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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for STK40 |
 Gene summary |
| Gene information | Gene symbol | STK40 | Gene ID | 83931 |
| Gene name | serine/threonine kinase 40 | |
| Synonyms | SHIK|SgK495 | |
| Cytomap | 1p34.3 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase 40SINK-homologous serine/threonine-protein kinaseSer/Thr-like kinasesugen kinase 495 | |
| Modification date | 20180519 | |
| UniProtAcc | Q8N2I9 | |
| Context | PubMed: STK40 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for STK40 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for STK40 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for STK40 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_24980 | 1 | 36805224:36807574:36808964:36809049:36809460:36809580 | 36808964:36809049 | ENSG00000196182.6 | ENST00000373132.3,ENST00000373129.3,ENST00000373130.3 |
| exon_skip_24981 | 1 | 36808964:36809049:36809460:36809580:36809720:36809865 | 36809460:36809580 | ENSG00000196182.6 | ENST00000359297.2,ENST00000373132.3,ENST00000373129.3,ENST00000373130.3 |
| exon_skip_24982 | 1 | 36819964:36820017:36820806:36821034:36823839:36823983 | 36820806:36821034 | ENSG00000196182.6 | ENST00000359297.2,ENST00000373132.3,ENST00000373129.3,ENST00000373130.3 |
| exon_skip_24985 | 1 | 36820889:36821034:36823839:36823983:36824337:36824423 | 36823839:36823983 | ENSG00000196182.6 | ENST00000473733.1,ENST00000359297.2,ENST00000460417.1,ENST00000373132.3,ENST00000373129.3,ENST00000482458.1,ENST00000373130.3 |
| exon_skip_24997 | 1 | 36823839:36823983:36824337:36824423:36826821:36826941 | 36824337:36824423 | ENSG00000196182.6 | ENST00000473733.1,ENST00000460417.1,ENST00000373132.3,ENST00000373129.3 |
| exon_skip_25000 | 1 | 36823839:36823983:36824337:36824438:36826821:36826941 | 36824337:36824438 | ENSG00000196182.6 | ENST00000482458.1,ENST00000373130.3 |
| exon_skip_25004 | 1 | 36824337:36824423:36826821:36826941:36833448:36833685 | 36826821:36826941 | ENSG00000196182.6 | ENST00000373129.3 |
| exon_skip_25007 | 1 | 36824337:36824423:36826821:36826941:36851323:36851477 | 36826821:36826941 | ENSG00000196182.6 | ENST00000373132.3 |
| exon_skip_25021 | 1 | 36826821:36826941:36833448:36833685:36851323:36851477 | 36833448:36833685 | ENSG00000196182.6 | ENST00000373129.3 |
| exon_skip_25024 | 1 | 36826821:36826941:36833452:36833685:36851323:36851477 | 36833452:36833685 | ENSG00000196182.6 | ENST00000482458.1 |
| exon_skip_25038 | 1 | 36833461:36833685:36838249:36838375:36851323:36851477 | 36838249:36838375 | ENSG00000196182.6 | ENST00000460017.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for STK40 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_24980 | 1 | 36805224:36807574:36808964:36809049:36809460:36809580 | 36808964:36809049 | ENSG00000196182.6 | ENST00000373129.3,ENST00000373130.3,ENST00000373132.3 |
| exon_skip_24981 | 1 | 36808964:36809049:36809460:36809580:36809720:36809865 | 36809460:36809580 | ENSG00000196182.6 | ENST00000359297.2,ENST00000373129.3,ENST00000373130.3,ENST00000373132.3 |
| exon_skip_24982 | 1 | 36819964:36820017:36820806:36821034:36823839:36823983 | 36820806:36821034 | ENSG00000196182.6 | ENST00000359297.2,ENST00000373129.3,ENST00000373130.3,ENST00000373132.3 |
