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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MAPKAPK3 |
 Gene summary |
| Gene information | Gene symbol | MAPKAPK3 | Gene ID | 7867 |
| Gene name | mitogen-activated protein kinase-activated protein kinase 3 | |
| Synonyms | 3PK|MAPKAP-K3|MAPKAP3|MAPKAPK-3|MDPT3|MK-3 | |
| Cytomap | 3p21.2 | |
| Type of gene | protein-coding | |
| Description | MAP kinase-activated protein kinase 3MAPK-activated protein kinase 3MAPKAP kinase 3chromosome 3p kinase | |
| Modification date | 20180523 | |
| UniProtAcc | Q16644 | |
| Context | PubMed: MAPKAPK3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MAPKAPK3 | GO:0018105 | peptidyl-serine phosphorylation | 15850461 |
| MAPKAPK3 | GO:0034097 | response to cytokine | 8774846 |
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Exon skipping events across known transcript of Ensembl for MAPKAPK3 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MAPKAPK3 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MAPKAPK3 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_374688 | 3 | 50649758:50650130:50650278:50650373:50651222:50651331 | 50650278:50650373 | ENSG00000114738.6 | ENST00000497283.1 |
| exon_skip_374690 | 3 | 50654600:50654657:50654944:50655215:50677796:50677936 | 50654944:50655215 | ENSG00000114738.6 | ENST00000357955.2 |
| exon_skip_374692 | 3 | 50654561:50654672:50654944:50655215:50677796:50677936 | 50654944:50655215 | ENSG00000114738.6 | ENST00000430409.1 |
| exon_skip_374696 | 3 | 50655140:50655215:50677796:50677936:50679137:50679202 | 50677796:50677936 | ENSG00000114738.6 | ENST00000357955.2,ENST00000446044.1,ENST00000430409.1 |
| exon_skip_374703 | 3 | 50677796:50677936:50679137:50679202:50679683:50679763 | 50679137:50679202 | ENSG00000114738.6 | ENST00000357955.2,ENST00000446044.1,ENST00000430409.1 |
| exon_skip_374706 | 3 | 50679686:50679763:50681839:50681963:50683140:50683216 | 50681839:50681963 | ENSG00000114738.6 | ENST00000357955.2,ENST00000446044.1,ENST00000430409.1 |
| exon_skip_374709 | 3 | 50683140:50683216:50683570:50683695:50684170:50684256 | 50683570:50683695 | ENSG00000114738.6 | ENST00000357955.2,ENST00000446044.1,ENST00000430409.1 |
| exon_skip_374712 | 3 | 50683642:50683695:50684170:50684256:50684553:50684634 | 50684170:50684256 | ENSG00000114738.6 | ENST00000357955.2,ENST00000446044.1,ENST00000430409.1 |
| exon_skip_374718 | 3 | 50684178:50684256:50684553:50684634:50685324:50686058 | 50684553:50684634 | ENSG00000114738.6 | ENST00000357955.2,ENST00000446044.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MAPKAPK3 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_374688 | 3 | 50649758:50650130:50650278:50650373:50651222:50651331 | 50650278:50650373 | ENSG00000114738.6 | ENST00000497283.1 |
| exon_skip_374690 | 3 | 50654600:50654657:50654944:50655215:50677796:50677936 | 50654944:50655215 | ENSG00000114738.6 | ENST00000357955.2 |
| exon_skip_374692 | 3 | 50654561:50654672:50654944:50655215:50677796:50677936 | 50654944:50655215 | ENSG00000114738.6 | ENST00000430409.1 |
| exon_skip_374696 | 3 | 50655140:50655215:50677796:50677936:50679137:50679202 | 50677796:50677936 | ENSG00000114738.6 | ENST00000446044.1,ENST00000430409.1,ENST00000357955.2 |
| exon_skip_374703 | 3 | 50677796:50677936:50679137:50679202:50679683:50679763 | 50679137:50679202 | ENSG00000114738.6 | ENST00000446044.1,ENST00000430409.1,ENST00000357955.2 |
| exon_skip_374706 | 3 | 50679686:50679763:50681839:50681963:50683140:50683216 | 50681839:50681963 | ENSG00000114738.6 | ENST00000446044.1,ENST00000430409.1,ENST00000357955.2 |
| exon_skip_374709 | 3 | 50683140:50683216:50683570:50683695:50684170:50684256 | 50683570:50683695 | ENSG00000114738.6 | ENST00000446044.1,ENST00000430409.1,ENST00000357955.2 |
