ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for CAPG

Gene summary

Gene information	Gene symbol	CAPG
	Gene ID	822
	Gene name	capping actin protein, gelsolin like
	Synonyms	AFCP\|HEL-S-66\|MCP
	Cytomap	2p11.2
	Type of gene	protein-coding
	Description	macrophage-capping proteinactin-regulatory protein CAP-Gcapping protein (actin filament), gelsolin-likeepididymis secretory protein Li 66gelsolin-like capping protein
	Modification date	20180522
	UniProtAcc	P40121
	Context	PubMed: CAPG [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Exon skipping events across known transcript of Ensembl for CAPG from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Gene isoform structures and expression levels for CAPG

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

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Exon skipping events with PSIs in TCGA for CAPG

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_340709	2	85622017:85622081:85622660:85622749:85625142:85625254	85622660:85622749	ENSG00000042493.11	ENST00000409724.1,ENST00000453973.1,ENST00000409670.1,ENST00000263867.4,ENST00000471064.1,ENST00000409921.1
exon_skip_340715	2	85622697:85622749:85623102:85623133:85625142:85625254	85623102:85623133	ENSG00000042493.11	ENST00000483659.1
exon_skip_340717	2	85622697:85622749:85625142:85625254:85625812:85625857	85625142:85625254	ENSG00000042493.11	ENST00000453973.1
exon_skip_340718	2	85622697:85622749:85625142:85625275:85625812:85625857	85625142:85625275	ENSG00000042493.11	ENST00000409724.1,ENST00000409670.1,ENST00000263867.4,ENST00000409921.1
exon_skip_340726	2	85623102:85623133:85625142:85625275:85625812:85625857	85625142:85625275	ENSG00000042493.11	ENST00000483659.1
exon_skip_340728	2	85625142:85625275:85625812:85625905:85626258:85626303	85625812:85625905	ENSG00000042493.11	ENST00000409724.1,ENST00000409670.1,ENST00000263867.4,ENST00000483659.1
exon_skip_340739	2	85626357:85626408:85628287:85628452:85628651:85628711	85628287:85628452	ENSG00000042493.11	ENST00000449030.1,ENST00000409724.1,ENST00000409670.1,ENST00000263867.4,ENST00000447219.2,ENST00000483659.1,ENST00000459793.2,ENST00000409275.1,ENST00000439385.1,ENST00000409921.1
exon_skip_340745	2	85628294:85628452:85628651:85628806:85628907:85629063	85628651:85628806	ENSG00000042493.11	ENST00000449030.1,ENST00000409724.1,ENST00000409670.1,ENST00000263867.4,ENST00000447219.2,ENST00000459793.2,ENST00000409275.1,ENST00000439385.1,ENST00000409921.1
exon_skip_340755	2	85629260:85629281:85640265:85640367:85640955:85641097	85640265:85640367	ENSG00000042493.11	ENST00000479651.1
exon_skip_340756	2	85629260:85629281:85640265:85640367:85641106:85641141	85640265:85640367	ENSG00000042493.11	ENST00000447219.2

PSI values of skipped exons in TCGA.

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Exon skipping events with PSIs in GTEx for CAPG

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_340709	2	85622017:85622081:85622660:85622749:85625142:85625254	85622660:85622749	ENSG00000042493.11	ENST00000263867.4,ENST00000453973.1,ENST00000409921.1,ENST00000409670.1,ENST00000409724.1,ENST00000471064.1
exon_skip_340715	2	85622697:85622749:85623102:85623133:85625142:85625254	85623102:85623133	ENSG00000042493.11	ENST00000483659.1
exon_skip_340717	2	85622697:85622749:85625142:85625254:85625812:85625857	85625142:85625254	ENSG00000042493.11	ENST00000453973.1
exon_skip_340718	2	85622697:85622749:85625142:85625275:85625812:85625857	85625142:85625275	ENSG00000042493.11	ENST00000263867.4,ENST00000409921.1,ENST00000409670.1,ENST00000409724.1
exon_skip_340726	2	85623102:85623133:85625142:85625275:85625812:85625857	85625142:85625275	ENSG00000042493.11	ENST00000483659.1
exon_skip_340728	2	85625142:85625275:85625812:85625905:85626258:85626303	85625812:85625905	ENSG00000042493.11	ENST00000263867.4,ENST00000409670.1,ENST00000409724.1,ENST00000483659.1
exon_skip_340739	2	85626357:85626408:85628287:85628452:85628651:85628711	85628287:85628452	ENSG00000042493.11	ENST00000263867.4,ENST00000409921.1,ENST00000409670.1,ENST00000409724.1,ENST00000483659.1,ENST00000439385.1,ENST00000449030.1,ENST00000447219.2,ENST00000459793.2,ENST00000409275.1
exon_skip_340745	2	85628294:85628452:85628651:85628806:85628907:85629063	85628651:85628806	ENSG00000042493.11	ENST00000263867.4,ENST00000409921.1,ENST00000409670.1,ENST00000409724.1,ENST00000439385.1,ENST00000449030.1,ENST00000447219.2,ENST00000459793.2,ENST00000409275.1
exon_skip_340756	2	85629260:85629281:85640265:85640367:85641106:85641141	85640265:85640367	ENSG00000042493.11	ENST00000447219.2

