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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for TRIP12

check button Gene summary
Gene informationGene symbol

TRIP12

Gene ID

9320

Gene namethyroid hormone receptor interactor 12
SynonymsMRD49|TRIP-12|ULF
Cytomap

2q36.3

Type of geneprotein-coding
DescriptionE3 ubiquitin-protein ligase TRIP12E3 ubiquitin-protein ligase for ArfHECT-type E3 ubiquitin transferase TRIP12TR-interacting protein 12probable E3 ubiquitin-protein ligase TRIP12thyroid receptor interacting protein 12
Modification date20180523
UniProtAcc

Q14669

ContextPubMed: TRIP12 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
TRIP12

GO:0006511

ubiquitin-dependent protein catabolic process

18627766|20208519


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Exon skipping events across known transcript of Ensembl for TRIP12 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for TRIP12

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for TRIP12

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3473162230632156:230632466:230633331:230633435:230633946:230634041230633331:230633435ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4
exon_skip_3473182230633946:230634041:230636234:230636348:230638812:230638977230636234:230636348ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4
exon_skip_3473222230636234:230636348:230638812:230638977:230642030:230642195230638812:230638977ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4
exon_skip_3473272230638812:230638977:230642030:230642195:230643148:230643181230642030:230642195ENSG00000153827.9ENST00000459841.1,ENST00000283943.5,ENST00000389045.3,ENST00000418123.1,ENST00000389044.4
exon_skip_3473312230643148:230643303:230643591:230643706:230650472:230650571230643591:230643706ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4
exon_skip_3473332230650472:230650571:230652220:230652377:230653513:230653656230652220:230652377ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4
exon_skip_3473362230653513:230653656:230654326:230654478:230655839:230655967230654326:230654478ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4
exon_skip_3473382230655839:230655967:230656581:230656781:230656868:230656942230656581:230656781ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4
exon_skip_3473392230659894:230660046:230661306:230661498:230662405:230662547230661306:230661498ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4
exon_skip_3473402230663590:230663765:230663998:230664099:230666967:230667175230663998:230664099ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4
exon_skip_3473412230668286:230668405:230668714:230668943:230670445:230670518230668714:230668943ENSG00000153827.9ENST00000487178.1,ENST00000283943.5,ENST00000389045.3,ENST00000389044.4
exon_skip_3473422230672423:230672580:230672967:230673085:230675595:230675761230672967:230673085ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000479037.1,ENST00000389044.4
exon_skip_3473462230675851:230675920:230678585:230678747:230678948:230679041230678585:230678747ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000479037.1,ENST00000477441.1,ENST00000389044.4
exon_skip_3473502230693908:230694004:230695471:230695537:230701563:230701700230695471:230695537ENSG00000153827.9ENST00000283943.5
exon_skip_3473512230693908:230694004:230695471:230695555:230701563:230701700230695471:230695555ENSG00000153827.9ENST00000389045.3,ENST00000479037.1,ENST00000389044.4
exon_skip_3473542230705537:230705643:230723487:230724290:230744697:230744844230723487:230724290ENSG00000153827.9ENST00000283943.5,ENST00000479037.1
exon_skip_3473562230724091:230724290:230725121:230725247:230744697:230744844230725121:230725247ENSG00000153827.9ENST00000389044.4,ENST00000409677.1,ENST00000543084.1,ENST00000430954.1
exon_skip_3473572230725121:230725247:230744697:230744844:230786595:230786619230744697:230744844ENSG00000153827.9ENST00000389044.4,ENST00000409677.1,ENST00000543084.1
exon_skip_3473582230744697:230744844:230765452:230765574:230786595:230786619230765452:230765574ENSG00000153827.9ENST00000343290.5

