ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for FCRL5

Gene summary

Gene information	Gene symbol	FCRL5
	Gene ID	83416
	Gene name	Fc receptor like 5
	Synonyms	BXMAS1\|CD307\|CD307e\|FCRH5\|IRTA2\|PRO820
	Cytomap	1q23.1
	Type of gene	protein-coding
	Description	Fc receptor-like protein 5fc receptor homolog 5fcR-like protein 5immune receptor translocation-associated protein 2immunoglobulin superfamily receptor translocation associated 2 (IRTA2)
	Modification date	20180519
	UniProtAcc	Q96RD9
	Context	PubMed: FCRL5 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Exon skipping events across known transcript of Ensembl for FCRL5 from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Gene isoform structures and expression levels for FCRL5

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

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Exon skipping events with PSIs in TCGA for FCRL5

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_33553	1	157489532:157489560:157490220:157490337:157490806:157491082	157490220:157490337	ENSG00000143297.14	ENST00000497286.1,ENST00000361835.3,ENST00000356953.4
exon_skip_33554	1	157489532:157489560:157490220:157490351:157490806:157491082	157490220:157490351	ENSG00000143297.14	ENST00000461387.1
exon_skip_33556	1	157490806:157491082:157494068:157494347:157497406:157497685	157494068:157494347	ENSG00000143297.14	ENST00000497286.1,ENST00000361835.3,ENST00000356953.4
exon_skip_33558	1	157497406:157497685:157504403:157504682:157508875:157509154	157504403:157504682	ENSG00000143297.14	ENST00000368191.3,ENST00000361835.3,ENST00000368190.3,ENST00000356953.4
exon_skip_33561	1	157508875:157509154:157512648:157512927:157514051:157514336	157512648:157512927	ENSG00000143297.14	ENST00000368191.3,ENST00000361835.3,ENST00000368190.3,ENST00000356953.4,ENST00000368189.3
exon_skip_33562	1	157514620:157514872:157515977:157516070:157516732:157516955	157515977:157516070	ENSG00000143297.14	ENST00000481082.1
exon_skip_33566	1	157514620:157514872:157516732:157516987:157519349:157519370	157516732:157516987	ENSG00000143297.14	ENST00000361835.3,ENST00000368190.3,ENST00000368189.3
exon_skip_33568	1	157516002:157516070:157516732:157516987:157519349:157519370	157516732:157516987	ENSG00000143297.14	ENST00000368188.2,ENST00000481082.1
exon_skip_33570	1	157516732:157516987:157519349:157519370:157522121:157522180	157519349:157519370	ENSG00000143297.14	ENST00000361835.3,ENST00000368188.2,ENST00000368190.3,ENST00000481082.1,ENST00000368189.3

PSI values of skipped exons in TCGA.

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Exon skipping events with PSIs in GTEx for FCRL5

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_33553	1	157489532:157489560:157490220:157490337:157490806:157491082	157490220:157490337	ENSG00000143297.14	ENST00000361835.3,ENST00000497286.1,ENST00000356953.4
exon_skip_33554	1	157489532:157489560:157490220:157490351:157490806:157491082	157490220:157490351	ENSG00000143297.14	ENST00000461387.1
exon_skip_33556	1	157490806:157491082:157494068:157494347:157497406:157497685	157494068:157494347	ENSG00000143297.14	ENST00000361835.3,ENST00000497286.1,ENST00000356953.4
exon_skip_33558	1	157497406:157497685:157504403:157504682:157508875:157509154	157504403:157504682	ENSG00000143297.14	ENST00000361835.3,ENST00000356953.4,ENST00000368190.3,ENST00000368191.3
exon_skip_33561	1	157508875:157509154:157512648:157512927:157514051:157514336	157512648:157512927	ENSG00000143297.14	ENST00000361835.3,ENST00000356953.4,ENST00000368190.3,ENST00000368191.3,ENST00000368189.3
exon_skip_33562	1	157514620:157514872:157515977:157516070:157516732:157516955	157515977:157516070	ENSG00000143297.14	ENST00000481082.1
exon_skip_33566	1	157514620:157514872:157516732:157516987:157519349:157519370	157516732:157516987	ENSG00000143297.14	ENST00000361835.3,ENST00000368190.3,ENST00000368189.3
exon_skip_33568	1	157516002:157516070:157516732:157516987:157519349:157519370	157516732:157516987	ENSG00000143297.14	ENST00000481082.1,ENST00000368188.2
exon_skip_33570	1	157516732:157516987:157519349:157519370:157522121:157522180	157519349:157519370	ENSG00000143297.14	ENST00000361835.3,ENST00000368190.3,ENST00000368189.3,ENST00000481082.1,ENST00000368188.2

