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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for CCNB3

check button Gene summary
Gene informationGene symbol

CCNB3

Gene ID

85417

Gene namecyclin B3
Synonyms-
Cytomap

Xp11.22

Type of geneprotein-coding
DescriptionG2/mitotic-specific cyclin-B3
Modification date20180523
UniProtAcc

Q8WWL7

ContextPubMed: CCNB3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Exon skipping events across known transcript of Ensembl for CCNB3 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for CCNB3

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for CCNB3

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_510552X50031779:50031887:50037862:50037993:50051504:5005449650037862:50037993ENSG00000147082.13ENST00000376042.1,ENST00000276014.7
exon_skip_510554X50037862:50037993:50051504:50054496:50055536:5005563250051504:50054496ENSG00000147082.13ENST00000376042.1,ENST00000276014.7
exon_skip_510555X50055536:50055632:50056855:50056948:50085200:5008533850056855:50056948ENSG00000147082.13ENST00000476167.1,ENST00000376042.1,ENST00000276014.7

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for CCNB3

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_510552X50031779:50031887:50037862:50037993:50051504:5005449650037862:50037993ENSG00000147082.13ENST00000376042.1,ENST00000276014.7
exon_skip_510555X50055536:50055632:50056855:50056948:50085200:5008533850056855:50056948ENSG00000147082.13ENST00000376042.1,ENST00000476167.1,ENST00000276014.7

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for CCNB3

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000002760145003786250037993Frame-shift
ENST000003760425003786250037993Frame-shift
ENST000002760145005150450054496Frame-shift
ENST000003760425005150450054496Frame-shift
ENST000002760145005685550056948In-frame
ENST000003760425005685550056948In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000002760145003786250037993Frame-shift
ENST000003760425003786250037993Frame-shift
ENST000002760145005685550056948In-frame
ENST000003760425005685550056948In-frame

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Infer the effects of exon skipping event on protein functional features for CCNB3

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000002760144526139550056855500569483538363011411172
ENST000003760424710139550056855500569483722381411411172

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000002760144526139550056855500569483538363011411172
ENST000003760424710139550056855500569483722381411411172

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q8WWL711411172691172Alternative sequenceID=VSP_010514;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11846420;Dbxref=PMID:11846420
Q8WWL711411172691172Alternative sequenceID=VSP_010514;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11846420;Dbxref=PMID:11846420
Q8WWL7114111721121395Alternative sequenceID=VSP_010515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11846420;Dbxref=PMID:11846420
Q8WWL7114111721121395Alternative sequenceID=VSP_010515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11846420;Dbxref=PMID:11846420
Q8WWL71141117211395ChainID=PRO_0000080373;Note=G2/mitotic-specific cyclin-B3
Q8WWL71141117211395ChainID=PRO_0000080373;Note=G2/mitotic-specific cyclin-B3


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q8WWL711411172691172Alternative sequenceID=VSP_010514;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11846420;Dbxref=PMID:11846420
Q8WWL711411172691172Alternative sequenceID=VSP_010514;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11846420;Dbxref=PMID:11846420
Q8WWL7114111721121395Alternative sequenceID=VSP_010515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11846420;Dbxref=PMID:11846420
Q8WWL7114111721121395Alternative sequenceID=VSP_010515;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11846420;Dbxref=PMID:11846420
Q8WWL71141117211395ChainID=PRO_0000080373;Note=G2/mitotic-specific cyclin-B3
Q8WWL71141117211395ChainID=PRO_0000080373;Note=G2/mitotic-specific cyclin-B3


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SNVs in the skipped exons for CCNB3

