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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for NRSN2 |
 Gene summary |
| Gene information | Gene symbol | NRSN2 | Gene ID | 80023 |
| Gene name | neurensin 2 | |
| Synonyms | C20orf98|dJ1103G7.6 | |
| Cytomap | 20p13 | |
| Type of gene | protein-coding | |
| Description | neurensin-2 | |
| Modification date | 20180519 | |
| UniProtAcc | Q9GZP1 | |
| Context | PubMed: NRSN2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for NRSN2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for NRSN2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for NRSN2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_348294 | 20 | 327763:327786:328077:328150:329892:330007 | 328077:328150 | ENSG00000125841.8 | ENST00000609504.1 |
| exon_skip_348296 | 20 | 327763:327786:328077:328156:329892:330007 | 328077:328156 | ENSG00000125841.8 | ENST00000382285.2 |
| exon_skip_348305 | 20 | 327763:327786:329892:330007:333853:333950 | 329892:330007 | ENSG00000125841.8 | ENST00000492242.1 |
| exon_skip_348310 | 20 | 329892:330007:330281:330476:333853:333950 | 330281:330476 | ENSG00000125841.8 | ENST00000382285.2,ENST00000609504.1,ENST00000609179.1,ENST00000382291.3,ENST00000470439.1 |
| exon_skip_348312 | 20 | 329892:330007:330281:330476:335969:335993 | 330281:330476 | ENSG00000125841.8 | ENST00000608467.1 |
| exon_skip_348322 | 20 | 330369:330476:335969:335993:339902:340049 | 335969:335993 | ENSG00000125841.8 | ENST00000608467.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for NRSN2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_348294 | 20 | 327763:327786:328077:328150:329892:330007 | 328077:328150 | ENSG00000125841.8 | ENST00000609504.1 |
| exon_skip_348296 | 20 | 327763:327786:328077:328156:329892:330007 | 328077:328156 | ENSG00000125841.8 | ENST00000382285.2 |
| exon_skip_348305 | 20 | 327763:327786:329892:330007:333853:333950 | 329892:330007 | ENSG00000125841.8 | ENST00000492242.1 |
| exon_skip_348310 | 20 | 329892:330007:330281:330476:333853:333950 | 330281:330476 | ENSG00000125841.8 | ENST00000609179.1,ENST00000382291.3,ENST00000609504.1,ENST00000382285.2,ENST00000470439.1 |
| exon_skip_348312 | 20 | 329892:330007:330281:330476:335969:335993 | 330281:330476 | ENSG00000125841.8 | ENST00000608467.1 |
| exon_skip_348322 | 20 | 330369:330476:335969:335993:339902:340049 | 335969:335993 | ENSG00000125841.8 | ENST00000608467.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for NRSN2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000382285 | 330281 | 330476 | 5CDS-5UTR |
| ENST00000382291 | 330281 | 330476 | 5CDS-5UTR |
| ENST00000382285 | 328077 | 328156 | 5UTR-5UTR |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000382285 | 330281 | 330476 | 5CDS-5UTR |
| ENST00000382291 | 330281 | 330476 | 5CDS-5UTR |
| ENST00000382285 | 328077 | 328156 | 5UTR-5UTR |
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Infer the effects of exon skipping event on protein functional features for NRSN2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for NRSN2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 330282 | 330476 | 330298 | 330298 | Missense_Mutation | G | C | p.S4T |
| VCAP_PROSTATE | 330282 | 330476 | 330328 | 330328 | Missense_Mutation | G | T | p.G14V |
| OE19_OESOPHAGUS | 330282 | 330476 | 330336 | 330336 | Missense_Mutation | G | A | p.V17M |
| JHUEM1_ENDOMETRIUM | 330282 | 330476 | 330385 | 330385 | Missense_Mutation | A | G | p.Y33C |
| NUGC3_STOMACH | 330282 | 330476 | 330400 | 330400 | Missense_Mutation | G | A | p.G38D |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NRSN2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NRSN2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NRSN2 |
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RelatedDrugs for NRSN2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NRSN2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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