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for FCRL5

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000361835	157490220	157490337	In-frame
ENST00000361835	157494068	157494347	In-frame
ENST00000361835	157504403	157504682	In-frame
ENST00000361835	157512648	157512927	In-frame
ENST00000361835	157516732	157516987	In-frame
ENST00000361835	157519349	157519370	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000361835	157490220	157490337	In-frame
ENST00000361835	157494068	157494347	In-frame
ENST00000361835	157504403	157504682	In-frame
ENST00000361835	157512648	157512927	In-frame
ENST00000361835	157516732	157516987	In-frame
ENST00000361835	157519349	157519370	In-frame

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Infer the effects of exon skipping event on protein functional features for FCRL5

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000361835	5407	977	157516732	157516987	211	465	17	102
ENST00000361835	5407	977	157512648	157512927	1003	1281	281	374
ENST00000361835	5407	977	157512648	157512927	1003	1281	281	374
ENST00000361835	5407	977	157504403	157504682	1561	1839	467	560
ENST00000361835	5407	977	157504403	157504682	1561	1839	467	560
ENST00000361835	5407	977	157494068	157494347	2119	2397	653	746
ENST00000361835	5407	977	157494068	157494347	2119	2397	653	746
ENST00000361835	5407	977	157494068	157494347	2119	2397	653	746
ENST00000361835	5407	977	157490220	157490337	2674	2790	838	877

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000361835	5407	977	157516732	157516987	211	465	17	102
ENST00000361835	5407	977	157512648	157512927	1003	1281	281	374
ENST00000361835	5407	977	157512648	157512927	1003	1281	281	374
ENST00000361835	5407	977	157504403	157504682	1561	1839	467	560
ENST00000361835	5407	977	157504403	157504682	1561	1839	467	560
ENST00000361835	5407	977	157494068	157494347	2119	2397	653	746
ENST00000361835	5407	977	157494068	157494347	2119	2397	653	746
ENST00000361835	5407	977	157494068	157494347	2119	2397	653	746
ENST00000361835	5407	977	157490220	157490337	2674	2790	838	877

