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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for NEK11 |
 Gene summary |
| Gene information | Gene symbol | NEK11 | Gene ID | 79858 |
| Gene name | NIMA related kinase 11 | |
| Synonyms | - | |
| Cytomap | 3q22.1 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase Nek11NIMA (never in mitosis gene a)- related kinase 11 | |
| Modification date | 20180523 | |
| UniProtAcc | Q8NG66 | |
| Context | PubMed: NEK11 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| NEK11 | GO:0006468 | protein phosphorylation | 15161910|19734889 |
| NEK11 | GO:0031573 | intra-S DNA damage checkpoint | 15161910 |
| NEK11 | GO:0035556 | intracellular signal transduction | 15161910 |
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Exon skipping events across known transcript of Ensembl for NEK11 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for NEK11 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for NEK11 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_377649 | 3 | 130745778:130745850:130746773:130746846:130748456:130748657 | 130746773:130746846 | ENSG00000114670.9 | ENST00000383366.4,ENST00000511262.1 |
| exon_skip_377651 | 3 | 130745794:130746046:130746773:130746846:130748456:130748657 | 130746773:130746846 | ENSG00000114670.9 | ENST00000507967.1 |
| exon_skip_377660 | 3 | 130748552:130748722:130799266:130799432:130828646:130828765 | 130799266:130799432 | ENSG00000114670.9 | ENST00000507910.1,ENST00000510688.1,ENST00000510769.1,ENST00000514915.1,ENST00000429253.2,ENST00000383366.4,ENST00000508196.1,ENST00000356918.4,ENST00000506695.1,ENST00000511262.1 |
| exon_skip_377667 | 3 | 130799266:130799432:130828646:130828765:130851588:130851653 | 130828646:130828765 | ENSG00000114670.9 | ENST00000507910.1,ENST00000602792.1,ENST00000510688.1,ENST00000510769.1,ENST00000514915.1,ENST00000429253.2,ENST00000383366.4,ENST00000508196.1,ENST00000356918.4,ENST00000506695.1,ENST00000511262.1 |
| exon_skip_377669 | 3 | 130851588:130851653:130852089:130852199:130852673:130852800 | 130852089:130852199 | ENSG00000114670.9 | ENST00000426022.2 |
| exon_skip_377671 | 3 | 130851588:130851653:130852120:130852199:130852673:130852800 | 130852120:130852199 | ENSG00000114670.9 | ENST00000514915.1 |
| exon_skip_377673 | 3 | 130852673:130852800:130871231:130871381:130871474:130871547 | 130871231:130871381 | ENSG00000114670.9 | ENST00000507910.1,ENST00000510688.1,ENST00000510926.1,ENST00000514915.1,ENST00000429253.2,ENST00000510474.1,ENST00000383366.4,ENST00000508196.1,ENST00000412440.2,ENST00000356918.4,ENST00000511262.1,ENST00000426022.2 |
| exon_skip_377677 | 3 | 130852673:130852800:130881251:130881371:130884269:130884363 | 130881251:130881371 | ENSG00000114670.9 | ENST00000510769.1 |
| exon_skip_377679 | 3 | 130871474:130871553:130873879:130873965:130881251:130881371 | 130873879:130873965 | ENSG00000114670.9 | ENST00000507910.1,ENST00000510688.1,ENST00000514915.1,ENST00000429253.2,ENST00000510474.1,ENST00000383366.4,ENST00000508196.1,ENST00000412440.2,ENST00000356918.4,ENST00000511262.1 |
| exon_skip_377680 | 3 | 130884273:130884363:130887673:130887781:130889616:130889731 | 130887673:130887781 | ENSG00000114670.9 | ENST00000510823.1,ENST00000507910.1,ENST00000510688.1,ENST00000510769.1,ENST00000514915.1,ENST00000429253.2,ENST00000383366.4,ENST00000508196.1,ENST00000356918.4,ENST00000511262.1 |
| exon_skip_377681 | 3 | 130884269:130884363:130889616:130889731:130947371:130947439 | 130889616:130889731 | ENSG00000114670.9 | ENST00000510474.1,ENST00000412440.2 |
| exon_skip_377683 | 3 | 130947371:130947532:130962279:130962340:130992321:130992418 | 130962279:130962340 | ENSG00000114670.9 | ENST00000510769.1,ENST00000514915.1,ENST00000429253.2,ENST00000510474.1,ENST00000383366.4,ENST00000508196.1,ENST00000412440.2 |
