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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for STEAP4 |
 Gene summary |
| Gene information | Gene symbol | STEAP4 | Gene ID | 79689 |
| Gene name | STEAP4 metalloreductase | |
| Synonyms | STAMP2|SchLAH|TIARP|TNFAIP9 | |
| Cytomap | 7q21.12 | |
| Type of gene | protein-coding | |
| Description | metalloreductase STEAP4STEAP family member 4seven chromosome locus associated with HCCsix transmembrane prostate protein 2six-transmembrane epithelial antigen of prostate 4sixTransMembrane protein of prostate 2tumor necrosis factor, alpha-induced pr | |
| Modification date | 20180523 | |
| UniProtAcc | Q687X5 | |
| Context | PubMed: STEAP4 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for STEAP4 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for STEAP4 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for STEAP4 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_476896 | 7 | 87910229:87910394:87911955:87912483:87913128:87913205 | 87911955:87912483 | ENSG00000127954.8 | ENST00000380079.4 |
| exon_skip_476900 | 7 | 87913128:87913586:87920230:87920329:87936106:87936195 | 87920230:87920329 | ENSG00000127954.8 | ENST00000414498.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for STEAP4 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_476896 | 7 | 87910229:87910394:87911955:87912483:87913128:87913205 | 87911955:87912483 | ENSG00000127954.8 | ENST00000380079.4 |
| exon_skip_476900 | 7 | 87913128:87913586:87920230:87920329:87936106:87936195 | 87920230:87920329 | ENSG00000127954.8 | ENST00000414498.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for STEAP4 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000380079 | 87911955 | 87912483 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000380079 | 87911955 | 87912483 | In-frame |
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Infer the effects of exon skipping event on protein functional features for STEAP4 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000380079 | 4468 | 459 | 87911955 | 87912483 | 559 | 1086 | 152 | 328 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000380079 | 4468 | 459 | 87911955 | 87912483 | 559 | 1086 | 152 | 328 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q687X5 | 152 | 328 | 153 | 328 | Alternative sequence | ID=VSP_024833;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q687X5 | 152 | 328 | 171 | 171 | Binding site | Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q4V8K1 |
| Q687X5 | 152 | 328 | 1 | 459 | Chain | ID=PRO_0000285174;Note=Metalloreductase STEAP4 |
| Q687X5 | 152 | 328 | 247 | 395 | Domain | Note=Ferric oxidoreductase;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q687X5 | 152 | 328 | 323 | 323 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218 |
| Q687X5 | 152 | 328 | 304 | 304 | Metal binding | Note=Iron (heme axial ligand);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P32791 |
| Q687X5 | 152 | 328 | 196 | 216 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q687X5 | 152 | 328 | 246 | 266 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q687X5 | 152 | 328 | 293 | 313 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q687X5 | 152 | 328 | 153 | 328 | Alternative sequence | ID=VSP_024833;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q687X5 | 152 | 328 | 171 | 171 | Binding site | Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q4V8K1 |
| Q687X5 | 152 | 328 | 1 | 459 | Chain | ID=PRO_0000285174;Note=Metalloreductase STEAP4 |
| Q687X5 | 152 | 328 | 247 | 395 | Domain | Note=Ferric oxidoreductase;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q687X5 | 152 | 328 | 323 | 323 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218 |
| Q687X5 | 152 | 328 | 304 | 304 | Metal binding | Note=Iron (heme axial ligand);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P32791 |
| Q687X5 | 152 | 328 | 196 | 216 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q687X5 | 152 | 328 | 246 | 266 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q687X5 | 152 | 328 | 293 | 313 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for STEAP4 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_476896 | 87911956 | 87912483 | 87912293 | 87912293 | Frame_Shift_Del | A | - | p.F216fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_476896 | 87911956 | 87912483 | 87912331 | 87912331 | Frame_Shift_Del | G | - | p.P203fs |
| STAD | TCGA-BR-8360-01 | exon_skip_476896 | 87911956 | 87912483 | 87912360 | 87912360 | Frame_Shift_Del | G | - | p.L194fs |
| UCEC | TCGA-AX-A0J0-01 | exon_skip_476896 | 87911956 | 87912483 | 87911988 | 87911988 | Nonsense_Mutation | G | A | p.R318* |
| PAAD | TCGA-IB-7651-01 | exon_skip_476896 | 87911956 | 87912483 | 87912325 | 87912325 | Nonsense_Mutation | A | C | p.Y205* |
| PAAD | TCGA-IB-7651-01 | exon_skip_476896 | 87911956 | 87912483 | 87912325 | 87912325 | Nonsense_Mutation | A | C | p.Y205X |
| UCEC | TCGA-AP-A059-01 | exon_skip_476896 | 87911956 | 87912483 | 87912378 | 87912378 | Nonsense_Mutation | C | A | p.E188* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| CROAP2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 87911956 | 87912483 | 87912263 | 87912263 | Frame_Shift_Del | G | - | p.P226fs |
| TOV21G_OVARY | 87911956 | 87912483 | 87912359 | 87912360 | Frame_Shift_Ins | - | G | p.L194fs |
| SISO_CERVIX | 87911956 | 87912483 | 87911964 | 87911964 | Missense_Mutation | C | T | p.V326I |
| GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 87911956 | 87912483 | 87911964 | 87911964 | Missense_Mutation | C | T | p.V326I |
| SNUC4_LARGE_INTESTINE | 87911956 | 87912483 | 87911984 | 87911984 | Missense_Mutation | C | A | p.W319L |
| NCIH630_LARGE_INTESTINE | 87911956 | 87912483 | 87912206 | 87912206 | Missense_Mutation | C | T | p.R245H |
| HS695T_SKIN | 87911956 | 87912483 | 87912207 | 87912207 | Missense_Mutation | G | A | p.R245C |
| C10_LARGE_INTESTINE | 87911956 | 87912483 | 87912213 | 87912213 | Missense_Mutation | G | A | p.P243S |
| KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 87911956 | 87912483 | 87912225 | 87912225 | Missense_Mutation | C | T | p.A239T |
| RERFGC1B_STOMACH | 87911956 | 87912483 | 87912230 | 87912230 | Missense_Mutation | C | A | p.R237L |
| SW48_LARGE_INTESTINE | 87911956 | 87912483 | 87912231 | 87912231 | Missense_Mutation | G | A | p.R237C |
| C2BBE1_LARGE_INTESTINE | 87911956 | 87912483 | 87912243 | 87912243 | Missense_Mutation | C | G | p.D233H |
| CW2_LARGE_INTESTINE | 87911956 | 87912483 | 87912446 | 87912446 | Missense_Mutation | C | A | p.R165I |
| HCC70_BREAST | 87911956 | 87912483 | 87912447 | 87912447 | Missense_Mutation | T | C | p.R165G |
| MCC13_SKIN | 87911956 | 87912483 | 87912000 | 87912000 | Nonsense_Mutation | G | A | p.R314* |
| HT115_LARGE_INTESTINE | 87911956 | 87912483 | 87912000 | 87912000 | Nonsense_Mutation | G | A | p.R314* |
| SNU81_LARGE_INTESTINE | 87911956 | 87912483 | 87912378 | 87912378 | Nonsense_Mutation | C | A | p.E188* |
| KMBC2_URINARY_TRACT | 87911956 | 87912483 | 87912483 | 87912483 | Splice_Site | C | A | p.V153L |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STEAP4 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STEAP4 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for STEAP4 |
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RelatedDrugs for STEAP4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STEAP4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| STEAP4 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| STEAP4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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