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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for KLF7 |
 Gene summary |
| Gene information | Gene symbol | KLF7 | Gene ID | 8609 |
| Gene name | Kruppel like factor 7 | |
| Synonyms | UKLF | |
| Cytomap | 2q33.3 | |
| Type of gene | protein-coding | |
| Description | Krueppel-like factor 7Kruppel-like factor 7 (ubiquitous)ubiquitous Kruppel-like factorubiquitous Kruppel-like transcription factor | |
| Modification date | 20180523 | |
| UniProtAcc | O75840 | |
| Context | PubMed: KLF7 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| KLF7 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9774444 |
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Exon skipping events across known transcript of Ensembl for KLF7 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for KLF7 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for KLF7 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_346268 | 2 | 207945739:207945988:207953181:207953305:207988497:207989128 | 207953181:207953305 | ENSG00000118263.10 | ENST00000412414.2,ENST00000309446.6,ENST00000421199.1 |
| exon_skip_346271 | 2 | 207953181:207953305:207988699:207989128:208030190:208030295 | 207988699:207989128 | ENSG00000118263.10 | ENST00000423015.1 |
| exon_skip_346272 | 2 | 207953181:207953305:207989067:207989128:208030190:208030295 | 207989067:207989128 | ENSG00000118263.10 | ENST00000458272.1 |
| exon_skip_346273 | 2 | 207989076:207989128:208013705:208013924:208030190:208030259 | 208013705:208013924 | ENSG00000118263.10 | ENST00000451244.1 |
| exon_skip_346274 | 2 | 207989076:207989128:208030190:208030430:208030636:208030699 | 208030190:208030430 | ENSG00000118263.10 | ENST00000426163.1 |
| exon_skip_346275 | 2 | 207989076:207989128:208030190:208030430:208031480:208031571 | 208030190:208030430 | ENSG00000118263.10 | ENST00000423015.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for KLF7 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_346268 | 2 | 207945739:207945988:207953181:207953305:207988497:207989128 | 207953181:207953305 | ENSG00000118263.10 | ENST00000309446.6,ENST00000421199.1,ENST00000412414.2 |
| exon_skip_346271 | 2 | 207953181:207953305:207988699:207989128:208030190:208030295 | 207988699:207989128 | ENSG00000118263.10 | ENST00000423015.1 |
| exon_skip_346272 | 2 | 207953181:207953305:207989067:207989128:208030190:208030295 | 207989067:207989128 | ENSG00000118263.10 | ENST00000458272.1 |
| exon_skip_346273 | 2 | 207989076:207989128:208013705:208013924:208030190:208030259 | 208013705:208013924 | ENSG00000118263.10 | ENST00000451244.1 |
| exon_skip_346274 | 2 | 207989076:207989128:208030190:208030430:208030636:208030699 | 208030190:208030430 | ENSG00000118263.10 | ENST00000426163.1 |
| exon_skip_346275 | 2 | 207989076:207989128:208030190:208030430:208031480:208031571 | 208030190:208030430 | ENSG00000118263.10 | ENST00000423015.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for KLF7 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000309446 | 207953181 | 207953305 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000309446 | 207953181 | 207953305 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for KLF7 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for KLF7 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_346268 | 207953182 | 207953305 | 207953199 | 207953199 | Frame_Shift_Del | T | - | p.K280fs |
| LIHC | TCGA-DD-A3A0-01 | 207988700 | 207989128 | 207988806 | 207988806 | Frame_Shift_Del | G | - | p.P142fs | |
| LIHC | TCGA-DD-A39Y-01 | 207988700 | 207989128 | 207989049 | 207989049 | Frame_Shift_Del | A | - | p.F61fs | |
| COAD | TCGA-A6-5665-01 | 207988700 | 207989128 | 207988762 | 207988763 | Frame_Shift_Ins | - | AG | p.A157fs | |
| UCEC | TCGA-BS-A0UV-01 | exon_skip_346268 | 207953182 | 207953305 | 207953246 | 207953246 | Nonsense_Mutation | C | A | p.E265* |