| exon_skip_377687 | 3 | 130962279:130962340:130992321:130992418:131068400:131068620 | 130992321:130992418 | ENSG00000114670.9 | ENST00000510769.1,ENST00000514915.1,ENST00000429253.2,ENST00000510474.1,ENST00000383366.4,ENST00000508196.1,ENST00000412440.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for NEK11 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_377649 | 3 | 130745778:130745850:130746773:130746846:130748456:130748657 | 130746773:130746846 | ENSG00000114670.9 | ENST00000511262.1,ENST00000383366.4 |
| exon_skip_377651 | 3 | 130745794:130746046:130746773:130746846:130748456:130748657 | 130746773:130746846 | ENSG00000114670.9 | ENST00000507967.1 |
| exon_skip_377660 | 3 | 130748552:130748722:130799266:130799432:130828646:130828765 | 130799266:130799432 | ENSG00000114670.9 | ENST00000510769.1,ENST00000429253.2,ENST00000356918.4,ENST00000506695.1,ENST00000510688.1,ENST00000511262.1,ENST00000383366.4,ENST00000514915.1,ENST00000507910.1,ENST00000508196.1 |
| exon_skip_377667 | 3 | 130799266:130799432:130828646:130828765:130851588:130851653 | 130828646:130828765 | ENSG00000114670.9 | ENST00000510769.1,ENST00000429253.2,ENST00000356918.4,ENST00000506695.1,ENST00000510688.1,ENST00000511262.1,ENST00000383366.4,ENST00000514915.1,ENST00000507910.1,ENST00000508196.1,ENST00000602792.1 |
| exon_skip_377669 | 3 | 130851588:130851653:130852089:130852199:130852673:130852800 | 130852089:130852199 | ENSG00000114670.9 | ENST00000426022.2 |
| exon_skip_377671 | 3 | 130851588:130851653:130852120:130852199:130852673:130852800 | 130852120:130852199 | ENSG00000114670.9 | ENST00000514915.1 |
| exon_skip_377673 | 3 | 130852673:130852800:130871231:130871381:130871474:130871547 | 130871231:130871381 | ENSG00000114670.9 | ENST00000429253.2,ENST00000356918.4,ENST00000510688.1,ENST00000511262.1,ENST00000383366.4,ENST00000514915.1,ENST00000510474.1,ENST00000412440.2,ENST00000507910.1,ENST00000508196.1,ENST00000426022.2,ENST00000510926.1 |
| exon_skip_377679 | 3 | 130871474:130871553:130873879:130873965:130881251:130881371 | 130873879:130873965 | ENSG00000114670.9 | ENST00000429253.2,ENST00000356918.4,ENST00000510688.1,ENST00000511262.1,ENST00000383366.4,ENST00000514915.1,ENST00000510474.1,ENST00000412440.2,ENST00000507910.1,ENST00000508196.1 |
| exon_skip_377680 | 3 | 130884273:130884363:130887673:130887781:130889616:130889731 | 130887673:130887781 | ENSG00000114670.9 | ENST00000510769.1,ENST00000429253.2,ENST00000356918.4,ENST00000510688.1,ENST00000511262.1,ENST00000383366.4,ENST00000514915.1,ENST00000507910.1,ENST00000508196.1,ENST00000510823.1 |
| exon_skip_377681 | 3 | 130884269:130884363:130889616:130889731:130947371:130947439 | 130889616:130889731 | ENSG00000114670.9 | ENST00000510474.1,ENST00000412440.2 |
| exon_skip_377683 | 3 | 130947371:130947532:130962279:130962340:130992321:130992418 | 130962279:130962340 | ENSG00000114670.9 | ENST00000510769.1,ENST00000429253.2,ENST00000383366.4,ENST00000514915.1,ENST00000510474.1,ENST00000412440.2,ENST00000508196.1 |
| exon_skip_377687 | 3 | 130962279:130962340:130992321:130992418:131068400:131068620 | 130992321:130992418 | ENSG00000114670.9 | ENST00000510769.1,ENST00000429253.2,ENST00000383366.4,ENST00000514915.1,ENST00000510474.1,ENST00000412440.2,ENST00000508196.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for NEK11 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000383366 | 130746773 | 130746846 | 5UTR-5UTR |
| ENST00000383366 | 130799266 | 130799432 | Frame-shift |
| ENST00000508196 | 130799266 | 130799432 | Frame-shift |
| ENST00000383366 | 130828646 | 130828765 | Frame-shift |
| ENST00000508196 | 130828646 | 130828765 | Frame-shift |
| ENST00000383366 | 130873879 | 130873965 | Frame-shift |
| ENST00000508196 | 130873879 | 130873965 | Frame-shift |
| ENST00000383366 | 130962279 | 130962340 | Frame-shift |
