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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MED25 |
 Gene summary |
| Gene information | Gene symbol | MED25 | Gene ID | 81857 |
| Gene name | mediator complex subunit 25 | |
| Synonyms | ACID1|ARC92|BVSYS|CMT2B2|P78|PTOV2|TCBAP0758 | |
| Cytomap | 19q13.33 | |
| Type of gene | protein-coding | |
| Description | mediator of RNA polymerase II transcription subunit 25ARC/mediator transcriptional coactivator subunitactivator interaction domain-containing protein 1activator-recruited cofactor 92 kDa componentmediator of RNA polymerase II transcription, subunit 25 | |
| Modification date | 20180519 | |
| UniProtAcc | Q71SY5 | |
| Context | PubMed: MED25 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MED25 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17641689 |
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Exon skipping events across known transcript of Ensembl for MED25 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MED25 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MED25 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_310095 | 19 | 50321827:50321873:50322428:50322553:50331705:50331804 | 50322428:50322553 | ENSG00000104973.10 | ENST00000312865.6,ENST00000595185.1 |
| exon_skip_310102 | 19 | 50322428:50322553:50331705:50331804:50332226:50332347 | 50331705:50331804 | ENSG00000104973.10 | ENST00000312865.6,ENST00000595185.1 |
| exon_skip_310109 | 19 | 50333078:50333205:50333344:50333475:50333767:50333855 | 50333344:50333475 | ENSG00000104973.10 | ENST00000312865.6 |
| exon_skip_310114 | 19 | 50333767:50333855:50333950:50334144:50334589:50334718 | 50333950:50334144 | ENSG00000104973.10 | ENST00000312865.6,ENST00000538643.1 |
| exon_skip_310115 | 19 | 50334099:50334144:50334589:50334718:50335192:50335278 | 50334589:50334718 | ENSG00000104973.10 | ENST00000312865.6,ENST00000599722.1,ENST00000538643.1 |
| exon_skip_310121 | 19 | 50338314:50338434:50338790:50338862:50338983:50338995 | 50338790:50338862 | ENSG00000104973.10 | ENST00000312865.6,ENST00000593767.1,ENST00000594998.1,ENST00000538643.1 |
| exon_skip_310123 | 19 | 50338983:50339202:50339482:50339663:50341836:50342073 | 50339482:50339663 | ENSG00000104973.10 | ENST00000593767.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MED25 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_310095 | 19 | 50321827:50321873:50322428:50322553:50331705:50331804 | 50322428:50322553 | ENSG00000104973.10 | ENST00000312865.6,ENST00000595185.1 |
| exon_skip_310102 | 19 | 50322428:50322553:50331705:50331804:50332226:50332347 | 50331705:50331804 | ENSG00000104973.10 | ENST00000312865.6,ENST00000595185.1 |
| exon_skip_310109 | 19 | 50333078:50333205:50333344:50333475:50333767:50333855 | 50333344:50333475 | ENSG00000104973.10 | ENST00000312865.6 |
| exon_skip_310114 | 19 | 50333767:50333855:50333950:50334144:50334589:50334718 | 50333950:50334144 | ENSG00000104973.10 | ENST00000312865.6,ENST00000538643.1 |
| exon_skip_310115 | 19 | 50334099:50334144:50334589:50334718:50335192:50335278 | 50334589:50334718 | ENSG00000104973.10 | ENST00000312865.6,ENST00000538643.1,ENST00000599722.1 |
| exon_skip_310121 | 19 | 50338314:50338434:50338790:50338862:50338983:50338995 | 50338790:50338862 | ENSG00000104973.10 | ENST00000312865.6,ENST00000538643.1,ENST00000594998.1,ENST00000593767.1 |
| exon_skip_310123 | 19 | 50338983:50339202:50339482:50339663:50341836:50342073 | 50339482:50339663 | ENSG00000104973.10 | ENST00000593767.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MED25 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000312865 | 50322428 | 50322553 | Frame-shift |
| ENST00000312865 | 50333344 | 50333475 | Frame-shift |
| ENST00000312865 | 50333950 | 50334144 | Frame-shift |
| ENST00000312865 | 50331705 | 50331804 | In-frame |
| ENST00000312865 | 50334589 | 50334718 | In-frame |
| ENST00000312865 | 50338790 | 50338862 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000312865 | 50322428 | 50322553 | Frame-shift |
| ENST00000312865 | 50333344 | 50333475 | Frame-shift |
| ENST00000312865 | 50333950 | 50334144 | Frame-shift |
| ENST00000312865 | 50331705 | 50331804 | In-frame |
| ENST00000312865 | 50334589 | 50334718 | In-frame |
| ENST00000312865 | 50338790 | 50338862 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MED25 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000312865 | 2349 | 747 | 50331705 | 50331804 | 359 | 457 | 102 | 134 |
