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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for STK17B |
 Gene summary |
| Gene information | Gene symbol | STK17B | Gene ID | 9262 |
| Gene name | serine/threonine kinase 17b | |
| Synonyms | DRAK2 | |
| Cytomap | 2q32.3 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase 17BDAP kinase-related apoptosis-inducing protein kinase 2death-associated protein kinase-related 2 | |
| Modification date | 20180523 | |
| UniProtAcc | O94768 | |
| Context | PubMed: STK17B [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| STK17B | GO:0006468 | protein phosphorylation | 9786912 |
| STK17B | GO:0035556 | intracellular signal transduction | 9786912 |
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Exon skipping events across known transcript of Ensembl for STK17B from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for STK17B |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for STK17B |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_345723 | 2 | 197004343:197004523:197005972:197006021:197008283:197008410 | 197005972:197006021 | ENSG00000081320.6 | ENST00000263955.4,ENST00000409228.1 |
| exon_skip_345724 | 2 | 197008283:197008410:197010634:197010779:197021162:197021375 | 197010634:197010779 | ENSG00000081320.6 | ENST00000263955.4,ENST00000409228.1 |
| exon_skip_345727 | 2 | 197010634:197010779:197021162:197021375:197027985:197028151 | 197021162:197021375 | ENSG00000081320.6 | ENST00000263955.4,ENST00000409228.1 |
| exon_skip_345730 | 2 | 197028087:197028151:197038972:197039131:197040949:197041051 | 197038972:197039131 | ENSG00000081320.6 | ENST00000420683.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for STK17B |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_345723 | 2 | 197004343:197004523:197005972:197006021:197008283:197008410 | 197005972:197006021 | ENSG00000081320.6 | ENST00000263955.4,ENST00000409228.1 |
| exon_skip_345724 | 2 | 197008283:197008410:197010634:197010779:197021162:197021375 | 197010634:197010779 | ENSG00000081320.6 | ENST00000263955.4,ENST00000409228.1 |
| exon_skip_345727 | 2 | 197010634:197010779:197021162:197021375:197027985:197028151 | 197021162:197021375 | ENSG00000081320.6 | ENST00000263955.4,ENST00000409228.1 |
| exon_skip_345730 | 2 | 197028087:197028151:197038972:197039131:197040949:197041051 | 197038972:197039131 | ENSG00000081320.6 | ENST00000420683.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for STK17B |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000263955 | 197005972 | 197006021 | Frame-shift |
| ENST00000409228 | 197005972 | 197006021 | Frame-shift |
| ENST00000263955 | 197010634 | 197010779 | Frame-shift |
| ENST00000409228 | 197010634 | 197010779 | Frame-shift |
| ENST00000263955 | 197021162 | 197021375 | In-frame |
| ENST00000409228 | 197021162 | 197021375 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000263955 | 197005972 | 197006021 | Frame-shift |
| ENST00000409228 | 197005972 | 197006021 | Frame-shift |
| ENST00000263955 | 197010634 | 197010779 | Frame-shift |
| ENST00000409228 | 197010634 | 197010779 | Frame-shift |
| ENST00000263955 | 197021162 | 197021375 | In-frame |
| ENST00000409228 | 197021162 | 197021375 | In-frame |
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Infer the effects of exon skipping event on protein functional features for STK17B |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000263955 | 5304 | 372 | 197021162 | 197021375 | 410 | 622 | 41 | 111 |
| ENST00000409228 | 1458 | 372 | 197021162 | 197021375 | 445 | 657 | 41 | 111 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000263955 | 5304 | 372 | 197021162 | 197021375 | 410 | 622 | 41 | 111 |
| ENST00000409228 | 1458 | 372 | 197021162 | 197021375 | 445 | 657 | 41 | 111 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O94768 | 41 | 111 | 32 | 42 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 32 | 42 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 45 | 52 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 45 | 52 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 58 | 68 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 58 | 68 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 96 | 101 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 96 | 101 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 103 | 111 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 103 | 111 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 62 | 62 | Binding site | Note=ATP |
| O94768 | 41 | 111 | 62 | 62 | Binding site | Note=ATP |
| O94768 | 41 | 111 | 1 | 372 | Chain | ID=PRO_0000086706;Note=Serine/threonine-protein kinase 17B |
| O94768 | 41 | 111 | 1 | 372 | Chain | ID=PRO_0000086706;Note=Serine/threonine-protein kinase 17B |
| O94768 | 41 | 111 | 33 | 293 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O94768 | 41 | 111 | 33 | 293 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O94768 | 41 | 111 | 74 | 86 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 74 | 86 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 62 | 62 | Mutagenesis | Note=Loss of activity and of apoptotic function. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9786912;Dbxref=PMID:9786912 |
