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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for VIPR1 |
 Gene summary |
| Gene information | Gene symbol | VIPR1 | Gene ID | 7433 |
| Gene name | vasoactive intestinal peptide receptor 1 | |
| Synonyms | HVR1|II|PACAP-R-2|PACAP-R2|RDC1|V1RG|VAPC1|VIP-R-1|VIPR|VIRG|VPAC1|VPAC1R|VPCAP1R | |
| Cytomap | 3p22.1 | |
| Type of gene | protein-coding | |
| Description | vasoactive intestinal polypeptide receptor 1PACAP type II receptorVIP and PACAP receptor 1VIP receptor, type IVPAC1 receptorpituitary adenylate cyclase activating polypeptide receptor, type IItype 1 vasoactive intestinal peptide receptor | |
| Modification date | 20180523 | |
| UniProtAcc | P32241 | |
| Context | PubMed: VIPR1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| VIPR1 | GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | 8390245 |
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Exon skipping events across known transcript of Ensembl for VIPR1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for VIPR1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for VIPR1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_373425 | 3 | 42543403:42543721:42555240:42555346:42560714:42560806 | 42555240:42555346 | ENSG00000114812.8 | ENST00000450274.1 |
| exon_skip_373426 | 3 | 42544155:42544305:42555240:42555346:42560714:42560806 | 42555240:42555346 | ENSG00000114812.8 | ENST00000439731.1,ENST00000325123.4 |
| exon_skip_373427 | 3 | 42555290:42555346:42560714:42560822:42567378:42567485 | 42560714:42560822 | ENSG00000114812.8 | ENST00000433647.1,ENST00000439731.1,ENST00000450274.1,ENST00000473575.1,ENST00000325123.4 |
| exon_skip_373428 | 3 | 42560714:42560822:42567378:42567485:42568884:42568988 | 42567378:42567485 | ENSG00000114812.8 | ENST00000433647.1,ENST00000439731.1,ENST00000446673.1,ENST00000443646.1,ENST00000450274.1,ENST00000473575.1,ENST00000325123.4 |
| exon_skip_373429 | 3 | 42560714:42560822:42567378:42567485:42572270:42572389 | 42567378:42567485 | ENSG00000114812.8 | ENST00000438259.2,ENST00000439910.1 |
| exon_skip_373440 | 3 | 42567378:42567485:42568884:42568988:42569482:42569615 | 42568884:42568988 | ENSG00000114812.8 | ENST00000433647.1,ENST00000446673.1,ENST00000443646.1,ENST00000325123.4 |
| exon_skip_373441 | 3 | 42567378:42567485:42568884:42568988:42572270:42572389 | 42568884:42568988 | ENSG00000114812.8 | ENST00000439731.1 |
| exon_skip_373447 | 3 | 42567378:42567485:42568887:42568988:42569482:42569615 | 42568887:42568988 | ENSG00000114812.8 | ENST00000543411.1,ENST00000436487.1 |
| exon_skip_373458 | 3 | 42567378:42567485:42572270:42572404:42572962:42573018 | 42572270:42572404 | ENSG00000114812.8 | ENST00000438259.2,ENST00000439910.1 |
| exon_skip_373468 | 3 | 42568887:42568988:42569482:42569615:42572270:42572389 | 42569482:42569615 | ENSG00000114812.8 | ENST00000543411.1,ENST00000433647.1,ENST00000436487.1,ENST00000443646.1,ENST00000325123.4 |
| exon_skip_373469 | 3 | 42568887:42568988:42569482:42569615:42572962:42573018 | 42569482:42569615 | ENSG00000114812.8 | ENST00000446673.1 |
| exon_skip_373481 | 3 | 42569542:42569615:42572270:42572424:42572962:42573023 | 42572270:42572424 | ENSG00000114812.8 | ENST00000543411.1,ENST00000433647.1,ENST00000436487.1,ENST00000443646.1,ENST00000325123.4 |
| exon_skip_373482 | 3 | 42569482:42569615:42572962:42573023:42573294:42573361 | 42572962:42573023 | ENSG00000114812.8 | ENST00000446673.1 |
