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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for GGNBP2 |
 Gene summary |
| Gene information | Gene symbol | GGNBP2 | Gene ID | 79893 |
| Gene name | gametogenetin binding protein 2 | |
| Synonyms | DIF-3|DIF3|LCRG1|LZK1|ZFP403|ZNF403 | |
| Cytomap | 17q12 | |
| Type of gene | protein-coding | |
| Description | gametogenetin-binding protein 2C3HC4-type zinc finger proteinlaryngeal carcinoma related gene 1laryngeal carcinoma-related protein 1zinc finger protein 403 | |
| Modification date | 20180523 | |
| UniProtAcc | Q9H3C7 | |
| Context | PubMed: GGNBP2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for GGNBP2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for GGNBP2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for GGNBP2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_151541 | 17 | 34900780:34900946:34901467:34901666:34910660:34910741 | 34901467:34901666 | ENSG00000005955.8 | ENST00000495023.1,ENST00000486208.2 |
| exon_skip_151543 | 17 | 34901467:34901666:34910660:34910741:34912922:34913176 | 34910660:34910741 | ENSG00000005955.8 | ENST00000593016.1,ENST00000495023.1,ENST00000486208.2,ENST00000304718.4 |
| exon_skip_151544 | 17 | 34910660:34910741:34912922:34913176:34916612:34916658 | 34912922:34913176 | ENSG00000005955.8 | ENST00000593016.1,ENST00000495023.1,ENST00000486208.2,ENST00000304718.4 |
| exon_skip_151545 | 17 | 34912922:34913176:34916612:34916711:34923501:34923615 | 34916612:34916711 | ENSG00000005955.8 | ENST00000495023.1,ENST00000486208.2,ENST00000304718.4 |
| exon_skip_151546 | 17 | 34916612:34916711:34923501:34923615:34934412:34934616 | 34923501:34923615 | ENSG00000005955.8 | ENST00000495023.1,ENST00000486208.2,ENST00000304718.4 |
| exon_skip_151551 | 17 | 34935674:34935849:34937773:34937968:34941729:34941880 | 34937773:34937968 | ENSG00000005955.8 | ENST00000495023.1,ENST00000304718.4,ENST00000483256.1 |
| exon_skip_151552 | 17 | 34941729:34941880:34942269:34942395:34942479:34942583 | 34942269:34942395 | ENSG00000005955.8 | ENST00000304718.4,ENST00000483256.1 |
| exon_skip_151553 | 17 | 34942563:34942628:34943426:34943675:34945637:34946007 | 34943426:34943675 | ENSG00000005955.8 | ENST00000304718.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for GGNBP2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_151541 | 17 | 34900780:34900946:34901467:34901666:34910660:34910741 | 34901467:34901666 | ENSG00000005955.8 | ENST00000486208.2,ENST00000495023.1 |
| exon_skip_151543 | 17 | 34901467:34901666:34910660:34910741:34912922:34913176 | 34910660:34910741 | ENSG00000005955.8 | ENST00000304718.4,ENST00000486208.2,ENST00000495023.1,ENST00000593016.1 |
| exon_skip_151544 | 17 | 34910660:34910741:34912922:34913176:34916612:34916658 | 34912922:34913176 | ENSG00000005955.8 | ENST00000304718.4,ENST00000486208.2,ENST00000495023.1,ENST00000593016.1 |
| exon_skip_151545 | 17 | 34912922:34913176:34916612:34916711:34923501:34923615 | 34916612:34916711 | ENSG00000005955.8 | ENST00000304718.4,ENST00000486208.2,ENST00000495023.1 |
| exon_skip_151546 | 17 | 34916612:34916711:34923501:34923615:34934412:34934616 | 34923501:34923615 | ENSG00000005955.8 | ENST00000304718.4,ENST00000486208.2,ENST00000495023.1 |
| exon_skip_151551 | 17 | 34935674:34935849:34937773:34937968:34941729:34941880 | 34937773:34937968 | ENSG00000005955.8 | ENST00000304718.4,ENST00000495023.1,ENST00000483256.1 |
| exon_skip_151552 | 17 | 34941729:34941880:34942269:34942395:34942479:34942583 | 34942269:34942395 | ENSG00000005955.8 | ENST00000304718.4,ENST00000483256.1 |
| exon_skip_151553 | 17 | 34942563:34942628:34943426:34943675:34945637:34946007 | 34943426:34943675 | ENSG00000005955.8 | ENST00000304718.4 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for GGNBP2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for GGNBP2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for GGNBP2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for GGNBP2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for GGNBP2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for GGNBP2 |
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RelatedDrugs for GGNBP2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GGNBP2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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