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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for CDK10 |
 Gene summary |
| Gene information | Gene symbol | CDK10 | Gene ID | 8558 |
| Gene name | cyclin dependent kinase 10 | |
| Synonyms | ALSAS|PISSLRE | |
| Cytomap | 16q24.3 | |
| Type of gene | protein-coding | |
| Description | cyclin-dependent kinase 10CDC2-related protein kinasecell division protein kinase 10cyclin-dependent kinase (CDC2-like) 10cyclin-dependent kinase related proteinserine/threonine protein kinase PISSLRE | |
| Modification date | 20180523 | |
| UniProtAcc | Q15131 | |
| Context | PubMed: CDK10 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CDK10 | GO:0018107 | peptidyl-threonine phosphorylation | 27104747 |
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Exon skipping events across known transcript of Ensembl for CDK10 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for CDK10 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for CDK10 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_139646 | 16 | 89753135:89753167:89753856:89753956:89755659:89755714 | 89753856:89753956 | ENSG00000185324.17 | ENST00000511415.1 |
| exon_skip_139650 | 16 | 89753135:89753167:89753996:89754223:89755659:89755714 | 89753996:89754223 | ENSG00000185324.17 | ENST00000508723.1,ENST00000514965.1 |
| exon_skip_139656 | 16 | 89753135:89753167:89755659:89755714:89756960:89756965 | 89755659:89755714 | ENSG00000185324.17 | ENST00000507205.1 |
| exon_skip_139658 | 16 | 89753135:89753167:89755659:89755732:89756960:89756965 | 89755659:89755732 | ENSG00000185324.17 | ENST00000505473.1,ENST00000564192.1 |
| exon_skip_139663 | 16 | 89753120:89753205:89753996:89754223:89755659:89755714 | 89753996:89754223 | ENSG00000185324.17 | ENST00000502547.1 |
| exon_skip_139664 | 16 | 89753120:89753205:89753996:89754223:89756960:89756965 | 89753996:89754223 | ENSG00000185324.17 | ENST00000512912.1 |
| exon_skip_139672 | 16 | 89753120:89753205:89755659:89755732:89756960:89756965 | 89755659:89755732 | ENSG00000185324.17 | ENST00000472018.1,ENST00000505733.1,ENST00000353379.7 |
| exon_skip_139681 | 16 | 89753379:89753742:89755659:89755732:89756960:89756965 | 89755659:89755732 | ENSG00000185324.17 | ENST00000503560.1 |
| exon_skip_139686 | 16 | 89753856:89753956:89755659:89755732:89756960:89756965 | 89755659:89755732 | ENSG00000185324.17 | ENST00000511415.1 |
| exon_skip_139689 | 16 | 89753996:89754223:89755659:89755732:89756960:89756965 | 89755659:89755732 | ENSG00000185324.17 | ENST00000502547.1,ENST00000508723.1,ENST00000514965.1 |
| exon_skip_139695 | 16 | 89756960:89757032:89757850:89757953:89758213:89758253 | 89757850:89757953 | ENSG00000185324.17 | ENST00000378277.4,ENST00000472018.1,ENST00000504473.1,ENST00000507205.1,ENST00000510811.2,ENST00000512912.1,ENST00000505473.1,ENST00000511415.1,ENST00000331006.8,ENST00000568456.1,ENST00000505733.1,ENST00000353379.7,ENST00000564192.1 |
| exon_skip_139696 | 16 | 89758233:89758295:89758856:89758924:89759681:89759734 | 89758856:89758924 | ENSG00000185324.17 | ENST00000472018.1,ENST00000504473.1,ENST00000507205.1,ENST00000510811.2,ENST00000505473.1,ENST00000511415.1,ENST00000331006.8,ENST00000561477.1,ENST00000505733.1,ENST00000353379.7,ENST00000564192.1 |
| exon_skip_139697 | 16 | 89758856:89758924:89759681:89759734:89759805:89759875 | 89759681:89759734 | ENSG00000185324.17 | ENST00000510811.2,ENST00000505473.1,ENST00000331006.8,ENST00000561477.1,ENST00000353379.7,ENST00000564192.1 |