| exon_skip_373483 | 3 | 42572270:42572404:42572962:42573023:42573294:42573361 | 42572962:42573023 | ENSG00000114812.8 | ENST00000438259.2,ENST00000439910.1 |
| exon_skip_373485 | 3 | 42573294:42573361:42573733:42573825:42576466:42576596 | 42573733:42573825 | ENSG00000114812.8 | ENST00000543411.1,ENST00000433647.1,ENST00000438259.2,ENST00000443646.1,ENST00000325123.4,ENST00000439910.1 |
| exon_skip_373500 | 3 | 42573733:42573825:42576466:42576596:42576834:42576876 | 42576466:42576596 | ENSG00000114812.8 | ENST00000543411.1,ENST00000433647.1,ENST00000438259.2,ENST00000443646.1,ENST00000325123.4,ENST00000439910.1 |
| exon_skip_373510 | 3 | 42576469:42576596:42576834:42576876:42577581:42577886 | 42576834:42576876 | ENSG00000114812.8 | ENST00000498102.1,ENST00000543411.1,ENST00000433647.1,ENST00000438259.2,ENST00000443646.1,ENST00000325123.4,ENST00000439910.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for VIPR1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_373425 | 3 | 42543403:42543721:42555240:42555346:42560714:42560806 | 42555240:42555346 | ENSG00000114812.8 | ENST00000450274.1 |
| exon_skip_373426 | 3 | 42544155:42544305:42555240:42555346:42560714:42560806 | 42555240:42555346 | ENSG00000114812.8 | ENST00000439731.1,ENST00000325123.4 |
| exon_skip_373427 | 3 | 42555290:42555346:42560714:42560822:42567378:42567485 | 42560714:42560822 | ENSG00000114812.8 | ENST00000433647.1,ENST00000450274.1,ENST00000439731.1,ENST00000325123.4,ENST00000473575.1 |
| exon_skip_373428 | 3 | 42560714:42560822:42567378:42567485:42568884:42568988 | 42567378:42567485 | ENSG00000114812.8 | ENST00000433647.1,ENST00000450274.1,ENST00000443646.1,ENST00000439731.1,ENST00000325123.4,ENST00000446673.1,ENST00000473575.1 |
| exon_skip_373429 | 3 | 42560714:42560822:42567378:42567485:42572270:42572389 | 42567378:42567485 | ENSG00000114812.8 | ENST00000439910.1,ENST00000438259.2 |
| exon_skip_373441 | 3 | 42567378:42567485:42568884:42568988:42572270:42572389 | 42568884:42568988 | ENSG00000114812.8 | ENST00000439731.1 |
| exon_skip_373458 | 3 | 42567378:42567485:42572270:42572404:42572962:42573018 | 42572270:42572404 | ENSG00000114812.8 | ENST00000439910.1,ENST00000438259.2 |
| exon_skip_373468 | 3 | 42568887:42568988:42569482:42569615:42572270:42572389 | 42569482:42569615 | ENSG00000114812.8 | ENST00000433647.1,ENST00000436487.1,ENST00000443646.1,ENST00000543411.1,ENST00000325123.4 |
| exon_skip_373469 | 3 | 42568887:42568988:42569482:42569615:42572962:42573018 | 42569482:42569615 | ENSG00000114812.8 | ENST00000446673.1 |
| exon_skip_373481 | 3 | 42569542:42569615:42572270:42572424:42572962:42573023 | 42572270:42572424 | ENSG00000114812.8 | ENST00000433647.1,ENST00000436487.1,ENST00000443646.1,ENST00000543411.1,ENST00000325123.4 |
| exon_skip_373482 | 3 | 42569482:42569615:42572962:42573023:42573294:42573361 | 42572962:42573023 | ENSG00000114812.8 | ENST00000446673.1 |
| exon_skip_373483 | 3 | 42572270:42572404:42572962:42573023:42573294:42573361 | 42572962:42573023 | ENSG00000114812.8 | ENST00000439910.1,ENST00000438259.2 |
| exon_skip_373485 | 3 | 42573294:42573361:42573733:42573825:42576466:42576596 | 42573733:42573825 | ENSG00000114812.8 | ENST00000433647.1,ENST00000443646.1,ENST00000543411.1,ENST00000439910.1,ENST00000438259.2,ENST00000325123.4 |
| exon_skip_373500 | 3 | 42573733:42573825:42576466:42576596:42576834:42576876 | 42576466:42576596 | ENSG00000114812.8 | ENST00000433647.1,ENST00000443646.1,ENST00000543411.1,ENST00000439910.1,ENST00000438259.2,ENST00000325123.4 |
