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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MICALL2 |
 Gene summary |
| Gene information | Gene symbol | MICALL2 | Gene ID | 79778 |
| Gene name | MICAL like 2 | |
| Synonyms | JRAB|MICAL-L2 | |
| Cytomap | 7p22.3 | |
| Type of gene | protein-coding | |
| Description | MICAL-like protein 2junctional Rab13-binding proteinmolecule interacting with CasL-like 2 | |
| Modification date | 20180519 | |
| UniProtAcc | Q8IY33 | |
| Context | PubMed: MICALL2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for MICALL2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MICALL2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MICALL2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_473034 | 7 | 1468254:1468427:1473845:1474783:1476377:1476472 | 1473845:1474783 | ENSG00000164877.14 | ENST00000472100.1 |
| exon_skip_473062 | 7 | 1474001:1474308:1474736:1474783:1476377:1476472 | 1474736:1474783 | ENSG00000164877.14 | ENST00000405088.4,ENST00000413446.1,ENST00000470807.1,ENST00000467394.1,ENST00000297508.7,ENST00000479007.1 |
| exon_skip_473080 | 7 | 1476378:1476492:1477170:1477244:1477732:1477856 | 1477170:1477244 | ENSG00000164877.14 | ENST00000487187.1 |
| exon_skip_473082 | 7 | 1477171:1477244:1477525:1477616:1477732:1477829 | 1477525:1477616 | ENSG00000164877.14 | ENST00000405088.4,ENST00000413446.1,ENST00000460198.1,ENST00000467394.1,ENST00000472100.1,ENST00000297508.7,ENST00000471899.1,ENST00000479007.1 |
| exon_skip_473084 | 7 | 1477732:1477856:1477924:1477989:1478475:1478598 | 1477924:1477989 | ENSG00000164877.14 | ENST00000405088.4,ENST00000413446.1,ENST00000467394.1,ENST00000472100.1,ENST00000297508.7,ENST00000471899.1,ENST00000479007.1 |
| exon_skip_473086 | 7 | 1478475:1478627:1479560:1479721:1480226:1480320 | 1479560:1479721 | ENSG00000164877.14 | ENST00000413446.1 |
| exon_skip_473087 | 7 | 1478560:1478631:1479560:1479721:1480226:1480320 | 1479560:1479721 | ENSG00000164877.14 | ENST00000405088.4,ENST00000467394.1,ENST00000472100.1,ENST00000297508.7 |
| exon_skip_473091 | 7 | 1480226:1480320:1481827:1482120:1484287:1484510 | 1481827:1482120 | ENSG00000164877.14 | ENST00000405088.4,ENST00000413446.1,ENST00000297508.7 |
| exon_skip_473104 | 7 | 1488255:1488397:1489875:1489924:1498819:1499001 | 1489875:1489924 | ENSG00000164877.14 | ENST00000472100.1,ENST00000297508.7 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MICALL2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_473034 | 7 | 1468254:1468427:1473845:1474783:1476377:1476472 | 1473845:1474783 | ENSG00000164877.14 | ENST00000472100.1 |
| exon_skip_473062 | 7 | 1474001:1474308:1474736:1474783:1476377:1476472 | 1474736:1474783 | ENSG00000164877.14 | ENST00000467394.1,ENST00000405088.4,ENST00000470807.1,ENST00000479007.1,ENST00000413446.1,ENST00000297508.7 |
| exon_skip_473080 | 7 | 1476378:1476492:1477170:1477244:1477732:1477856 | 1477170:1477244 | ENSG00000164877.14 | ENST00000487187.1 |
| exon_skip_473082 | 7 | 1477171:1477244:1477525:1477616:1477732:1477829 | 1477525:1477616 | ENSG00000164877.14 | ENST00000472100.1,ENST00000467394.1,ENST00000405088.4,ENST00000471899.1,ENST00000479007.1,ENST00000413446.1,ENST00000297508.7,ENST00000460198.1 |
| exon_skip_473084 | 7 | 1477732:1477856:1477924:1477989:1478475:1478598 | 1477924:1477989 | ENSG00000164877.14 | ENST00000472100.1,ENST00000467394.1,ENST00000405088.4,ENST00000471899.1,ENST00000479007.1,ENST00000413446.1,ENST00000297508.7 |
| exon_skip_473086 | 7 | 1478475:1478627:1479560:1479721:1480226:1480320 | 1479560:1479721 | ENSG00000164877.14 | ENST00000413446.1 |
| exon_skip_473087 | 7 | 1478560:1478631:1479560:1479721:1480226:1480320 | 1479560:1479721 | ENSG00000164877.14 | ENST00000472100.1,ENST00000467394.1,ENST00000405088.4,ENST00000297508.7 |
| exon_skip_473091 | 7 | 1480226:1480320:1481827:1482120:1484287:1484510 | 1481827:1482120 | ENSG00000164877.14 | ENST00000405088.4,ENST00000413446.1,ENST00000297508.7 |
| exon_skip_473104 | 7 | 1488255:1488397:1489875:1489924:1498819:1499001 | 1489875:1489924 | ENSG00000164877.14 | ENST00000472100.1,ENST00000297508.7 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MICALL2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000297508 | 1474736 | 1474783 | Frame-shift |
| ENST00000297508 | 1477525 | 1477616 | Frame-shift |
| ENST00000297508 | 1477924 | 1477989 | Frame-shift |
| ENST00000297508 | 1479560 | 1479721 | Frame-shift |
| ENST00000297508 | 1481827 | 1482120 | Frame-shift |
| ENST00000297508 | 1489875 | 1489924 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000297508 | 1474736 | 1474783 | Frame-shift |
| ENST00000297508 | 1477525 | 1477616 | Frame-shift |