| exon_skip_139702 | 16 | 89759681:89759734:89759805:89759875:89760580:89760640 | 89759805:89759875 | ENSG00000185324.17 | ENST00000510811.2,ENST00000505473.1,ENST00000331006.8,ENST00000561477.1,ENST00000353379.7,ENST00000564192.1 |
| exon_skip_139706 | 16 | 89760591:89760640:89760976:89761196:89761338:89761380 | 89760976:89761196 | ENSG00000185324.17 | ENST00000564192.1 |
| exon_skip_139709 | 16 | 89760591:89760640:89761072:89761196:89761338:89761380 | 89761072:89761196 | ENSG00000185324.17 | ENST00000472018.1,ENST00000510811.2,ENST00000505473.1,ENST00000331006.8,ENST00000505733.1,ENST00000353379.7 |
| exon_skip_139712 | 16 | 89760591:89760640:89761338:89761460:89761700:89761753 | 89761338:89761460 | ENSG00000185324.17 | ENST00000565470.1 |
| exon_skip_139715 | 16 | 89761072:89761196:89761338:89761478:89761700:89761753 | 89761338:89761478 | ENSG00000185324.17 | ENST00000472018.1,ENST00000510811.2,ENST00000505473.1,ENST00000331006.8,ENST00000505733.1,ENST00000353379.7 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for CDK10 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_139646 | 16 | 89753135:89753167:89753856:89753956:89755659:89755714 | 89753856:89753956 | ENSG00000185324.17 | ENST00000511415.1 |
| exon_skip_139650 | 16 | 89753135:89753167:89753996:89754223:89755659:89755714 | 89753996:89754223 | ENSG00000185324.17 | ENST00000508723.1,ENST00000514965.1 |
| exon_skip_139656 | 16 | 89753135:89753167:89755659:89755714:89756960:89756965 | 89755659:89755714 | ENSG00000185324.17 | ENST00000507205.1 |
| exon_skip_139658 | 16 | 89753135:89753167:89755659:89755732:89756960:89756965 | 89755659:89755732 | ENSG00000185324.17 | ENST00000505473.1,ENST00000564192.1 |
| exon_skip_139663 | 16 | 89753120:89753205:89753996:89754223:89755659:89755714 | 89753996:89754223 | ENSG00000185324.17 | ENST00000502547.1 |
| exon_skip_139664 | 16 | 89753120:89753205:89753996:89754223:89756960:89756965 | 89753996:89754223 | ENSG00000185324.17 | ENST00000512912.1 |
| exon_skip_139672 | 16 | 89753120:89753205:89755659:89755732:89756960:89756965 | 89755659:89755732 | ENSG00000185324.17 | ENST00000353379.7,ENST00000505733.1,ENST00000472018.1 |
| exon_skip_139681 | 16 | 89753379:89753742:89755659:89755732:89756960:89756965 | 89755659:89755732 | ENSG00000185324.17 | ENST00000503560.1 |
| exon_skip_139686 | 16 | 89753856:89753956:89755659:89755732:89756960:89756965 | 89755659:89755732 | ENSG00000185324.17 | ENST00000511415.1 |
| exon_skip_139689 | 16 | 89753996:89754223:89755659:89755732:89756960:89756965 | 89755659:89755732 | ENSG00000185324.17 | ENST00000508723.1,ENST00000502547.1,ENST00000514965.1 |
| exon_skip_139695 | 16 | 89756960:89757032:89757850:89757953:89758213:89758253 | 89757850:89757953 | ENSG00000185324.17 | ENST00000331006.8,ENST00000353379.7,ENST00000505473.1,ENST00000511415.1,ENST00000512912.1,ENST00000505733.1,ENST00000510811.2,ENST00000507205.1,ENST00000472018.1,ENST00000564192.1,ENST00000378277.4,ENST00000504473.1,ENST00000568456.1 |
| exon_skip_139696 | 16 | 89758233:89758295:89758856:89758924:89759681:89759734 | 89758856:89758924 | ENSG00000185324.17 | ENST00000331006.8,ENST00000353379.7,ENST00000505473.1,ENST00000511415.1,ENST00000505733.1,ENST00000510811.2,ENST00000507205.1,ENST00000472018.1,ENST00000564192.1,ENST00000504473.1,ENST00000561477.1 |
