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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for DCLK1 |
 Gene summary |
| Gene information | Gene symbol | DCLK1 | Gene ID | 9201 |
| Gene name | doublecortin like kinase 1 | |
| Synonyms | CL1|CLICK1|DCAMKL1|DCDC3A|DCLK | |
| Cytomap | 13q13.3 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase DCLK1doublecortin domain-containing protein 3Adoublecortin-like and CAM kinase-like 1 | |
| Modification date | 20180527 | |
| UniProtAcc | O15075 | |
| Context | PubMed: DCLK1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for DCLK1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for DCLK1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for DCLK1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_102900 | 13 | 36345477:36348836:36362348:36362422:36367502:36367616 | 36362348:36362422 | ENSG00000133083.10 | ENST00000255448.4 |
| exon_skip_102901 | 13 | 36382360:36382457:36383154:36383232:36384971:36385105 | 36383154:36383232 | ENSG00000133083.10 | ENST00000360631.3,ENST00000255448.4,ENST00000379893.1 |
| exon_skip_102903 | 13 | 36413228:36413313:36428635:36428730:36445360:36445477 | 36428635:36428730 | ENSG00000133083.10 | ENST00000360631.3,ENST00000255448.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for DCLK1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_102900 | 13 | 36345477:36348836:36362348:36362422:36367502:36367616 | 36362348:36362422 | ENSG00000133083.10 | ENST00000255448.4 |
| exon_skip_102901 | 13 | 36382360:36382457:36383154:36383232:36384971:36385105 | 36383154:36383232 | ENSG00000133083.10 | ENST00000379893.1,ENST00000255448.4,ENST00000360631.3 |
| exon_skip_102903 | 13 | 36413228:36413313:36428635:36428730:36445360:36445477 | 36428635:36428730 | ENSG00000133083.10 | ENST00000255448.4,ENST00000360631.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for DCLK1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000360631 | 36428635 | 36428730 | Frame-shift |
| ENST00000360631 | 36383154 | 36383232 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000360631 | 36428635 | 36428730 | Frame-shift |
| ENST00000360631 | 36383154 | 36383232 | In-frame |
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Infer the effects of exon skipping event on protein functional features for DCLK1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000360631 | 5646 | 740 | 36383154 | 36383232 | 1901 | 1978 | 563 | 588 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000360631 | 5646 | 740 | 36383154 | 36383232 | 1901 | 1978 | 563 | 588 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O15075 | 563 | 588 | 1 | 740 | Chain | ID=PRO_0000085919;Note=Serine/threonine-protein kinase DCLK1 |
| O15075 | 563 | 588 | 390 | 647 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O15075 | 563 | 588 | 568 | 582 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JZJ |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O15075 | 563 | 588 | 1 | 740 | Chain | ID=PRO_0000085919;Note=Serine/threonine-protein kinase DCLK1 |
| O15075 | 563 | 588 | 390 | 647 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O15075 | 563 | 588 | 568 | 582 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JZJ |
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SNVs in the skipped exons for DCLK1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A1-01 | exon_skip_102903 | 36428636 | 36428730 | 36428718 | 36428718 | Frame_Shift_Del | G | - | p.P318fs |
| STAD | TCGA-BR-A4PE-01 | exon_skip_102903 | 36428636 | 36428730 | 36428642 | 36428643 | Frame_Shift_Ins | - | CC | p.K343fs |
| READ | TCGA-AF-4110-01 | exon_skip_102901 | 36383155 | 36383232 | 36383222 | 36383222 | Nonsense_Mutation | T | A | p.K260X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| COLO679_SKIN | 36383155 | 36383232 | 36383168 | 36383168 | Missense_Mutation | G | A | p.P585S |
| 2313287_STOMACH | 36383155 | 36383232 | 36383227 | 36383227 | Missense_Mutation | C | T | p.G565D |
| SNU1040_LARGE_INTESTINE | 36428636 | 36428730 | 36428708 | 36428708 | Missense_Mutation | C | A | p.Q321H |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DCLK1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DCLK1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DCLK1 |
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RelatedDrugs for DCLK1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| O15075 | DB12010 | Fostamatinib | Serine/threonine-protein kinase DCLK1 | small molecule | approved|investigational |
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RelatedDiseases for DCLK1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| DCLK1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| DCLK1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| DCLK1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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