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for TRIP12

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3473162230632156:230632466:230633331:230633435:230633946:230634041230633331:230633435ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4
exon_skip_3473182230633946:230634041:230636234:230636348:230638812:230638977230636234:230636348ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4
exon_skip_3473222230636234:230636348:230638812:230638977:230642030:230642195230638812:230638977ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4
exon_skip_3473272230638812:230638977:230642030:230642195:230643148:230643181230642030:230642195ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4,ENST00000418123.1,ENST00000459841.1
exon_skip_3473312230643148:230643303:230643591:230643706:230650472:230650571230643591:230643706ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4
exon_skip_3473332230650472:230650571:230652220:230652377:230653513:230653656230652220:230652377ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4
exon_skip_3473362230653513:230653656:230654326:230654478:230655839:230655967230654326:230654478ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4
exon_skip_3473382230655839:230655967:230656581:230656781:230656868:230656942230656581:230656781ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4
exon_skip_3473392230659894:230660046:230661306:230661498:230662405:230662547230661306:230661498ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4
exon_skip_3473402230663590:230663765:230663998:230664099:230666967:230667175230663998:230664099ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4
exon_skip_3473412230668286:230668405:230668714:230668943:230670445:230670518230668714:230668943ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4,ENST00000487178.1
exon_skip_3473422230672423:230672580:230672967:230673085:230675595:230675761230672967:230673085ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4,ENST00000479037.1
exon_skip_3473462230675851:230675920:230678585:230678747:230678948:230679041230678585:230678747ENSG00000153827.9ENST00000283943.5,ENST00000389045.3,ENST00000389044.4,ENST00000479037.1,ENST00000477441.1
exon_skip_3473502230693908:230694004:230695471:230695537:230701563:230701700230695471:230695537ENSG00000153827.9ENST00000283943.5
exon_skip_3473512230693908:230694004:230695471:230695555:230701563:230701700230695471:230695555ENSG00000153827.9ENST00000389045.3,ENST00000389044.4,ENST00000479037.1
exon_skip_3473542230705537:230705643:230723487:230724290:230744697:230744844230723487:230724290ENSG00000153827.9ENST00000283943.5,ENST00000479037.1
exon_skip_3473562230724091:230724290:230725121:230725247:230744697:230744844230725121:230725247ENSG00000153827.9ENST00000389044.4,ENST00000543084.1,ENST00000409677.1,ENST00000430954.1
exon_skip_3473582230744697:230744844:230765452:230765574:230786595:230786619230765452:230765574ENSG00000153827.9ENST00000343290.5

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for TRIP12

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000283943230633331230633435Frame-shift
ENST00000283943230643591230643706Frame-shift
ENST00000283943230652220230652377Frame-shift
ENST00000283943230654326230654478Frame-shift
ENST00000283943230656581230656781Frame-shift
ENST00000283943230663998230664099Frame-shift
ENST00000283943230668714230668943Frame-shift
ENST00000283943230672967230673085Frame-shift
ENST00000283943230723487230724290Frame-shift
ENST00000283943230636234230636348In-frame
ENST00000283943230638812230638977In-frame
ENST00000283943230642030230642195In-frame
ENST00000283943230661306230661498In-frame
ENST00000283943230678585230678747In-frame
ENST00000283943230695471230695537In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000283943230633331230633435Frame-shift
ENST00000283943230643591230643706Frame-shift
ENST00000283943230652220230652377Frame-shift
ENST00000283943230654326230654478Frame-shift
ENST00000283943230656581230656781Frame-shift
ENST00000283943230663998230664099Frame-shift
ENST00000283943230668714230668943Frame-shift
ENST00000283943230672967230673085Frame-shift
ENST00000283943230723487230724290Frame-shift
ENST00000283943230636234230636348In-frame
ENST00000283943230638812230638977In-frame
ENST00000283943230642030230642195In-frame
ENST00000283943230661306230661498In-frame
ENST00000283943230678585230678747In-frame
ENST00000283943230695471230695537In-frame

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Infer the effects of exon skipping event on protein functional features for TRIP12

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000002839439891199223069547123069553713241389381403
ENST000002839439891199223067858523067874718602021560614
ENST00000283943989119922306613062306614983579377011331197
ENST00000283943989119922306420302306421955319548317131768
ENST00000283943989119922306388122306389775484564817681823
ENST00000283943989119922306362342306363485649576218231861

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000002839439891199223069547123069553713241389381403
ENST000002839439891199223067858523067874718602021560614
ENST00000283943989119922306613062306614983579377011331197
ENST00000283943989119922306420302306421955319548317131768
ENST00000283943989119922306388122306389775484564817681823
ENST00000283943989119922306362342306363485649576218231861

