ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for LRRC27

Gene summary

Gene information	Gene symbol	LRRC27
	Gene ID	80313
	Gene name	leucine rich repeat containing 27
	Synonyms	-
	Cytomap	10q26.3
	Type of gene	protein-coding
	Description	leucine-rich repeat-containing protein 27testicular tissue protein Li 108
	Modification date	20180523
	UniProtAcc	Q9C0I9
	Context	PubMed: LRRC27 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Exon skipping events across known transcript of Ensembl for LRRC27 from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Gene isoform structures and expression levels for LRRC27

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

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Exon skipping events with PSIs in TCGA for LRRC27

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_46527	10	134145729:134145760:134146980:134147238:134151068:134151199	134146980:134147238	ENSG00000148814.13	ENST00000344079.5,ENST00000368614.3,ENST00000392638.2,ENST00000356571.4,ENST00000462656.1
exon_skip_46528	10	134151169:134151199:134155716:134155775:134158001:134158154	134155716:134155775	ENSG00000148814.13	ENST00000490055.1,ENST00000368612.1,ENST00000344079.5,ENST00000450442.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000392638.2,ENST00000368610.3,ENST00000368613.4,ENST00000489204.1
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENSG00000148814.13	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4
exon_skip_46532	10	134161695:134161860:134162466:134162561:134165110:134165257	134162466:134162561	ENSG00000148814.13	ENST00000344079.5,ENST00000392638.2,ENST00000462656.1,ENST00000472387.1
exon_skip_46534	10	134165113:134165257:134169293:134169390:134174960:134175093	134169293:134169390	ENSG00000148814.13	ENST00000368612.1,ENST00000472556.1,ENST00000368614.3,ENST00000432555.2,ENST00000392638.2,ENST00000368610.3,ENST00000462656.1,ENST00000475747.1,ENST00000368613.4
exon_skip_46535	10	134169293:134169390:134174960:134175079:134178927:134179054	134174960:134175079	ENSG00000148814.13	ENST00000368612.1,ENST00000472556.1,ENST00000368614.3,ENST00000432555.2,ENST00000392638.2,ENST00000368610.3,ENST00000462656.1,ENST00000475747.1,ENST00000368613.4
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENSG00000148814.13	ENST00000462656.1
exon_skip_46538	10	134178984:134179054:134180118:134180181:134180349:134180462	134180118:134180181	ENSG00000148814.13	ENST00000476889.1

PSI values of skipped exons in TCGA.

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Exon skipping events with PSIs in GTEx for LRRC27

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_46527	10	134145729:134145760:134146980:134147238:134151068:134151199	134146980:134147238	ENSG00000148814.13	ENST00000392638.2,ENST00000344079.5,ENST00000356571.4,ENST00000368614.3,ENST00000462656.1
exon_skip_46528	10	134151169:134151199:134155716:134155775:134158001:134158154	134155716:134155775	ENSG00000148814.13	ENST00000368615.3,ENST00000392638.2,ENST00000344079.5,ENST00000368614.3,ENST00000368613.4,ENST00000368612.1,ENST00000450442.1,ENST00000368610.3,ENST00000490055.1,ENST00000432555.2,ENST00000489204.1
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENSG00000148814.13	ENST00000368615.3,ENST00000368614.3,ENST00000368613.4,ENST00000368612.1,ENST00000368610.3,ENST00000432555.2
exon_skip_46532	10	134161695:134161860:134162466:134162561:134165110:134165257	134162466:134162561	ENSG00000148814.13	ENST00000392638.2,ENST00000344079.5,ENST00000462656.1,ENST00000472387.1
exon_skip_46534	10	134165113:134165257:134169293:134169390:134174960:134175093	134169293:134169390	ENSG00000148814.13	ENST00000392638.2,ENST00000368614.3,ENST00000462656.1,ENST00000368613.4,ENST00000368612.1,ENST00000368610.3,ENST00000432555.2,ENST00000475747.1,ENST00000472556.1
exon_skip_46535	10	134169293:134169390:134174960:134175079:134178927:134179054	134174960:134175079	ENSG00000148814.13	ENST00000392638.2,ENST00000368614.3,ENST00000462656.1,ENST00000368613.4,ENST00000368612.1,ENST00000368610.3,ENST00000432555.2,ENST00000475747.1,ENST00000472556.1
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENSG00000148814.13	ENST00000462656.1
exon_skip_46538	10	134178984:134179054:134180118:134180181:134180349:134180462	134180118:134180181	ENSG00000148814.13	ENST00000476889.1