| exon_skip_139697 | 16 | 89758856:89758924:89759681:89759734:89759805:89759875 | 89759681:89759734 | ENSG00000185324.17 | ENST00000331006.8,ENST00000353379.7,ENST00000505473.1,ENST00000510811.2,ENST00000564192.1,ENST00000561477.1 |
| exon_skip_139702 | 16 | 89759681:89759734:89759805:89759875:89760580:89760640 | 89759805:89759875 | ENSG00000185324.17 | ENST00000331006.8,ENST00000353379.7,ENST00000505473.1,ENST00000510811.2,ENST00000564192.1,ENST00000561477.1 |
| exon_skip_139706 | 16 | 89760591:89760640:89760976:89761196:89761338:89761380 | 89760976:89761196 | ENSG00000185324.17 | ENST00000564192.1 |
| exon_skip_139709 | 16 | 89760591:89760640:89761072:89761196:89761338:89761380 | 89761072:89761196 | ENSG00000185324.17 | ENST00000331006.8,ENST00000353379.7,ENST00000505473.1,ENST00000505733.1,ENST00000510811.2,ENST00000472018.1 |
| exon_skip_139712 | 16 | 89760591:89760640:89761338:89761460:89761700:89761753 | 89761338:89761460 | ENSG00000185324.17 | ENST00000565470.1 |
| exon_skip_139715 | 16 | 89761072:89761196:89761338:89761478:89761700:89761753 | 89761338:89761478 | ENSG00000185324.17 | ENST00000331006.8,ENST00000353379.7,ENST00000505473.1,ENST00000505733.1,ENST00000510811.2,ENST00000472018.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for CDK10 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000353379 | 89755659 | 89755732 | Frame-shift |
| ENST00000353379 | 89757850 | 89757953 | Frame-shift |
| ENST00000353379 | 89758856 | 89758924 | Frame-shift |
| ENST00000353379 | 89759681 | 89759734 | Frame-shift |
| ENST00000353379 | 89759805 | 89759875 | Frame-shift |
| ENST00000353379 | 89761072 | 89761196 | Frame-shift |
| ENST00000353379 | 89761338 | 89761478 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000353379 | 89755659 | 89755732 | Frame-shift |
| ENST00000353379 | 89757850 | 89757953 | Frame-shift |
| ENST00000353379 | 89758856 | 89758924 | Frame-shift |
| ENST00000353379 | 89759681 | 89759734 | Frame-shift |
| ENST00000353379 | 89759805 | 89759875 | Frame-shift |
| ENST00000353379 | 89761072 | 89761196 | Frame-shift |
| ENST00000353379 | 89761338 | 89761478 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for CDK10 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for CDK10 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_139695 | 89757851 | 89757953 | 89757936 | 89757936 | Frame_Shift_Del | G | - | p.V59fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_139702 | 89759806 | 89759875 | 89759854 | 89759854 | Frame_Shift_Del | C | - | p.T149fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_139702 | 89759806 | 89759875 | 89759854 | 89759854 | Frame_Shift_Del | C | - | p.T149fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| C33A_CERVIX | 89759806 | 89759875 | 89759854 | 89759854 | Frame_Shift_Del | C | - | p.T196fs |
| EN_ENDOMETRIUM | 89755660 | 89755732 | 89755670 | 89755670 | Missense_Mutation | G | A | p.C33Y |
| EN_ENDOMETRIUM | 89755660 | 89755714 | 89755670 | 89755670 | Missense_Mutation | G | A | p.C33Y |
| SNU1040_LARGE_INTESTINE | 89755660 | 89755732 | 89755702 | 89755702 | Missense_Mutation | C | T | p.R44C |
| SNU1040_LARGE_INTESTINE | 89755660 | 89755714 | 89755702 | 89755702 | Missense_Mutation | C | T | p.R44C |
| NCIH23_LUNG | 89755660 | 89755732 | 89755726 | 89755726 | Missense_Mutation | A | T | p.I52F |
| HKA1_SKIN | 89757851 | 89757953 | 89757856 | 89757856 | Missense_Mutation | C | T | p.P80S |