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q1466938140321992ChainID=PRO_0000173872;Note=E3 ubiquitin-protein ligase TRIP12
Q146693814033381992Natural variantID=VAR_080432;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q146693814033521992Natural variantID=VAR_080433;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q1466956061421992ChainID=PRO_0000173872;Note=E3 ubiquitin-protein ligase TRIP12
Q146695606143381992Natural variantID=VAR_080432;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q146695606143521992Natural variantID=VAR_080433;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q146691133119721992ChainID=PRO_0000173872;Note=E3 ubiquitin-protein ligase TRIP12
Q14669113311973381992Natural variantID=VAR_080432;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q14669113311973521992Natural variantID=VAR_080433;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q146691713176821992ChainID=PRO_0000173872;Note=E3 ubiquitin-protein ligase TRIP12
Q14669171317683381992Natural variantID=VAR_080432;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q14669171317683521992Natural variantID=VAR_080433;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q146691713176814491992Natural variantID=VAR_080435;Note=In MRD49. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28251352;Dbxref=PMID:28251352
Q146691768182321992ChainID=PRO_0000173872;Note=E3 ubiquitin-protein ligase TRIP12
Q14669176818233381992Natural variantID=VAR_080432;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q14669176818233521992Natural variantID=VAR_080433;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q146691768182314491992Natural variantID=VAR_080435;Note=In MRD49. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28251352;Dbxref=PMID:28251352
Q146691823186121992ChainID=PRO_0000173872;Note=E3 ubiquitin-protein ligase TRIP12
Q14669182318613381992Natural variantID=VAR_080432;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q14669182318613521992Natural variantID=VAR_080433;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q146691823186114491992Natural variantID=VAR_080435;Note=In MRD49. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28251352;Dbxref=PMID:28251352
Q146691823186118401840Natural variantID=VAR_080438;Note=In MRD49. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q1466938140321992ChainID=PRO_0000173872;Note=E3 ubiquitin-protein ligase TRIP12
Q146693814033381992Natural variantID=VAR_080432;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q146693814033521992Natural variantID=VAR_080433;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q1466956061421992ChainID=PRO_0000173872;Note=E3 ubiquitin-protein ligase TRIP12
Q146695606143381992Natural variantID=VAR_080432;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q146695606143521992Natural variantID=VAR_080433;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q146691133119721992ChainID=PRO_0000173872;Note=E3 ubiquitin-protein ligase TRIP12
Q14669113311973381992Natural variantID=VAR_080432;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q14669113311973521992Natural variantID=VAR_080433;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q146691713176821992ChainID=PRO_0000173872;Note=E3 ubiquitin-protein ligase TRIP12
Q14669171317683381992Natural variantID=VAR_080432;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q14669171317683521992Natural variantID=VAR_080433;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q146691713176814491992Natural variantID=VAR_080435;Note=In MRD49. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28251352;Dbxref=PMID:28251352
Q146691768182321992ChainID=PRO_0000173872;Note=E3 ubiquitin-protein ligase TRIP12
Q14669176818233381992Natural variantID=VAR_080432;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q14669176818233521992Natural variantID=VAR_080433;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q146691768182314491992Natural variantID=VAR_080435;Note=In MRD49. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28251352;Dbxref=PMID:28251352
Q146691823186121992ChainID=PRO_0000173872;Note=E3 ubiquitin-protein ligase TRIP12
Q14669182318613381992Natural variantID=VAR_080432;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q14669182318613521992Natural variantID=VAR_080433;Note=In MRD49%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077
Q146691823186114491992Natural variantID=VAR_080435;Note=In MRD49. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28251352;Dbxref=PMID:28251352
Q146691823186118401840Natural variantID=VAR_080438;Note=In MRD49. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27848077;Dbxref=PMID:27848077


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SNVs in the skipped exons for TRIP12