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for LRRC27

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000368614	134146980	134147238	5CDS-5UTR
ENST00000368613	134155716	134155775	Frame-shift
ENST00000368614	134155716	134155775	Frame-shift
ENST00000368613	134161487	134161860	Frame-shift
ENST00000368614	134161487	134161860	Frame-shift
ENST00000368613	134169293	134169390	Frame-shift
ENST00000368614	134169293	134169390	Frame-shift
ENST00000368613	134174960	134175079	Frame-shift
ENST00000368614	134174960	134175079	Frame-shift

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000368614	134146980	134147238	5CDS-5UTR
ENST00000368613	134155716	134155775	Frame-shift
ENST00000368614	134155716	134155775	Frame-shift
ENST00000368613	134161487	134161860	Frame-shift
ENST00000368614	134161487	134161860	Frame-shift
ENST00000368613	134169293	134169390	Frame-shift
ENST00000368614	134169293	134169390	Frame-shift
ENST00000368613	134174960	134175079	Frame-shift
ENST00000368614	134174960	134175079	Frame-shift

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Infer the effects of exon skipping event on protein functional features for LRRC27

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

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SNVs in the skipped exons for LRRC27

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
STAD	TCGA-CD-A4MJ-01	exon_skip_46527	134146981	134147238	134147117	134147117	Frame_Shift_Del	C	-	p.T30fs
PCPG	TCGA-RW-A68F-01	exon_skip_46534	134169294	134169390	134169317	134169317	Frame_Shift_Del	G	-	p.W304fs
SKCM	TCGA-D3-A2JN-06	exon_skip_46531	134161488	134161860	134161692	134161692	Nonsense_Mutation	G	A	p.W253*
SKCM	TCGA-D3-A2JN-06	exon_skip_46531	134161488	134161860	134161692	134161692	Nonsense_Mutation	G	A	p.W253X
COAD	TCGA-AD-6889-01	exon_skip_46535	134174961	134175079	134174960	134174960	Splice_Site	G	T	.

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons

Mutation description

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
DV90_LUNG	134161488	134161860	134161637	134161637	Frame_Shift_Del	G	-	p.V235fs
NCIH2172_LUNG	134161488	134161860	134161737	134161748	In_Frame_Del	AGATTGTTGAGC	-	p.268_272EIVEH>D
NCIH1703_LUNG	134146981	134147238	134147154	134147154	Missense_Mutation	C	G	p.I42M
SKLU1_LUNG	134146981	134147238	134147184	134147184	Missense_Mutation	G	C	p.L52F
HEC108_ENDOMETRIUM	134161488	134161860	134161559	134161559	Missense_Mutation	G	A	p.A209T
NCIH1618_LUNG	134161488	134161860	134161593	134161593	Missense_Mutation	C	T	p.P220L
SNU1066_UPPER_AERODIGESTIVE_TRACT	134161488	134161860	134161685	134161685	Missense_Mutation	G	C	p.E251Q
CORL23_LUNG	134161488	134161860	134161715	134161715	Missense_Mutation	C	T	p.R261C
HCC95_LUNG	134161488	134161860	134161716	134161716	Missense_Mutation	G	A	p.R261H
NCIH684_LIVER	134169294	134169390	134169297	134169297	Missense_Mutation	G	C	p.E359D
OVTOKO_OVARY	134169294	134169390	134169329	134169329	Missense_Mutation	C	G	p.A370G
MC116_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	134174961	134175079	134174988	134174988	Missense_Mutation	G	A	p.D400N
KPL1_BREAST	134146981	134147238	134147188	134147188	Nonsense_Mutation	G	T	p.E54*
SKN_ENDOMETRIUM	134161488	134161860	134161613	134161613	Nonsense_Mutation	G	T	p.E227*

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for LRRC27

sQTL information located at the skipped exons.

