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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TNFRSF10B |
 Gene summary |
| Gene information | Gene symbol | TNFRSF10B | Gene ID | 8795 |
| Gene name | TNF receptor superfamily member 10b | |
| Synonyms | CD262|DR5|KILLER|KILLER/DR5|TRAIL-R2|TRAILR2|TRICK2|TRICK2A|TRICK2B|TRICKB|ZTNFR9 | |
| Cytomap | 8p21.3 | |
| Type of gene | protein-coding | |
| Description | tumor necrosis factor receptor superfamily member 10BFas-like proteinTNF-related apoptosis-inducing ligand receptor 2apoptosis inducing protein TRICK2A/2Bapoptosis inducing receptor TRAIL-R2cytotoxic TRAIL receptor-2death domain containing receptor | |
| Modification date | 20180527 | |
| UniProtAcc | O14763 | |
| Context | PubMed: TNFRSF10B [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TNFRSF10B | GO:0034976 | response to endoplasmic reticulum stress | 15322075 |
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Exon skipping events across known transcript of Ensembl for TNFRSF10B from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TNFRSF10B |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TNFRSF10B |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_488775 | 8 | 22884645:22884801:22885234:22885266:22885843:22885954 | 22885234:22885266 | ENSG00000120889.8 | ENST00000542226.1,ENST00000347739.3,ENST00000523504.1,ENST00000276431.4 |
| exon_skip_488777 | 8 | 22885234:22885266:22885843:22885954:22886041:22886115 | 22885843:22885954 | ENSG00000120889.8 | ENST00000542226.1,ENST00000347739.3,ENST00000523504.1 |
| exon_skip_488781 | 8 | 22888282:22888385:22900650:22900756:22926263:22926534 | 22900650:22900756 | ENSG00000120889.8 | ENST00000347739.3,ENST00000276431.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TNFRSF10B |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_488775 | 8 | 22884645:22884801:22885234:22885266:22885843:22885954 | 22885234:22885266 | ENSG00000120889.8 | ENST00000276431.4,ENST00000347739.3,ENST00000523504.1,ENST00000542226.1 |
| exon_skip_488777 | 8 | 22885234:22885266:22885843:22885954:22886041:22886115 | 22885843:22885954 | ENSG00000120889.8 | ENST00000347739.3,ENST00000523504.1,ENST00000542226.1 |
| exon_skip_488781 | 8 | 22888282:22888385:22900650:22900756:22926263:22926534 | 22900650:22900756 | ENSG00000120889.8 | ENST00000276431.4,ENST00000347739.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TNFRSF10B |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000276431 | 22885234 | 22885266 | Frame-shift |
| ENST00000276431 | 22900650 | 22900756 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000276431 | 22885234 | 22885266 | Frame-shift |
| ENST00000276431 | 22900650 | 22900756 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for TNFRSF10B |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for TNFRSF10B |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| UCEC | TCGA-AP-A0LM-01 | exon_skip_488777 | 22885844 | 22885954 | 22885943 | 22885943 | Nonsense_Mutation | C | A | p.G217* |
| LIHC | TCGA-2Y-A9HB-01 | exon_skip_488775 | 22885235 | 22885266 | 22885267 | 22885267 | Splice_Site | C | T | . |
| STAD | TCGA-CG-5721-01 | exon_skip_488781 | 22900651 | 22900756 | 22900649 | 22900649 | Splice_Site | A | G | p.G84_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NUGC4_STOMACH | 22885844 | 22885954 | 22885917 | 22885917 | Frame_Shift_Del | C | - | p.L225fs |
| NCIH2286_LUNG | 22885235 | 22885266 | 22885255 | 22885255 | Missense_Mutation | C | A | p.D254Y |
| SW1271_LUNG | 22885844 | 22885954 | 22885892 | 22885892 | Missense_Mutation | A | C | p.S234A |
| KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 22885844 | 22885954 | 22885901 | 22885901 | Missense_Mutation | C | T | p.V231I |
| TC71_BONE | 22900651 | 22900756 | 22900727 | 22900727 | Missense_Mutation | T | A | p.Q58H |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TNFRSF10B |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TNFRSF10B |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TNFRSF10B |
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RelatedDrugs for TNFRSF10B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TNFRSF10B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TNFRSF10B | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
| TNFRSF10B | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
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