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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ZNF90 |
 Gene summary |
| Gene information | Gene symbol | ZNF90 | Gene ID | 7643 |
| Gene name | zinc finger protein 90 | |
| Synonyms | HTF9 | |
| Cytomap | 19p12 | |
| Type of gene | protein-coding | |
| Description | zinc finger protein 90zinc finger protein HTF9 | |
| Modification date | 20180403 | |
| UniProtAcc | Q03938 | |
| Context | PubMed: ZNF90 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ZNF90 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ZNF90 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ZNF90 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_304356 | 19 | 20188845:20188944:20215047:20215174:20216029:20216125 | 20215047:20215174 | ENSG00000213988.5 | ENST00000418063.2,ENST00000473524.1 |
| exon_skip_304358 | 19 | 20188845:20188944:20216029:20216125:20235814:20235952 | 20216029:20216125 | ENSG00000213988.5 | ENST00000474284.1 |
| exon_skip_304359 | 19 | 20215047:20215174:20216029:20216125:20228589:20228853 | 20216029:20216125 | ENSG00000213988.5 | ENST00000418063.2 |
| exon_skip_304363 | 19 | 20216029:20216125:20217756:20217894:20228589:20228709 | 20217756:20217894 | ENSG00000213988.5 | ENST00000473524.1 |
| exon_skip_304367 | 19 | 20216029:20216125:20232030:20232155:20235814:20235951 | 20232030:20232155 | ENSG00000213988.5 | ENST00000469078.1 |
| exon_skip_304368 | 19 | 20216029:20216125:20235814:20236975:20237560:20237827 | 20235814:20236975 | ENSG00000213988.5 | ENST00000474284.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ZNF90 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_304356 | 19 | 20188845:20188944:20215047:20215174:20216029:20216125 | 20215047:20215174 | ENSG00000213988.5 | ENST00000473524.1,ENST00000418063.2 |
| exon_skip_304358 | 19 | 20188845:20188944:20216029:20216125:20235814:20235952 | 20216029:20216125 | ENSG00000213988.5 | ENST00000474284.1 |
| exon_skip_304359 | 19 | 20215047:20215174:20216029:20216125:20228589:20228853 | 20216029:20216125 | ENSG00000213988.5 | ENST00000418063.2 |
| exon_skip_304363 | 19 | 20216029:20216125:20217756:20217894:20228589:20228709 | 20217756:20217894 | ENSG00000213988.5 | ENST00000473524.1 |
| exon_skip_304367 | 19 | 20216029:20216125:20232030:20232155:20235814:20235951 | 20232030:20232155 | ENSG00000213988.5 | ENST00000469078.1 |
| exon_skip_304368 | 19 | 20216029:20216125:20235814:20236975:20237560:20237827 | 20235814:20236975 | ENSG00000213988.5 | ENST00000474284.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF90 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000418063 | 20215047 | 20215174 | Frame-shift |
| ENST00000418063 | 20216029 | 20216125 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000418063 | 20215047 | 20215174 | Frame-shift |
| ENST00000418063 | 20216029 | 20216125 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZNF90 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000418063 | 2327 | 601 | 20216029 | 20216125 | 243 | 338 | 43 | 75 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000418063 | 2327 | 601 | 20216029 | 20216125 | 243 | 338 | 43 | 75 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q03938 | 43 | 75 | 1 | 601 | Chain | ID=PRO_0000047399;Note=Zinc finger protein 90 |
| Q03938 | 43 | 75 | 4 | 75 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q03938 | 43 | 75 | 1 | 601 | Chain | ID=PRO_0000047399;Note=Zinc finger protein 90 |
| Q03938 | 43 | 75 | 4 | 75 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
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SNVs in the skipped exons for ZNF90 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| UCEC | TCGA-BG-A0M9-01 | exon_skip_304358 exon_skip_304359 | 20216030 | 20216125 | 20216075 | 20216076 | Frame_Shift_Ins | - | A | p.G59fs |
| BLCA | TCGA-MV-A51V-01 | exon_skip_304356 | 20215048 | 20215174 | 20215090 | 20215090 | Nonsense_Mutation | G | T | p.E16* |
| PAAD | TCGA-IB-7651-01 | exon_skip_304356 | 20215048 | 20215174 | 20215098 | 20215098 | Nonsense_Mutation | G | A | p.W18* |
| PAAD | TCGA-IB-7651-01 | exon_skip_304356 | 20215048 | 20215174 | 20215098 | 20215098 | Nonsense_Mutation | G | A | p.W18X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| COLO684_ENDOMETRIUM | 20216030 | 20216125 | 20216076 | 20216076 | Frame_Shift_Del | A | - | p.G59fs |
| SUDHL10_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 20216030 | 20216125 | 20216075 | 20216076 | Frame_Shift_Ins | - | A | p.GK59fs |
| A375_SKIN | 20215048 | 20215174 | 20215051 | 20215051 | Missense_Mutation | C | T | p.P3S |
| HCC2998_LARGE_INTESTINE | 20215048 | 20215174 | 20215123 | 20215123 | Missense_Mutation | A | C | p.N27H |
| UACC257_SKIN | 20215048 | 20215174 | 20215135 | 20215135 | Missense_Mutation | G | A | p.D31N |
| EW3_BONE | 20215048 | 20215174 | 20215151 | 20215151 | Missense_Mutation | A | T | p.N36I |
| HEC251_ENDOMETRIUM | 20215048 | 20215174 | 20215078 | 20215078 | Nonsense_Mutation | G | T | p.E12* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF90 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF90 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF90 |
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RelatedDrugs for ZNF90 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF90 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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