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for CAPG

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000263867	85622660	85622749	Frame-shift
ENST00000409670	85622660	85622749	Frame-shift
ENST00000409724	85622660	85622749	Frame-shift
ENST00000263867	85625142	85625275	Frame-shift
ENST00000409670	85625142	85625275	Frame-shift
ENST00000409724	85625142	85625275	Frame-shift
ENST00000263867	85628651	85628806	Frame-shift
ENST00000409670	85628651	85628806	Frame-shift
ENST00000409724	85628651	85628806	Frame-shift
ENST00000263867	85625812	85625905	In-frame
ENST00000409670	85625812	85625905	In-frame
ENST00000409724	85625812	85625905	In-frame
ENST00000263867	85628287	85628452	In-frame
ENST00000409670	85628287	85628452	In-frame
ENST00000409724	85628287	85628452	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000263867	85622660	85622749	Frame-shift
ENST00000409670	85622660	85622749	Frame-shift
ENST00000409724	85622660	85622749	Frame-shift
ENST00000263867	85625142	85625275	Frame-shift
ENST00000409670	85625142	85625275	Frame-shift
ENST00000409724	85625142	85625275	Frame-shift
ENST00000263867	85628651	85628806	Frame-shift
ENST00000409670	85628651	85628806	Frame-shift
ENST00000409724	85628651	85628806	Frame-shift
ENST00000263867	85625812	85625905	In-frame
ENST00000409670	85625812	85625905	In-frame
ENST00000409724	85625812	85625905	In-frame
ENST00000263867	85628287	85628452	In-frame
ENST00000409670	85628287	85628452	In-frame
ENST00000409724	85628287	85628452	In-frame

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Infer the effects of exon skipping event on protein functional features for CAPG

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000263867	1459	348	85628287	85628452	602	766	117	172
ENST00000409670	1200	348	85628287	85628452	423	587	117	172
ENST00000409724	1168	348	85628287	85628452	456	620	117	172
ENST00000263867	1459	348	85625812	85625905	917	1009	222	253
ENST00000409670	1200	348	85625812	85625905	738	830	222	253
ENST00000409724	1168	348	85625812	85625905	771	863	222	253

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000263867	1459	348	85628287	85628452	602	766	117	172
ENST00000409670	1200	348	85628287	85628452	423	587	117	172
ENST00000409724	1168	348	85628287	85628452	456	620	117	172
ENST00000263867	1459	348	85625812	85625905	917	1009	222	253
ENST00000409670	1200	348	85625812	85625905	738	830	222	253
ENST00000409724	1168	348	85625812	85625905	771	863	222	253

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P40121	117	172	115	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	115	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	115	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	135	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	135	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	135	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	145	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	145	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	145	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	149	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	149	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	149	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	164	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	164	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	164	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	1	348	Chain	ID=PRO_0000218753;Note=Macrophage-capping protein
P40121	117	172	1	348	Chain	ID=PRO_0000218753;Note=Macrophage-capping protein
P40121	117	172	1	348	Chain	ID=PRO_0000218753;Note=Macrophage-capping protein
P40121	117	172	157	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	157	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	157	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	137	146	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40121	117	172	137	146	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40121	117	172	137	146	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40121	117	172	148	188	Repeat	Note=Gelsolin-like 2
P40121	117	172	148	188	Repeat	Note=Gelsolin-like 2
P40121	117	172	148	188	Repeat	Note=Gelsolin-like 2
P40121	222	253	242	246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	222	253	242	246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	222	253	242	246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	222	253	250	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	222	253	250	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	222	253	250	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	222	253	1	348	Chain	ID=PRO_0000218753;Note=Macrophage-capping protein
P40121	222	253	1	348	Chain	ID=PRO_0000218753;Note=Macrophage-capping protein
P40121	222	253	1	348	Chain	ID=PRO_0000218753;Note=Macrophage-capping protein
P40121	222	253	218	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	222	253	218	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	222	253	218	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P40121	117	172	115	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	115	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	115	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	135	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	135	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	135	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	145	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	145	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	145	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	149	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	149	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	149	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	164	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	164	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	164	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	1	348	Chain	ID=PRO_0000218753;Note=Macrophage-capping protein
P40121	117	172	1	348	Chain	ID=PRO_0000218753;Note=Macrophage-capping protein
P40121	117	172	1	348	Chain	ID=PRO_0000218753;Note=Macrophage-capping protein
P40121	117	172	157	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	157	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	157	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	117	172	137	146	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40121	117	172	137	146	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40121	117	172	137	146	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40121	117	172	148	188	Repeat	Note=Gelsolin-like 2
P40121	117	172	148	188	Repeat	Note=Gelsolin-like 2
P40121	117	172	148	188	Repeat	Note=Gelsolin-like 2
P40121	222	253	242	246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	222	253	242	246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	222	253	242	246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	222	253	250	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	222	253	250	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	222	253	250	255	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	222	253	1	348	Chain	ID=PRO_0000218753;Note=Macrophage-capping protein
P40121	222	253	1	348	Chain	ID=PRO_0000218753;Note=Macrophage-capping protein
P40121	222	253	1	348	Chain	ID=PRO_0000218753;Note=Macrophage-capping protein
P40121	222	253	218	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	222	253	218	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72
P40121	222	253	218	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1J72