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q96RD9	17	102	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
Q96RD9	17	102	44	85	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114
Q96RD9	17	102	23	101	Domain	Note=Ig-like C2-type 1
Q96RD9	17	102	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q96RD9	281	374	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:12975309,ECO:0000303\|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
Q96RD9	281	374	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:12975309,ECO:0000303\|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
Q96RD9	281	374	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	281	374	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	281	374	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
Q96RD9	281	374	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
Q96RD9	281	374	308	355	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114
Q96RD9	281	374	308	355	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114
Q96RD9	281	374	287	374	Domain	Note=Ig-like C2-type 3
Q96RD9	281	374	287	374	Domain	Note=Ig-like C2-type 3
Q96RD9	281	374	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q96RD9	281	374	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q96RD9	467	560	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:12975309,ECO:0000303\|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
Q96RD9	467	560	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:12975309,ECO:0000303\|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
Q96RD9	467	560	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	467	560	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	467	560	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
Q96RD9	467	560	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
Q96RD9	467	560	494	541	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114
Q96RD9	467	560	494	541	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114
Q96RD9	467	560	473	556	Domain	Note=Ig-like C2-type 5
Q96RD9	467	560	473	556	Domain	Note=Ig-like C2-type 5
Q96RD9	467	560	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q96RD9	467	560	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q96RD9	653	746	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:12975309,ECO:0000303\|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
Q96RD9	653	746	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:12975309,ECO:0000303\|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
Q96RD9	653	746	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:12975309,ECO:0000303\|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
Q96RD9	653	746	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	653	746	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	653	746	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	653	746	593	977	Alternative sequence	ID=VSP_017384;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	653	746	593	977	Alternative sequence	ID=VSP_017384;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	653	746	593	977	Alternative sequence	ID=VSP_017384;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	653	746	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
Q96RD9	653	746	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
Q96RD9	653	746	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
Q96RD9	653	746	680	727	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114
Q96RD9	653	746	680	727	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114
Q96RD9	653	746	680	727	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114
Q96RD9	653	746	659	744	Domain	Note=Ig-like C2-type 7
Q96RD9	653	746	659	744	Domain	Note=Ig-like C2-type 7
Q96RD9	653	746	659	744	Domain	Note=Ig-like C2-type 7
Q96RD9	653	746	687	687	Natural variant	ID=VAR_035514;Note=In a breast cancer sample%3B somatic mutation. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q96RD9	653	746	687	687	Natural variant	ID=VAR_035514;Note=In a breast cancer sample%3B somatic mutation. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q96RD9	653	746	687	687	Natural variant	ID=VAR_035514;Note=In a breast cancer sample%3B somatic mutation. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q96RD9	653	746	733	733	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q96RD9	653	746	733	733	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q96RD9	653	746	733	733	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q96RD9	653	746	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q96RD9	653	746	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q96RD9	653	746	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q96RD9	838	877	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:12975309,ECO:0000303\|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
Q96RD9	838	877	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	838	877	593	977	Alternative sequence	ID=VSP_017384;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	838	877	760	977	Alternative sequence	ID=VSP_017386;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	838	877	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
Q96RD9	838	877	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q96RD9	838	877	873	977	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q96RD9	838	877	852	872	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q96RD9	17	102	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
Q96RD9	17	102	44	85	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114
Q96RD9	17	102	23	101	Domain	Note=Ig-like C2-type 1
Q96RD9	17	102	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q96RD9	281	374	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:12975309,ECO:0000303\|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
Q96RD9	281	374	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:12975309,ECO:0000303\|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
Q96RD9	281	374	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	281	374	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	281	374	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
Q96RD9	281	374	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
Q96RD9	281	374	308	355	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114
Q96RD9	281	374	308	355	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114
Q96RD9	281	374	287	374	Domain	Note=Ig-like C2-type 3
Q96RD9	281	374	287	374	Domain	Note=Ig-like C2-type 3
Q96RD9	281	374	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q96RD9	281	374	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q96RD9	467	560	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:12975309,ECO:0000303\|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
Q96RD9	467	560	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:12975309,ECO:0000303\|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
Q96RD9	467	560	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	467	560	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	467	560	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
Q96RD9	467	560	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
Q96RD9	467	560	494	541	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114
Q96RD9	467	560	494	541	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114
Q96RD9	467	560	473	556	Domain	Note=Ig-like C2-type 5
Q96RD9	467	560	473	556	Domain	Note=Ig-like C2-type 5
Q96RD9	467	560	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q96RD9	467	560	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q96RD9	653	746	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:12975309,ECO:0000303\|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
Q96RD9	653	746	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:12975309,ECO:0000303\|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
Q96RD9	653	746	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:12975309,ECO:0000303\|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
Q96RD9	653	746	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	653	746	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	653	746	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	653	746	593	977	Alternative sequence	ID=VSP_017384;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	653	746	593	977	Alternative sequence	ID=VSP_017384;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	653	746	593	977	Alternative sequence	ID=VSP_017384;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	653	746	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
Q96RD9	653	746	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
Q96RD9	653	746	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
Q96RD9	653	746	680	727	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114
Q96RD9	653	746	680	727	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114
Q96RD9	653	746	680	727	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00114
Q96RD9	653	746	659	744	Domain	Note=Ig-like C2-type 7
Q96RD9	653	746	659	744	Domain	Note=Ig-like C2-type 7
Q96RD9	653	746	659	744	Domain	Note=Ig-like C2-type 7
Q96RD9	653	746	687	687	Natural variant	ID=VAR_035514;Note=In a breast cancer sample%3B somatic mutation. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q96RD9	653	746	687	687	Natural variant	ID=VAR_035514;Note=In a breast cancer sample%3B somatic mutation. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q96RD9	653	746	687	687	Natural variant	ID=VAR_035514;Note=In a breast cancer sample%3B somatic mutation. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q96RD9	653	746	733	733	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q96RD9	653	746	733	733	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q96RD9	653	746	733	733	Sequence conflict	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q96RD9	653	746	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q96RD9	653	746	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q96RD9	653	746	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q96RD9	838	877	125	977	Alternative sequence	ID=VSP_017380;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:12975309,ECO:0000303\|PubMed:17974005;Dbxref=PMID:12975309,PMID:17974005
Q96RD9	838	877	153	977	Alternative sequence	ID=VSP_017382;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	838	877	593	977	Alternative sequence	ID=VSP_017384;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	838	877	760	977	Alternative sequence	ID=VSP_017386;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11290337;Dbxref=PMID:11290337
Q96RD9	838	877	16	977	Chain	ID=PRO_0000225622;Note=Fc receptor-like protein 5
Q96RD9	838	877	16	851	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q96RD9	838	877	873	977	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q96RD9	838	877	852	872	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255