| O94768 | 41 | 111 | 62 | 62 | Mutagenesis | Note=Loss of activity and of apoptotic function. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9786912;Dbxref=PMID:9786912 |
| O94768 | 41 | 111 | 39 | 47 | Nucleotide binding | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O94768 | 41 | 111 | 39 | 47 | Nucleotide binding | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O94768 | 41 | 111 | 53 | 55 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 53 | 55 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 87 | 89 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 87 | 89 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O94768 | 41 | 111 | 32 | 42 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 32 | 42 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 45 | 52 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 45 | 52 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 58 | 68 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 58 | 68 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 96 | 101 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 96 | 101 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 103 | 111 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 103 | 111 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 62 | 62 | Binding site | Note=ATP |
| O94768 | 41 | 111 | 62 | 62 | Binding site | Note=ATP |
| O94768 | 41 | 111 | 1 | 372 | Chain | ID=PRO_0000086706;Note=Serine/threonine-protein kinase 17B |
| O94768 | 41 | 111 | 1 | 372 | Chain | ID=PRO_0000086706;Note=Serine/threonine-protein kinase 17B |
| O94768 | 41 | 111 | 33 | 293 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O94768 | 41 | 111 | 33 | 293 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O94768 | 41 | 111 | 74 | 86 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 74 | 86 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 62 | 62 | Mutagenesis | Note=Loss of activity and of apoptotic function. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9786912;Dbxref=PMID:9786912 |
| O94768 | 41 | 111 | 62 | 62 | Mutagenesis | Note=Loss of activity and of apoptotic function. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9786912;Dbxref=PMID:9786912 |
| O94768 | 41 | 111 | 39 | 47 | Nucleotide binding | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O94768 | 41 | 111 | 39 | 47 | Nucleotide binding | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O94768 | 41 | 111 | 53 | 55 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 53 | 55 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 87 | 89 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
| O94768 | 41 | 111 | 87 | 89 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LM5 |
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SNVs in the skipped exons for STK17B |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| COAD | TCGA-CM-5861-01 | exon_skip_345727 | 197021163 | 197021375 | 197021224 | 197021224 | Frame_Shift_Del | G | - | p.R92fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_345727 | 197021163 | 197021375 | 197021224 | 197021224 | Frame_Shift_Del | G | - | p.R92fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_345727 | 197021163 | 197021375 | 197021309 | 197021309 | Frame_Shift_Del | A | - | p.F63fs |
| STAD | TCGA-FP-A4BE-01 | exon_skip_345727 | 197021163 | 197021375 | 197021326 | 197021327 | Frame_Shift_Ins | - | T | p.E58fs |
| STAD | TCGA-FP-A4BE-01 | exon_skip_345727 | 197021163 | 197021375 | 197021327 | 197021328 | Frame_Shift_Ins | - | T | p.Q57fs |
| BRCA | TCGA-AR-A0TX-01 | exon_skip_345724 | 197010635 | 197010779 | 197010664 | 197010664 | Nonsense_Mutation | G | A | p.Q151* |
| SKCM | TCGA-YD-A9TA-06 | exon_skip_345724 | 197010635 | 197010779 | 197010674 | 197010674 | Nonsense_Mutation | A | T | p.Y147* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 197010635 | 197010779 | 197010746 | 197010747 | Frame_Shift_Ins | - | A | p.L123fs |
| SNU1033_LARGE_INTESTINE | 197021163 | 197021375 | 197021291 | 197021293 | In_Frame_Del | TCT | - | p.R69del |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 197010635 | 197010779 | 197010676 | 197010676 | Missense_Mutation | A | G | p.Y147H |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 197010635 | 197010779 | 197010681 | 197010681 | Missense_Mutation | C | T | p.G145E |
| LCLC97TM1_LUNG | 197010635 | 197010779 | 197010700 | 197010700 | Missense_Mutation | T | C | p.I139V |
| SNU449_LIVER | 197021163 | 197021375 | 197021194 | 197021194 | Missense_Mutation | T | A | p.N102Y |
| FTC133_THYROID | 197021163 | 197021375 | 197021262 | 197021262 | Missense_Mutation | T | C | p.H79R |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STK17B |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK17B |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK17B |
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RelatedDrugs for STK17B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| O94768 | DB12010 | Fostamatinib | Serine/threonine-protein kinase 17B | small molecule | approved|investigational |
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RelatedDiseases for STK17B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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