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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ZAN |
 Gene summary |
| Gene information | Gene symbol | ZAN | Gene ID | 7455 |
| Gene name | zonadhesin (gene/pseudogene) | |
| Synonyms | - | |
| Cytomap | 7q22.1 | |
| Type of gene | protein-coding | |
| Description | zonadhesin | |
| Modification date | 20180329 | |
| UniProtAcc | Q9Y493 | |
| Context | PubMed: ZAN [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ZAN from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ZAN |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ZAN |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_469278 | 7 | 100334431:100334703:100334884:100334972:100336083:100336236 | 100334884:100334972 | ENSG00000146839.14 | ENST00000546292.1,ENST00000443370.1,ENST00000349350.6,ENST00000421100.1,ENST00000538115.1,ENST00000348028.3,ENST00000449052.1,ENST00000427578.1,ENST00000546213.1,ENST00000542585.1 |
| exon_skip_469279 | 7 | 100336083:100336236:100344160:100344325:100345172:100345264 | 100344160:100344325 | ENSG00000146839.14 | ENST00000546292.1,ENST00000443370.1,ENST00000349350.6,ENST00000421100.1,ENST00000538115.1,ENST00000348028.3,ENST00000449052.1,ENST00000427578.1,ENST00000546213.1,ENST00000542585.1 |
| exon_skip_469280 | 7 | 100367502:100367597:100369466:100369643:100370907:100370978 | 100369466:100369643 | ENSG00000146839.14 | ENST00000546292.1,ENST00000443370.1,ENST00000349350.6,ENST00000421100.1,ENST00000538115.1,ENST00000348028.3,ENST00000449052.1,ENST00000427578.1,ENST00000546213.1,ENST00000542585.1 |
| exon_skip_469281 | 7 | 100386839:100386969:100388563:100388735:100389587:100389770 | 100388563:100388735 | ENSG00000146839.14 | ENST00000546292.1,ENST00000443370.1,ENST00000349350.6,ENST00000421100.1,ENST00000538115.1,ENST00000348028.3,ENST00000449052.1,ENST00000427578.1,ENST00000542585.1 |
| exon_skip_469282 | 7 | 100388563:100388735:100389587:100389770:100390026:100390101 | 100389587:100389770 | ENSG00000146839.14 | ENST00000546292.1,ENST00000443370.1,ENST00000349350.6,ENST00000421100.1,ENST00000538115.1,ENST00000348028.3,ENST00000449052.1,ENST00000427578.1,ENST00000542585.1 |
| exon_skip_469285 | 7 | 100390026:100390166:100391441:100391640:100391741:100391880 | 100391441:100391640 | ENSG00000146839.14 | ENST00000449052.1,ENST00000542585.1 |
| exon_skip_469286 | 7 | 100390026:100390166:100391441:100391880:100392817:100392958 | 100391441:100391880 | ENSG00000146839.14 | ENST00000427578.1 |
| exon_skip_469287 | 7 | 100390026:100390166:100391741:100391880:100392817:100392958 | 100391741:100391880 | ENSG00000146839.14 | ENST00000443370.1,ENST00000538115.1,ENST00000546213.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ZAN |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_469278 | 7 | 100334431:100334703:100334884:100334972:100336083:100336236 | 100334884:100334972 | ENSG00000146839.14 | ENST00000349350.6,ENST00000427578.1,ENST00000443370.1,ENST00000421100.1,ENST00000449052.1,ENST00000348028.3,ENST00000546292.1,ENST00000538115.1,ENST00000542585.1,ENST00000546213.1 |
| exon_skip_469279 | 7 | 100336083:100336236:100344160:100344325:100345172:100345264 | 100344160:100344325 | ENSG00000146839.14 | ENST00000349350.6,ENST00000427578.1,ENST00000443370.1,ENST00000421100.1,ENST00000449052.1,ENST00000348028.3,ENST00000546292.1,ENST00000538115.1,ENST00000542585.1,ENST00000546213.1 |
| exon_skip_469280 | 7 | 100367502:100367597:100369466:100369643:100370907:100370978 | 100369466:100369643 | ENSG00000146839.14 | ENST00000349350.6,ENST00000427578.1,ENST00000443370.1,ENST00000421100.1,ENST00000449052.1,ENST00000348028.3,ENST00000546292.1,ENST00000538115.1,ENST00000542585.1,ENST00000546213.1 |
| exon_skip_469282 | 7 | 100388563:100388735:100389587:100389770:100390026:100390101 | 100389587:100389770 | ENSG00000146839.14 | ENST00000349350.6,ENST00000427578.1,ENST00000443370.1,ENST00000421100.1,ENST00000449052.1,ENST00000348028.3,ENST00000546292.1,ENST00000538115.1,ENST00000542585.1 |
| exon_skip_469285 | 7 | 100390026:100390166:100391441:100391640:100391741:100391880 | 100391441:100391640 | ENSG00000146839.14 | ENST00000449052.1,ENST00000542585.1 |
| exon_skip_469286 | 7 | 100390026:100390166:100391441:100391880:100392817:100392958 | 100391441:100391880 | ENSG00000146839.14 | ENST00000427578.1 |
| exon_skip_469287 | 7 | 100390026:100390166:100391741:100391880:100392817:100392958 | 100391741:100391880 | ENSG00000146839.14 | ENST00000443370.1,ENST00000538115.1,ENST00000546213.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ZAN |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for ZAN |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for ZAN |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LUAD | TCGA-78-7536-01 | exon_skip_469286 | 100391442 | 100391880 | 100391834 | 100391834 | Frame_Shift_Del | G | - | p.A2693fs |
| LUAD | TCGA-78-7536-01 | exon_skip_469287 | 100391742 | 100391880 | 100391834 | 100391834 | Frame_Shift_Del | G | - | p.A2693fs |
| LUAD | TCGA-49-6744-01 | exon_skip_469281 | 100388564 | 100388735 | 100388611 | 100388611 | Nonsense_Mutation | G | T | p.G2469* |
| CESC | TCGA-DG-A2KM-01 | exon_skip_469282 | 100389588 | 100389770 | 100389622 | 100389622 | Nonsense_Mutation | G | T | p.E2521* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZAN |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZAN |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZAN |
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RelatedDrugs for ZAN |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZAN |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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