| ENST00000508196 | 130962279 | 130962340 | Frame-shift |
| ENST00000383366 | 130992321 | 130992418 | Frame-shift |
| ENST00000508196 | 130992321 | 130992418 | Frame-shift |
| ENST00000383366 | 130871231 | 130871381 | In-frame |
| ENST00000508196 | 130871231 | 130871381 | In-frame |
| ENST00000383366 | 130887673 | 130887781 | In-frame |
| ENST00000508196 | 130887673 | 130887781 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000383366 | 130746773 | 130746846 | 5UTR-5UTR |
| ENST00000383366 | 130799266 | 130799432 | Frame-shift |
| ENST00000508196 | 130799266 | 130799432 | Frame-shift |
| ENST00000383366 | 130828646 | 130828765 | Frame-shift |
| ENST00000508196 | 130828646 | 130828765 | Frame-shift |
| ENST00000383366 | 130873879 | 130873965 | Frame-shift |
| ENST00000508196 | 130873879 | 130873965 | Frame-shift |
| ENST00000383366 | 130962279 | 130962340 | Frame-shift |
| ENST00000508196 | 130962279 | 130962340 | Frame-shift |
| ENST00000383366 | 130992321 | 130992418 | Frame-shift |
| ENST00000508196 | 130992321 | 130992418 | Frame-shift |
| ENST00000383366 | 130871231 | 130871381 | In-frame |
| ENST00000508196 | 130871231 | 130871381 | In-frame |
| ENST00000383366 | 130887673 | 130887781 | In-frame |
| ENST00000508196 | 130887673 | 130887781 | In-frame |
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Infer the effects of exon skipping event on protein functional features for NEK11 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000383366 | 2931 | 645 | 130871231 | 130871381 | 941 | 1090 | 216 | 265 |
| ENST00000508196 | 1955 | 645 | 130871231 | 130871381 | 648 | 797 | 216 | 265 |
| ENST00000383366 | 2931 | 645 | 130887673 | 130887781 | 1470 | 1577 | 392 | 428 |
| ENST00000508196 | 1955 | 645 | 130887673 | 130887781 | 1177 | 1284 | 392 | 428 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000383366 | 2931 | 645 | 130871231 | 130871381 | 941 | 1090 | 216 | 265 |
| ENST00000508196 | 1955 | 645 | 130871231 | 130871381 | 648 | 797 | 216 | 265 |
| ENST00000383366 | 2931 | 645 | 130887673 | 130887781 | 1470 | 1577 | 392 | 428 |
| ENST00000508196 | 1955 | 645 | 130887673 | 130887781 | 1177 | 1284 | 392 | 428 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8NG66 | 216 | 265 | 1 | 645 | Chain | ID=PRO_0000086438;Note=Serine/threonine-protein kinase Nek11 |
| Q8NG66 | 216 | 265 | 1 | 645 | Chain | ID=PRO_0000086438;Note=Serine/threonine-protein kinase Nek11 |
| Q8NG66 | 216 | 265 | 29 | 287 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q8NG66 | 216 | 265 | 29 | 287 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q8NG66 | 216 | 265 | 263 | 263 | Natural variant | ID=VAR_040938;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35567155,PMID:17344846 |
| Q8NG66 | 216 | 265 | 263 | 263 | Natural variant | ID=VAR_040938;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35567155,PMID:17344846 |
| Q8NG66 | 392 | 428 | 1 | 645 | Chain | ID=PRO_0000086438;Note=Serine/threonine-protein kinase Nek11 |
| Q8NG66 | 392 | 428 | 1 | 645 | Chain | ID=PRO_0000086438;Note=Serine/threonine-protein kinase Nek11 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8NG66 | 216 | 265 | 1 | 645 | Chain | ID=PRO_0000086438;Note=Serine/threonine-protein kinase Nek11 |
| Q8NG66 | 216 | 265 | 1 | 645 | Chain | ID=PRO_0000086438;Note=Serine/threonine-protein kinase Nek11 |
| Q8NG66 | 216 | 265 | 29 | 287 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q8NG66 | 216 | 265 | 29 | 287 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q8NG66 | 216 | 265 | 263 | 263 | Natural variant | ID=VAR_040938;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35567155,PMID:17344846 |
| Q8NG66 | 216 | 265 | 263 | 263 | Natural variant | ID=VAR_040938;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35567155,PMID:17344846 |
