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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for PRR14 |
 Gene summary |
| Gene information | Gene symbol | PRR14 | Gene ID | 78994 |
| Gene name | proline rich 14 | |
| Synonyms | - | |
| Cytomap | 16p11.2 | |
| Type of gene | protein-coding | |
| Description | proline-rich protein 14 | |
| Modification date | 20180519 | |
| UniProtAcc | Q9BWN1 | |
| Context | PubMed: PRR14 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for PRR14 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for PRR14 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for PRR14 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_135797 | 16 | 30662100:30662127:30662313:30662448:30662916:30662989 | 30662313:30662448 | ENSG00000156858.7 | ENST00000569864.1 |
| exon_skip_135800 | 16 | 30662100:30662127:30662916:30662989:30663116:30663285 | 30662916:30662989 | ENSG00000156858.7 | ENST00000563211.1,ENST00000568754.1 |
| exon_skip_135801 | 16 | 30662313:30662448:30662916:30662989:30663116:30663285 | 30662916:30662989 | ENSG00000156858.7 | ENST00000565410.1,ENST00000300835.4,ENST00000287463.4,ENST00000569864.1 |
| exon_skip_135803 | 16 | 30664234:30664424:30664685:30664729:30665550:30665660 | 30664685:30664729 | ENSG00000156858.7 | ENST00000542965.2,ENST00000300835.4,ENST00000564946.1,ENST00000568754.1,ENST00000287463.4 |
| exon_skip_135806 | 16 | 30665550:30665660:30665949:30666535:30666671:30666741 | 30665949:30666535 | ENSG00000156858.7 | ENST00000542965.2,ENST00000300835.4,ENST00000567322.1,ENST00000287463.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for PRR14 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_135797 | 16 | 30662100:30662127:30662313:30662448:30662916:30662989 | 30662313:30662448 | ENSG00000156858.7 | ENST00000569864.1 |
| exon_skip_135800 | 16 | 30662100:30662127:30662916:30662989:30663116:30663285 | 30662916:30662989 | ENSG00000156858.7 | ENST00000568754.1,ENST00000563211.1 |
| exon_skip_135801 | 16 | 30662313:30662448:30662916:30662989:30663116:30663285 | 30662916:30662989 | ENSG00000156858.7 | ENST00000569864.1,ENST00000300835.4,ENST00000565410.1,ENST00000287463.4 |
| exon_skip_135803 | 16 | 30664234:30664424:30664685:30664729:30665550:30665660 | 30664685:30664729 | ENSG00000156858.7 | ENST00000568754.1,ENST00000564946.1,ENST00000300835.4,ENST00000287463.4,ENST00000542965.2 |
| exon_skip_135806 | 16 | 30665550:30665660:30665949:30666535:30666671:30666741 | 30665949:30666535 | ENSG00000156858.7 | ENST00000300835.4,ENST00000287463.4,ENST00000542965.2,ENST00000567322.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for PRR14 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000300835 | 30662916 | 30662989 | 5CDS-5UTR |
| ENST00000300835 | 30664685 | 30664729 | Frame-shift |
| ENST00000542965 | 30664685 | 30664729 | Frame-shift |
| ENST00000300835 | 30665949 | 30666535 | Frame-shift |
| ENST00000542965 | 30665949 | 30666535 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000300835 | 30662916 | 30662989 | 5CDS-5UTR |
| ENST00000300835 | 30664685 | 30664729 | Frame-shift |
| ENST00000542965 | 30664685 | 30664729 | Frame-shift |
| ENST00000300835 | 30665949 | 30666535 | Frame-shift |
| ENST00000542965 | 30665949 | 30666535 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for PRR14 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for PRR14 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
PRR14_COAD_exon_skip_135806_psi_boxplot.png |
PRR14_PAAD_exon_skip_135806_psi_boxplot.png |