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LGGTCGA-HT-7677-01exon_skip_347322
230638813230638977230638967230638968Frame_Shift_DelCT-p.1772_1772del
LGGTCGA-HT-7677-01exon_skip_347322
230638813230638977230638967230638968Frame_Shift_DelCT-p.S1772fs
LIHCTCGA-DD-A3A0-01exon_skip_347327
230642031230642195230642054230642054Frame_Shift_DelT-p.R1761fs
STADTCGA-CD-8527-01exon_skip_347333
230652221230652377230652221230652221Frame_Shift_DelT-p.K1590fs
LIHCTCGA-DD-A1EG-01exon_skip_347336
230654327230654478230654373230654373Frame_Shift_DelA-p.L1475fs
PRADTCGA-KK-A8IB-01exon_skip_347338
230656582230656781230656648230656649Frame_Shift_DelTC-p.E1375fs
KIRPTCGA-5P-A9JY-01exon_skip_347338
230656582230656781230656737230656737Frame_Shift_DelC-p.F1346fs
COADTCGA-AA-3492-01exon_skip_347339
230661307230661498230661315230661315Frame_Shift_DelA-p.S1195fs
COADTCGA-AD-6889-01exon_skip_347339
230661307230661498230661315230661315Frame_Shift_DelA-p.S1195fs
COADTCGA-G4-6586-01exon_skip_347339
230661307230661498230661315230661315Frame_Shift_DelA-p.S1195fs
COADTCGA-G4-6588-01exon_skip_347339
230661307230661498230661315230661315Frame_Shift_DelA-p.S1195fs
LIHCTCGA-G3-A3CJ-01exon_skip_347339
230661307230661498230661315230661315Frame_Shift_DelA-p.S1196fs
LUADTCGA-55-8506-01exon_skip_347339
230661307230661498230661315230661315Frame_Shift_DelA-p.S1196fs
UCECTCGA-AX-A06H-01exon_skip_347339
230661307230661498230661315230661315Frame_Shift_DelA-p.S1243fs
LIHCTCGA-O8-A75V-01exon_skip_347339
230661307230661498230661327230661327Frame_Shift_DelG-p.H1191fs
LIHCTCGA-DD-A3A0-01exon_skip_347339
230661307230661498230661375230661375Frame_Shift_DelT-p.S1175fs
LIHCTCGA-G3-A3CJ-01exon_skip_347341
230668715230668943230668730230668730Frame_Shift_DelT-p.N880fs
READTCGA-AG-4022-01exon_skip_347354
230723488230724290230723891230723891Frame_Shift_DelA-p.G167fs
HNSCTCGA-CN-5369-01exon_skip_347354
230723488230724290230724116230724116Frame_Shift_DelT-p.K91fs
LIHCTCGA-DD-A1EG-01exon_skip_347354
230723488230724290230724116230724116Frame_Shift_DelT-p.K91fs
LIHCTCGA-G3-A3CJ-01exon_skip_347356
230725122230725247230725175230725175Frame_Shift_DelG-p.P57fs
LIHCTCGA-DD-A3A0-01exon_skip_347357
230744698230744844230744763230744763Frame_Shift_DelC-p.G11fs
UCECTCGA-D1-A101-01exon_skip_347357
230744698230744844230744763230744763Frame_Shift_DelC-p.G11fs
KIRCTCGA-CW-5587-01exon_skip_347338
230656582230656781230656670230656671Frame_Shift_Ins-Ap.I1368fs
BRCATCGA-E9-A1ND-01exon_skip_347339
230661307230661498230661314230661315Frame_Shift_Ins-Ap.S1195fs
LUADTCGA-75-5126-01exon_skip_347339
230661307230661498230661474230661475Frame_Shift_Ins-Ap.L1141fs
LUADTCGA-75-5126-01exon_skip_347339
230661307230661498230661474230661475Frame_Shift_Ins-Ap.R1142fs
COADTCGA-AU-6004-01exon_skip_347341
230668715230668943230668729230668730Frame_Shift_Ins-Tp.N880fs
STADTCGA-BR-4256-01exon_skip_347354
230723488230724290230724115230724116Frame_Shift_Ins-Tp.P92fs
STADTCGA-BR-4370-01exon_skip_347354
230723488230724290230724115230724116Frame_Shift_Ins-Tp.P92fs
UCECTCGA-B5-A0K2-01exon_skip_347354