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SNVs in the skipped exons for FCRL5

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
COAD	TCGA-AZ-6598-01	exon_skip_33553	157490221	157490337	157490289	157490289	Frame_Shift_Del	C	-	p.G855fs
COAD	TCGA-AZ-6598-01	exon_skip_33554	157490221	157490351	157490289	157490289	Frame_Shift_Del	C	-	p.G855fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_33558	157504404	157504682	157504411	157504411	Frame_Shift_Del	A	-	p.F558fs
LUAD	TCGA-05-4398-01	exon_skip_33558	157504404	157504682	157504517	157504517	Frame_Shift_Del	C	-	p.G523fs
LIHC	TCGA-DD-A39Y-01	exon_skip_33561	157512649	157512927	157512790	157512790	Frame_Shift_Del	G	-	p.L328fs
LIHC	TCGA-DD-A39Y-01	exon_skip_33561	157512649	157512927	157512875	157512875	Frame_Shift_Del	A	-	p.F299fs
LIHC	TCGA-DD-A39Y-01	exon_skip_33568 exon_skip_33566	157516733	157516987	157516739	157516739	Frame_Shift_Del	A	-	p.S102fs
LIHC	TCGA-DD-A3A0-01	exon_skip_33568 exon_skip_33566	157516733	157516987	157516848	157516848	Frame_Shift_Del	T	-	p.K64fs
LUAD	TCGA-55-7994-01	exon_skip_33556	157494069	157494347	157494145	157494146	Frame_Shift_Ins	-	T	p.L721fs
SKCM	TCGA-DA-A3F3-06	exon_skip_33558	157504404	157504682	157504541	157504541	Nonsense_Mutation	C	T	p.W515*
CESC	TCGA-JW-A5VL-01	exon_skip_33561	157512649	157512927	157512838	157512838	Nonsense_Mutation	C	A	p.E312*
SKCM	TCGA-GN-A266-06	exon_skip_33568 exon_skip_33566	157516733	157516987	157516808	157516808	Nonsense_Mutation	G	A	p.Q78*
SKCM	TCGA-GN-A266-06	exon_skip_33568 exon_skip_33566	157516733	157516987	157516808	157516808	Nonsense_Mutation	G	A	p.Q78X
SKCM	TCGA-D3-A8GK-06	exon_skip_33568 exon_skip_33566	157516733	157516987	157516948	157516948	Nonsense_Mutation	C	T	p.W31*
LGG	TCGA-FG-A6J3-01	exon_skip_33568 exon_skip_33566	157516733	157516987	157516958	157516958	Nonsense_Mutation	G	A	p.Q28*
UCEC	TCGA-AP-A05N-01	exon_skip_33568 exon_skip_33566	157516733	157516987	157516731	157516731	Splice_Site	A	G	p.A103_splice

