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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for NR4A3 |
 Gene summary |
| Gene information | Gene symbol | NR4A3 | Gene ID | 8013 |
| Gene name | nuclear receptor subfamily 4 group A member 3 | |
| Synonyms | CHN|CSMF|MINOR|NOR1|TEC | |
| Cytomap | 9q31.1 | |
| Type of gene | protein-coding | |
| Description | nuclear receptor subfamily 4 group A member 3chondrosarcoma, extraskeletal myxoid, fused to EWSmitogen-induced nuclear orphan receptorneuron-derived orphan receptor 1nuclear hormone receptor NOR-1translocated in extraskeletal chondrosarcoma | |
| Modification date | 20180527 | |
| UniProtAcc | Q92570 | |
| Context | PubMed: NR4A3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| NR4A3 | GO:0010828 | positive regulation of glucose transmembrane transport | 24022864 |
| NR4A3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20558821 |
| NR4A3 | GO:0048008 | platelet-derived growth factor receptor signaling pathway | 23554459 |
| NR4A3 | GO:0048660 | regulation of smooth muscle cell proliferation | 25852083 |
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Exon skipping events across known transcript of Ensembl for NR4A3 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for NR4A3 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for NR4A3 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_497786 | 9 | 102590322:102591275:102594970:102595100:102595563:102595736 | 102594970:102595100 | ENSG00000119508.13 | ENST00000395097.2,ENST00000330847.1,ENST00000338488.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for NR4A3 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_497786 | 9 | 102590322:102591275:102594970:102595100:102595563:102595736 | 102594970:102595100 | ENSG00000119508.13 | ENST00000338488.4,ENST00000395097.2,ENST00000330847.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for NR4A3 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000395097 | 102594970 | 102595100 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000395097 | 102594970 | 102595100 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for NR4A3 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for NR4A3 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| UCS | TCGA-N8-A4PO-01 | exon_skip_497786 | 102594971 | 102595100 | 102595040 | 102595040 | Nonsense_Mutation | C | T | p.R352* |
| UCS | TCGA-N8-A4PO-01 | exon_skip_497786 | 102594971 | 102595100 | 102595040 | 102595040 | Nonsense_Mutation | C | T | p.R352X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LNCAPCLONEFGC_PROSTATE | 102594971 | 102595100 | 102594981 | 102594981 | Missense_Mutation | A | G | p.Q321R |
| JHUEM7_ENDOMETRIUM | 102594971 | 102595100 | 102595047 | 102595047 | Missense_Mutation | G | A | p.R343Q |
| HLE_LIVER | 102594971 | 102595100 | 102595054 | 102595054 | Missense_Mutation | G | C | p.Q345H |
| HLF_LIVER | 102594971 | 102595100 | 102595054 | 102595054 | Missense_Mutation | G | C | p.Q345H |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NR4A3 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NR4A3 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NR4A3 |
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RelatedDrugs for NR4A3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q92570 | DB01254 | Dasatinib | Nuclear receptor subfamily 4 group A member 3 | small molecule | approved|investigational |
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RelatedDiseases for NR4A3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| NR4A3 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| NR4A3 | C0020443 | Hypercholesterolemia | 1 | CTD_human |
| NR4A3 | C0021655 | Insulin Resistance | 1 | CTD_human |
| NR4A3 | C3495559 | Juvenile arthritis | 1 | CTD_human |
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