230723488230724290230724115230724116Frame_Shift_Ins-Tp.K133fs
UCECTCGA-B5-A0K7-01exon_skip_347354
230723488230724290230724115230724116Frame_Shift_Ins-Tp.K133fs
UCECTCGA-BG-A0M0-01exon_skip_347354
230723488230724290230724115230724116Frame_Shift_Ins-Tp.K133fs
UCECTCGA-BG-A0M3-01exon_skip_347354
230723488230724290230724115230724116Frame_Shift_Ins-Tp.K133fs
UCECTCGA-BG-A0M9-01exon_skip_347354
230723488230724290230724115230724116Frame_Shift_Ins-Tp.K133fs
STADTCGA-BR-4256-01exon_skip_347354
230723488230724290230724116230724117Frame_Shift_Ins-Tp.K133fs
STADTCGA-BR-4370-01exon_skip_347354
230723488230724290230724116230724117Frame_Shift_Ins-Tp.K133fs
LUSCTCGA-60-2698-01exon_skip_347322
230638813230638977230638827230638827Nonsense_MutationCAp.E1867*
KIRCTCGA-CJ-6030-01exon_skip_347327
230642031230642195230642131230642131Nonsense_MutationGTp.S1735*
KIRCTCGA-CJ-6030-01exon_skip_347327
230642031230642195230642131230642131Nonsense_MutationGTp.S1735X
HNSCTCGA-BA-6869-01exon_skip_347333
230652221230652377230652349230652349Nonsense_MutationGAp.Q1548*
UCECTCGA-A5-A0GP-01exon_skip_347336
230654327230654478230654350230654350Nonsense_MutationGAp.R1483*
BLCATCGA-XF-AAN5-01exon_skip_347339
230661307230661498230661446230661446Nonsense_MutationGCp.S1151*
LUADTCGA-75-5126-01exon_skip_347339
230661307230661498230661452230661452Nonsense_MutationGCp.S1149*
THCATCGA-DJ-A2Q1-01exon_skip_347340
230663999230664099230664036230664036Nonsense_MutationGTp.Y1015*
STADTCGA-FP-A4BE-01exon_skip_347340
230663999230664099230664071230664071Nonsense_MutationGAp.R1004*
STADTCGA-FP-A4BE-01exon_skip_347340
230663999230664099230664071230664071Nonsense_MutationGAp.R1004X
LGGTCGA-HT-7610-01exon_skip_347341
230668715230668943230668911230668911Nonsense_MutationGAp.R820*
LGGTCGA-HT-7610-01exon_skip_347341
230668715230668943230668911230668911Nonsense_MutationGAp.R820X
BLCATCGA-E7-A541-01exon_skip_347341
230668715230668943230668934230668934Nonsense_MutationGCp.S812*
CESCTCGA-DS-A1OC-01exon_skip_347354
230723488230724290230723526230723526Nonsense_MutationGCp.S288*
LUADTCGA-17-Z031-01exon_skip_347354
230723488230724290230723819230723819Nonsense_MutationATp.C190*
CESCTCGA-FU-A23L-01exon_skip_347354
230723488230724290230723835230723835Nonsense_MutationGCp.S185*
LUADTCGA-69-A59K-01exon_skip_347354
230723488230724290230723835230723835Nonsense_MutationGCp.S185*
BLCATCGA-GC-A3I6-01exon_skip_347354
230723488230724290230723895230723895Nonsense_MutationGCp.S165*
LUADTCGA-50-5941-01exon_skip_347354
230723488230724290230724103230724103Nonsense_MutationGAp.Q96*
UCECTCGA-BG-A0LX-01exon_skip_347341
230668715230668943230668714230668714Splice_SiteCTe17+1
UCECTCGA-BG-A0LX-01exon_skip_347341
230668715230668943230668714230668714Splice_SiteCTp.S933_splice
TGCTTCGA-2G-AAFV-01exon_skip_347341
230668715230668943230668944230668944Splice_SiteCG.
UCECTCGA-AP-A0LM-01exon_skip_347342
230672968230673085230673086230673086Splice_SiteCAe14-1
STADTCGA-R5-A7ZI-01exon_skip_347346
230678586230678747230678584230678584Splice_SiteAT.
LUADTCGA-50-5931-01exon_skip_347346
230678586230678747230678748230678748Splice_SiteCAp.G561_splice