| exon_skip_374712 | 3 | 50683642:50683695:50684170:50684256:50684553:50684634 | 50684170:50684256 | ENSG00000114738.6 | ENST00000446044.1,ENST00000430409.1,ENST00000357955.2 |
| exon_skip_374718 | 3 | 50684178:50684256:50684553:50684634:50685324:50686058 | 50684553:50684634 | ENSG00000114738.6 | ENST00000446044.1,ENST00000357955.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MAPKAPK3 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000357955 | 50654944 | 50655215 | 5CDS-5UTR |
| ENST00000357955 | 50677796 | 50677936 | Frame-shift |
| ENST00000446044 | 50677796 | 50677936 | Frame-shift |
| ENST00000357955 | 50679137 | 50679202 | Frame-shift |
| ENST00000446044 | 50679137 | 50679202 | Frame-shift |
| ENST00000357955 | 50681839 | 50681963 | Frame-shift |
| ENST00000446044 | 50681839 | 50681963 | Frame-shift |
| ENST00000357955 | 50683570 | 50683695 | Frame-shift |
| ENST00000446044 | 50683570 | 50683695 | Frame-shift |
| ENST00000357955 | 50684170 | 50684256 | Frame-shift |
| ENST00000446044 | 50684170 | 50684256 | Frame-shift |
| ENST00000357955 | 50684553 | 50684634 | In-frame |
| ENST00000446044 | 50684553 | 50684634 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000357955 | 50654944 | 50655215 | 5CDS-5UTR |
| ENST00000357955 | 50677796 | 50677936 | Frame-shift |
| ENST00000446044 | 50677796 | 50677936 | Frame-shift |
| ENST00000357955 | 50679137 | 50679202 | Frame-shift |
| ENST00000446044 | 50679137 | 50679202 | Frame-shift |
| ENST00000357955 | 50681839 | 50681963 | Frame-shift |
| ENST00000446044 | 50681839 | 50681963 | Frame-shift |
| ENST00000357955 | 50683570 | 50683695 | Frame-shift |
| ENST00000446044 | 50683570 | 50683695 | Frame-shift |
| ENST00000357955 | 50684170 | 50684256 | Frame-shift |
| ENST00000446044 | 50684170 | 50684256 | Frame-shift |
| ENST00000357955 | 50684553 | 50684634 | In-frame |
| ENST00000446044 | 50684553 | 50684634 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MAPKAPK3 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000357955 | 2517 | 382 | 50684553 | 50684634 | 1025 | 1105 | 305 | 332 |
| ENST00000446044 | 3005 | 382 | 50684553 | 50684634 | 1512 | 1592 | 305 | 332 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000357955 | 2517 | 382 | 50684553 | 50684634 | 1025 | 1105 | 305 | 332 |
| ENST00000446044 | 3005 | 382 | 50684553 | 50684634 | 1512 | 1592 | 305 | 332 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q16644 | 305 | 332 | 1 | 382 | Chain | ID=PRO_0000086293;Note=MAP kinase-activated protein kinase 3 |
| Q16644 | 305 | 332 | 1 | 382 | Chain | ID=PRO_0000086293;Note=MAP kinase-activated protein kinase 3 |
| Q16644 | 305 | 332 | 302 | 305 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR |
| Q16644 | 305 | 332 | 302 | 305 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR |
| Q16644 | 305 | 332 | 307 | 309 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR |
| Q16644 | 305 | 332 | 307 | 309 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR |
| Q16644 | 305 | 332 | 317 | 323 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR |
| Q16644 | 305 | 332 | 317 | 323 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR |
| Q16644 | 305 | 332 | 325 | 327 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR |
| Q16644 | 305 | 332 | 325 | 327 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR |
| Q16644 | 305 | 332 | 328 | 343 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR |
| Q16644 | 305 | 332 | 328 | 343 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR |
