72	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	70	72	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	45	81	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	81	96	82	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	81	96	82	85	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	81	96	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
Q13427	81	96	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
Q13427	81	96	11	176	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00156
Q13427	81	96	11	176	Domain	Note=PPIase cyclophilin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00156
Q13427	81	96	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	81	96	79	81	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2WFI
Q13427	254	309	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
Q13427	254	309	1	754	Chain	ID=PRO_0000064150;Note=Peptidyl-prolyl cis-trans isomerase G
Q13427	254	309	254	254	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
Q13427	254	309	254	254	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
Q13427	254	309	256	256	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
Q13427	254	309	256	256	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
Q13427	254	309	257	257	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
Q13427	254	309	257	257	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
Q13427	254	309	259	259	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
Q13427	254	309	259	259	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
Q13427	254	309	290	290	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
Q13427	254	309	290	290	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569

Top

SNVs in the skipped exons for PPIG

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
LIHC	TCGA-DD-A1EG-01	exon_skip_330904	170462549	170462656	170462625	170462625	Frame_Shift_Del	T	-	p.D71fs
LIHC	TCGA-DD-A1EG-01	exon_skip_330905	170462613	170462656	170462625	170462625	Frame_Shift_Del	T	-	p.D71fs
LIHC	TCGA-DD-A3A0-01	exon_skip_330904	170462549	170462656	170462625	170462625	Frame_Shift_Del	T	-	p.D71fs
LIHC	TCGA-DD-A3A0-01	exon_skip_330905	170462613	170462656	170462625	170462625	Frame_Shift_Del	T	-	p.D71fs
UCEC	TCGA-BS-A0TA-01	exon_skip_330906	170463614	170463658	170463649	170463649	Frame_Shift_Del	T	-	p.F94fs
LIHC	TCGA-DD-A3A0-01	exon_skip_330912	170489670	170489757	170489711	170489711	Frame_Shift_Del	T	-	p.L325fs
LIHC	TCGA-BC-A112-01	exon_skip_330906	170463614	170463658	170463648	170463649	Frame_Shift_Ins	-	T	p.GF93fs
BLCA	TCGA-E7-A4IJ-01	exon_skip_330907	170465181	170465268	170465233	170465234	Frame_Shift_Ins	-	AG	p.R115fs
UCEC	TCGA-AP-A051-01	exon_skip_330912	170489670	170489757	170489707	170489707	Nonsense_Mutation	C	T	p.R323*
UCEC	TCGA-AP-A0LM-01	exon_skip_330912	170489670	170489757	170489743	170489743	Nonsense_Mutation	G	T	p.G335*
BLCA	TCGA-XF-A9SW-01	exon_skip_330906	170463614	170463658	170463658	170463659	Splice_Site	-	GTA	p.96_97insV
LUSC	TCGA-22-1016-01	exon_skip_330907	170465181	170465268	170465179	170465179	Splice_Site	A	G	p.D97_splice

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons

Mutation description

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
HEC59_ENDOMETRIUM	170463614	170463658	170463649	170463649	Frame_Shift_Del	T	-	p.F95fs
MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	170488285	170488443	170488418	170488419	Frame_Shift_Del	AG	-	p.R302fs
MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	170488276	170488443	170488418	170488419	Frame_Shift_Del	AG	-	p.R302fs
SUPHD1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	170460697	170460771	170460748	170460748	Missense_Mutation	A	T	p.E38V
COLO320_LARGE_INTESTINE	170460697	170460771	170460756	170460756	Missense_Mutation	C	T	p.R41C
SNGM_ENDOMETRIUM	170465181	170465268	170465192	170465192	Missense_Mutation	G	A	p.A101T
HEC251_ENDOMETRIUM	170488285	170488443	170488290	170488290	Missense_Mutation	G	A	p.S259N
HEC251_ENDOMETRIUM	170488276	170488443	170488290	170488290	Missense_Mutation	G	A	p.S259N
UMUC6_URINARY_TRACT	170488285	170488443	170488316	170488316	Missense_Mutation	C	T	p.P268S
UMUC6_URINARY_TRACT	170488276	170488443	170488316	170488316	Missense_Mutation	C	T	p.P268S
HEC108_ENDOMETRIUM	170488285	170488443	170488325	170488325	Missense_Mutation	A	G	p.T271A
HEC108_ENDOMETRIUM	170488276	170488443	170488325	170488325	Missense_Mutation	A	G	p.T271A
SKMEL3_SKIN	170488285	170488443	170488327	170488328	Missense_Mutation	TG	AC	p.V272L
SKMEL3_SKIN	170488276	170488443	170488327	170488328	Missense_Mutation	TG	AC	p.V272L
SKMEL3_SKIN	170488285	170488443	170488328	170488328	Missense_Mutation	G	C	p.V272L
SKMEL3_SKIN	170488276	170488443	170488328	170488328	Missense_Mutation	G	C	p.V272L
UPCISCC152_UPPER_AERODIGESTIVE_TRACT	170488285	170488443	170488342	170488342	Missense_Mutation	G	C	p.E276D
UPCISCC152_UPPER_AERODIGESTIVE_TRACT	170488276	170488443	170488342	170488342	Missense_Mutation	G	C	p.E276D
SCC90_UPPER_AERODIGESTIVE_TRACT	170488285	170488443	170488342	170488342	Missense_Mutation	G	C	p.E276D
SCC90_UPPER_AERODIGESTIVE_TRACT	170488276	170488443	170488342	170488342	Missense_Mutation	G	C	p.E276D
KMH2_THYROID	170492602	170492738	170492639	170492639	Missense_Mutation	G	A	p.R352H
KLE_ENDOMETRIUM	170492602	170492738	170492669	170492669	Nonsense_Mutation	G	A	p.W362*
NCIH1155_LUNG	170492602	170492738	170492683	170492683	Nonsense_Mutation	C	T	p.Q367*

Top

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PPIG

sQTL information located at the skipped exons.

Exon skip ID

Chromosome

Three exons

Skippped exon

ENST

Cancer type

SNP id

Location

DNA change (ref/var)

P-value

Top

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PPIG

Top

Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PPIG

Top

RelatedDrugs for PPIG

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for PPIG

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

Home

Download

Statistics

Landscape

Help

Contact