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
SNUC2A_LARGE_INTESTINE230652221230652377230652337230652337Frame_Shift_DelA-p.Y1552fs
HEC151_ENDOMETRIUM230656582230656781230656733230656733Frame_Shift_DelA-p.Y1347fs
CCK81_LARGE_INTESTINE230723488230724290230724116230724116Frame_Shift_DelT-p.K91fs
MDAPCA2B_PROSTATE230723488230724290230724211230724211Frame_Shift_DelT-p.T60fs
TGBC11TKB_STOMACH230723488230724290230724211230724211Frame_Shift_DelT-p.T60fs
HEC151_ENDOMETRIUM230723488230724290230724115230724116Frame_Shift_Ins-Tp.P92fs
LOVO_LARGE_INTESTINE230723488230724290230724115230724116Frame_Shift_Ins-Tp.P92fs
SKUT1_SOFT_TISSUE230723488230724290230724115230724116Frame_Shift_Ins-Tp.P92fs
A253_SALIVARY_GLAND230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
ACHN_KIDNEY230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
AM38_CENTRAL_NERVOUS_SYSTEM230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
BICR56_UPPER_AERODIGESTIVE_TRACT230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
BXPC3_PANCREAS230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
CAL120_BREAST230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
CCFSTTG1_CENTRAL_NERVOUS_SYSTEM230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
COLO678_LARGE_INTESTINE230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
DV90_LUNG230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
EFM192A_BREAST230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
EOL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
GB1_CENTRAL_NERVOUS_SYSTEM230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
HEC108_ENDOMETRIUM230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
HEC151_ENDOMETRIUM230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
HS274T_BREAST230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
HS739T_FIBROBLAST230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
HS822T_FIBROBLAST230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
HS840T_FIBROBLAST230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
HS944T_SKIN230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
HT144_SKIN230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
HT55_LARGE_INTESTINE230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
HUT102_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
IGR39_SKIN230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
ISHIKAWAHERAKLIO02ER_ENDOMETRIUM230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
JHOM1_OVARY230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
KMRC1_KIDNEY230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
KPNYN_AUTONOMIC_GANGLIA230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
LMSU_STOMACH230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
LN464_CENTRAL_NERVOUS_SYSTEM230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
MDST8_LARGE_INTESTINE230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
MPP89_PLEURA230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
NCIH1105_LUNG230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
NCIH1792_LUNG230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
NCIH854_LUNG230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
NCIH929_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
OAW42_OVARY230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
RI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
RMGI_OVARY230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
SKOV3_OVARY230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
SNB75_CENTRAL_NERVOUS_SYSTEM230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
SNU1066_UPPER_AERODIGESTIVE_TRACT230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
SNU1076_UPPER_AERODIGESTIVE_TRACT230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
SNU201_CENTRAL_NERVOUS_SYSTEM230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
SNU308_BILIARY_TRACT230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
SNU349_KIDNEY230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
SUDHL6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
TCCSUP_URINARY_TRACT230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
TE1_OESOPHAGUS230723488230724290230724210230724211Frame_Shift_Ins-Tp.T60fs
SNU216_STOMACH230636235230636348230636299230636299Missense_MutationGAp.S1840L
KASUMI2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE230638813230638977230638883230638883Missense_MutationGAp.P1800L
HEC108_ENDOMETRIUM230638813230638977230638890230638890Missense_MutationCAp.G1798W
HEC6_ENDOMETRIUM230643592230643706230643647230643647Missense_MutationCAp.Q1643H
