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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for WEE1 |
 Gene summary |
| Gene information | Gene symbol | WEE1 | Gene ID | 7465 |
| Gene name | WEE1 G2 checkpoint kinase | |
| Synonyms | WEE1A|WEE1hu | |
| Cytomap | 11p15.4 | |
| Type of gene | protein-coding | |
| Description | wee1-like protein kinaseWEE1 homologWEE1+ homologwee1A kinase | |
| Modification date | 20180523 | |
| UniProtAcc | P30291 | |
| Context | PubMed: WEE1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for WEE1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for WEE1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for WEE1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_56884 | 11 | 9598688:9598810:9603078:9603225:9606804:9606900 | 9603078:9603225 | ENSG00000166483.6 | ENST00000299613.6,ENST00000450114.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for WEE1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_56884 | 11 | 9598688:9598810:9603078:9603225:9606804:9606900 | 9603078:9603225 | ENSG00000166483.6 | ENST00000450114.2,ENST00000299613.6 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for WEE1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000450114 | 9603078 | 9603225 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000450114 | 9603078 | 9603225 | In-frame |
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Infer the effects of exon skipping event on protein functional features for WEE1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000450114 | 2816 | 646 | 9603078 | 9603225 | 1395 | 1541 | 380 | 429 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000450114 | 2816 | 646 | 9603078 | 9603225 | 1395 | 1541 | 380 | 429 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P30291 | 380 | 429 | 426 | 426 | Active site | Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027 |
| P30291 | 380 | 429 | 1 | 646 | Chain | ID=PRO_0000086810;Note=Wee1-like protein kinase |
| P30291 | 380 | 429 | 299 | 569 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P30291 | 380 | 429 | 384 | 394 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X8B |
| P30291 | 380 | 429 | 400 | 419 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X8B |
| P30291 | 380 | 429 | 429 | 431 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X8B |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P30291 | 380 | 429 | 426 | 426 | Active site | Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027 |
| P30291 | 380 | 429 | 1 | 646 | Chain | ID=PRO_0000086810;Note=Wee1-like protein kinase |
| P30291 | 380 | 429 | 299 | 569 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P30291 | 380 | 429 | 384 | 394 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X8B |
| P30291 | 380 | 429 | 400 | 419 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X8B |
| P30291 | 380 | 429 | 429 | 431 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1X8B |
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SNVs in the skipped exons for WEE1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| STAD | TCGA-BR-8360-01 | exon_skip_56884 | 9603079 | 9603225 | 9603177 | 9603177 | Frame_Shift_Del | T | - | p.G413fs |
| ESCA | TCGA-L5-A8NK-01 | exon_skip_56884 | 9603079 | 9603225 | 9603162 | 9603162 | Nonsense_Mutation | C | T | p.Q409* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for WEE1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for WEE1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for WEE1 |
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RelatedDrugs for WEE1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P30291 | DB12010 | Fostamatinib | Wee1-like protein kinase | small molecule | approved|investigational |
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RelatedDiseases for WEE1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| WEE1 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
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