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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for CDK13 |
 Gene summary |
| Gene information | Gene symbol | CDK13 | Gene ID | 8621 |
| Gene name | cyclin dependent kinase 13 | |
| Synonyms | CDC2L|CDC2L5|CHDFIDD|CHED|hCDK13 | |
| Cytomap | 7p14.1 | |
| Type of gene | protein-coding | |
| Description | cyclin-dependent kinase 13CDC2-related protein kinase 5cell division cycle 2-like protein kinase 5cell division protein kinase 13cholinesterase-related cell division controller | |
| Modification date | 20180523 | |
| UniProtAcc | Q14004 | |
| Context | PubMed: CDK13 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CDK13 | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain | 20952539 |
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Exon skipping events across known transcript of Ensembl for CDK13 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for CDK13 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for CDK13 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_465496 | 7 | 39990108:39991451:40027197:40027857:40037092:40037263 | 40027197:40027857 | ENSG00000065883.10 | ENST00000340829.5 |
| exon_skip_465500 | 7 | 40041459:40041630:40085434:40085624:40087419:40087476 | 40085434:40085624 | ENSG00000065883.10 | ENST00000484589.1,ENST00000181839.4,ENST00000340829.5 |
| exon_skip_465503 | 7 | 40102424:40102526:40102621:40102699:40117603:40117720 | 40102621:40102699 | ENSG00000065883.10 | ENST00000181839.4,ENST00000340829.5 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for CDK13 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_465496 | 7 | 39990108:39991451:40027197:40027857:40037092:40037263 | 40027197:40027857 | ENSG00000065883.10 | ENST00000340829.5 |
| exon_skip_465500 | 7 | 40041459:40041630:40085434:40085624:40087419:40087476 | 40085434:40085624 | ENSG00000065883.10 | ENST00000181839.4,ENST00000340829.5,ENST00000484589.1 |
| exon_skip_465503 | 7 | 40102424:40102526:40102621:40102699:40117603:40117720 | 40102621:40102699 | ENSG00000065883.10 | ENST00000181839.4,ENST00000340829.5 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for CDK13 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000181839 | 40085434 | 40085624 | Frame-shift |
| ENST00000181839 | 40102621 | 40102699 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000181839 | 40085434 | 40085624 | Frame-shift |
| ENST00000181839 | 40102621 | 40102699 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CDK13 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000181839 | 7315 | 1512 | 40102621 | 40102699 | 3308 | 3385 | 901 | 926 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000181839 | 7315 | 1512 | 40102621 | 40102699 | 3308 | 3385 | 901 | 926 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for CDK13 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
CDK13_PRAD_exon_skip_465500_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_465496 | 40027198 | 40027857 | 40027355 | 40027355 | Frame_Shift_Del | A | - | p.K458fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_465496 | 40027198 | 40027857 | 40027447 | 40027447 | Frame_Shift_Del | A | - | p.A487fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_465496 | 40027198 | 40027857 | 40027582 | 40027582 | Frame_Shift_Del | A | - | p.L532fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_465496 | 40027198 | 40027857 | 40027652 | 40027652 | Frame_Shift_Del | A | - | p.K556fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_465496 | 40027198 | 40027857 | 40027733 | 40027733 | Frame_Shift_Del | A | - | p.K583fs |
| BLCA | TCGA-DK-A1A7-01 | exon_skip_465496 | 40027198 | 40027857 | 40027759 | 40027772 | Frame_Shift_Del | AGGAGCCAAGGAGA | - | p.GAKEK592fs |
| BLCA | TCGA-DK-A1A7-01 | exon_skip_465496 | 40027198 | 40027857 | 40027759 | 40027772 | Frame_Shift_Del | AGGAGCCAAGGAGA | - | p.I591fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_465496 | 40027198 | 40027857 | 40027789 | 40027789 | Frame_Shift_Del | T | - | p.A601fs |
