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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for IL33

check button Gene summary
Gene informationGene symbol

IL33

Gene ID

90865

Gene nameinterleukin 33
SynonymsC9orf26|DVS27|IL1F11|NF-HEV|NFEHEV
Cytomap

9p24.1

Type of geneprotein-coding
Descriptioninterleukin-33DVS27-related proteininterleukin-1 family member 11nuclear factor for high endothelial venulesnuclear factor from high endothelial venules
Modification date20180523
UniProtAcc

O95760

ContextPubMed: IL33 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
IL33

GO:0043032

positive regulation of macrophage activation

19841166

IL33

GO:0090197

positive regulation of chemokine secretion

19841166


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Exon skipping events across known transcript of Ensembl for IL33 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for IL33

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for IL33

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_49498296215808:6215852:6241683:6241785:6250473:62505996241683:6241785ENSG00000137033.7ENST00000456383.2
exon_skip_49498496241692:6241785:6250473:6250599:6251139:62512656250473:6250599ENSG00000137033.7ENST00000381434.3,ENST00000456383.2
exon_skip_49499596250473:6250599:6251139:6251265:6252865:62529916251139:6251265ENSG00000137033.7ENST00000381434.3
exon_skip_49499796250473:6250599:6251139:6251265:6253551:62536026251139:6251265ENSG00000137033.7ENST00000456383.2
exon_skip_49500096251139:6251265:6252865:6252991:6253551:62536026252865:6252991ENSG00000137033.7ENST00000381434.3

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for IL33

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_49498296215808:6215852:6241683:6241785:6250473:62505996241683:6241785ENSG00000137033.7ENST00000456383.2
exon_skip_49498496241692:6241785:6250473:6250599:6251139:62512656250473:6250599ENSG00000137033.7ENST00000456383.2,ENST00000381434.3
exon_skip_49499596250473:6250599:6251139:6251265:6252865:62529916251139:6251265ENSG00000137033.7ENST00000381434.3
exon_skip_49499796250473:6250599:6251139:6251265:6253551:62536026251139:6251265ENSG00000137033.7ENST00000456383.2
exon_skip_49500096251139:6251265:6252865:6252991:6253551:62536026252865:6252991ENSG00000137033.7ENST00000381434.3

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for IL33

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000038143462504736250599In-frame
ENST0000038143462511396251265In-frame
ENST0000038143462528656252991In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000038143462504736250599In-frame
ENST0000038143462511396251265In-frame
ENST0000038143462528656252991In-frame

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Infer the effects of exon skipping event on protein functional features for IL33

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000003814342658270625047362505991052303072
ENST0000038143426582706251139625126523135672114
ENST00000381434265827062528656252991357482114156

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000003814342658270625047362505991052303072
ENST0000038143426582706251139625126523135672114
ENST00000381434265827062528656252991357482114156