| ENST00000312865 | 2349 | 747 | 50334589 | 50334718 | 1155 | 1283 | 367 | 410 |
| ENST00000312865 | 2349 | 747 | 50338790 | 50338862 | 1728 | 1799 | 558 | 582 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000312865 | 2349 | 747 | 50331705 | 50331804 | 359 | 457 | 102 | 134 |
| ENST00000312865 | 2349 | 747 | 50334589 | 50334718 | 1155 | 1283 | 367 | 410 |
| ENST00000312865 | 2349 | 747 | 50338790 | 50338862 | 1728 | 1799 | 558 | 582 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for MED25 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
MED25_LIHC_exon_skip_310114_psi_boxplot.png |
MED25_STAD_exon_skip_310114_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_310095 | 50322429 | 50322553 | 50322432 | 50322432 | Frame_Shift_Del | G | - | p.G63fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_310109 | 50333345 | 50333475 | 50333452 | 50333452 | Frame_Shift_Del | C | - | p.P267fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_310109 | 50333345 | 50333475 | 50333452 | 50333452 | Frame_Shift_Del | C | - | p.P267fs |
| LUAD | TCGA-55-7283-01 | exon_skip_310109 | 50333345 | 50333475 | 50333452 | 50333452 | Frame_Shift_Del | C | - | p.P266fs |
| LUAD | TCGA-55-7283-01 | exon_skip_310109 | 50333345 | 50333475 | 50333452 | 50333452 | Frame_Shift_Del | C | - | p.P267fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_310109 | 50333345 | 50333475 | 50333460 | 50333460 | Frame_Shift_Del | C | - | p.V268fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_310114 | 50333951 | 50334144 | 50333963 | 50333963 | Frame_Shift_Del | C | - | p.T307fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_310114 | 50333951 | 50334144 | 50333983 | 50333983 | Frame_Shift_Del | C | - | p.P314fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_310114 | 50333951 | 50334144 | 50333991 | 50333991 | Frame_Shift_Del | G | - | p.V316fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_310114 | 50333951 | 50334144 | 50334028 | 50334028 | Frame_Shift_Del | C | - | p.P330fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_310114 | 50333951 | 50334144 | 50334055 | 50334055 | Frame_Shift_Del | C | - | p.P340fs |
| PCPG | TCGA-QR-A6H2-01 | exon_skip_310121 | 50338791 | 50338862 | 50338834 | 50338834 | Frame_Shift_Del | A | - | p.E573fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_310123 | 50339483 | 50339663 | 50339594 | 50339594 | Frame_Shift_Del | C | - | p.P694fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_310123 | 50339483 | 50339663 | 50339642 | 50339642 | Frame_Shift_Del | C | - | p.P710fs |
| KIRP | TCGA-B9-4117-01 | exon_skip_310109 | 50333345 | 50333475 | 50333382 | 50333383 | Frame_Shift_Ins | - | C | p.K242fs |
| LUAD | TCGA-17-Z055-01 | exon_skip_310109 | 50333345 | 50333475 | 50333382 | 50333383 | Frame_Shift_Ins | - | C | p.KA242fs |
| STAD | TCGA-HU-A4GT-01 | exon_skip_310114 | 50333951 | 50334144 | 50333994 | 50333995 | Frame_Shift_Ins | - | C | p.G317fs |
| STAD | TCGA-HU-A4GT-01 | exon_skip_310114 | 50333951 | 50334144 | 50333995 | 50333996 | Frame_Shift_Ins | - | C | p.G317fs |
| BLCA | TCGA-GU-A766-01 | exon_skip_310109 | 50333345 | 50333475 | 50333414 | 50333414 | Nonsense_Mutation | C | G | p.S253* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-HU-A4GT-01 |
| Cancer type: STAD | |
| ESID: exon_skip_310114 | |
| Skipped exon start: 50333951 | |
| Skipped exon end: 50334144 | |
| Mutation start: 50333994 | |
| Mutation end: 50333995 | |
| Mutation type: Frame_Shift_Ins | |
| Reference seq: - | |
| Mutation seq: C | |
| AAchange: p.G317fs | |
| Sample: TCGA-HU-A4GT-01 |
| Cancer type: STAD | |
| ESID: exon_skip_310114 | |
| Skipped exon start: 50333951 | |
| Skipped exon end: 50334144 | |
| Mutation start: 50333995 | |
| Mutation end: 50333996 | |
| Mutation type: Frame_Shift_Ins | |
| Reference seq: - | |
| Mutation seq: C | |
| AAchange: p.G317fs | |
exon_skip_121685_STAD_TCGA-HU-A4GT-01.png | |
exon_skip_135112_STAD_TCGA-HU-A4GT-01.png | |
exon_skip_135114_STAD_TCGA-HU-A4GT-01.png | |
exon_skip_295812_STAD_TCGA-HU-A4GT-01.png | |
exon_skip_310114_STAD_TCGA-HU-A4GT-01.png | |
exon_skip_314971_STAD_TCGA-HU-A4GT-01.png | |
exon_skip_328008_STAD_TCGA-HU-A4GT-01.png | |
exon_skip_347979_STAD_TCGA-HU-A4GT-01.png | |