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SNVs in the skipped exons for CAPG

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
ESCA	TCGA-L5-A4OI-01	exon_skip_340709	85622661	85622749	85622671	85622671	Frame_Shift_Del	G	-	p.P324fs
LIHC	TCGA-DD-A39Y-01	exon_skip_340739	85628288	85628452	85628372	85628372	Frame_Shift_Del	C	-	p.G144fs
LIHC	TCGA-DD-A1EG-01	exon_skip_340739	85628288	85628452	85628406	85628406	Frame_Shift_Del	G	-	p.P133fs
LUAD	TCGA-44-A4SS-01	exon_skip_340739	85628288	85628452	85628406	85628406	Frame_Shift_Del	G	-	p.P133fs
LIHC	TCGA-DD-A3A0-01	exon_skip_340745	85628652	85628806	85628792	85628792	Frame_Shift_Del	G	-	p.R71fs
BLCA	TCGA-DK-A3IT-01	exon_skip_340728	85625813	85625905	85625866	85625866	Nonsense_Mutation	C	A	p.E236*
LUSC	TCGA-22-5489-01	exon_skip_340745	85628652	85628806	85628714	85628714	Nonsense_Mutation	C	A	p.E97*

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons

Mutation description

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
HEC59_ENDOMETRIUM	85622661	85622749	85622686	85622686	Missense_Mutation	C	T	p.R304H
SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	85622661	85622749	85622746	85622746	Missense_Mutation	C	T	p.R284Q
KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	85625143	85625275	85625159	85625159	Missense_Mutation	C	A	p.K277N
KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	85625143	85625254	85625159	85625159	Missense_Mutation	C	A	p.K277N
LNCAPCLONEFGC_PROSTATE	85625143	85625275	85625173	85625173	Missense_Mutation	C	A	p.G273W
LNCAPCLONEFGC_PROSTATE	85625143	85625254	85625173	85625173	Missense_Mutation	C	A	p.G273W
SJSA1_BONE	85625143	85625275	85625259	85625259	Missense_Mutation	C	T	p.G244E
SJSA1_BONE	85625143	85625254	85625259	85625259	Missense_Mutation	C	T	p.G244E
FTC238_THYROID	85625813	85625905	85625876	85625876	Missense_Mutation	C	A	p.E217D
SNU423_LIVER	85628288	85628452	85628322	85628322	Missense_Mutation	T	C	p.N161S
SUPB15_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	85628288	85628452	85628340	85628340	Missense_Mutation	A	T	p.L155Q
CHSA8926_BONE	85628288	85628452	85628359	85628359	Missense_Mutation	G	A	p.R149C
SW1116_LARGE_INTESTINE	85628288	85628452	85628440	85628440	Missense_Mutation	C	G	p.E122Q
HEP3B217_LIVER	85628652	85628806	85628656	85628656	Missense_Mutation	T	C	p.Y116C
MM415_SKIN	85628652	85628806	85628674	85628674	Missense_Mutation	A	T	p.F110Y
SNUC5_LARGE_INTESTINE	85622661	85622749	85622747	85622747	Nonsense_Mutation	G	A	p.R284*
HCT116_LARGE_INTESTINE	85628652	85628806	85628801	85628801	Nonsense_Mutation	G	A	p.Q68*
NCIH660_PROSTATE	85628288	85628452	85628288	85628288	Splice_Site	C	T	p.Q172Q

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CAPG

sQTL information located at the skipped exons.

