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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for YES1 |
 Gene summary |
| Gene information | Gene symbol | YES1 | Gene ID | 7525 |
| Gene name | YES proto-oncogene 1, Src family tyrosine kinase | |
| Synonyms | HsT441|P61-YES|Yes|c-yes | |
| Cytomap | 18p11.32 | |
| Type of gene | protein-coding | |
| Description | tyrosine-protein kinase YesYES1 proto-oncogene, Src family tyrosine kinaseYamaguchi sarcoma oncogenecellular yes-1 proteinproto-oncogene c-Yesproto-oncogene tyrosine-protein kinase YESv-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 | |
| Modification date | 20180523 | |
| UniProtAcc | P07947 | |
| Context | PubMed: YES1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for YES1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for YES1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for YES1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_297775 | 18 | 721747:724632:732833:732965:736807:736961 | 732833:732965 | ENSG00000176105.9 | ENST00000314574.4,ENST00000577961.1,ENST00000584307.1 |
| exon_skip_297776 | 18 | 736807:736961:739734:739811:742917:743097 | 739734:739811 | ENSG00000176105.9 | ENST00000314574.4,ENST00000577961.1,ENST00000584307.1 |
| exon_skip_297778 | 18 | 745947:746051:747919:748018:751704:751804 | 747919:748018 | ENSG00000176105.9 | ENST00000314574.4,ENST00000577961.1,ENST00000584307.1 |
| exon_skip_297781 | 18 | 747919:748018:751704:751804:756556:756835 | 751704:751804 | ENSG00000176105.9 | ENST00000314574.4,ENST00000577961.1,ENST00000584307.1 |
| exon_skip_297784 | 18 | 751723:751804:756556:756835:812114:812239 | 756556:756835 | ENSG00000176105.9 | ENST00000314574.4 |
| exon_skip_297787 | 18 | 756676:756835:775058:775113:812114:812239 | 775058:775113 | ENSG00000176105.9 | ENST00000577611.1 |
| exon_skip_297788 | 18 | 756676:756835:787903:787987:812114:812358 | 787903:787987 | ENSG00000176105.9 | ENST00000581960.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for YES1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_297775 | 18 | 721747:724632:732833:732965:736807:736961 | 732833:732965 | ENSG00000176105.9 | ENST00000577961.1,ENST00000584307.1,ENST00000314574.4 |
| exon_skip_297776 | 18 | 736807:736961:739734:739811:742917:743097 | 739734:739811 | ENSG00000176105.9 | ENST00000577961.1,ENST00000584307.1,ENST00000314574.4 |
| exon_skip_297778 | 18 | 745947:746051:747919:748018:751704:751804 | 747919:748018 | ENSG00000176105.9 | ENST00000577961.1,ENST00000584307.1,ENST00000314574.4 |
| exon_skip_297781 | 18 | 747919:748018:751704:751804:756556:756835 | 751704:751804 | ENSG00000176105.9 | ENST00000577961.1,ENST00000584307.1,ENST00000314574.4 |
| exon_skip_297784 | 18 | 751723:751804:756556:756835:812114:812239 | 756556:756835 | ENSG00000176105.9 | ENST00000314574.4 |
| exon_skip_297787 | 18 | 756676:756835:775058:775113:812114:812239 | 775058:775113 | ENSG00000176105.9 | ENST00000577611.1 |
| exon_skip_297788 | 18 | 756676:756835:787903:787987:812114:812358 | 787903:787987 | ENSG00000176105.9 | ENST00000581960.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for YES1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000314574 | 756556 | 756835 | 3UTR-3CDS |
| ENST00000314574 | 739734 | 739811 | Frame-shift |
| ENST00000584307 | 739734 | 739811 | Frame-shift |
| ENST00000314574 | 751704 | 751804 | Frame-shift |
| ENST00000584307 | 751704 | 751804 | Frame-shift |
| ENST00000314574 | 732833 | 732965 | In-frame |
| ENST00000584307 | 732833 | 732965 | In-frame |
| ENST00000314574 | 747919 | 748018 | In-frame |
| ENST00000584307 | 747919 | 748018 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000314574 | 756556 | 756835 | 3UTR-3CDS |
| ENST00000314574 | 739734 | 739811 | Frame-shift |
| ENST00000584307 | 739734 | 739811 | Frame-shift |
| ENST00000314574 | 751704 | 751804 | Frame-shift |
| ENST00000584307 | 751704 | 751804 | Frame-shift |
| ENST00000314574 | 732833 | 732965 | In-frame |
| ENST00000584307 | 732833 | 732965 | In-frame |
| ENST00000314574 | 747919 | 748018 | In-frame |
| ENST00000584307 | 747919 | 748018 | In-frame |
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Infer the effects of exon skipping event on protein functional features for YES1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000314574 | 4458 | 543 | 747919 | 748018 | 505 | 603 | 124 | 156 |
| ENST00000584307 | 4656 | 543 | 747919 | 748018 | 543 | 641 | 124 | 156 |
| ENST00000314574 | 4458 | 543 | 732833 | 732965 | 1425 | 1556 | 430 | 474 |
| ENST00000584307 | 4656 | 543 | 732833 | 732965 | 1463 | 1594 | 430 | 474 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000314574 | 4458 | 543 | 747919 | 748018 | 505 | 603 | 124 | 156 |
| ENST00000584307 | 4656 | 543 | 747919 | 748018 | 543 | 641 | 124 | 156 |
| ENST00000314574 | 4458 | 543 | 732833 | 732965 | 1425 | 1556 | 430 | 474 |
| ENST00000584307 | 4656 | 543 | 732833 | 732965 | 1463 | 1594 | 430 | 474 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P07947 | 124 | 156 | 126 | 133 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA |
| P07947 | 124 | 156 | 126 | 133 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA |
| P07947 | 124 | 156 | 139 | 143 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA |
| P07947 | 124 | 156 | 139 | 143 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA |
| P07947 | 124 | 156 | 147 | 149 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA |
| P07947 | 124 | 156 | 147 | 149 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA |
| P07947 | 124 | 156 | 2 | 543 | Chain | ID=PRO_0000088181;Note=Tyrosine-protein kinase Yes |
| P07947 | 124 | 156 | 2 | 543 | Chain | ID=PRO_0000088181;Note=Tyrosine-protein kinase Yes |