| Q16644 | 305 | 332 | 307 | 307 | Modified residue | Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q16644 | 305 | 332 | 307 | 307 | Modified residue | Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q16644 | 305 | 332 | 313 | 313 | Modified residue | Note=Phosphothreonine%3B by MAPK14;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q16644 | 305 | 332 | 313 | 313 | Modified residue | Note=Phosphothreonine%3B by MAPK14;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q16644 | 305 | 332 | 307 | 343 | Region | Note=Autoinhibitory helix;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q16644 | 305 | 332 | 307 | 343 | Region | Note=Autoinhibitory helix;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q16644 | 305 | 332 | 1 | 382 | Chain | ID=PRO_0000086293;Note=MAP kinase-activated protein kinase 3 |
| Q16644 | 305 | 332 | 1 | 382 | Chain | ID=PRO_0000086293;Note=MAP kinase-activated protein kinase 3 |
| Q16644 | 305 | 332 | 302 | 305 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR |
| Q16644 | 305 | 332 | 302 | 305 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR |
| Q16644 | 305 | 332 | 307 | 309 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR |
| Q16644 | 305 | 332 | 307 | 309 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR |
| Q16644 | 305 | 332 | 317 | 323 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR |
| Q16644 | 305 | 332 | 317 | 323 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR |
| Q16644 | 305 | 332 | 325 | 327 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR |
| Q16644 | 305 | 332 | 325 | 327 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR |
| Q16644 | 305 | 332 | 328 | 343 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR |
| Q16644 | 305 | 332 | 328 | 343 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3FHR |
| Q16644 | 305 | 332 | 307 | 307 | Modified residue | Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q16644 | 305 | 332 | 307 | 307 | Modified residue | Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q16644 | 305 | 332 | 313 | 313 | Modified residue | Note=Phosphothreonine%3B by MAPK14;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q16644 | 305 | 332 | 313 | 313 | Modified residue | Note=Phosphothreonine%3B by MAPK14;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q16644 | 305 | 332 | 307 | 343 | Region | Note=Autoinhibitory helix;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q16644 | 305 | 332 | 307 | 343 | Region | Note=Autoinhibitory helix;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
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SNVs in the skipped exons for MAPKAPK3 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| PRAD | TCGA-CH-5788-01 | exon_skip_374692 exon_skip_374690 | 50654945 | 50655215 | 50655021 | 50655042 | Frame_Shift_Del | CAGGGGGGCCCTGTGCCCCCGC | - | p.QGGPVPPP9fs |
| BLCA | TCGA-E7-A85H-01 | exon_skip_374692 exon_skip_374690 | 50654945 | 50655215 | 50655026 | 50655032 | Frame_Shift_Del | GGGCCCT | - | p.GGP10fs |
| COAD | TCGA-AD-6964-01 | exon_skip_374692 exon_skip_374690 | 50654945 | 50655215 | 50655080 | 50655080 | Frame_Shift_Del | G | - | p.P28fs |
| COAD | TCGA-CM-6162-01 | exon_skip_374692 exon_skip_374690 | 50654945 | 50655215 | 50655080 | 50655080 | Frame_Shift_Del | G | - | p.P28fs |
| UCEC | TCGA-D1-A176-01 | exon_skip_374692 exon_skip_374690 | 50654945 | 50655215 | 50655080 | 50655080 | Frame_Shift_Del | G | - | p.P28fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_374692 exon_skip_374690 | 50654945 | 50655215 | 50655152 | 50655152 | Frame_Shift_Del | G | - | p.L52fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_374696 | 50677797 | 50677936 | 50677859 | 50677859 | Frame_Shift_Del | C | - | p.G94fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_374696 | 50677797 | 50677936 | 50677919 | 50677919 | Frame_Shift_Del | C | - | p.L115fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_374706 | 50681840 | 50681963 | 50681896 | 50681896 | Frame_Shift_Del | T | - | p.D187fs |