Exon skip ID	Chromosome	Three exons	Skippped exon	ENST	Cancer type	SNP id	Location	DNA change (ref/var)	P-value
exon_skip_340718	2	85622697:85622749:85625142:85625275:85625812:85625857	85625142:85625275	ENST00000409724.1,ENST00000409670.1,ENST00000263867.4,ENST00000409921.1	LGG	rs6885	chr2:85625222	T/G	1.29e-05
exon_skip_340718	2	85622697:85622749:85625142:85625275:85625812:85625857	85625142:85625275	ENST00000409724.1,ENST00000409670.1,ENST00000263867.4,ENST00000409921.1	LGG	rs6885	chr2:85625222	T/G	1.32e-05
exon_skip_340718	2	85622697:85622749:85625142:85625275:85625812:85625857	85625142:85625275	ENST00000409724.1,ENST00000409670.1,ENST00000263867.4,ENST00000409921.1	PRAD	rs6885	chr2:85625222	T/G	9.90e-04
exon_skip_340718	2	85622697:85622749:85625142:85625275:85625812:85625857	85625142:85625275	ENST00000409724.1,ENST00000409670.1,ENST00000263867.4,ENST00000409921.1	PRAD	rs6885	chr2:85625222	T/G	1.69e-03
exon_skip_340715	2	85622697:85622749:85623102:85623133:85625142:85625254	85623102:85623133	ENST00000483659.1	LGG	rs77016175	chr2:85623097	C/T	5.96e-04
exon_skip_340715	2	85622697:85622749:85623102:85623133:85625142:85625254	85623102:85623133	ENST00000483659.1	LGG	rs77016175	chr2:85623097	C/T	3.20e-03
exon_skip_340717	2	85622697:85622749:85625142:85625254:85625812:85625857	85625142:85625254	ENST00000453973.1	LGG	rs6885	chr2:85625222	T/G	1.29e-05
exon_skip_340717	2	85622697:85622749:85625142:85625254:85625812:85625857	85625142:85625254	ENST00000453973.1	LGG	rs6885	chr2:85625222	T/G	1.32e-05
exon_skip_340717	2	85622697:85622749:85625142:85625254:85625812:85625857	85625142:85625254	ENST00000453973.1	PRAD	rs6885	chr2:85625222	T/G	9.90e-04
exon_skip_340717	2	85622697:85622749:85625142:85625254:85625812:85625857	85625142:85625254	ENST00000453973.1	PRAD	rs6885	chr2:85625222	T/G	1.69e-03
exon_skip_340726	2	85623102:85623133:85625142:85625275:85625812:85625857	85625142:85625275	ENST00000483659.1	LGG	rs6885	chr2:85625222	T/G	1.29e-05
exon_skip_340726	2	85623102:85623133:85625142:85625275:85625812:85625857	85625142:85625275	ENST00000483659.1	LGG	rs6885	chr2:85625222	T/G	1.32e-05
exon_skip_340726	2	85623102:85623133:85625142:85625275:85625812:85625857	85625142:85625275	ENST00000483659.1	PRAD	rs6885	chr2:85625222	T/G	9.90e-04
exon_skip_340726	2	85623102:85623133:85625142:85625275:85625812:85625857	85625142:85625275	ENST00000483659.1	PRAD	rs6885	chr2:85625222	T/G	1.69e-03
exon_skip_340745	2	85628294:85628452:85628651:85628806:85628907:85629063	85628651:85628806	ENST00000449030.1,ENST00000409724.1,ENST00000409670.1,ENST00000263867.4,ENST00000447219.2,ENST00000459793.2,ENST00000409275.1,ENST00000439385.1,ENST00000409921.1	LGG	rs2229669	chr2:85628745	C/T	6.69e-04
exon_skip_340745	2	85628294:85628452:85628651:85628806:85628907:85629063	85628651:85628806	ENST00000449030.1,ENST00000409724.1,ENST00000409670.1,ENST00000263867.4,ENST00000447219.2,ENST00000459793.2,ENST00000409275.1,ENST00000439385.1,ENST00000409921.1	LGG	rs2229669	chr2:85628745	C/T	3.57e-03

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CAPG

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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CAPG

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RelatedDrugs for CAPG

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CAPG

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
CAPG	C0007134	Renal Cell Carcinoma	1	CTD_human
CAPG	C0022548	Keloid	1	CTD_human
CAPG	C0023467	Leukemia, Myelocytic, Acute	1	CTD_human
CAPG	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
CAPG	C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

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