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
O95760307231157Alternative sequenceID=VSP_045440;Note=In isoform 4. KSQQKAKEVCPMYFMKLRSGLMIKKEACYFRRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPITEYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKD->N;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O95760307272113Alternative sequenceID=VSP_044948;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21454686;Dbxref=PMID:21454686
O9576030721270ChainID=PRO_0000096790;Note=Interleukin-33
O957603072194PropeptideID=PRO_0000430083;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22307629;Dbxref=PMID:22307629
O957603072165RegionNote=Homeodomain-like HTH domain
O95760307266111RegionNote=Interaction with RELA;Ontology_term=ECO:0000250;evidence=ECO:0000250
O957607211431157Alternative sequenceID=VSP_045440;Note=In isoform 4. KSQQKAKEVCPMYFMKLRSGLMIKKEACYFRRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPITEYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKD->N;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O957607211472113Alternative sequenceID=VSP_044948;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21454686;Dbxref=PMID:21454686
O9576072114112115Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KLL
O95760721141270ChainID=PRO_0000096790;Note=Interleukin-33
O957607211495270ChainID=PRO_0000430084;Note=Interleukin-33 (95-270)
O957607211499270ChainID=PRO_0000430085;Note=Interleukin-33 (99-270)
O9576072114109270ChainID=PRO_0000430086;Note=Interleukin-33 (109-270)
O9576072114194PropeptideID=PRO_0000430083;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22307629;Dbxref=PMID:22307629
O957607211466111RegionNote=Interaction with RELA;Ontology_term=ECO:0000250;evidence=ECO:0000250
O95760721149495SiteNote=Cleavage%3B by CTSG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22307629;Dbxref=PMID:22307629
O95760721149899SiteNote=Cleavage%3B by ELANE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22307629;Dbxref=PMID:22307629
O9576072114108109SiteNote=Cleavage%3B by CTSG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22307629;Dbxref=PMID:22307629
O9576011415631157Alternative sequenceID=VSP_045440;Note=In isoform 4. KSQQKAKEVCPMYFMKLRSGLMIKKEACYFRRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPITEYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKD->N;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O95760114156115156Alternative sequenceID=VSP_042728;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O95760114156112115Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KLL
O95760114156119127Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KC3
O95760114156133138Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KC3
O95760114156140148Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KC3
O957601141561270ChainID=PRO_0000096790;Note=Interleukin-33
O9576011415695270ChainID=PRO_0000430084;Note=Interleukin-33 (95-270)
O9576011415699270ChainID=PRO_0000430085;Note=Interleukin-33 (99-270)
O95760114156109270ChainID=PRO_0000430086;Note=Interleukin-33 (109-270)
O95760114156144144MutagenesisNote=Decreases affinity for IL1RL1. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23980170;Dbxref=PMID:23980170
O95760114156148148MutagenesisNote=7-fold decrease in affinity for IL1RL1. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23980170;Dbxref=PMID:23980170
O95760114156149149MutagenesisNote=Almost abolishes binding to IL1RL1. D->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23980170;Dbxref=PMID:23980170
O95760114156139139Sequence conflictNote=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O95760114156129131TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KLL


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
O95760307231157Alternative sequenceID=VSP_045440;Note=In isoform 4. KSQQKAKEVCPMYFMKLRSGLMIKKEACYFRRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPITEYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKD->N;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O95760307272113Alternative sequenceID=VSP_044948;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21454686;Dbxref=PMID:21454686
O9576030721270ChainID=PRO_0000096790;Note=Interleukin-33
O957603072194PropeptideID=PRO_0000430083;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22307629;Dbxref=PMID:22307629
O957603072165RegionNote=Homeodomain-like HTH domain
O95760307266111RegionNote=Interaction with RELA;Ontology_term=ECO:0000250;evidence=ECO:0000250
O957607211431157Alternative sequenceID=VSP_045440;Note=In isoform 4. KSQQKAKEVCPMYFMKLRSGLMIKKEACYFRRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPITEYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKD->N;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O957607211472113Alternative sequenceID=VSP_044948;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21454686;Dbxref=PMID:21454686
O9576072114112115Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KLL
O95760721141270ChainID=PRO_0000096790;Note=Interleukin-33
O957607211495270ChainID=PRO_0000430084;Note=Interleukin-33 (95-270)
O957607211499270ChainID=PRO_0000430085;Note=Interleukin-33 (99-270)
O9576072114109270ChainID=PRO_0000430086;Note=Interleukin-33 (109-270)
O9576072114194PropeptideID=PRO_0000430083;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22307629;Dbxref=PMID:22307629
O957607211466111RegionNote=Interaction with RELA;Ontology_term=ECO:0000250;evidence=ECO:0000250
O95760721149495SiteNote=Cleavage%3B by CTSG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22307629;Dbxref=PMID:22307629
O95760721149899SiteNote=Cleavage%3B by ELANE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22307629;Dbxref=PMID:22307629
O9576072114108109SiteNote=Cleavage%3B by CTSG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22307629;Dbxref=PMID:22307629
O9576011415631157Alternative sequenceID=VSP_045440;Note=In isoform 4. KSQQKAKEVCPMYFMKLRSGLMIKKEACYFRRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPITEYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKD->N;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O95760114156115156Alternative sequenceID=VSP_042728;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
O95760114156112115Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KLL
O95760114156119127Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KC3
O95760114156133138Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KC3
O95760114156140148Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KC3
O957601141561270ChainID=PRO_0000096790;Note=Interleukin-33
O9576011415695270ChainID=PRO_0000430084;Note=Interleukin-33 (95-270)
O9576011415699270ChainID=PRO_0000430085;Note=Interleukin-33 (99-270)
O95760114156109270ChainID=PRO_0000430086;Note=Interleukin-33 (109-270)
O95760114156144144MutagenesisNote=Decreases affinity for IL1RL1. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23980170;Dbxref=PMID:23980170
O95760114156148148MutagenesisNote=7-fold decrease in affinity for IL1RL1. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23980170;Dbxref=PMID:23980170
O95760114156149149MutagenesisNote=Almost abolishes binding to IL1RL1. D->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23980170;Dbxref=PMID:23980170
O95760114156139139Sequence conflictNote=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O95760114156129131TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KLL