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons

Mutation description

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
NCIH650_LUNG	157504404	157504682	157504543	157504543	Frame_Shift_Del	C	-	p.L514fs
NCIH69_LUNG	157504404	157504682	157504679	157504679	Frame_Shift_Del	G	-	p.P469fs
DU145_PROSTATE	157490221	157490337	157490232	157490232	Missense_Mutation	G	A	p.S874L
DU145_PROSTATE	157490221	157490351	157490232	157490232	Missense_Mutation	G	A	p.S874L
SCMCRM2_SOFT_TISSUE	157490221	157490337	157490263	157490263	Missense_Mutation	C	A	p.A864S
SCMCRM2_SOFT_TISSUE	157490221	157490351	157490263	157490263	Missense_Mutation	C	A	p.A864S
TTC442_SOFT_TISSUE	157490221	157490337	157490275	157490275	Missense_Mutation	C	A	p.A860S
TTC442_SOFT_TISSUE	157490221	157490351	157490275	157490275	Missense_Mutation	C	A	p.A860S
NCIH1435_LUNG	157490221	157490337	157490292	157490292	Missense_Mutation	C	A	p.G854V
NCIH1435_LUNG	157490221	157490351	157490292	157490292	Missense_Mutation	C	A	p.G854V
BT20_BREAST	157490221	157490337	157490296	157490296	Missense_Mutation	C	T	p.A853T
BT20_BREAST	157490221	157490351	157490296	157490296	Missense_Mutation	C	T	p.A853T
H4_CENTRAL_NERVOUS_SYSTEM	157494069	157494347	157494169	157494169	Missense_Mutation	G	T	p.F713L
KYSE70_OESOPHAGUS	157494069	157494347	157494174	157494174	Missense_Mutation	A	T	p.S712T
JHUEM7_ENDOMETRIUM	157494069	157494347	157494219	157494219	Missense_Mutation	C	A	p.D697Y
M14_SKIN	157494069	157494347	157494223	157494223	Missense_Mutation	A	C	p.H695Q
SNU175_LARGE_INTESTINE	157494069	157494347	157494230	157494230	Missense_Mutation	A	C	p.F693C
HCC2157_BREAST	157494069	157494347	157494248	157494248	Missense_Mutation	G	C	p.S687C
NCIH513_PLEURA	157494069	157494347	157494297	157494297	Missense_Mutation	C	A	p.V671L
HCC515_LUNG	157494069	157494347	157494309	157494309	Missense_Mutation	T	A	p.R667W
NCIH23_LUNG	157494069	157494347	157494318	157494318	Missense_Mutation	T	C	p.R664G
IHH4_THYROID	157504404	157504682	157504417	157504417	Missense_Mutation	G	T	p.S556R
PL4_PANCREAS	157504404	157504682	157504417	157504417	Missense_Mutation	G	T	p.S556R
786O_KIDNEY	157504404	157504682	157504448	157504448	Missense_Mutation	C	A	p.G546V
HCC2108_LUNG	157504404	157504682	157504461	157504461	Missense_Mutation	T	A	p.T542S
MORCPR_LUNG	157504404	157504682	157504461	157504461	Missense_Mutation	T	A	p.T542S
D283MED_CENTRAL_NERVOUS_SYSTEM	157504404	157504682	157504496	157504496	Missense_Mutation	G	C	p.S530C
SARC9371_BONE	157504404	157504682	157504523	157504523	Missense_Mutation	G	A	p.S521F
BE2M17_AUTONOMIC_GANGLIA	157504404	157504682	157504549	157504549	Missense_Mutation	C	A	p.M512I
HS939T_SKIN	157504404	157504682	157504560	157504560	Missense_Mutation	G	A	p.H509Y
SW684_SOFT_TISSUE	157504404	157504682	157504560	157504560	Missense_Mutation	G	A	p.H509Y
MAC2A_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	157504404	157504682	157504592	157504592	Missense_Mutation	C	T	p.R498K
HCC2450_LUNG	157504404	157504682	157504644	157504644	Missense_Mutation	C	T	p.E481K