MZ7MEL_SKIN230643592230643706230643672230643672Missense_MutationTCp.Y1635C
FU97_STOMACH230652221230652377230652226230652226Missense_MutationTGp.K1589Q
HCC2157_BREAST230652221230652377230652244230652244Missense_MutationCAp.A1583S
HEC151_ENDOMETRIUM230652221230652377230652319230652319Missense_MutationGAp.R1558W
MFE319_ENDOMETRIUM230652221230652377230652367230652367Missense_MutationATp.F1542I
OUMS23_LARGE_INTESTINE230654327230654478230654358230654358Missense_MutationGTp.A1480D
HCT15_LARGE_INTESTINE230654327230654478230654370230654370Missense_MutationCAp.R1476I
BICR18_UPPER_AERODIGESTIVE_TRACT230654327230654478230654458230654458Missense_MutationACp.S1447A
KG1C_CENTRAL_NERVOUS_SYSTEM230654327230654478230654466230654466Missense_MutationGTp.P1444Q
SHP77_LUNG230656582230656781230656584230656584Missense_MutationTCp.I1396M
TE14_OESOPHAGUS230656582230656781230656640230656640Missense_MutationCTp.D1378N
DERL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE230656582230656781230656721230656721Missense_MutationGAp.H1351Y
NO11_CENTRAL_NERVOUS_SYSTEM230661307230661498230661319230661319Missense_MutationATp.F1193L
MZ7MEL_SKIN230661307230661498230661387230661387Missense_MutationATp.L1171M
NHAHTDD_CENTRAL_NERVOUS_SYSTEM230661307230661498230661416230661416Missense_MutationCTp.S1161N
NCIH378_LUNG230663999230664099230664061230664061Missense_MutationTAp.K1007I
SNU1040_LARGE_INTESTINE230663999230664099230664065230664065Missense_MutationGAp.P1006S
HCT15_LARGE_INTESTINE230668715230668943230668744230668744Missense_MutationCAp.K875N
HS578T_BREAST230668715230668943230668805230668805Missense_MutationCAp.R855I
ISTSL2_LUNG230668715230668943230668896230668896Missense_MutationTCp.K825E
BICR18_UPPER_AERODIGESTIVE_TRACT230668715230668943230668928230668928Missense_MutationGAp.S814L
S117_SOFT_TISSUE230668715230668943230668928230668928Missense_MutationGAp.S814L
GP2D_LARGE_INTESTINE230672968230673085230672971230672971Missense_MutationAGp.I731T
GP5D_LARGE_INTESTINE230672968230673085230672971230672971Missense_MutationAGp.I731T
JHOM1_OVARY230672968230673085230673046230673046Missense_MutationGAp.S706F
LN18_CENTRAL_NERVOUS_SYSTEM230678586230678747230678674230678674Missense_MutationGTp.A585E
SNU668_STOMACH230723488230724290230723680230723680Missense_MutationCTp.A237T
EFO27_OVARY230723488230724290230723680230723680Missense_MutationCTp.A237T
MEG01_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE230723488230724290230723680230723680Missense_MutationCTp.A237T
BC3C_URINARY_TRACT230723488230724290230723800230723800Missense_MutationATp.S197T
TTC1240_SOFT_TISSUE230723488230724290230723871230723871Missense_MutationGTp.A173E
JHUEM7_ENDOMETRIUM230723488230724290230723925230723925Missense_MutationGTp.S155Y
JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE230723488230724290230723955230723955Missense_MutationCTp.R145Q
639V_URINARY_TRACT230723488230724290230723955230723955Missense_MutationCTp.R145Q
CCK81_LARGE_INTESTINE230723488230724290230724004230724004Missense_MutationAGp.S129P
HMEL_BREAST230723488230724290230724063230724063Missense_MutationCTp.S109N
JHUEM7_ENDOMETRIUM230723488230724290230724112230724112Missense_MutationTCp.K93E
DU145_PROSTATE230723488230724290230724124230724124Missense_MutationCTp.A89T
KNS60_CENTRAL_NERVOUS_SYSTEM230723488230724290230724157230724157Missense_MutationGAp.P78S
ESS1_ENDOMETRIUM230723488230724290230724214230724214Missense_MutationTGp.K59Q
SISO_CERVIX230723488230724290230724235230724235Missense_MutationCTp.A52T
GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE230723488230724290230724235230724235Missense_MutationCTp.A52T
HEC108_ENDOMETRIUM230723488230724290230724241230724241Missense_MutationCTp.D50N
CCK81_LARGE_INTESTINE230744698230744844230744714230744714Missense_MutationCTp.D28N
NCIH2081_LUNG230744698230744844230744723230744723Missense_MutationGAp.P25S
SW1271_LUNG230744698230744844230744729230744729Missense_MutationCAp.A23S
YD38_UPPER_AERODIGESTIVE_TRACT230723488230724290230723830230723830Nonsense_MutationTAp.K187*
MFE319_ENDOMETRIUM230643592230643706230643592230643592Splice_SiteCAp.G1662W

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRIP12

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value
exon_skip_3473542230705537:230705643:230723487:230724290:230744697:230744844230723487:230724290ENST00000283943.5,ENST00000479037.1LUSCrs544480chr2:230723777G/C1.99e-03

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRIP12


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRIP12


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RelatedDrugs for TRIP12

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIP12

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource