|
||||||
|
 | |
| |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
| |
|
Gene summary for TRIM26 |
 Gene summary |
| Gene information | Gene symbol | TRIM26 | Gene ID | 7726 |
| Gene name | tripartite motif containing 26 | |
| Synonyms | AFP|RNF95|ZNF173 | |
| Cytomap | 6p22.1 | |
| Type of gene | protein-coding | |
| Description | tripartite motif-containing protein 26RING finger protein 95acid finger proteinwidely expressed acid zinc finger proteinzinc finger protein 173 | |
| Modification date | 20180519 | |
| UniProtAcc | Q12899 | |
| Context | PubMed: TRIM26 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TRIM26 | GO:0045087 | innate immune response | 18248090 |
| TRIM26 | GO:0046597 | negative regulation of viral entry into host cell | 18248090 |
| TRIM26 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 23077300 |
| TRIM26 | GO:1902187 | negative regulation of viral release from host cell | 18248090 |
Top |
Exon skipping events across known transcript of Ensembl for TRIM26 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Gene isoform structures and expression levels for TRIM26 |
| Expression levels of gene isoforms across TCGA. |
 |
| Expression levels of gene isoforms across GTEx. |
 |
Top |
Exon skipping events with PSIs in TCGA for TRIM26 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_456985 | 6 | 30156943:30156976:30157194:30157310:30157789:30157812 | 30157194:30157310 | ENSG00000234127.4 | ENST00000453195.1,ENST00000454678.2,ENST00000437089.1 |
| exon_skip_456987 | 6 | 30157789:30157812:30164292:30164523:30166205:30166301 | 30164292:30164523 | ENSG00000234127.4 | ENST00000453195.1,ENST00000454678.2,ENST00000437089.1 |
| exon_skip_456992 | 6 | 30166540:30166767:30168811:30168915:30172432:30172542 | 30168811:30168915 | ENSG00000234127.4 | ENST00000487829.1 |
| exon_skip_457009 | 6 | 30166514:30166924:30172432:30172542:30181081:30181142 | 30172432:30172542 | ENSG00000234127.4 | ENST00000434785.1 |
| exon_skip_457014 | 6 | 30166442:30166930:30168811:30168860:30172432:30172535 | 30168811:30168860 | ENSG00000234127.4 | ENST00000437089.1 |
| exon_skip_457020 | 6 | 30166442:30166930:30168811:30168915:30172432:30172535 | 30168811:30168915 | ENSG00000234127.4 | ENST00000416596.1 |
| exon_skip_457022 | 6 | 30166442:30166930:30168811:30168915:30181081:30181142 | 30168811:30168915 | ENSG00000234127.4 | ENST00000453195.1 |
| exon_skip_457030 | 6 | 30166442:30167041:30168811:30168915:30172432:30172535 | 30168811:30168915 | ENSG00000234127.4 | ENST00000454678.2 |
| exon_skip_457045 | 6 | 30168811:30168915:30172432:30172542:30181081:30181142 | 30172432:30172542 | ENSG00000234127.4 | ENST00000416596.1,ENST00000487829.1,ENST00000454678.2 |
| PSI values of skipped exons in TCGA. |
 |
Top |
Exon skipping events with PSIs in GTEx for TRIM26 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_456985 | 6 | 30156943:30156976:30157194:30157310:30157789:30157812 | 30157194:30157310 | ENSG00000234127.4 | ENST00000437089.1,ENST00000454678.2,ENST00000453195.1 |
| exon_skip_456987 | 6 | 30157789:30157812:30164292:30164523:30166205:30166301 | 30164292:30164523 | ENSG00000234127.4 | ENST00000437089.1,ENST00000454678.2,ENST00000453195.1 |
| exon_skip_457009 | 6 | 30166514:30166924:30172432:30172542:30181081:30181142 | 30172432:30172542 | ENSG00000234127.4 | ENST00000434785.1 |
| exon_skip_457014 | 6 | 30166442:30166930:30168811:30168860:30172432:30172535 | 30168811:30168860 | ENSG00000234127.4 | ENST00000437089.1 |
| exon_skip_457020 | 6 | 30166442:30166930:30168811:30168915:30172432:30172535 | 30168811:30168915 | ENSG00000234127.4 | ENST00000416596.1 |
| exon_skip_457022 | 6 | 30166442:30166930:30168811:30168915:30181081:30181142 | 30168811:30168915 | ENSG00000234127.4 | ENST00000453195.1 |
| exon_skip_457030 | 6 | 30166442:30167041:30168811:30168915:30172432:30172535 | 30168811:30168915 | ENSG00000234127.4 | ENST00000454678.2 |
| exon_skip_457045 | 6 | 30168811:30168915:30172432:30172542:30181081:30181142 | 30172432:30172542 | ENSG00000234127.4 | ENST00000454678.2,ENST00000416596.1,ENST00000487829.1 |
| PSI values of skipped exons in GTEx. |
 |
| * Skipped exon sequences. |
Top |
Open reading frame (ORF) annotation in the exon skipping event for TRIM26 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000437089 | 30168811 | 30168860 | 3UTR-3UTR |
| ENST00000453195 | 30168811 | 30168915 | 3UTR-3UTR |
| ENST00000454678 | 30168811 | 30168915 | 3UTR-3UTR |
| ENST00000454678 | 30172432 | 30172542 | 3UTR-3UTR |
| ENST00000437089 | 30157194 | 30157310 | Frame-shift |
| ENST00000453195 | 30157194 | 30157310 | Frame-shift |
| ENST00000454678 | 30157194 | 30157310 | Frame-shift |
| ENST00000437089 | 30164292 | 30164523 | In-frame |
| ENST00000453195 | 30164292 | 30164523 | In-frame |
| ENST00000454678 | 30164292 | 30164523 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000437089 | 30168811 | 30168860 | 3UTR-3UTR |
| ENST00000453195 | 30168811 | 30168915 | 3UTR-3UTR |
| ENST00000454678 | 30168811 | 30168915 | 3UTR-3UTR |
| ENST00000454678 | 30172432 | 30172542 | 3UTR-3UTR |
| ENST00000437089 | 30157194 | 30157310 | Frame-shift |
| ENST00000453195 | 30157194 | 30157310 | Frame-shift |
| ENST00000454678 | 30157194 | 30157310 | Frame-shift |
| ENST00000437089 | 30164292 | 30164523 | In-frame |
| ENST00000453195 | 30164292 | 30164523 | In-frame |
| ENST00000454678 | 30164292 | 30164523 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for TRIM26 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
 |
| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000437089 | 3267 | 539 | 30164292 | 30164523 | 744 | 974 | 178 | 255 |
| ENST00000453195 | 3335 | 539 | 30164292 | 30164523 | 812 | 1042 | 178 | 255 |
| ENST00000454678 | 3495 | 539 | 30164292 | 30164523 | 972 | 1202 | 178 | 255 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000437089 | 3267 | 539 | 30164292 | 30164523 | 744 | 974 | 178 | 255 |
| ENST00000453195 | 3335 | 539 | 30164292 | 30164523 | 812 | 1042 | 178 | 255 |
| ENST00000454678 | 3495 | 539 | 30164292 | 30164523 | 972 | 1202 | 178 | 255 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q12899 | 178 | 255 | 1 | 539 | Chain | ID=PRO_0000056235;Note=Tripartite motif-containing protein 26 |
| Q12899 | 178 | 255 | 1 | 539 | Chain | ID=PRO_0000056235;Note=Tripartite motif-containing protein 26 |
| Q12899 | 178 | 255 | 1 | 539 | Chain | ID=PRO_0000056235;Note=Tripartite motif-containing protein 26 |
| Q12899 | 178 | 255 | 188 | 227 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q12899 | 178 | 255 | 188 | 227 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q12899 | 178 | 255 | 188 | 227 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q12899 | 178 | 255 | 197 | 197 | Natural variant | ID=VAR_052138;Note=Q->H;Dbxref=dbSNP:rs17194565 |
| Q12899 | 178 | 255 | 197 | 197 | Natural variant | ID=VAR_052138;Note=Q->H;Dbxref=dbSNP:rs17194565 |
| Q12899 | 178 | 255 | 197 | 197 | Natural variant | ID=VAR_052138;Note=Q->H;Dbxref=dbSNP:rs17194565 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q12899 | 178 | 255 | 1 | 539 | Chain | ID=PRO_0000056235;Note=Tripartite motif-containing protein 26 |
| Q12899 | 178 | 255 | 1 | 539 | Chain | ID=PRO_0000056235;Note=Tripartite motif-containing protein 26 |
| Q12899 | 178 | 255 | 1 | 539 | Chain | ID=PRO_0000056235;Note=Tripartite motif-containing protein 26 |
| Q12899 | 178 | 255 | 188 | 227 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q12899 | 178 | 255 | 188 | 227 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q12899 | 178 | 255 | 188 | 227 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q12899 | 178 | 255 | 197 | 197 | Natural variant | ID=VAR_052138;Note=Q->H;Dbxref=dbSNP:rs17194565 |
| Q12899 | 178 | 255 | 197 | 197 | Natural variant | ID=VAR_052138;Note=Q->H;Dbxref=dbSNP:rs17194565 |
| Q12899 | 178 | 255 | 197 | 197 | Natural variant | ID=VAR_052138;Note=Q->H;Dbxref=dbSNP:rs17194565 |
Top |
SNVs in the skipped exons for TRIM26 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
 |
| - Differential PSIs between mutated versus non-mutated samples. |
TRIM26_ESCA_exon_skip_456985_psi_boxplot.png |
TRIM26_LIHC_exon_skip_456987_psi_boxplot.png |