| exon_skip_373510 | 3 | 42576469:42576596:42576834:42576876:42577581:42577886 | 42576834:42576876 | ENSG00000114812.8 | ENST00000433647.1,ENST00000443646.1,ENST00000543411.1,ENST00000439910.1,ENST00000438259.2,ENST00000325123.4,ENST00000498102.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for VIPR1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000325123 | 42555240 | 42555346 | Frame-shift |
| ENST00000325123 | 42567378 | 42567485 | Frame-shift |
| ENST00000325123 | 42568884 | 42568988 | Frame-shift |
| ENST00000325123 | 42569482 | 42569615 | Frame-shift |
| ENST00000325123 | 42572270 | 42572424 | Frame-shift |
| ENST00000325123 | 42573733 | 42573825 | Frame-shift |
| ENST00000325123 | 42576466 | 42576596 | Frame-shift |
| ENST00000325123 | 42560714 | 42560822 | In-frame |
| ENST00000325123 | 42576834 | 42576876 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000325123 | 42555240 | 42555346 | Frame-shift |
| ENST00000325123 | 42567378 | 42567485 | Frame-shift |
| ENST00000325123 | 42569482 | 42569615 | Frame-shift |
| ENST00000325123 | 42572270 | 42572424 | Frame-shift |
| ENST00000325123 | 42573733 | 42573825 | Frame-shift |
| ENST00000325123 | 42576466 | 42576596 | Frame-shift |
| ENST00000325123 | 42560714 | 42560822 | In-frame |
| ENST00000325123 | 42576834 | 42576876 | In-frame |
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Infer the effects of exon skipping event on protein functional features for VIPR1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000325123 | 2790 | 457 | 42560714 | 42560822 | 298 | 405 | 61 | 97 |
| ENST00000325123 | 2790 | 457 | 42576834 | 42576876 | 1254 | 1295 | 380 | 394 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000325123 | 2790 | 457 | 42560714 | 42560822 | 298 | 405 | 61 | 97 |
| ENST00000325123 | 2790 | 457 | 42576834 | 42576876 | 1254 | 1295 | 380 | 394 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for VIPR1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_373458 | 42572271 | 42572404 | 42572291 | 42572291 | Frame_Shift_Del | G | - | p.M178fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_373481 | 42572271 | 42572424 | 42572291 | 42572291 | Frame_Shift_Del | G | - | p.M178fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_373458 | 42572271 | 42572404 | 42572295 | 42572295 | Frame_Shift_Del | T | - | p.F181fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_373481 | 42572271 | 42572424 | 42572295 | 42572295 | Frame_Shift_Del | T | - | p.F181fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_373458 | 42572271 | 42572404 | 42572401 | 42572401 | Frame_Shift_Del | G | - | p.W215fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_373481 | 42572271 | 42572424 | 42572401 | 42572401 | Frame_Shift_Del | G | - | p.W215fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_373485 | 42573734 | 42573825 | 42573788 | 42573788 | Frame_Shift_Del | C | - | p.P285fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_373485 | 42573734 | 42573825 | 42573788 | 42573788 | Frame_Shift_Del | C | - | p.R324fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_373500 | 42576467 | 42576596 | 42576497 | 42576497 | Frame_Shift_Del | C | - | p.I306fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_373500 | 42576467 | 42576596 | 42576497 | 42576497 | Frame_Shift_Del | C | - | p.I347fs |
| SKCM | TCGA-D3-A5GS-06 | exon_skip_373481 | 42572271 | 42572424 | 42572422 | 42572422 | Nonsense_Mutation | G | A | p.W222* |