Exon skip ID	Chromosome	Three exons	Skippped exon	ENST	Cancer type	SNP id	Location	DNA change (ref/var)	P-value
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	COAD	rs7476631	chr10:134179859	A/T	4.37e-11
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	COAD	rs7476631	chr10:134179859	A/T	1.96e-06
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	HNSC	rs7476631	chr10:134179859	A/T	2.61e-08
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	HNSC	rs7476631	chr10:134179859	A/T	1.67e-06
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	LGG	rs7476631	chr10:134179859	A/T	1.62e-27
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	LGG	rs10870298	chr10:134180097	C/T	1.98e-18
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	LGG	rs7476631	chr10:134179859	A/T	6.71e-11
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	LGG	rs10870298	chr10:134180097	C/T	1.33e-05
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	KIRC	rs7476631	chr10:134179859	A/T	4.06e-23
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	KIRC	rs10870298	chr10:134180097	C/T	4.28e-20
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	KIRC	rs7476631	chr10:134179859	A/T	9.57e-18
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	KIRC	rs10870298	chr10:134180097	C/T	5.19e-09
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	KIRC	rs10870298	chr10:134180097	C/T	3.80e-04
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	KIRC	rs7476631	chr10:134179859	A/T	7.85e-04
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	KIRC	rs7476631	chr10:134179859	A/T	1.86e-03
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	LIHC	rs7476631	chr10:134179859	A/T	6.55e-04
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	LUSC	rs7476631	chr10:134179859	A/T	1.17e-07
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	LUSC	rs7476631	chr10:134179859	A/T	1.24e-07
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	PCPG	rs7476631	chr10:134179859	A/T	5.68e-04
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	PCPG	rs12220327	chr10:134179827	A/G	6.82e-04
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	PRAD	rs7476631	chr10:134179859	A/T	5.59e-15
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	PRAD	rs10870298	chr10:134180097	C/T	1.32e-12
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	PRAD	rs7476631	chr10:134179859	A/T	2.25e-10
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	PRAD	rs10870298	chr10:134180097	C/T	1.09e-06
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	TGCT	rs10870298	chr10:134180097	C/T	1.75e-06
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	TGCT	rs7476631	chr10:134179859	A/T	5.77e-05
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	THCA	rs10870298	chr10:134180097	C/T	5.85e-22
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	THCA	rs7476631	chr10:134179859	A/T	4.15e-19
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	THCA	rs7476631	chr10:134179859	A/T	1.13e-17
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	THCA	rs10870298	chr10:134180097	C/T	1.77e-06
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	THCA	rs7476631	chr10:134179859	A/T	1.82e-05
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	THCA	rs7476631	chr10:134179859	A/T	5.67e-05
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	UCEC	rs7476631	chr10:134179859	A/T	3.26e-04
exon_skip_46537	10	134178984:134179054:134179802:134180181:134188569:134188959	134179802:134180181	ENST00000462656.1	UCEC	rs7476631	chr10:134179859	A/T	5.33e-04
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	CESC	rs2474329	chr10:134161517	C/T	1.10e-05
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	CESC	rs2474329	chr10:134161517	C/T	4.35e-04
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	CESC	rs2474328	chr10:134161633	A/G	1.25e-03
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	COAD	rs2474329	chr10:134161517	C/T	1.75e-11
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	COAD	rs2474329	chr10:134161517	C/T	2.47e-05
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	COAD	rs2474328	chr10:134161633	A/G	3.41e-04
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	COAD	rs2474328	chr10:134161633	A/G	3.48e-04
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	BLCA	rs2474329	chr10:134161517	C/T	1.05e-09
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	BLCA	rs2474328	chr10:134161633	A/G	1.03e-06