TRIM26_THCA_exon_skip_456985_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| ESCA | TCGA-2H-A9GK-01 | exon_skip_456985 | 30157195 | 30157310 | 30157254 | 30157254 | Frame_Shift_Del | T | - | p.K282fs |
| THCA | TCGA-FY-A3I4-01 | exon_skip_456985 | 30157195 | 30157310 | 30157254 | 30157254 | Frame_Shift_Del | T | - | p.K282fs |
| UCEC | TCGA-A5-A0GW-01 | exon_skip_456985 | 30157195 | 30157310 | 30157254 | 30157254 | Frame_Shift_Del | T | - | p.K282fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_456987 | 30164293 | 30164523 | 30164367 | 30164367 | Frame_Shift_Del | C | - | p.E231fs |
| LIHC | TCGA-BC-A3KG-01 | exon_skip_456987 | 30164293 | 30164523 | 30164446 | 30164446 | Frame_Shift_Del | T | - | p.E204fs |
| UCEC | TCGA-AP-A0LD-01 | exon_skip_456985 | 30157195 | 30157310 | 30157253 | 30157254 | Frame_Shift_Ins | - | T | p.K282fs |
| UCEC | TCGA-AP-A051-01 | exon_skip_456985 | 30157195 | 30157310 | 30157216 | 30157216 | Nonsense_Mutation | G | A | p.R295* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-BC-A3KG-01 |
| Cancer type: LIHC | |
| ESID: exon_skip_456987 | |
| Skipped exon start: 30164293 | |
| Skipped exon end: 30164523 | |
| Mutation start: 30164446 | |
| Mutation end: 30164446 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: T | |
| Mutation seq: - | |
| AAchange: p.E204fs | |
exon_skip_107008_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_107009_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_107010_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_10760_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_11532_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_123519_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_17069_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_300924_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_346623_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_374970_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_387350_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_423555_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_441299_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_441300_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_444819_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_450818_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_456987_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_459274_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_494352_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_64409_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_64412_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_69788_LIHC_TCGA-BC-A3KG-01.png | |
exon_skip_98384_LIHC_TCGA-BC-A3KG-01.png | |
 | Sample: TCGA-FY-A3I4-01 |
| Cancer type: THCA | |
| ESID: exon_skip_456985 | |
| Skipped exon start: 30157195 | |
| Skipped exon end: 30157310 | |
| Mutation start: 30157254 | |
| Mutation end: 30157254 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: T | |
| Mutation seq: - | |
| AAchange: p.K282fs | |
exon_skip_456985_THCA_TCGA-FY-A3I4-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC151_ENDOMETRIUM | 30157195 | 30157310 | 30157254 | 30157254 | Frame_Shift_Del | T | - | p.K282fs |
| IGROV1_OVARY | 30157195 | 30157310 | 30157254 | 30157254 | Frame_Shift_Del | T | - | p.K282fs |
| MHHPREB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 30157195 | 30157310 | 30157254 | 30157254 | Frame_Shift_Del | T | - | p.K282fs |
| EN_ENDOMETRIUM | 30157195 | 30157310 | 30157253 | 30157254 | Frame_Shift_Ins | - | T | p.K282fs |
| CAL72_BONE | 30164293 | 30164523 | 30164426 | 30164426 | Missense_Mutation | G | A | p.A211V |
| K5_THYROID | 30164293 | 30164523 | 30164426 | 30164426 | Missense_Mutation | G | A | p.A211V |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRIM26 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
Top |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRIM26 |
 |
Top |
Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRIM26 |
Top |
RelatedDrugs for TRIM26 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TRIM26 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|