| SKCM | TCGA-D3-A5GS-06 | exon_skip_373481 | 42572271 | 42572424 | 42572422 | 42572422 | Nonsense_Mutation | G | A | p.W222X |
| PAAD | TCGA-IB-7651-01 | exon_skip_373447 exon_skip_373440 exon_skip_373441 | 42568885 | 42568988 | 42568884 | 42568884 | Splice_Site | G | T | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NCIH1092_LUNG | 42555241 | 42555346 | 42555251 | 42555251 | Missense_Mutation | C | A | p.A30E |
| ALLPO_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 42560715 | 42560822 | 42560768 | 42560768 | Missense_Mutation | C | A | p.Q80K |
| CROAP2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 42567379 | 42567485 | 42567408 | 42567408 | Missense_Mutation | G | A | p.E108K |
| TTC549_SOFT_TISSUE | 42567379 | 42567485 | 42567444 | 42567444 | Missense_Mutation | A | G | p.I120V |
| SW684_SOFT_TISSUE | 42567379 | 42567485 | 42567480 | 42567480 | Missense_Mutation | G | A | p.D132N |
| 22RV1_PROSTATE | 42569483 | 42569615 | 42569494 | 42569494 | Missense_Mutation | G | A | p.C172Y |
| IM95_STOMACH | 42569483 | 42569615 | 42569499 | 42569499 | Missense_Mutation | C | T | p.R174W |
| JHUEM7_ENDOMETRIUM | 42569483 | 42569615 | 42569565 | 42569565 | Missense_Mutation | G | T | p.D196Y |
| HCC1171_LUNG | 42572271 | 42572424 | 42572278 | 42572278 | Missense_Mutation | G | A | p.C215Y |
| HCC1171_LUNG | 42572271 | 42572404 | 42572278 | 42572278 | Missense_Mutation | G | A | p.C215Y |
| EMCBAC1_LUNG | 42572271 | 42572424 | 42572286 | 42572286 | Missense_Mutation | G | A | p.A218T |
| EMCBAC1_LUNG | 42572271 | 42572404 | 42572286 | 42572286 | Missense_Mutation | G | A | p.A218T |
| NCIH1793_LUNG | 42572271 | 42572424 | 42572291 | 42572291 | Missense_Mutation | G | T | p.M219I |
| NCIH1793_LUNG | 42572271 | 42572404 | 42572291 | 42572291 | Missense_Mutation | G | T | p.M219I |
| UMUC5_URINARY_TRACT | 42572271 | 42572424 | 42572370 | 42572370 | Missense_Mutation | G | A | p.V246I |
| UMUC5_URINARY_TRACT | 42572271 | 42572404 | 42572370 | 42572370 | Missense_Mutation | G | A | p.V246I |
| HLFA_FIBROBLAST | 42572271 | 42572424 | 42572378 | 42572378 | Missense_Mutation | C | A | p.F248L |
| HLFA_FIBROBLAST | 42572271 | 42572404 | 42572378 | 42572378 | Missense_Mutation | C | A | p.F248L |
| HCT15_LARGE_INTESTINE | 42572271 | 42572424 | 42572418 | 42572418 | Missense_Mutation | G | A | p.G262S |
| SNU1033_LARGE_INTESTINE | 42573734 | 42573825 | 42573747 | 42573747 | Missense_Mutation | T | C | p.L311P |
| DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 42573734 | 42573825 | 42573785 | 42573785 | Missense_Mutation | C | T | p.R324W |
| CW2_LARGE_INTESTINE | 42576467 | 42576596 | 42576586 | 42576586 | Missense_Mutation | G | A | p.G377E |
| SUDHL10_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 42569483 | 42569615 | 42569589 | 42569589 | Nonsense_Mutation | G | T | p.E204* |
| QGP1_PANCREAS | 42573734 | 42573825 | 42573764 | 42573764 | Nonsense_Mutation | C | T | p.R317* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for VIPR1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for VIPR1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for VIPR1 |
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RelatedDrugs for VIPR1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for VIPR1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| VIPR1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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