PRR14_SARC_exon_skip_135806_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_135803 | 30664686 | 30664729 | 30664702 | 30664702 | Frame_Shift_Del | C | - | p.T174fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_135806 | 30665950 | 30666535 | 30665998 | 30665998 | Frame_Shift_Del | T | - | p.L237fs |
| COAD | TCGA-A6-5665-01 | exon_skip_135806 | 30665950 | 30666535 | 30666121 | 30666121 | Frame_Shift_Del | C | - | p.S277fs |
| SARC | TCGA-K1-A6RT-01 | exon_skip_135806 | 30665950 | 30666535 | 30666121 | 30666121 | Frame_Shift_Del | C | - | p.S277fs |
| UCEC | TCGA-D1-A0ZS-01 | exon_skip_135806 | 30665950 | 30666535 | 30666121 | 30666121 | Frame_Shift_Del | C | - | p.S277fs |
| COAD | TCGA-AD-5900-01 | exon_skip_135806 | 30665950 | 30666535 | 30666120 | 30666121 | Frame_Shift_Ins | - | C | p.S277fs |
| COAD | TCGA-F4-6570-01 | exon_skip_135806 | 30665950 | 30666535 | 30666120 | 30666121 | Frame_Shift_Ins | - | C | p.S277fs |
| COAD | TCGA-G4-6588-01 | exon_skip_135806 | 30665950 | 30666535 | 30666120 | 30666121 | Frame_Shift_Ins | - | C | p.S277fs |
| PAAD | TCGA-IB-7651-01 | exon_skip_135806 | 30665950 | 30666535 | 30666168 | 30666168 | Nonsense_Mutation | C | T | p.Q293* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-IB-7651-01 |
| Cancer type: PAAD | |
| ESID: exon_skip_135806 | |
| Skipped exon start: 30665950 | |
| Skipped exon end: 30666535 | |
| Mutation start: 30666168 | |
| Mutation end: 30666168 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: C | |
| Mutation seq: T | |
| AAchange: p.Q293* | |
exon_skip_113241_PAAD_TCGA-IB-7651-01.png | |
exon_skip_115380_PAAD_TCGA-IB-7651-01.png | |
exon_skip_124564_PAAD_TCGA-IB-7651-01.png | |
exon_skip_135806_PAAD_TCGA-IB-7651-01.png | |
exon_skip_139341_PAAD_TCGA-IB-7651-01.png | |
exon_skip_153733_PAAD_TCGA-IB-7651-01.png | |
exon_skip_155805_PAAD_TCGA-IB-7651-01.png | |
exon_skip_18053_PAAD_TCGA-IB-7651-01.png | |
exon_skip_18056_PAAD_TCGA-IB-7651-01.png | |
exon_skip_23067_PAAD_TCGA-IB-7651-01.png | |
exon_skip_287059_PAAD_TCGA-IB-7651-01.png | |
exon_skip_294631_PAAD_TCGA-IB-7651-01.png | |
exon_skip_298512_PAAD_TCGA-IB-7651-01.png | |
exon_skip_306900_PAAD_TCGA-IB-7651-01.png | |
exon_skip_307723_PAAD_TCGA-IB-7651-01.png | |
exon_skip_315960_PAAD_TCGA-IB-7651-01.png | |
exon_skip_324675_PAAD_TCGA-IB-7651-01.png | |
exon_skip_330351_PAAD_TCGA-IB-7651-01.png | |
exon_skip_334330_PAAD_TCGA-IB-7651-01.png | |
exon_skip_341784_PAAD_TCGA-IB-7651-01.png | |
exon_skip_343314_PAAD_TCGA-IB-7651-01.png | |
exon_skip_348329_PAAD_TCGA-IB-7651-01.png | |
exon_skip_354232_PAAD_TCGA-IB-7651-01.png | |
exon_skip_370626_PAAD_TCGA-IB-7651-01.png | |
exon_skip_377740_PAAD_TCGA-IB-7651-01.png | |
exon_skip_385032_PAAD_TCGA-IB-7651-01.png | |
exon_skip_390031_PAAD_TCGA-IB-7651-01.png | |
exon_skip_422548_PAAD_TCGA-IB-7651-01.png | |
exon_skip_424536_PAAD_TCGA-IB-7651-01.png | |
exon_skip_431753_PAAD_TCGA-IB-7651-01.png | |
exon_skip_432982_PAAD_TCGA-IB-7651-01.png | |
exon_skip_435489_PAAD_TCGA-IB-7651-01.png | |
exon_skip_435729_PAAD_TCGA-IB-7651-01.png | |
exon_skip_441705_PAAD_TCGA-IB-7651-01.png | |
exon_skip_448879_PAAD_TCGA-IB-7651-01.png | |
exon_skip_468347_PAAD_TCGA-IB-7651-01.png | |
exon_skip_494000_PAAD_TCGA-IB-7651-01.png | |
exon_skip_494029_PAAD_TCGA-IB-7651-01.png | |
exon_skip_499410_PAAD_TCGA-IB-7651-01.png | |
exon_skip_499695_PAAD_TCGA-IB-7651-01.png | |
exon_skip_499697_PAAD_TCGA-IB-7651-01.png | |
exon_skip_79905_PAAD_TCGA-IB-7651-01.png | |
exon_skip_80096_PAAD_TCGA-IB-7651-01.png | |
exon_skip_95924_PAAD_TCGA-IB-7651-01.png | |
 | Sample: TCGA-AD-5900-01 |
| Cancer type: COAD | |
| ESID: exon_skip_135806 | |
| Skipped exon start: 30665950 | |
| Skipped exon end: 30666535 | |
| Mutation start: 30666120 | |
| Mutation end: 30666121 | |
| Mutation type: Frame_Shift_Ins | |
| Reference seq: - | |