| LUAD | TCGA-17-Z030-01 | 207988700 | 207989128 | 207988804 | 207988804 | Nonsense_Mutation | C | A | p.E143* | |
| BRCA | TCGA-EW-A1PG-01 | 207988700 | 207989128 | 207988824 | 207988824 | Nonsense_Mutation | A | T | p.L136* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NCIH513_PLEURA | 207988700 | 207989128 | 207988695 | 207988695 | Frame_Shift_Del | C | - | p.G180fs |
| DV90_LUNG | 207988700 | 207989128 | 207988993 | 207988993 | Frame_Shift_Del | G | - | p.L82fs |
| SNU407_LARGE_INTESTINE | 207988700 | 207989128 | 207989028 | 207989028 | Frame_Shift_Del | G | - | p.P68fs |
| DG75_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 207988700 | 207989128 | 207989089 | 207989089 | Frame_Shift_Del | G | - | p.R49fs |
| DG75_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 207989068 | 207989128 | 207989089 | 207989089 | Frame_Shift_Del | G | - | p.R49fs |
| MDAMB157_BREAST | 207953182 | 207953305 | 207953290 | 207953290 | Missense_Mutation | T | C | p.K250R |
| PECAPJ41CLONED2_UPPER_AERODIGESTIVE_TRACT | 207988700 | 207989128 | 207988759 | 207988759 | Missense_Mutation | C | T | p.V158M |
| MEWO_SKIN | 207988700 | 207989128 | 207988809 | 207988809 | Missense_Mutation | G | A | p.S141F |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 207988700 | 207989128 | 207988888 | 207988889 | Missense_Mutation | CC | TT | p.A115T |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 207988700 | 207989128 | 207988888 | 207988889 | Missense_Mutation | CC | TT | p.A115T |
| OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 207988700 | 207989128 | 207988888 | 207988889 | Missense_Mutation | CC | TT | p.A115T |
| S117_SOFT_TISSUE | 207988700 | 207989128 | 207988888 | 207988889 | Missense_Mutation | CC | TT | p.A115T |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 207988700 | 207989128 | 207988888 | 207988888 | Missense_Mutation | C | T | p.A115T |
| HEC59_ENDOMETRIUM | 207988700 | 207989128 | 207989004 | 207989004 | Missense_Mutation | C | T | p.R76H |
| GB1_CENTRAL_NERVOUS_SYSTEM | 207988700 | 207989128 | 207989025 | 207989025 | Missense_Mutation | C | T | p.C69Y |
| GCT_SOFT_TISSUE | 207988700 | 207989128 | 207989037 | 207989037 | Missense_Mutation | G | A | p.S65F |
| MEWO_SKIN | 207988700 | 207989128 | 207989044 | 207989044 | Missense_Mutation | G | A | p.H63Y |
| NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 207988700 | 207989128 | 207989089 | 207989089 | Missense_Mutation | G | A | p.R48W |
| NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 207989068 | 207989128 | 207989089 | 207989089 | Missense_Mutation | G | A | p.R48W |
| NCIH889_LUNG | 207988700 | 207989128 | 207989109 | 207989109 | Missense_Mutation | C | T | p.R41H |
| NCIH889_LUNG | 207989068 | 207989128 | 207989109 | 207989109 | Missense_Mutation | C | T | p.R41H |
| LOVO_LARGE_INTESTINE | 207988700 | 207989128 | 207989109 | 207989109 | Missense_Mutation | C | T | p.R41H |
| LOVO_LARGE_INTESTINE | 207989068 | 207989128 | 207989109 | 207989109 | Missense_Mutation | C | T | p.R41H |
| COLO678_LARGE_INTESTINE | 207988700 | 207989128 | 207989109 | 207989109 | Missense_Mutation | C | T | p.R41H |
| COLO678_LARGE_INTESTINE | 207989068 | 207989128 | 207989109 | 207989109 | Missense_Mutation | C | T | p.R41H |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 208030191 | 208030430 | 208030223 | 208030223 | Missense_Mutation | C | T | p.A24T |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for KLF7 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for KLF7 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for KLF7 |
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RelatedDrugs for KLF7 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KLF7 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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