BICR18_UPPER_AERODIGESTIVE_TRACT	157504404	157504682	157504644	157504644	Missense_Mutation	C	T	p.E481K
JSC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	157512649	157512927	157512768	157512768	Missense_Mutation	C	A	p.C335F
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	157512649	157512927	157512771	157512771	Missense_Mutation	C	A	p.R334L
HEC59_ENDOMETRIUM	157512649	157512927	157512822	157512822	Missense_Mutation	G	A	p.T317I
NCIH446_LUNG	157512649	157512927	157512849	157512849	Missense_Mutation	C	G	p.C308S
NCIH650_LUNG	157512649	157512927	157512925	157512925	Missense_Mutation	G	T	p.P283T
RL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	157516733	157516987	157516810	157516810	Missense_Mutation	A	C	p.V77G
MFE319_ENDOMETRIUM	157516733	157516987	157516818	157516818	Missense_Mutation	G	C	p.I74M
NCIH69_LUNG	157516733	157516987	157516831	157516831	Missense_Mutation	G	A	p.T70I
KM12_LARGE_INTESTINE	157516733	157516987	157516867	157516867	Missense_Mutation	T	C	p.Y58C
NUDUL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	157516733	157516987	157516897	157516897	Missense_Mutation	C	T	p.R48H
NCIH1339_LUNG	157516733	157516987	157516930	157516930	Missense_Mutation	C	A	p.G37V
PK45H_PANCREAS	157519350	157519370	157519361	157519361	Missense_Mutation	C	T	p.S14N
KYSE410_OESOPHAGUS	157490221	157490337	157490227	157490227	Nonsense_Mutation	T	A	p.K876*
KYSE410_OESOPHAGUS	157490221	157490351	157490227	157490227	Nonsense_Mutation	T	A	p.K876*
NCIH1339_LUNG	157512649	157512927	157512815	157512815	Nonsense_Mutation	G	T	p.Y319*
NB12_AUTONOMIC_GANGLIA	157512649	157512927	157512871	157512871	Nonsense_Mutation	C	A	p.G301*
SW48_LARGE_INTESTINE	157516733	157516987	157516869	157516869	Nonsense_Mutation	C	T	p.W57*
DU145_PROSTATE	157512649	157512927	157512926	157512926	Splice_Site	G	C	p.I282M

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FCRL5

sQTL information located at the skipped exons.

Exon skip ID

Chromosome

Three exons

Skippped exon

ENST

Cancer type

SNP id

Location

DNA change (ref/var)

P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FCRL5

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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FCRL5

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RelatedDrugs for FCRL5

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for FCRL5

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for FCRL5

Exon skipping events across known transcript of Ensembl for FCRL5 from UCSC genome browser

Gene isoform structures and expression levels for FCRL5

Exon skipping events with PSIs in TCGA for FCRL5

Exon skipping events with PSIs in GTEx for FCRL5

Open reading frame (ORF) annotation in the exon skipping event for FCRL5

Infer the effects of exon skipping event on protein functional features for FCRL5

SNVs in the skipped exons for FCRL5

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FCRL5

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FCRL5

Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FCRL5

RelatedDrugs for FCRL5

RelatedDiseases for FCRL5