| ENST00000297508 | 1477924 | 1477989 | Frame-shift |
| ENST00000297508 | 1479560 | 1479721 | Frame-shift |
| ENST00000297508 | 1481827 | 1482120 | Frame-shift |
| ENST00000297508 | 1489875 | 1489924 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for MICALL2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for MICALL2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_473087 exon_skip_473086 | 1479561 | 1479721 | 1479613 | 1479613 | Frame_Shift_Del | G | - | p.P638fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_473087 exon_skip_473086 | 1479561 | 1479721 | 1479621 | 1479621 | Frame_Shift_Del | G | - | p.L636fs |
| COAD | TCGA-A6-5665-01 | exon_skip_473091 | 1481828 | 1482120 | 1481941 | 1481941 | Frame_Shift_Del | G | - | p.P533fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_473091 | 1481828 | 1482120 | 1481941 | 1481941 | Frame_Shift_Del | G | - | p.P533fs |
| BLCA | TCGA-DK-A1AG-01 | exon_skip_473034 | 1473846 | 1474783 | 1474248 | 1474249 | Frame_Shift_Ins | - | T | p.S900fs |
| BLCA | TCGA-2F-A9KO-01 | exon_skip_473091 | 1481828 | 1482120 | 1482086 | 1482086 | Nonsense_Mutation | G | A | p.Q485* |
| KIRP | TCGA-B9-A5W8-01 | exon_skip_473084 | 1477925 | 1477989 | 1477990 | 1477990 | Splice_Site | C | G | p.G708_splice |
| LUSC | TCGA-43-5668-01 | exon_skip_473104 | 1489876 | 1489924 | 1489875 | 1489875 | Splice_Site | C | A | p.L64_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIM1215_LARGE_INTESTINE | 1479561 | 1479721 | 1479672 | 1479672 | Frame_Shift_Del | C | - | p.E619fs |
| HEC151_ENDOMETRIUM | 1481828 | 1482120 | 1481846 | 1481846 | Frame_Shift_Del | T | - | p.S565fs |
| MFE319_ENDOMETRIUM | 1473846 | 1474783 | 1474248 | 1474248 | Missense_Mutation | C | T | p.S900N |
| C33A_CERVIX | 1473846 | 1474783 | 1474758 | 1474758 | Missense_Mutation | G | A | p.R873W |
| C33A_CERVIX | 1474737 | 1474783 | 1474758 | 1474758 | Missense_Mutation | G | A | p.R873W |
| JVM3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1473846 | 1474783 | 1474778 | 1474778 | Missense_Mutation | T | C | p.Q866R |
| JVM3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1474737 | 1474783 | 1474778 | 1474778 | Missense_Mutation | T | C | p.Q866R |
| KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1477171 | 1477244 | 1477186 | 1477186 | Missense_Mutation | G | A | p.L821F |
| HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1477526 | 1477616 | 1477596 | 1477596 | Missense_Mutation | T | C | p.M778V |
| HDQP1_BREAST | 1477526 | 1477616 | 1477608 | 1477608 | Missense_Mutation | C | T | p.E774K |
| HSC4_UPPER_AERODIGESTIVE_TRACT | 1477526 | 1477616 | 1477614 | 1477614 | Missense_Mutation | C | T | p.D772N |
| COGN278_AUTONOMIC_GANGLIA | 1477925 | 1477989 | 1477944 | 1477944 | Missense_Mutation | G | A | p.T723M |
| HCT116_LARGE_INTESTINE | 1477925 | 1477989 | 1477962 | 1477962 | Missense_Mutation | G | T | p.P717H |
| DMS114_LUNG | 1479561 | 1479721 | 1479578 | 1479578 | Missense_Mutation | G | C | p.P650R |
| NCIH661_LUNG | 1479561 | 1479721 | 1479699 | 1479699 | Missense_Mutation | G | A | p.R610W |
| NCIH838_LUNG | 1479561 | 1479721 | 1479701 | 1479701 | Missense_Mutation | G | T | p.P609Q |
| SNU668_STOMACH | 1481828 | 1482120 | 1481863 | 1481863 | Missense_Mutation | G | A | p.P559L |
| SKUT1_SOFT_TISSUE | 1481828 | 1482120 | 1481900 | 1481900 | Missense_Mutation | T | C | p.R547G |
| IMR5_AUTONOMIC_GANGLIA | 1481828 | 1482120 | 1481921 | 1481921 | Missense_Mutation | C | G | p.A540P |
| SF126_CENTRAL_NERVOUS_SYSTEM | 1481828 | 1482120 | 1481965 | 1481965 | Missense_Mutation | G | A | p.T525I |
| HEC59_ENDOMETRIUM | 1481828 | 1482120 | 1481977 | 1481977 | Missense_Mutation | C | T | p.S521N |
| SW684_SOFT_TISSUE | 1481828 | 1482120 | 1482004 | 1482004 | Missense_Mutation | G | A | p.S512L |
| NCIH1793_LUNG | 1481828 | 1482120 | 1482022 | 1482022 | Missense_Mutation | C | G | p.R506P |
| TE11_OESOPHAGUS | 1481828 | 1482120 | 1482043 | 1482043 | Missense_Mutation | G | A | p.P499L |
| SW780_URINARY_TRACT | 1481828 | 1482120 | 1482059 | 1482059 | Missense_Mutation | T | C | p.S494G |
| SW780_URINARY_TRACT | 1481828 | 1482120 | 1482061 | 1482061 | Missense_Mutation | G | A | p.A493V |
| MDAMB415_BREAST | 1481828 | 1482120 | 1481960 | 1481960 | Nonsense_Mutation | G | A | p.Q527* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MICALL2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MICALL2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MICALL2 |
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RelatedDrugs for MICALL2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MICALL2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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