| P07947 | 124 | 156 | 91 | 152 | Domain | Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192 |
| P07947 | 124 | 156 | 91 | 152 | Domain | Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192 |
| P07947 | 124 | 156 | 144 | 146 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA |
| P07947 | 124 | 156 | 144 | 146 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA |
| P07947 | 124 | 156 | 134 | 136 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA |
| P07947 | 124 | 156 | 134 | 136 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA |
| P07947 | 430 | 474 | 2 | 543 | Chain | ID=PRO_0000088181;Note=Tyrosine-protein kinase Yes |
| P07947 | 430 | 474 | 2 | 543 | Chain | ID=PRO_0000088181;Note=Tyrosine-protein kinase Yes |
| P07947 | 430 | 474 | 277 | 530 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P07947 | 430 | 474 | 277 | 530 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P07947 | 430 | 474 | 446 | 446 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P07947 | 430 | 474 | 446 | 446 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P07947 | 124 | 156 | 126 | 133 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA |
| P07947 | 124 | 156 | 126 | 133 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA |
| P07947 | 124 | 156 | 139 | 143 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA |
| P07947 | 124 | 156 | 139 | 143 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA |
| P07947 | 124 | 156 | 147 | 149 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA |
| P07947 | 124 | 156 | 147 | 149 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA |
| P07947 | 124 | 156 | 2 | 543 | Chain | ID=PRO_0000088181;Note=Tyrosine-protein kinase Yes |
| P07947 | 124 | 156 | 2 | 543 | Chain | ID=PRO_0000088181;Note=Tyrosine-protein kinase Yes |
| P07947 | 124 | 156 | 91 | 152 | Domain | Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192 |
| P07947 | 124 | 156 | 91 | 152 | Domain | Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192 |
| P07947 | 124 | 156 | 144 | 146 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA |
| P07947 | 124 | 156 | 144 | 146 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA |
| P07947 | 124 | 156 | 134 | 136 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA |
| P07947 | 124 | 156 | 134 | 136 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HDA |
| P07947 | 430 | 474 | 2 | 543 | Chain | ID=PRO_0000088181;Note=Tyrosine-protein kinase Yes |
| P07947 | 430 | 474 | 2 | 543 | Chain | ID=PRO_0000088181;Note=Tyrosine-protein kinase Yes |
| P07947 | 430 | 474 | 277 | 530 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P07947 | 430 | 474 | 277 | 530 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P07947 | 430 | 474 | 446 | 446 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P07947 | 430 | 474 | 446 | 446 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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SNVs in the skipped exons for YES1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| UCEC | TCGA-BG-A0VW-01 | exon_skip_297775 | 732834 | 732965 | 732851 | 732851 | Frame_Shift_Del | C | - | p.G469fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| EN_ENDOMETRIUM | 732834 | 732965 | 732891 | 732891 | Missense_Mutation | A | G | p.W456R |
| UT7_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 739735 | 739811 | 739749 | 739749 | Missense_Mutation | C | T | p.D375N |
| REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 747920 | 748018 | 747941 | 747941 | Missense_Mutation | G | A | p.A150V |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 747920 | 748018 | 747947 | 747947 | Missense_Mutation | G | A | p.A148V |
| SNU324_PANCREAS | 751705 | 751804 | 751793 | 751793 | Missense_Mutation | T | C | p.I95V |
| YT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 751705 | 751804 | 751796 | 751796 | Missense_Mutation | T | C | p.T94A |
| VAESBJ_SOFT_TISSUE | 756557 | 756835 | 756650 | 756650 | Missense_Mutation | T | C | p.T60A |
| HS445_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 756557 | 756835 | 756656 | 756656 | Missense_Mutation | A | G | p.S58P |
| HEC108_ENDOMETRIUM | 756557 | 756835 | 756751 | 756751 | Missense_Mutation | C | T | p.S26N |
| SW1088_CENTRAL_NERVOUS_SYSTEM | 756557 | 756835 | 756764 | 756764 | Missense_Mutation | G | T | p.P22T |
| SCLC22H_LUNG | 756557 | 756835 | 756820 | 756820 | Missense_Mutation | C | G | p.C3S |
| SCLC21H_LUNG | 756557 | 756835 | 756820 | 756820 | Missense_Mutation | C | G | p.C3S |
| HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 751705 | 751804 | 751803 | 751803 | Splice_Site | A | G | p.G91G |
| SKHEP1_LIVER | 756557 | 756835 | 756557 | 756557 | Splice_Site | C | G | p.G91R |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for YES1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for YES1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for YES1 |
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RelatedDrugs for YES1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P07947 | DB01254 | Dasatinib | Tyrosine-protein kinase Yes | small molecule | approved|investigational | |
| P07947 | DB12010 | Fostamatinib | Tyrosine-protein kinase Yes | small molecule | approved|investigational |
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RelatedDiseases for YES1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| YES1 | C0013069 | Double Outlet Right Ventricle | 1 | CTD_human |
| YES1 | C0018818 | Ventricular Septal Defects | 1 | CTD_human |
| YES1 | C0158570 | Vascular anomaly | 1 | CTD_human |
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