| Mutation seq: C | |
| AAchange: p.S277fs | |
exon_skip_123601_COAD_TCGA-AD-5900-01.png | |
exon_skip_135806_COAD_TCGA-AD-5900-01.png | |
exon_skip_146733_COAD_TCGA-AD-5900-01.png | |
exon_skip_291928_COAD_TCGA-AD-5900-01.png | |
exon_skip_303809_COAD_TCGA-AD-5900-01.png | |
exon_skip_315782_COAD_TCGA-AD-5900-01.png | |
exon_skip_367235_COAD_TCGA-AD-5900-01.png | |
exon_skip_376149_COAD_TCGA-AD-5900-01.png | |
exon_skip_457524_COAD_TCGA-AD-5900-01.png | |
exon_skip_459148_COAD_TCGA-AD-5900-01.png | |
exon_skip_68768_COAD_TCGA-AD-5900-01.png | |
 | Sample: TCGA-F4-6570-01 |
| Cancer type: COAD | |
| ESID: exon_skip_135806 | |
| Skipped exon start: 30665950 | |
| Skipped exon end: 30666535 | |
| Mutation start: 30666120 | |
| Mutation end: 30666121 | |
| Mutation type: Frame_Shift_Ins | |
| Reference seq: - | |
| Mutation seq: C | |
| AAchange: p.S277fs | |
exon_skip_135806_COAD_TCGA-F4-6570-01.png | |
exon_skip_422548_COAD_TCGA-F4-6570-01.png | |
exon_skip_454428_COAD_TCGA-F4-6570-01.png | |
exon_skip_454431_COAD_TCGA-F4-6570-01.png | |
exon_skip_454433_COAD_TCGA-F4-6570-01.png | |
exon_skip_89413_COAD_TCGA-F4-6570-01.png | |
 | Sample: TCGA-G4-6588-01 |
| Cancer type: COAD | |
| ESID: exon_skip_135806 | |
| Skipped exon start: 30665950 | |
| Skipped exon end: 30666535 | |
| Mutation start: 30666120 | |
| Mutation end: 30666121 | |
| Mutation type: Frame_Shift_Ins | |
| Reference seq: - | |
| Mutation seq: C | |
| AAchange: p.S277fs | |
exon_skip_135806_COAD_TCGA-G4-6588-01.png | |
exon_skip_136696_COAD_TCGA-G4-6588-01.png | |
exon_skip_313058_COAD_TCGA-G4-6588-01.png | |
exon_skip_322889_COAD_TCGA-G4-6588-01.png | |
exon_skip_322890_COAD_TCGA-G4-6588-01.png | |
exon_skip_330818_COAD_TCGA-G4-6588-01.png | |
exon_skip_382354_COAD_TCGA-G4-6588-01.png | |
exon_skip_386802_COAD_TCGA-G4-6588-01.png | |
exon_skip_4028_COAD_TCGA-G4-6588-01.png | |
exon_skip_434039_COAD_TCGA-G4-6588-01.png | |
exon_skip_434040_COAD_TCGA-G4-6588-01.png | |
exon_skip_5121_COAD_TCGA-G4-6588-01.png | |
exon_skip_5861_COAD_TCGA-G4-6588-01.png | |
exon_skip_68768_COAD_TCGA-G4-6588-01.png | |
exon_skip_76742_COAD_TCGA-G4-6588-01.png | |
 | Sample: TCGA-K1-A6RT-01 |
| Cancer type: SARC | |
| ESID: exon_skip_135806 | |
| Skipped exon start: 30665950 | |
| Skipped exon end: 30666535 | |
| Mutation start: 30666121 | |
| Mutation end: 30666121 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: C | |
| Mutation seq: - | |
| AAchange: p.S277fs | |
exon_skip_135806_SARC_TCGA-K1-A6RT-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30665950 | 30666535 | 30666121 | 30666121 | Frame_Shift_Del | C | - | p.S277fs |
| SNU520_STOMACH | 30665950 | 30666535 | 30666121 | 30666121 | Frame_Shift_Del | C | - | p.S277fs |
| TOV21G_OVARY | 30665950 | 30666535 | 30666121 | 30666121 | Frame_Shift_Del | C | - | p.S277fs |
| CCK81_LARGE_INTESTINE | 30665950 | 30666535 | 30666121 | 30666121 | Frame_Shift_Del | C | - | p.S277fs |
| GP2D_LARGE_INTESTINE | 30665950 | 30666535 | 30666121 | 30666121 | Frame_Shift_Del | C | - | p.S277fs |
| RL952_ENDOMETRIUM | 30665950 | 30666535 | 30666121 | 30666121 | Frame_Shift_Del | C | - | p.S277fs |
| SW48_LARGE_INTESTINE | 30665950 | 30666535 | 30666121 | 30666121 | Frame_Shift_Del | C | - | p.S277fs |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30665950 | 30666535 | 30666121 | 30666121 | Frame_Shift_Del | C | - | p.S277fs |
| GP5D_LARGE_INTESTINE | 30665950 | 30666535 | 30666121 | 30666121 | Frame_Shift_Del | C | - | p.S277fs |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30665950 | 30666535 | 30666121 | 30666121 | Frame_Shift_Del | C | - | p.S277fs |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30665950 | 30666535 | 30666203 | 30666203 | Frame_Shift_Del | C | - | p.S304fs |
