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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for VRK2 |
 Gene summary |
| Gene information | Gene symbol | VRK2 | Gene ID | 7444 |
| Gene name | vaccinia related kinase 2 | |
| Synonyms | - | |
| Cytomap | 2p16.1 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase VRK2vaccinia virus B1R-related kinase 2 | |
| Modification date | 20180527 | |
| UniProtAcc | Q86Y07 | |
| Context | PubMed: VRK2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| VRK2 | GO:0046777 | protein autophosphorylation | 14645249|16704422 |
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Exon skipping events across known transcript of Ensembl for VRK2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for VRK2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for VRK2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_325733 | 2 | 58134790:58134974:58245150:58245221:58252799:58252905 | 58245150:58245221 | ENSG00000028116.12 | ENST00000478687.1 |
| exon_skip_325737 | 2 | 58253878:58253996:58255432:58255533:58260361:58260688 | 58255432:58255533 | ENSG00000028116.12 | ENST00000478687.1 |
| exon_skip_325742 | 2 | 58274009:58274263:58275661:58275722:58275961:58276102 | 58275661:58275722 | ENSG00000028116.12 | ENST00000428021.1 |
| exon_skip_325745 | 2 | 58276015:58276102:58285486:58285623:58311223:58311273 | 58285486:58285623 | ENSG00000028116.12 | ENST00000432057.1 |
| exon_skip_325755 | 2 | 58311223:58311273:58312015:58312085:58313473:58313561 | 58312015:58312085 | ENSG00000028116.12 | ENST00000432057.1,ENST00000435505.2,ENST00000440705.2,ENST00000412104.2,ENST00000417641.2,ENST00000340157.4 |
| exon_skip_325764 | 2 | 58312015:58312085:58313473:58313561:58315475:58315581 | 58313473:58313561 | ENSG00000028116.12 | ENST00000432057.1,ENST00000435505.2,ENST00000440705.2,ENST00000412104.2,ENST00000417641.2,ENST00000340157.4 |
| exon_skip_325765 | 2 | 58316765:58316858:58350235:58350368:58358942:58359063 | 58350235:58350368 | ENSG00000028116.12 | ENST00000432057.1,ENST00000435505.2,ENST00000440705.2,ENST00000412104.2,ENST00000417641.2,ENST00000340157.4 |
| exon_skip_325768 | 2 | 58358942:58359063:58362275:58362334:58366800:58366967 | 58362275:58362334 | ENSG00000028116.12 | ENST00000432057.1,ENST00000435505.2,ENST00000440705.2,ENST00000412104.2,ENST00000417641.2,ENST00000340157.4 |
| exon_skip_325772 | 2 | 58373450:58373609:58381888:58381937:58386483:58386919 | 58381888:58381937 | ENSG00000028116.12 | ENST00000412104.2,ENST00000417641.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for VRK2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_325733 | 2 | 58134790:58134974:58245150:58245221:58252799:58252905 | 58245150:58245221 | ENSG00000028116.12 | ENST00000478687.1 |
| exon_skip_325734 | 2 | 58252799:58252905:58253878:58253996:58255432:58255533 | 58253878:58253996 | ENSG00000028116.12 | ENST00000478687.1 |
| exon_skip_325735 | 2 | 58252799:58252905:58253878:58253996:58260361:58260688 | 58253878:58253996 | ENSG00000028116.12 | ENST00000435505.2 |
| exon_skip_325736 | 2 | 58252799:58252905:58255432:58255533:58260361:58260688 | 58255432:58255533 | ENSG00000028116.12 | ENST00000463222.1 |
| exon_skip_325737 | 2 | 58253878:58253996:58255432:58255533:58260361:58260688 | 58255432:58255533 | ENSG00000028116.12 | ENST00000478687.1 |
| exon_skip_325742 | 2 | 58274009:58274263:58275661:58275722:58275961:58276102 | 58275661:58275722 | ENSG00000028116.12 | ENST00000428021.1 |
| exon_skip_325745 | 2 | 58276015:58276102:58285486:58285623:58311223:58311273 | 58285486:58285623 | ENSG00000028116.12 | ENST00000432057.1 |
| exon_skip_325755 | 2 | 58311223:58311273:58312015:58312085:58313473:58313561 | 58312015:58312085 | ENSG00000028116.12 | ENST00000435505.2,ENST00000417641.2,ENST00000412104.2,ENST00000340157.4,ENST00000432057.1,ENST00000440705.2 |
| exon_skip_325764 | 2 | 58312015:58312085:58313473:58313561:58315475:58315581 | 58313473:58313561 | ENSG00000028116.12 | ENST00000435505.2,ENST00000417641.2,ENST00000412104.2,ENST00000340157.4,ENST00000432057.1,ENST00000440705.2 |
| exon_skip_325765 | 2 | 58316765:58316858:58350235:58350368:58358942:58359063 | 58350235:58350368 | ENSG00000028116.12 | ENST00000435505.2,ENST00000417641.2,ENST00000412104.2,ENST00000340157.4,ENST00000432057.1,ENST00000440705.2 |