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	BLCA	rs2474329	chr10:134161517	C/T	3.49e-06
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	BLCA	rs2474328	chr10:134161633	A/G	1.17e-05
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	BLCA	rs2474328	chr10:134161633	A/G	3.63e-05
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	BLCA	rs2474329	chr10:134161517	C/T	7.18e-05
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	ESCA	rs2474328	chr10:134161633	A/G	2.91e-04
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	ESCA	rs2474329	chr10:134161517	C/T	1.05e-03
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	HNSC	rs2474328	chr10:134161633	A/G	2.60e-08
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	HNSC	rs2474329	chr10:134161517	C/T	8.63e-08
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	HNSC	rs2474329	chr10:134161517	C/T	4.92e-07
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	HNSC	rs2474328	chr10:134161633	A/G	5.06e-04
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	KIRP	rs2474329	chr10:134161517	C/T	9.82e-09
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	KIRP	rs2474329	chr10:134161517	C/T	3.54e-06
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	KIRP	rs2474328	chr10:134161633	A/G	1.23e-03
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	LGG	rs2474328	chr10:134161633	A/G	5.69e-18
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	LGG	rs2474328	chr10:134161633	A/G	5.82e-09
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	LGG	rs2474328	chr10:134161633	A/G	3.22e-06
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	KIRC	rs2474329	chr10:134161517	C/T	1.80e-19
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	KIRC	rs2474329	chr10:134161517	C/T	1.01e-17
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	KIRC	rs2474328	chr10:134161633	A/G	1.41e-04
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	KIRC	rs2474329	chr10:134161517	C/T	1.22e-03
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	KIRC	rs2474328	chr10:134161633	A/G	1.88e-03
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	KIRC	rs2474329	chr10:134161517	C/T	2.73e-03
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	LUAD	rs2474329	chr10:134161517	C/T	1.08e-15
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	LUAD	rs2474329	chr10:134161517	C/T	1.07e-09
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	LUAD	rs2474328	chr10:134161633	A/G	1.49e-08
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	LUAD	rs2474328	chr10:134161633	A/G	2.15e-06
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	LUAD	rs2474328	chr10:134161633	A/G	1.24e-04
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	LIHC	rs2474328	chr10:134161633	A/G	1.08e-05
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	LIHC	rs2474329	chr10:134161517	C/T	1.13e-05
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	LIHC	rs2474329	chr10:134161517	C/T	6.58e-04
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	LUSC	rs2474329	chr10:134161517	C/T	5.45e-08
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	LUSC	rs2474329	chr10:134161517	C/T	1.17e-06
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	LUSC	rs2474328	chr10:134161633	A/G	4.95e-04
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	OV	rs2474328	chr10:134161633	A/G	3.16e-09
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	OV	rs2474328	chr10:134161633	A/G	1.33e-03
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	READ	rs2474329	chr10:134161517	C/T	5.82e-04
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	PCPG	rs2474329	chr10:134161517	C/T	3.12e-04
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	PRAD	rs2474329	chr10:134161517	C/T	1.25e-14
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	PRAD	rs2474329	chr10:134161517	C/T	4.44e-11
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	PRAD	rs2474328	chr10:134161633	A/G	6.43e-11
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	PRAD	rs2474328	chr10:134161633	A/G	3.11e-06
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	PRAD	rs2474329	chr10:134161517	C/T	6.22e-04
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	PRAD	rs2474329	chr10:134161517	C/T	6.69e-04
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	PRAD	rs2474328	chr10:134161633	A/G	3.18e-03