| JOPACA1_PANCREAS | 89757851 | 89757953 | 89757893 | 89757893 | Missense_Mutation | G | A | p.R92H |
| EN_ENDOMETRIUM | 89757851 | 89757953 | 89757929 | 89757929 | Missense_Mutation | T | C | p.V104A |
| SNUC4_LARGE_INTESTINE | 89758857 | 89758924 | 89758867 | 89758867 | Missense_Mutation | T | C | p.I143T |
| HEC6_ENDOMETRIUM | 89758857 | 89758924 | 89758917 | 89758917 | Missense_Mutation | A | G | p.I160V |
| P31FUJ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 89759682 | 89759734 | 89759717 | 89759717 | Missense_Mutation | A | C | p.K174T |
| MFE296_ENDOMETRIUM | 89759806 | 89759875 | 89759814 | 89759814 | Missense_Mutation | G | A | p.G183S |
| UMUC3_URINARY_TRACT | 89759806 | 89759875 | 89759823 | 89759823 | Missense_Mutation | C | T | p.R186W |
| HS739T_FIBROBLAST | 89761073 | 89761196 | 89761125 | 89761125 | Missense_Mutation | G | A | p.G241S |
| HS739T_FIBROBLAST | 89760977 | 89761196 | 89761125 | 89761125 | Missense_Mutation | G | A | p.G241S |
| A375_SKIN | 89761073 | 89761196 | 89761158 | 89761158 | Missense_Mutation | G | A | p.V252M |
| A375_SKIN | 89760977 | 89761196 | 89761158 | 89761158 | Missense_Mutation | G | A | p.V252M |
| MDAMB361_BREAST | 89761073 | 89761196 | 89761158 | 89761158 | Missense_Mutation | G | A | p.V252M |
| MDAMB361_BREAST | 89760977 | 89761196 | 89761158 | 89761158 | Missense_Mutation | G | A | p.V252M |
| GDM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 89761339 | 89761460 | 89761349 | 89761349 | Missense_Mutation | A | G | p.K268R |
| GDM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 89761339 | 89761478 | 89761349 | 89761349 | Missense_Mutation | A | G | p.K268R |
| JHOC5_OVARY | 89761339 | 89761460 | 89761363 | 89761363 | Missense_Mutation | G | A | p.G273S |
| JHOC5_OVARY | 89761339 | 89761478 | 89761363 | 89761363 | Missense_Mutation | G | A | p.G273S |
| P30OHK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 89761339 | 89761460 | 89761363 | 89761363 | Missense_Mutation | G | A | p.G273S |
| P30OHK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 89761339 | 89761478 | 89761363 | 89761363 | Missense_Mutation | G | A | p.G273S |
| IGROV1_OVARY | 89761339 | 89761460 | 89761364 | 89761364 | Missense_Mutation | G | C | p.G273A |
| IGROV1_OVARY | 89761339 | 89761478 | 89761364 | 89761364 | Missense_Mutation | G | C | p.G273A |
| SNU1040_LARGE_INTESTINE | 89761339 | 89761460 | 89761364 | 89761364 | Missense_Mutation | G | A | p.G273D |
| SNU1040_LARGE_INTESTINE | 89761339 | 89761478 | 89761364 | 89761364 | Missense_Mutation | G | A | p.G273D |
| BXPC3_PANCREAS | 89761339 | 89761460 | 89761424 | 89761424 | Missense_Mutation | C | T | p.S293L |
| BXPC3_PANCREAS | 89761339 | 89761478 | 89761424 | 89761424 | Missense_Mutation | C | T | p.S293L |
| NCIH1299_LUNG | 89761339 | 89761460 | 89761448 | 89761448 | Missense_Mutation | A | C | p.H301P |
| NCIH1299_LUNG | 89761339 | 89761478 | 89761448 | 89761448 | Missense_Mutation | A | C | p.H301P |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CDK10 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CDK10 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CDK10 |
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RelatedDrugs for CDK10 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDK10 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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