| Q8NG66 | 392 | 428 | 1 | 645 | Chain | ID=PRO_0000086438;Note=Serine/threonine-protein kinase Nek11 |
| Q8NG66 | 392 | 428 | 1 | 645 | Chain | ID=PRO_0000086438;Note=Serine/threonine-protein kinase Nek11 |
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SNVs in the skipped exons for NEK11 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_377673 | 130871232 | 130871381 | 130871310 | 130871310 | Frame_Shift_Del | A | - | p.L242fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_377677 | 130881252 | 130881371 | 130881254 | 130881254 | Frame_Shift_Del | A | - | p.Q322fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_377677 | 130881252 | 130881371 | 130881254 | 130881254 | Frame_Shift_Del | A | - | p.Q322fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_377677 | 130881252 | 130881371 | 130881254 | 130881254 | Frame_Shift_Del | A | - | p.Q322fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_377680 | 130887674 | 130887781 | 130887702 | 130887702 | Frame_Shift_Del | A | - | p.E402fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_377680 | 130887674 | 130887781 | 130887702 | 130887702 | Frame_Shift_Del | A | - | p.E402fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_377680 | 130887674 | 130887781 | 130887777 | 130887777 | Frame_Shift_Del | A | - | p.E429fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_377687 | 130992322 | 130992418 | 130992373 | 130992373 | Frame_Shift_Del | T | - | p.I558fs |
| LUAD | TCGA-44-5644-01 | exon_skip_377660 | 130799267 | 130799432 | 130799421 | 130799421 | Nonsense_Mutation | G | T | p.E109* |
| BLCA | TCGA-H4-A2HQ-01 | exon_skip_377667 | 130828647 | 130828765 | 130828671 | 130828671 | Nonsense_Mutation | C | T | p.Q121* |
| BLCA | TCGA-FD-A6TE-01 | exon_skip_377680 | 130887674 | 130887781 | 130887719 | 130887719 | Nonsense_Mutation | G | T | p.E408* |
| BLCA | TCGA-FD-A6TE-01 | exon_skip_377680 | 130887674 | 130887781 | 130887755 | 130887755 | Nonsense_Mutation | G | T | p.E420* |
| BLCA | TCGA-DK-A3X1-01 | exon_skip_377660 | 130799267 | 130799432 | 130799266 | 130799266 | Splice_Site | G | C | p.L57_splice |
| UCEC | TCGA-BS-A0UV-01 | exon_skip_377679 | 130873880 | 130873965 | 130873879 | 130873879 | Splice_Site | G | T | e8-1 |
| LUAD | TCGA-44-2655-01 | exon_skip_377677 | 130881252 | 130881371 | 130881250 | 130881250 | Splice_Site | A | T | p.M321_splice |
| ESCA | TCGA-V5-AASW-01 | exon_skip_377681 | 130889617 | 130889731 | 130889732 | 130889732 | Splice_Site | G | T | . |
| ESCA | TCGA-V5-AASW-01 | exon_skip_377681 | 130889617 | 130889731 | 130889732 | 130889732 | Splice_Site | G | T | e12+1 |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SNU1040_LARGE_INTESTINE | 130828647 | 130828765 | 130828691 | 130828691 | Frame_Shift_Del | A | - | p.G127fs |
| LOVO_LARGE_INTESTINE | 130881252 | 130881371 | 130881254 | 130881254 | Frame_Shift_Del | A | - | p.Q217fs |
| SNU81_LARGE_INTESTINE | 130871232 | 130871381 | 130871346 | 130871346 | Missense_Mutation | G | T | p.E254D |
| A375_SKIN | 130873880 | 130873965 | 130873913 | 130873913 | Missense_Mutation | G | A | p.E304K |
| MEWO_SKIN | 130873880 | 130873965 | 130873944 | 130873944 | Missense_Mutation | C | T | p.A314V |
| MS751_CERVIX | 130881252 | 130881371 | 130881326 | 130881326 | Missense_Mutation | G | A | p.R241Q |
| SKRC20_KIDNEY | 130881252 | 130881371 | 130881332 | 130881332 | Missense_Mutation | G | T | p.R243M |
| SKMES1_LUNG | 130881252 | 130881371 | 130881341 | 130881341 | Missense_Mutation | A | T | p.Q246L |
| HEC1B_ENDOMETRIUM | 130887674 | 130887781 | 130887704 | 130887704 | Missense_Mutation | A | C | p.K298Q |
| MM386_SKIN | 130887674 | 130887781 | 130887732 | 130887732 | Missense_Mutation | C | T | p.S307F |
| HCC44_LUNG | 130887674 | 130887781 | 130887773 | 130887773 | Missense_Mutation | A | T | p.R321W |