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SNVs in the skipped exons for IL33

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-G3-A3CJ-01exon_skip_494982
6241684624178562417046241704Frame_Shift_DelA-p.K4fs
LIHCTCGA-DD-A3A1-01exon_skip_494982
6241684624178562417396241739Frame_Shift_DelA-p.A15fs
LIHCTCGA-DD-A3A0-01exon_skip_494982
6241684624178562417726241772Frame_Shift_DelT-p.C26fs
LIHCTCGA-DD-A1EG-01exon_skip_494982
6241684624178562417816241781Frame_Shift_DelG-p.L29fs
LIHCTCGA-BC-A112-01exon_skip_495000
6252866625299162529726252973Frame_Shift_Ins-Ap.LK150fs
LIHCTCGA-BC-A112-01exon_skip_495000
6252866625299162529826252983Frame_Shift_Ins-Ap.K154fs
PAADTCGA-IB-7651-01exon_skip_494982
6241684624178562417456241745Nonsense_MutationGAp.W17*
PAADTCGA-IB-7651-01exon_skip_494982
6241684624178562417456241745Nonsense_MutationGAp.W17X
ESCATCGA-VR-AA4G-01exon_skip_494984
6250474625059962504946250494Nonsense_MutationGTp.E38X
UCECTCGA-AX-A05Z-01exon_skip_494997
exon_skip_494995
6251140625126562512546251254Nonsense_MutationCAp.S111*
CHOLTCGA-W5-AA36-01exon_skip_495000
6252866625299162529926252992Splice_SiteGA.

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
RKO_LARGE_INTESTINE6250474625059962505416250541Frame_Shift_DelA-p.I53fs
HEC108_ENDOMETRIUM6241684624178562417326241732Missense_MutationCTp.S13F
FEPD_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE6241684624178562417456241745Missense_MutationGCp.W17C
JHU028_LUNG6241684624178562417486241748Missense_MutationGTp.K18N
MCC13_SKIN6250474625059962505646250564Missense_MutationGAp.R61K
SNU81_LARGE_INTESTINE6250474625059962504946250494Nonsense_MutationGTp.E38*
RH4_SOFT_TISSUE6250474625059962505566250556Nonsense_MutationTAp.C58*

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for IL33

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for IL33


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for IL33


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RelatedDrugs for IL33

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IL33

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
IL33C0004096Asthma4CTD_human
IL33C0011615Dermatitis, Atopic1CTD_human
IL33C0020523Immediate hypersensitivity1CTD_human
IL33C0022658Kidney Diseases1CTD_human
IL33C0023893Liver Cirrhosis, Experimental1CTD_human
IL33C0993582Arthritis, Experimental1CTD_human