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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for DCLK3 |
 Gene summary |
| Gene information | Gene symbol | DCLK3 | Gene ID | 85443 |
| Gene name | doublecortin like kinase 3 | |
| Synonyms | CLR|DCAMKL3|DCDC3C|DCK3 | |
| Cytomap | 3p22.2 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase DCLK3CLICK-I,II-relateddoublecortin and CaM kinase-like 3doublecortin domain-containing protein 3Cdoublecortin-like and CAM kinase-like 3 | |
| Modification date | 20180523 | |
| UniProtAcc | Q9C098 | |
| Context | PubMed: DCLK3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for DCLK3 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for DCLK3 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for DCLK3 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_382320 | 3 | 36753912:36757012:36759500:36759668:36763017:36763150 | 36759500:36759668 | ENSG00000163673.6 | ENST00000416516.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for DCLK3 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_382320 | 3 | 36753912:36757012:36759500:36759668:36763017:36763150 | 36759500:36759668 | ENSG00000163673.6 | ENST00000416516.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for DCLK3 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000416516 | 36759500 | 36759668 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000416516 | 36759500 | 36759668 | In-frame |
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Infer the effects of exon skipping event on protein functional features for DCLK3 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000416516 | 5361 | 648 | 36759500 | 36759668 | 2077 | 2244 | 528 | 584 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000416516 | 5361 | 648 | 36759500 | 36759668 | 2077 | 2244 | 528 | 584 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9C098 | 528 | 584 | 1 | 648 | Chain | ID=PRO_0000252254;Note=Serine/threonine-protein kinase DCLK3 |
| Q9C098 | 528 | 584 | 356 | 613 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q9C098 | 528 | 584 | 554 | 554 | Natural variant | ID=VAR_040448;Note=In a lung squamous cell carcinoma sample%3B somatic mutation. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs374711533,PMID:17344846 |
| Q9C098 | 528 | 584 | 570 | 570 | Natural variant | ID=VAR_040449;Note=In a renal clear cell carcinoma sample%3B somatic mutation. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9C098 | 528 | 584 | 1 | 648 | Chain | ID=PRO_0000252254;Note=Serine/threonine-protein kinase DCLK3 |
| Q9C098 | 528 | 584 | 356 | 613 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q9C098 | 528 | 584 | 554 | 554 | Natural variant | ID=VAR_040448;Note=In a lung squamous cell carcinoma sample%3B somatic mutation. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs374711533,PMID:17344846 |
| Q9C098 | 528 | 584 | 570 | 570 | Natural variant | ID=VAR_040449;Note=In a renal clear cell carcinoma sample%3B somatic mutation. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 |
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SNVs in the skipped exons for DCLK3 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SKCM | TCGA-EE-A2MS-06 | exon_skip_382320 | 36759501 | 36759668 | 36759552 | 36759552 | Nonsense_Mutation | G | A | p.Q568* |
| SKCM | TCGA-EE-A2MS-06 | exon_skip_382320 | 36759501 | 36759668 | 36759552 | 36759552 | Nonsense_Mutation | G | A | p.Q568X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LB996RCC_KIDNEY | 36759501 | 36759668 | 36759546 | 36759546 | Missense_Mutation | C | G | p.G570R |
| WSUNHL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 36759501 | 36759668 | 36759571 | 36759571 | Missense_Mutation | G | T | p.D561E |
| T3M10_LUNG | 36759501 | 36759668 | 36759520 | 36759520 | Nonsense_Mutation | G | T | p.Y578* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DCLK3 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DCLK3 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DCLK3 |
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RelatedDrugs for DCLK3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q9C098 | DB12010 | Fostamatinib | Serine/threonine-protein kinase DCLK3 | small molecule | approved|investigational |
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RelatedDiseases for DCLK3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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