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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ANP32A |
 Gene summary |
| Gene information | Gene symbol | ANP32A | Gene ID | 8125 |
| Gene name | acidic nuclear phosphoprotein 32 family member A | |
| Synonyms | C15orf1|HPPCn|I1PP2A|LANP|MAPM|PHAP1|PHAPI|PP32 | |
| Cytomap | 15q23 | |
| Type of gene | protein-coding | |
| Description | acidic leucine-rich nuclear phosphoprotein 32 family member Aacidic (leucine-rich) nuclear phosphoprotein 32 family, member Aacidic nuclear phosphoprotein pp32cerebellar leucine rich acidic nuclear proteinhepatopoietin Cninhibitor-1 of protein phosph | |
| Modification date | 20180523 | |
| UniProtAcc | P39687 | |
| Context | PubMed: ANP32A [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ANP32A | GO:0006913 | nucleocytoplasmic transport | 11729309 |
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Exon skipping events across known transcript of Ensembl for ANP32A from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ANP32A |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ANP32A |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_128790 | 15 | 69072751:69072812:69075294:69075392:69076735:69076805 | 69075294:69075392 | ENSG00000140350.11 | ENST00000483551.2,ENST00000267918.5,ENST00000409628.2,ENST00000465139.2 |
| exon_skip_128795 | 15 | 69076735:69076934:69079751:69079834:69080108:69080258 | 69079751:69079834 | ENSG00000140350.11 | ENST00000409628.2 |
| exon_skip_128796 | 15 | 69076735:69076934:69079751:69079874:69080108:69080168 | 69079751:69079874 | ENSG00000140350.11 | ENST00000483551.2,ENST00000561430.1,ENST00000267918.5,ENST00000465139.2,ENST00000560303.1 |
| exon_skip_128799 | 15 | 69079751:69079874:69080108:69080258:69113036:69113207 | 69080108:69080258 | ENSG00000140350.11 | ENST00000495420.1,ENST00000560303.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ANP32A |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_128790 | 15 | 69072751:69072812:69075294:69075392:69076735:69076805 | 69075294:69075392 | ENSG00000140350.11 | ENST00000465139.2,ENST00000409628.2,ENST00000267918.5,ENST00000483551.2 |
| exon_skip_128795 | 15 | 69076735:69076934:69079751:69079834:69080108:69080258 | 69079751:69079834 | ENSG00000140350.11 | ENST00000409628.2 |
| exon_skip_128796 | 15 | 69076735:69076934:69079751:69079874:69080108:69080168 | 69079751:69079874 | ENSG00000140350.11 | ENST00000465139.2,ENST00000267918.5,ENST00000483551.2,ENST00000560303.1,ENST00000561430.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ANP32A |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000465139 | 69075294 | 69075392 | Frame-shift |
| ENST00000465139 | 69079751 | 69079874 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000465139 | 69075294 | 69075392 | Frame-shift |
| ENST00000465139 | 69079751 | 69079874 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ANP32A |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000465139 | 2457 | 249 | 69079751 | 69079874 | 349 | 471 | 68 | 109 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000465139 | 2457 | 249 | 69079751 | 69079874 | 349 | 471 | 68 | 109 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P39687 | 68 | 109 | 68 | 70 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XOS |
| P39687 | 68 | 109 | 92 | 94 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XOS |
| P39687 | 68 | 109 | 1 | 249 | Chain | ID=PRO_0000137592;Note=Acidic leucine-rich nuclear phosphoprotein 32 family member A |
| P39687 | 68 | 109 | 81 | 86 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XOS |
| P39687 | 68 | 109 | 103 | 106 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XOS |
| P39687 | 68 | 109 | 107 | 111 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XOS |
| P39687 | 68 | 109 | 65 | 87 | Repeat | Note=LRR 3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17567741;Dbxref=PMID:17567741 |
| P39687 | 68 | 109 | 89 | 110 | Repeat | Note=LRR 4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17567741;Dbxref=PMID:17567741 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P39687 | 68 | 109 | 68 | 70 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XOS |
| P39687 | 68 | 109 | 92 | 94 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XOS |
| P39687 | 68 | 109 | 1 | 249 | Chain | ID=PRO_0000137592;Note=Acidic leucine-rich nuclear phosphoprotein 32 family member A |
| P39687 | 68 | 109 | 81 | 86 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XOS |
| P39687 | 68 | 109 | 103 | 106 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XOS |
| P39687 | 68 | 109 | 107 | 111 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XOS |
| P39687 | 68 | 109 | 65 | 87 | Repeat | Note=LRR 3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17567741;Dbxref=PMID:17567741 |
| P39687 | 68 | 109 | 89 | 110 | Repeat | Note=LRR 4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17567741;Dbxref=PMID:17567741 |
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SNVs in the skipped exons for ANP32A |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_128799 | 69080109 | 69080258 | 69080240 | 69080240 | Frame_Shift_Del | C | - | p.D25fs |
| SKCM | TCGA-EE-A29D-06 | exon_skip_128799 | 69080109 | 69080258 | 69080189 | 69080189 | Nonsense_Mutation | C | A | p.E42* |
| SKCM | TCGA-EE-A29D-06 | exon_skip_128799 | 69080109 | 69080258 | 69080189 | 69080189 | Nonsense_Mutation | C | A | p.E42X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SNU16_STOMACH | 69075295 | 69075392 | 69075332 | 69075346 | In_Frame_Del | TCCTCCTCATCCTCG | - | p.DEDEE191del |
| SEKI_SKIN | 69075295 | 69075392 | 69075355 | 69075355 | Missense_Mutation | G | C | p.D188E |
| TE10_OESOPHAGUS | 69075295 | 69075392 | 69075355 | 69075355 | Missense_Mutation | G | C | p.D188E |
| MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 69075295 | 69075392 | 69075355 | 69075355 | Missense_Mutation | G | C | p.D188E |
| DJM1_SKIN | 69079752 | 69079834 | 69079760 | 69079760 | Missense_Mutation | C | G | p.E107Q |
| DJM1_SKIN | 69079752 | 69079874 | 69079760 | 69079760 | Missense_Mutation | C | G | p.E107Q |
| NCIH2087_LUNG | 69079752 | 69079834 | 69079789 | 69079789 | Missense_Mutation | C | A | p.G97V |
| NCIH2087_LUNG | 69079752 | 69079874 | 69079789 | 69079789 | Missense_Mutation | C | A | p.G97V |
| HPBALL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 69080109 | 69080258 | 69080125 | 69080125 | Missense_Mutation | A | G | p.L63S |
| CH157MN_CENTRAL_NERVOUS_SYSTEM | 69080109 | 69080258 | 69080128 | 69080128 | Missense_Mutation | T | C | p.K62R |
| LS123_LARGE_INTESTINE | 69080109 | 69080258 | 69080160 | 69080160 | Missense_Mutation | G | C | p.N51K |
| LS411N_LARGE_INTESTINE | 69080109 | 69080258 | 69080200 | 69080200 | Missense_Mutation | G | A | p.T38I |
| LI7_LIVER | 69080109 | 69080258 | 69080238 | 69080238 | Missense_Mutation | G | C | p.D25E |
| NCIH2342_LUNG | 69080109 | 69080258 | 69080173 | 69080173 | Nonsense_Mutation | A | T | p.L47* |
| SNU81_LARGE_INTESTINE | 69080109 | 69080258 | 69080252 | 69080252 | Nonsense_Mutation | C | A | p.E21* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ANP32A |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ANP32A |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ANP32A |
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RelatedDrugs for ANP32A |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANP32A |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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