| exon_skip_24985 | 1 | 36820889:36821034:36823839:36823983:36824337:36824423 | 36823839:36823983 | ENSG00000196182.6 | ENST00000359297.2,ENST00000373129.3,ENST00000373130.3,ENST00000373132.3,ENST00000460417.1,ENST00000473733.1,ENST00000482458.1 |
| exon_skip_24997 | 1 | 36823839:36823983:36824337:36824423:36826821:36826941 | 36824337:36824423 | ENSG00000196182.6 | ENST00000373129.3,ENST00000373132.3,ENST00000460417.1,ENST00000473733.1 |
| exon_skip_25000 | 1 | 36823839:36823983:36824337:36824438:36826821:36826941 | 36824337:36824438 | ENSG00000196182.6 | ENST00000373130.3,ENST00000482458.1 |
| exon_skip_25004 | 1 | 36824337:36824423:36826821:36826941:36833448:36833685 | 36826821:36826941 | ENSG00000196182.6 | ENST00000373129.3 |
| exon_skip_25007 | 1 | 36824337:36824423:36826821:36826941:36851323:36851477 | 36826821:36826941 | ENSG00000196182.6 | ENST00000373132.3 |
| exon_skip_25021 | 1 | 36826821:36826941:36833448:36833685:36851323:36851477 | 36833448:36833685 | ENSG00000196182.6 | ENST00000373129.3 |
| exon_skip_25024 | 1 | 36826821:36826941:36833452:36833685:36851323:36851477 | 36833452:36833685 | ENSG00000196182.6 | ENST00000482458.1 |
| exon_skip_25038 | 1 | 36833461:36833685:36838249:36838375:36851323:36851477 | 36838249:36838375 | ENSG00000196182.6 | ENST00000460017.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for STK40 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000373129 | 36826821 | 36826941 | 3UTR-3CDS |
| ENST00000373132 | 36826821 | 36826941 | 3UTR-3CDS |
| ENST00000373129 | 36833448 | 36833685 | 3UTR-3UTR |
| ENST00000373129 | 36808964 | 36809049 | Frame-shift |
| ENST00000373132 | 36808964 | 36809049 | Frame-shift |
| ENST00000373129 | 36824337 | 36824423 | Frame-shift |
| ENST00000373132 | 36824337 | 36824423 | Frame-shift |
| ENST00000373129 | 36809460 | 36809580 | In-frame |
| ENST00000373132 | 36809460 | 36809580 | In-frame |
| ENST00000373129 | 36820806 | 36821034 | In-frame |
| ENST00000373132 | 36820806 | 36821034 | In-frame |
| ENST00000373129 | 36823839 | 36823983 | In-frame |
| ENST00000373132 | 36823839 | 36823983 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000373129 | 36826821 | 36826941 | 3UTR-3CDS |
| ENST00000373132 | 36826821 | 36826941 | 3UTR-3CDS |
| ENST00000373129 | 36833448 | 36833685 | 3UTR-3UTR |
| ENST00000373129 | 36808964 | 36809049 | Frame-shift |
| ENST00000373132 | 36808964 | 36809049 | Frame-shift |
| ENST00000373129 | 36824337 | 36824423 | Frame-shift |
| ENST00000373132 | 36824337 | 36824423 | Frame-shift |
| ENST00000373129 | 36809460 | 36809580 | In-frame |
| ENST00000373132 | 36809460 | 36809580 | In-frame |
| ENST00000373129 | 36820806 | 36821034 | In-frame |
| ENST00000373132 | 36820806 | 36821034 | In-frame |
| ENST00000373129 | 36823839 | 36823983 | In-frame |
| ENST00000373132 | 36823839 | 36823983 | In-frame |
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Infer the effects of exon skipping event on protein functional features for STK40 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000373129 | 3863 | 435 | 36823839 | 36823983 | 606 | 749 | 66 | 114 |
| ENST00000373132 | 3638 | 435 | 36823839 | 36823983 | 381 | 524 | 66 | 114 |
| ENST00000373129 | 3863 | 435 | 36820806 | 36821034 | 750 | 977 | 114 | 190 |
| ENST00000373132 | 3638 | 435 | 36820806 | 36821034 | 525 | 752 | 114 | 190 |
| ENST00000373129 | 3863 | 435 | 36809460 | 36809580 | 1292 | 1411 | 295 | 334 |