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
BRCATCGA-AR-A1AI-01exon_skip_510554
50051505500544965005200850052008Frame_Shift_DelC-p.H281fs
ESCATCGA-L5-A8NM-01exon_skip_510554
50051505500544965005261650052616Frame_Shift_DelC-p.T485fs
LIHCTCGA-DD-A1EG-01exon_skip_510554
50051505500544965005361750053617Frame_Shift_DelC-p.L816fs
LIHCTCGA-DD-A39Y-01exon_skip_510554
50051505500544965005362450053624Frame_Shift_DelC-p.P819fs
ACCTCGA-OR-A5KB-01exon_skip_510554
50051505500544965005408350054083Frame_Shift_DelG-p.G972fs
ACCTCGA-OR-A5KB-01exon_skip_510554
50051505500544965005408350054083Frame_Shift_DelG-p.V971fs
LUADTCGA-95-7567-01exon_skip_510554
50051505500544965005170250051703Frame_Shift_Ins-Ap.*178fs
LUADTCGA-95-7567-01exon_skip_510554
50051505500544965005170250051703Frame_Shift_Ins-Ap.L178fs
LIHCTCGA-BC-A112-01exon_skip_510554
50051505500544965005293750052938Frame_Shift_Ins-Ap.K590fs
UCECTCGA-BS-A0UF-01exon_skip_510554
50051505500544965005179450051794Nonsense_MutationGTp.E209*
UCECTCGA-B5-A0JY-01exon_skip_510554
50051505500544965005190550051905Nonsense_MutationGTp.E246*
SKCMTCGA-DA-A95Z-06exon_skip_510554
50051505500544965005215150052151Nonsense_MutationCTp.Q328*
UCECTCGA-BS-A0TC-01exon_skip_510554
50051505500544965005216750052167Nonsense_MutationTAp.L333*
UCECTCGA-BS-A0UV-01exon_skip_510554
50051505500544965005221550052215Nonsense_MutationCAp.S349*
UCECTCGA-AP-A0LM-01exon_skip_510554
50051505500544965005243350052433Nonsense_MutationGTp.E422*
UCECTCGA-BS-A0UF-01exon_skip_510554
50051505500544965005243350052433Nonsense_MutationGTp.E422*
LUADTCGA-55-A494-01exon_skip_510554
50051505500544965005292350052923Nonsense_MutationCAp.S585*
LUADTCGA-86-8073-01exon_skip_510554
50051505500544965005308150053081Nonsense_MutationGTp.E638*
UCECTCGA-AX-A05Z-01exon_skip_510554
50051505500544965005313850053138Nonsense_MutationGTp.E657*
UCECTCGA-BS-A0UV-01exon_skip_510554
50051505500544965005329150053291Nonsense_MutationATp.K708*
UCECTCGA-B5-A0JY-01exon_skip_510554
50051505500544965005333050053330Nonsense_MutationGTp.E721*
THYMTCGA-XU-A92Y-01exon_skip_510554
50051505500544965005347750053477Nonsense_MutationGTp.E770X
UCECTCGA-A5-A0GP-01exon_skip_510554
50051505500544965005437450054374Nonsense_MutationGTp.E1069*