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	SARC	rs2474329	chr10:134161517	C/T	8.47e-10
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	SARC	rs2474329	chr10:134161517	C/T	3.73e-04
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	TGCT	rs2474329	chr10:134161517	C/T	4.67e-05
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	SKCM	rs2474329	chr10:134161517	C/T	9.00e-06
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	STAD	rs2474329	chr10:134161517	C/T	8.70e-06
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	STAD	rs2474329	chr10:134161517	C/T	1.35e-04
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	STAD	rs2474328	chr10:134161633	A/G	2.23e-04
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	STAD	rs2474329	chr10:134161517	C/T	1.48e-03
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	THCA	rs2474329	chr10:134161517	C/T	7.86e-18
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	THCA	rs2474329	chr10:134161517	C/T	6.04e-16
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	THCA	rs2474328	chr10:134161633	A/G	1.06e-08
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	THCA	rs2474329	chr10:134161517	C/T	7.96e-06
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	THCA	rs2474329	chr10:134161517	C/T	3.05e-05
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	THCA	rs2474328	chr10:134161633	A/G	7.92e-04
exon_skip_46531	10	134158001:134158154:134161487:134161860:134165110:134165257	134161487:134161860	ENST00000368612.1,ENST00000368615.3,ENST00000368614.3,ENST00000432555.2,ENST00000368610.3,ENST00000368613.4	UCEC	rs2474329	chr10:134161517	C/T	1.83e-05
exon_skip_46527	10	134145729:134145760:134146980:134147238:134151068:134151199	134146980:134147238	ENST00000344079.5,ENST00000368614.3,ENST00000392638.2,ENST00000356571.4,ENST00000462656.1	COAD	rs12414718	chr10:134147172	G/A	2.45e-04
exon_skip_46527	10	134145729:134145760:134146980:134147238:134151068:134151199	134146980:134147238	ENST00000344079.5,ENST00000368614.3,ENST00000392638.2,ENST00000356571.4,ENST00000462656.1	KIRP	rs12414718	chr10:134147172	G/A	6.60e-04
exon_skip_46527	10	134145729:134145760:134146980:134147238:134151068:134151199	134146980:134147238	ENST00000344079.5,ENST00000368614.3,ENST00000392638.2,ENST00000356571.4,ENST00000462656.1	LUSC	rs12414718	chr10:134147172	G/A	1.73e-03
exon_skip_46527	10	134145729:134145760:134146980:134147238:134151068:134151199	134146980:134147238	ENST00000344079.5,ENST00000368614.3,ENST00000392638.2,ENST00000356571.4,ENST00000462656.1	OV	rs12414718	chr10:134147172	G/A	1.54e-03
exon_skip_46527	10	134145729:134145760:134146980:134147238:134151068:134151199	134146980:134147238	ENST00000344079.5,ENST00000368614.3,ENST00000392638.2,ENST00000356571.4,ENST00000462656.1	PRAD	rs12414718	chr10:134147172	G/A	1.39e-05
exon_skip_46527	10	134145729:134145760:134146980:134147238:134151068:134151199	134146980:134147238	ENST00000344079.5,ENST00000368614.3,ENST00000392638.2,ENST00000356571.4,ENST00000462656.1	PRAD	rs12414718	chr10:134147172	G/A	2.36e-05
exon_skip_46527	10	134145729:134145760:134146980:134147238:134151068:134151199	134146980:134147238	ENST00000344079.5,ENST00000368614.3,ENST00000392638.2,ENST00000356571.4,ENST00000462656.1	THCA	rs12414718	chr10:134147172	G/A	1.69e-04

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for LRRC27

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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for LRRC27

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RelatedDrugs for LRRC27

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for LRRC27

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for LRRC27

Exon skipping events across known transcript of Ensembl for LRRC27 from UCSC genome browser

Gene isoform structures and expression levels for LRRC27

Exon skipping events with PSIs in TCGA for LRRC27

Exon skipping events with PSIs in GTEx for LRRC27

Open reading frame (ORF) annotation in the exon skipping event for LRRC27

Infer the effects of exon skipping event on protein functional features for LRRC27

SNVs in the skipped exons for LRRC27

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for LRRC27

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for LRRC27

Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for LRRC27

RelatedDrugs for LRRC27

RelatedDiseases for LRRC27