| COAD | TCGA-A6-6781-01 | exon_skip_465503 | 40102622 | 40102699 | 40102647 | 40102647 | Frame_Shift_Del | A | - | p.T909fs |
| STAD | TCGA-BR-6566-01 | exon_skip_465503 | 40102622 | 40102699 | 40102647 | 40102647 | Frame_Shift_Del | A | - | p.T909fs |
| SKCM | TCGA-YD-A89C-06 | exon_skip_465496 | 40027198 | 40027857 | 40027214 | 40027214 | Nonsense_Mutation | C | T | p.R410* |
| BLCA | TCGA-GU-A763-01 | exon_skip_465500 | 40085435 | 40085624 | 40085528 | 40085528 | Nonsense_Mutation | C | A | p.S816* |
| LUAD | TCGA-69-7979-01 | exon_skip_465503 | 40102622 | 40102699 | 40102635 | 40102635 | Nonsense_Mutation | G | T | p.E906* |
| PRAD | TCGA-EJ-7330-01 | exon_skip_465500 | 40085435 | 40085624 | 40085626 | 40085626 | Splice_Site | T | C | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-EJ-7330-01 |
| Cancer type: PRAD | |
| ESID: exon_skip_465500 | |
| Skipped exon start: 40085435 | |
| Skipped exon end: 40085624 | |
| Mutation start: 40085626 | |
| Mutation end: 40085626 | |
| Mutation type: Splice_Site | |
| Reference seq: T | |
| Mutation seq: C | |
| AAchange: . | |
exon_skip_378981_PRAD_TCGA-EJ-7330-01.png | |
exon_skip_465500_PRAD_TCGA-EJ-7330-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| OVK18_OVARY | 40102622 | 40102699 | 40102647 | 40102647 | Frame_Shift_Del | A | - | p.K911fs |
| LS513_LARGE_INTESTINE | 40027198 | 40027857 | 40027200 | 40027200 | Missense_Mutation | G | A | p.R405Q |
| HCC1588_LUNG | 40027198 | 40027857 | 40027200 | 40027200 | Missense_Mutation | G | A | p.R405Q |
| CP50MELB_SKIN | 40027198 | 40027857 | 40027253 | 40027253 | Missense_Mutation | C | T | p.R423C |
| SNGM_ENDOMETRIUM | 40027198 | 40027857 | 40027254 | 40027254 | Missense_Mutation | G | A | p.R423H |
| HT144_SKIN | 40027198 | 40027857 | 40027412 | 40027412 | Missense_Mutation | G | A | p.A476T |
| HGC27_STOMACH | 40027198 | 40027857 | 40027422 | 40027422 | Missense_Mutation | C | A | p.A479D |
| CAPAN1_PANCREAS | 40027198 | 40027857 | 40027511 | 40027511 | Missense_Mutation | A | G | p.T509A |
| NCIBL1395_MATCHED_NORMAL_TISSUE | 40027198 | 40027857 | 40027602 | 40027602 | Missense_Mutation | C | T | p.T539I |
| CAPAN1_PANCREAS | 40027198 | 40027857 | 40027640 | 40027640 | Missense_Mutation | T | G | p.L552V |
| CAPAN1_PANCREAS | 40027198 | 40027857 | 40027666 | 40027666 | Missense_Mutation | A | T | p.K560N |
| HEC108_ENDOMETRIUM | 40027198 | 40027857 | 40027667 | 40027667 | Missense_Mutation | G | A | p.A561T |
| SKN_ENDOMETRIUM | 40027198 | 40027857 | 40027832 | 40027832 | Missense_Mutation | C | A | p.L616M |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 40027198 | 40027857 | 40027849 | 40027849 | Missense_Mutation | A | T | p.E621D |
| NCIH1568_LUNG | 40085435 | 40085624 | 40085523 | 40085523 | Missense_Mutation | A | G | p.I814M |
| DG75_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 40102622 | 40102699 | 40102632 | 40102632 | Missense_Mutation | G | C | p.G905R |
| SW756_CERVIX | 40027198 | 40027857 | 40027541 | 40027541 | Nonsense_Mutation | A | T | p.K519* |
| QIMRWIL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 40085435 | 40085624 | 40085488 | 40085488 | Nonsense_Mutation | G | T | p.E803* |
| HO1U1_UPPER_AERODIGESTIVE_TRACT | 40085435 | 40085624 | 40085436 | 40085436 | Splice_Site | T | C | p.G785G |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 40102622 | 40102699 | 40102622 | 40102622 | Splice_Site | C | A | p.G901G |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CDK13 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CDK13 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CDK13 |
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RelatedDrugs for CDK13 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDK13 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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