exon_skip_347981_STAD_TCGA-HU-A4GT-01.png | |
exon_skip_45131_STAD_TCGA-HU-A4GT-01.png | |
exon_skip_45132_STAD_TCGA-HU-A4GT-01.png | |
exon_skip_65658_STAD_TCGA-HU-A4GT-01.png | |
exon_skip_86427_STAD_TCGA-HU-A4GT-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50322429 | 50322553 | 50322432 | 50322432 | Frame_Shift_Del | G | - | p.G63fs |
| SNUC5_LARGE_INTESTINE | 50333345 | 50333475 | 50333452 | 50333452 | Frame_Shift_Del | C | - | p.P267fs |
| TOV21G_OVARY | 50338791 | 50338862 | 50338793 | 50338793 | Frame_Shift_Del | G | - | p.M559fs |
| RKO_LARGE_INTESTINE | 50338791 | 50338862 | 50338809 | 50338809 | Frame_Shift_Del | C | - | p.P566fs |
| SISO_CERVIX | 50333345 | 50333475 | 50333451 | 50333452 | Frame_Shift_Ins | - | C | p.P266fs |
| GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50333345 | 50333475 | 50333451 | 50333452 | Frame_Shift_Ins | - | C | p.P266fs |
| MDAMB175VII_BREAST | 50333345 | 50333475 | 50333460 | 50333462 | In_Frame_Del | CCC | - | p.P270del |
| CCK81_LARGE_INTESTINE | 50331706 | 50331804 | 50331716 | 50331716 | Missense_Mutation | G | A | p.G106R |
| CMK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50331706 | 50331804 | 50331744 | 50331744 | Missense_Mutation | C | T | p.A115V |
| MHHPREB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50331706 | 50331804 | 50331771 | 50331771 | Missense_Mutation | T | G | p.L124R |
| FARAGE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50333345 | 50333475 | 50333368 | 50333368 | Missense_Mutation | C | A | p.P238T |
| KG1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50333345 | 50333475 | 50333390 | 50333390 | Missense_Mutation | T | C | p.V245A |
| MZ1B_MATCHED_NORMAL_TISSUE | 50333345 | 50333475 | 50333390 | 50333390 | Missense_Mutation | T | C | p.V245A |
| MZ7B_MATCHED_NORMAL_TISSUE | 50333345 | 50333475 | 50333390 | 50333390 | Missense_Mutation | T | C | p.V245A |
| NCIH250_LUNG | 50333345 | 50333475 | 50333390 | 50333390 | Missense_Mutation | T | C | p.V245A |
| SW156_KIDNEY | 50333345 | 50333475 | 50333390 | 50333390 | Missense_Mutation | T | C | p.V245A |
| SNU869_BILIARY_TRACT | 50333345 | 50333475 | 50333458 | 50333458 | Missense_Mutation | G | A | p.V268I |
| SNU16_STOMACH | 50333345 | 50333475 | 50333458 | 50333458 | Missense_Mutation | G | A | p.V268I |
| YD8_UPPER_AERODIGESTIVE_TRACT | 50333951 | 50334144 | 50333963 | 50333963 | Missense_Mutation | C | T | p.T307I |
| DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50333951 | 50334144 | 50333980 | 50333980 | Missense_Mutation | G | A | p.A313T |
| RPMI7951_SKIN | 50333951 | 50334144 | 50333999 | 50333999 | Missense_Mutation | C | T | p.P319L |
| LB373MELD_SKIN | 50333951 | 50334144 | 50333999 | 50333999 | Missense_Mutation | C | T | p.P319L |
| 647V_URINARY_TRACT | 50333951 | 50334144 | 50334028 | 50334028 | Missense_Mutation | C | T | p.P329S |
| MZ7MEL_SKIN | 50333951 | 50334144 | 50334050 | 50334050 | Missense_Mutation | C | T | p.P336L |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50333951 | 50334144 | 50334086 | 50334086 | Missense_Mutation | C | T | p.S348F |
| SW1990_PANCREAS | 50334590 | 50334718 | 50334678 | 50334678 | Missense_Mutation | A | G | p.N397S |
| JAR_PLACENTA | 50338791 | 50338862 | 50338801 | 50338801 | Missense_Mutation | A | C | p.Q562P |
| GSS_STOMACH | 50339483 | 50339663 | 50339633 | 50339633 | Missense_Mutation | G | A | p.A706T |
| OVMANA_OVARY | 50339483 | 50339663 | 50339633 | 50339633 | Missense_Mutation | G | A | p.A706T |
| MOLT16_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50339483 | 50339663 | 50339633 | 50339633 | Missense_Mutation | G | A | p.A706T |
| HEC1A_ENDOMETRIUM | 50333345 | 50333475 | 50333472 | 50333472 | Nonsense_Mutation | C | G | p.Y272* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MED25 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MED25 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MED25 |
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RelatedDrugs for MED25 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MED25 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| MED25 | C1854150 | Charcot-Marie-Tooth disease, Type 2B2 | 1 | CTD_human;ORPHANET;UNIPROT |
| MED25 | C4225323 | BASEL-VANAGAITE-SMIRIN-YOSEF SYNDROME | 1 | ORPHANET;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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