| SNU407_LARGE_INTESTINE | 30665950 | 30666535 | 30666247 | 30666247 | Frame_Shift_Del | C | - | p.T319fs |
| SNU407_LARGE_INTESTINE | 30665950 | 30666535 | 30666306 | 30666306 | Frame_Shift_Del | C | - | p.P340fs |
| D425_CENTRAL_NERVOUS_SYSTEM | 30665950 | 30666535 | 30666107 | 30666108 | Frame_Shift_Ins | - | C | p.P273fs |
| A4FUK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30665950 | 30666535 | 30666113 | 30666114 | Frame_Shift_Ins | - | C | p.P275fs |
| HCC2450_LUNG | 30665950 | 30666535 | 30666113 | 30666114 | Frame_Shift_Ins | - | C | p.P275fs |
| MERO84_LUNG | 30665950 | 30666535 | 30666113 | 30666114 | Frame_Shift_Ins | - | C | p.P275fs |
| MM386_SKIN | 30665950 | 30666535 | 30666113 | 30666114 | Frame_Shift_Ins | - | C | p.P275fs |
| MM426_SKIN | 30665950 | 30666535 | 30666113 | 30666114 | Frame_Shift_Ins | - | C | p.P275fs |
| PACADD188_PANCREAS | 30665950 | 30666535 | 30666113 | 30666114 | Frame_Shift_Ins | - | C | p.P275fs |
| SKGT2_STOMACH | 30665950 | 30666535 | 30666113 | 30666114 | Frame_Shift_Ins | - | C | p.P275fs |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30664686 | 30664729 | 30664700 | 30664700 | Missense_Mutation | G | T | p.E173D |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30665950 | 30666535 | 30665961 | 30665961 | Missense_Mutation | G | A | p.A224T |
| BICR31_UPPER_AERODIGESTIVE_TRACT | 30665950 | 30666535 | 30666009 | 30666009 | Missense_Mutation | C | T | p.R240C |
| 647V_URINARY_TRACT | 30665950 | 30666535 | 30666126 | 30666126 | Missense_Mutation | C | A | p.P279T |
| NCIH2085_LUNG | 30665950 | 30666535 | 30666132 | 30666132 | Missense_Mutation | A | G | p.K281E |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30665950 | 30666535 | 30666150 | 30666150 | Missense_Mutation | G | A | p.A287T |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30665950 | 30666535 | 30666220 | 30666220 | Missense_Mutation | G | A | p.R310H |
| K5_THYROID | 30665950 | 30666535 | 30666240 | 30666240 | Missense_Mutation | C | T | p.H317Y |
| LN464_CENTRAL_NERVOUS_SYSTEM | 30665950 | 30666535 | 30666286 | 30666286 | Missense_Mutation | A | G | p.Y332C |
| ACN_AUTONOMIC_GANGLIA | 30665950 | 30666535 | 30666286 | 30666286 | Missense_Mutation | A | G | p.Y332C |
| LN464_CENTRAL_NERVOUS_SYSTEM | 30665950 | 30666535 | 30666289 | 30666289 | Missense_Mutation | C | A | p.S333Y |
| ACN_AUTONOMIC_GANGLIA | 30665950 | 30666535 | 30666289 | 30666289 | Missense_Mutation | C | A | p.S333Y |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30665950 | 30666535 | 30666328 | 30666328 | Missense_Mutation | C | A | p.T346N |
| TE1_OESOPHAGUS | 30665950 | 30666535 | 30666360 | 30666360 | Missense_Mutation | C | A | p.P357T |
| REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30665950 | 30666535 | 30666447 | 30666447 | Missense_Mutation | C | T | p.P386S |
| SW1783_CENTRAL_NERVOUS_SYSTEM | 30665950 | 30666535 | 30666453 | 30666453 | Missense_Mutation | G | A | p.G388R |
| C33A_CERVIX | 30665950 | 30666535 | 30666468 | 30666468 | Missense_Mutation | T | C | p.S393P |
| SUDHL16_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30665950 | 30666535 | 30666357 | 30666357 | Nonsense_Mutation | C | T | p.R356* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PRR14 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PRR14 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PRR14 |
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RelatedDrugs for PRR14 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRR14 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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