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
A498_KIDNEY50037863500379935003794550037946Frame_Shift_DelAC-p.N96fs
SNU761_LIVER50051505500544965005186950051869Frame_Shift_DelA-p.K234fs
JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE50051505500544965005261650052616Frame_Shift_DelC-p.P484fs
CW2_LARGE_INTESTINE50051505500544965005266350052663Frame_Shift_DelG-p.Q498fs
UMUC5_URINARY_TRACT50037863500379935003797350037973Missense_MutationGCp.K105N
SNU81_LARGE_INTESTINE50051505500544965005156550051565Missense_MutationGTp.E132D
MCC13_SKIN50051505500544965005162650051626Missense_MutationCTp.L153F
CROAP3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE50051505500544965005168950051689Missense_MutationAGp.K174E
HCC2998_LARGE_INTESTINE50051505500544965005169050051690Missense_MutationACp.K174T
AN3CA_ENDOMETRIUM50051505500544965005169650051696Missense_MutationTCp.L176S
ESS1_ENDOMETRIUM50051505500544965005171950051719Missense_MutationCAp.H184N
KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE50051505500544965005174350051743Missense_MutationAGp.K192E
SCC3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE50051505500544965005174350051743Missense_MutationAGp.K192E
CW2_LARGE_INTESTINE50051505500544965005192550051925Missense_MutationGTp.Q252H
JHUEM7_ENDOMETRIUM50051505500544965005197650051976Missense_MutationGTp.K269N
RKO_LARGE_INTESTINE50051505500544965005198950051989Missense_MutationACp.T274P
HEC251_ENDOMETRIUM50051505500544965005202350052023Missense_MutationCAp.S285Y
HUPT4_PANCREAS50051505500544965005204350052043Missense_MutationAGp.I292V
KARPAS422_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE50051505500544965005205350052053Missense_MutationACp.K295T
HUH28_BILIARY_TRACT50051505500544965005212850052128Missense_MutationCTp.T320I
PL21_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE50051505500544965005214150052141Missense_MutationGTp.E324D
EN_ENDOMETRIUM50051505500544965005218850052188Missense_MutationAGp.E340G
MIAPACA2_PANCREAS50051505500544965005220850052208Missense_MutationAGp.K347E
MCC13_SKIN50051505500544965005225350052253Missense_MutationCTp.L362F
LU139_LUNG50051505500544965005235750052358Missense_MutationCCTTp.R397C
LNCAPCLONEFGC_PROSTATE50051505500544965005237350052373Missense_MutationGTp.V402L
FARAGE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE50051505500544965005243750052437Missense_MutationACp.K423T
SNU1040_LARGE_INTESTINE50051505500544965005250650052506Missense_MutationAGp.E446G
NCIH2171_LUNG50051505500544965005253050052530Missense_MutationCAp.P454H
KMH2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE50051505500544965005263150052631Missense_MutationCGp.P488A
HEC251_ENDOMETRIUM50051505500544965005269450052694Missense_MutationAGp.I509V
HEC59_ENDOMETRIUM50051505500544965005270750052707Missense_MutationCTp.T513I
JHUEM7_ENDOMETRIUM50051505500544965005289250052892Missense_MutationACp.T575P
MERO48A_LUNG50051505500544965005290350052903Missense_MutationGTp.E578D
HEC251_ENDOMETRIUM50051505500544965005291650052916Missense_MutationAGp.K583E
NCIH1836_LUNG50051505500544965005295550052955Missense_MutationGTp.G596W
RPMI8866_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE50051505500544965005301050053010Missense_MutationAGp.E614G
JHUEM7_ENDOMETRIUM50051505500544965005302050053020Missense_MutationCAp.F617L
NCIH1915_LUNG50051505500544965005303550053035Missense_MutationGTp.L622F
CCFSTTG1_CENTRAL_NERVOUS_SYSTEM50051505500544965005306450053064Missense_MutationAGp.E632G
EFM192A_BREAST50051505500544965005306650053066Missense_MutationAGp.K633E
HGC27_STOMACH50051505500544965005312750053127Missense_MutationCTp.S653F
HGC27_STOMACH50051505500544965005312750053128Missense_MutationCCTTp.S653F
RKO_LARGE_INTESTINE50051505500544965005315150053151Missense_MutationTCp.I661T
FUOV1_OVARY50051505500544965005327650053276Missense_MutationGAp.E703K
ESS1_ENDOMETRIUM50051505500544965005341950053419Missense_MutationGTp.K750N
MEWO_SKIN50051505500544965005343950053439Missense_MutationGAp.G757E
LN18_CENTRAL_NERVOUS_SYSTEM50051505500544965005346350053463Missense_MutationACp.Q765P
SISO_CERVIX50051505500544965005363050053630Missense_MutationAGp.I821V
GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE50051505500544965005363050053630Missense_MutationAGp.I821V
OVCAR4_OVARY50051505500544965005365150053651Missense_MutationAGp.K828E
NCIH1435_LUNG50051505500544965005374050053740Missense_MutationGTp.K857N
JHUEM7_ENDOMETRIUM50051505500544965005378250053782Missense_MutationGTp.E871D
NCIBL2126_MATCHED_NORMAL_TISSUE50051505500544965005381050053810Missense_MutationTCp.W881R
NCIH2126_LUNG50051505500544965005381050053810Missense_MutationTCp.W881R
MDAMB361_BREAST50051505500544965005381750053817Missense_MutationATp.K883M
SW982_SOFT_TISSUE50051505500544965005381850053818Missense_MutationGTp.K883N
MEWO_SKIN50051505500544965005407150054071Missense_MutationGTp.V968F
KYSE140_OESOPHAGUS50051505500544965005411350054113Missense_MutationCTp.P982S
MESSA_SOFT_TISSUE50051505500544965005426350054263Missense_MutationGAp.A1032T
HCC366_LUNG50051505500544965005433650054336Missense_MutationGAp.S1056N
HT115_LARGE_INTESTINE50051505500544965005437650054376Missense_MutationGTp.E1069D
NCIH3255_LUNG50051505500544965005438150054381Missense_MutationCAp.S1071Y
BE13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE50051505500544965005438150054381Missense_MutationCTp.S1071F
HCT15_LARGE_INTESTINE50056856500569485005686350056863Missense_MutationTCp.F1144S
YT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE50056856500569485005690450056904Missense_MutationATp.S1158C
KMBC2_URINARY_TRACT50056856500569485005691250056912Missense_MutationGAp.M1160I
HS445_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE50051505500544965005194150051941Nonsense_MutationGTp.E258*
SW403_LARGE_INTESTINE50051505500544965005243350052433Nonsense_MutationGTp.E422*
LB647SCLC_LUNG50051505500544965005377950053780Nonsense_MutationGGATp.E871*
DOK_UPPER_AERODIGESTIVE_TRACT50051505500544965005379550053795Nonsense_MutationCTp.R876*

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CCNB3

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CCNB3


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CCNB3


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RelatedDrugs for CCNB3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCNB3

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
CCNB3C0029463Osteosarcoma1CTD_human