| ENST00000373132 | 3638 | 435 | 36809460 | 36809580 | 1067 | 1186 | 295 | 334 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000373129 | 3863 | 435 | 36823839 | 36823983 | 606 | 749 | 66 | 114 |
| ENST00000373132 | 3638 | 435 | 36823839 | 36823983 | 381 | 524 | 66 | 114 |
| ENST00000373129 | 3863 | 435 | 36820806 | 36821034 | 750 | 977 | 114 | 190 |
| ENST00000373132 | 3638 | 435 | 36820806 | 36821034 | 525 | 752 | 114 | 190 |
| ENST00000373129 | 3863 | 435 | 36809460 | 36809580 | 1292 | 1411 | 295 | 334 |
| ENST00000373132 | 3638 | 435 | 36809460 | 36809580 | 1067 | 1186 | 295 | 334 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for STK40 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_24981 | 36809461 | 36809580 | 36809486 | 36809486 | Frame_Shift_Del | C | - | p.A327fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_24981 | 36809461 | 36809580 | 36809519 | 36809519 | Frame_Shift_Del | G | - | p.Q317fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_24997 | 36824338 | 36824423 | 36824418 | 36824418 | Frame_Shift_Del | G | - | p.R40fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_25000 | 36824338 | 36824438 | 36824418 | 36824418 | Frame_Shift_Del | G | - | p.R40fs |
| STAD | TCGA-CG-4305-01 | exon_skip_24985 | 36823840 | 36823983 | 36823958 | 36823959 | Frame_Shift_Ins | - | C | p.D75fs |
| STAD | TCGA-CG-4305-01 | exon_skip_24985 | 36823840 | 36823983 | 36823959 | 36823960 | Frame_Shift_Ins | - | C | p.D75fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SUPHD1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 36809461 | 36809580 | 36809470 | 36809470 | Missense_Mutation | A | T | p.I332N |
| 201T_LUNG | 36809461 | 36809580 | 36809474 | 36809474 | Missense_Mutation | T | C | p.I331V |
| HCT15_LARGE_INTESTINE | 36809461 | 36809580 | 36809506 | 36809506 | Missense_Mutation | G | A | p.A320V |
| NCIH1568_LUNG | 36809461 | 36809580 | 36809555 | 36809555 | Missense_Mutation | C | A | p.V304L |
| CAMA1_BREAST | 36820807 | 36821034 | 36820812 | 36820812 | Missense_Mutation | G | A | p.H189Y |
| MN60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 36820807 | 36821034 | 36820836 | 36820836 | Missense_Mutation | C | T | p.V181M |
| RPMI7951_SKIN | 36820807 | 36821034 | 36820877 | 36820877 | Missense_Mutation | T | C | p.K167R |
| EN_ENDOMETRIUM | 36820807 | 36821034 | 36820892 | 36820892 | Missense_Mutation | T | C | p.Y162C |
| ISHIKAWAHERAKLIO02ER_ENDOMETRIUM | 36820807 | 36821034 | 36820979 | 36820979 | Missense_Mutation | A | G | p.M133T |
| HEC6_ENDOMETRIUM | 36823840 | 36823983 | 36823931 | 36823931 | Missense_Mutation | C | T | p.R84Q |
| RKO_LARGE_INTESTINE | 36824338 | 36824438 | 36824418 | 36824418 | Missense_Mutation | G | A | p.R40C |
| RKO_LARGE_INTESTINE | 36824338 | 36824423 | 36824418 | 36824418 | Missense_Mutation | G | A | p.R40C |
| L82_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 36808965 | 36809049 | 36808994 | 36808994 | Nonsense_Mutation | G | A | p.Q354* |
| NCIH841_LUNG | 36826822 | 36826941 | 36826924 | 36826924 | Nonsense_Mutation | T | A | p.R4* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STK40 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK40 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STK40 |
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RelatedDrugs for STK40 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STK40 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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