| exon_skip_325768 | 2 | 58358942:58359063:58362275:58362334:58366800:58366967 | 58362275:58362334 | ENSG00000028116.12 | ENST00000435505.2,ENST00000417641.2,ENST00000412104.2,ENST00000340157.4,ENST00000432057.1,ENST00000440705.2 |
| exon_skip_325772 | 2 | 58373450:58373609:58381888:58381937:58386483:58386919 | 58381888:58381937 | ENSG00000028116.12 | ENST00000417641.2,ENST00000412104.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for VRK2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000340157 | 58312015 | 58312085 | Frame-shift |
| ENST00000435505 | 58312015 | 58312085 | Frame-shift |
| ENST00000340157 | 58313473 | 58313561 | Frame-shift |
| ENST00000435505 | 58313473 | 58313561 | Frame-shift |
| ENST00000340157 | 58350235 | 58350368 | Frame-shift |
| ENST00000435505 | 58350235 | 58350368 | Frame-shift |
| ENST00000340157 | 58362275 | 58362334 | Frame-shift |
| ENST00000435505 | 58362275 | 58362334 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000435505 | 58253878 | 58253996 | 5UTR-5UTR |
| ENST00000340157 | 58312015 | 58312085 | Frame-shift |
| ENST00000435505 | 58312015 | 58312085 | Frame-shift |
| ENST00000340157 | 58313473 | 58313561 | Frame-shift |
| ENST00000435505 | 58313473 | 58313561 | Frame-shift |
| ENST00000340157 | 58350235 | 58350368 | Frame-shift |
| ENST00000435505 | 58350235 | 58350368 | Frame-shift |
| ENST00000340157 | 58362275 | 58362334 | Frame-shift |
| ENST00000435505 | 58362275 | 58362334 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for VRK2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for VRK2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SKCM | TCGA-D3-A3C6-06 | exon_skip_325755 | 58312016 | 58312085 | 58312026 | 58312026 | Frame_Shift_Del | A | - | p.E66fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_325755 | 58312016 | 58312085 | 58312061 | 58312061 | Frame_Shift_Del | C | - | p.Q78fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_325755 | 58312016 | 58312085 | 58312072 | 58312072 | Frame_Shift_Del | A | - | p.A81fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_325755 | 58312016 | 58312085 | 58312072 | 58312072 | Frame_Shift_Del | A | - | p.A81fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_325764 | 58313474 | 58313561 | 58313524 | 58313524 | Frame_Shift_Del | T | - | p.F103fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_325764 | 58313474 | 58313561 | 58313524 | 58313524 | Frame_Shift_Del | T | - | p.F103fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_325764 | 58313474 | 58313561 | 58313524 | 58313524 | Frame_Shift_Del | T | - | p.F103fs |
| KIRC | TCGA-B8-4621-01 | exon_skip_325765 | 58350236 | 58350368 | 58350342 | 58350342 | Frame_Shift_Del | C | - | p.T217fs |
| READ | TCGA-AG-A002-01 | exon_skip_325755 | 58312016 | 58312085 | 58312046 | 58312046 | Nonsense_Mutation | G | T | p.E73X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 58312016 | 58312085 | 58312035 | 58312035 | Missense_Mutation | C | T | p.P69L |
| BICR78_UPPER_AERODIGESTIVE_TRACT | 58312016 | 58312085 | 58312053 | 58312053 | Missense_Mutation | A | C | p.K75T |
| SW684_SOFT_TISSUE | 58312016 | 58312085 | 58312073 | 58312073 | Missense_Mutation | A | G | p.K82E |
| EW13_BONE | 58313474 | 58313561 | 58313500 | 58313500 | Missense_Mutation | C | T | p.L95F |
| SNUC2A_LARGE_INTESTINE | 58313474 | 58313561 | 58313553 | 58313553 | Missense_Mutation | G | T | p.K112N |
| HCC515_LUNG | 58350236 | 58350368 | 58350245 | 58350245 | Missense_Mutation | G | T | p.A185S |
| RH36_SOFT_TISSUE | 58350236 | 58350368 | 58350246 | 58350246 | Missense_Mutation | C | T | p.A185V |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for VRK2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for VRK2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for VRK2 |
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RelatedDrugs for VRK2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for VRK2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| VRK2 | C0036341 | Schizophrenia | 2 | PSYGENET |
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