| HEC59_ENDOMETRIUM | 130889617 | 130889731 | 130889677 | 130889677 | Missense_Mutation | C | A | p.L344I |
| NCIH1793_LUNG | 130889617 | 130889731 | 130889677 | 130889677 | Missense_Mutation | C | A | p.L344I |
| LAN2_AUTONOMIC_GANGLIA | 130962280 | 130962340 | 130962326 | 130962326 | Missense_Mutation | G | T | p.G431V |
| D423MG_CENTRAL_NERVOUS_SYSTEM | 130992322 | 130992418 | 130992340 | 130992340 | Missense_Mutation | C | G | p.T442S |
| VMRCLCP_LUNG | 130992322 | 130992418 | 130992384 | 130992384 | Missense_Mutation | G | A | p.V457M |
| SNU81_LARGE_INTESTINE | 130799267 | 130799432 | 130799295 | 130799295 | Nonsense_Mutation | G | T | p.E67* |
| KS1_CENTRAL_NERVOUS_SYSTEM | 130828647 | 130828765 | 130828650 | 130828650 | Nonsense_Mutation | C | T | p.R114* |
| TCCSUP_URINARY_TRACT | 130828647 | 130828765 | 130828683 | 130828683 | Nonsense_Mutation | C | T | p.Q125* |
| NCIH810_LUNG | 130881252 | 130881371 | 130881256 | 130881256 | Nonsense_Mutation | A | T | p.K218* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NEK11 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_377671 | 3 | 130851588:130851653:130852120:130852199:130852673:130852800 | 130852120:130852199 | ENST00000514915.1 | BRCA | rs2674612 | chr3:130852186 | G/A | 1.91e-04 |
| exon_skip_377669 | 3 | 130851588:130851653:130852089:130852199:130852673:130852800 | 130852089:130852199 | ENST00000426022.2 | BRCA | rs2674612 | chr3:130852186 | G/A | 1.91e-04 |
| exon_skip_377687 | 3 | 130962279:130962340:130992321:130992418:131068400:131068620 | 130992321:130992418 | ENST00000510769.1,ENST00000514915.1,ENST00000429253.2,ENST00000510474.1,ENST00000383366.4,ENST00000508196.1,ENST00000412440.2 | CESC | rs16836266 | chr3:130992385 | T/C | 5.97e-04 |
| exon_skip_377687 | 3 | 130962279:130962340:130992321:130992418:131068400:131068620 | 130992321:130992418 | ENST00000510769.1,ENST00000514915.1,ENST00000429253.2,ENST00000510474.1,ENST00000383366.4,ENST00000508196.1,ENST00000412440.2 | ESCA | rs16836266 | chr3:130992385 | T/C | 7.38e-05 |
| exon_skip_377687 | 3 | 130962279:130962340:130992321:130992418:131068400:131068620 | 130992321:130992418 | ENST00000510769.1,ENST00000514915.1,ENST00000429253.2,ENST00000510474.1,ENST00000383366.4,ENST00000508196.1,ENST00000412440.2 | HNSC | rs16836266 | chr3:130992385 | T/C | 2.15e-04 |
| exon_skip_377687 | 3 | 130962279:130962340:130992321:130992418:131068400:131068620 | 130992321:130992418 | ENST00000510769.1,ENST00000514915.1,ENST00000429253.2,ENST00000510474.1,ENST00000383366.4,ENST00000508196.1,ENST00000412440.2 | KIRP | rs16836266 | chr3:130992385 | T/C | 2.55e-04 |
| exon_skip_377687 | 3 | 130962279:130962340:130992321:130992418:131068400:131068620 | 130992321:130992418 | ENST00000510769.1,ENST00000514915.1,ENST00000429253.2,ENST00000510474.1,ENST00000383366.4,ENST00000508196.1,ENST00000412440.2 | LGG | rs16836266 | chr3:130992385 | T/C | 1.35e-10 |
| exon_skip_377687 | 3 | 130962279:130962340:130992321:130992418:131068400:131068620 | 130992321:130992418 | ENST00000510769.1,ENST00000514915.1,ENST00000429253.2,ENST00000510474.1,ENST00000383366.4,ENST00000508196.1,ENST00000412440.2 | KIRC | rs16836266 | chr3:130992385 | T/C | 6.59e-05 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NEK11 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NEK11 |
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RelatedDrugs for NEK11 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q8NG66 | DB08912 | Dabrafenib | Serine/threonine-protein kinase Nek11 | small molecule | approved|investigational | |
| Q8NG66 | DB12010 | Fostamatinib | Serine/threonine-protein kinase Nek11 | small molecule | approved|investigational |
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RelatedDiseases for NEK11 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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