| STAD | TCGA-BR-4201-01 | exon_skip_374712 | 50684171 | 50684256 | 50684208 | 50684209 | Frame_Shift_Del | CA | - | p.P289fs |
| LUSC | TCGA-60-2726-01 | exon_skip_374696 | 50677797 | 50677936 | 50677815 | 50677815 | Nonsense_Mutation | A | T | p.K80* |
| LIHC | TCGA-DD-A73D-01 | exon_skip_374696 | 50677797 | 50677936 | 50677796 | 50677796 | Splice_Site | G | A | . |
| COAD | TCGA-G4-6628-01 | exon_skip_374696 | 50677797 | 50677936 | 50677938 | 50677938 | Splice_Site | T | C | . |
| COAD | TCGA-AA-3663-01 | exon_skip_374703 | 50679138 | 50679202 | 50679204 | 50679204 | Splice_Site | T | C | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC151_ENDOMETRIUM | 50654945 | 50655215 | 50655080 | 50655080 | Frame_Shift_Del | G | - | p.P28fs |
| MHHPREB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50654945 | 50655215 | 50655080 | 50655080 | Frame_Shift_Del | G | - | p.P28fs |
| HEC59_ENDOMETRIUM | 50654945 | 50655215 | 50655080 | 50655080 | Frame_Shift_Del | G | - | p.P28fs |
| HT3_CERVIX | 50654945 | 50655215 | 50655081 | 50655081 | Missense_Mutation | G | A | p.G29R |
| OC316_OVARY | 50654945 | 50655215 | 50655087 | 50655087 | Missense_Mutation | C | G | p.R31G |
| CCK81_LARGE_INTESTINE | 50654945 | 50655215 | 50655144 | 50655144 | Missense_Mutation | C | A | p.L50M |
| MFE319_ENDOMETRIUM | 50654945 | 50655215 | 50655163 | 50655163 | Missense_Mutation | G | A | p.G56D |
| JHH5_LIVER | 50654945 | 50655215 | 50655202 | 50655202 | Missense_Mutation | A | T | p.K69M |
| OC316_OVARY | 50677797 | 50677936 | 50677817 | 50677817 | Missense_Mutation | G | T | p.K80N |
| OC314_OVARY | 50677797 | 50677936 | 50677817 | 50677817 | Missense_Mutation | G | T | p.K80N |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50677797 | 50677936 | 50677873 | 50677873 | Missense_Mutation | G | A | p.C99Y |
| NCIH322_LUNG | 50677797 | 50677936 | 50677912 | 50677912 | Missense_Mutation | G | T | p.R112L |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 50677797 | 50677936 | 50677926 | 50677926 | Missense_Mutation | A | G | p.I117V |
| MORCPR_LUNG | 50679138 | 50679202 | 50679146 | 50679146 | Missense_Mutation | G | T | p.G123V |
| PRECLH_PROSTATE | 50681840 | 50681963 | 50681852 | 50681852 | Missense_Mutation | C | T | p.L173F |
| 22RV1_PROSTATE | 50681840 | 50681963 | 50681894 | 50681894 | Missense_Mutation | G | A | p.D187N |
| SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50683571 | 50683695 | 50683603 | 50683603 | Missense_Mutation | C | T | p.T246M |
| JHU028_LUNG | 50683571 | 50683695 | 50683683 | 50683683 | Missense_Mutation | G | A | p.V273I |
| CP66EBV_MATCHED_NORMAL_TISSUE | 50683571 | 50683695 | 50683692 | 50683692 | Missense_Mutation | G | T | p.D276Y |
| CP66MEL_SKIN | 50683571 | 50683695 | 50683692 | 50683692 | Missense_Mutation | G | T | p.D276Y |
| LOVO_LARGE_INTESTINE | 50684554 | 50684634 | 50684594 | 50684594 | Missense_Mutation | G | A | p.R319Q |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50684554 | 50684634 | 50684594 | 50684594 | Missense_Mutation | G | A | p.R319Q |
| SKOV3_OVARY | 50679138 | 50679202 | 50679139 | 50679139 | Splice_Site | A | G | p.M121V |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAPKAPK3 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAPKAPK3 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAPKAPK3 |
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RelatedDrugs for MAPKAPK3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAPKAPK3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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