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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for TNS1

check button Gene summary
Gene informationGene symbol

TNS1

Gene ID

7145

Gene nametensin 1
SynonymsMST091|MST122|MST127|MSTP091|MSTP122|MSTP127|MXRA6|PPP1R155|TNS
Cytomap

2q35

Type of geneprotein-coding
Descriptiontensin-1Matrix-remodelling-associated protein 6matrix-remodelling associated 6protein phosphatase 1, regulatory subunit 155
Modification date20180519
UniProtAcc

Q9HBL0

ContextPubMed: TNS1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Exon skipping events across known transcript of Ensembl for TNS1 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for TNS1

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for TNS1

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3465932218668588:218669326:218672797:218672830:218673325:218673394218672797:218672830ENSG00000079308.12ENST00000430930.1,ENST00000490566.1,ENST00000419504.1,ENST00000446688.1,ENST00000171887.4
exon_skip_3465942218673325:218673394:218674545:218674714:218674970:218675027218674545:218674714ENSG00000079308.12ENST00000430930.1,ENST00000490566.1,ENST00000419504.1,ENST00000446688.1,ENST00000171887.4
exon_skip_3465952218677090:218677168:218677937:218678027:218678407:218678539218677937:218678027ENSG00000079308.12ENST00000419504.1
exon_skip_3465962218677090:218677168:218677937:218678030:218678407:218678539218677937:218678030ENSG00000079308.12ENST00000430930.1,ENST00000490566.1,ENST00000446688.1,ENST00000171887.4
exon_skip_3465972218686462:218686661:218694566:218694605:218695089:218695113218694566:218694605ENSG00000079308.12ENST00000171887.4
exon_skip_3466022218686462:218686661:218695089:218695113:218696177:218696270218695089:218695113ENSG00000079308.12ENST00000419504.1
exon_skip_3466032218686462:218686661:218696177:218696270:218699813:218699889218696177:218696270ENSG00000079308.12ENST00000430930.1,ENST00000446688.1
exon_skip_3466042218694566:218694605:218695089:218695113:218696177:218696270218695089:218695113ENSG00000079308.12ENST00000171887.4
exon_skip_3466102218700737:218700934:218712232:218713810:218745620:218745737218712232:218713810ENSG00000079308.12ENST00000430930.1,ENST00000419504.1,ENST00000171887.4
exon_skip_3466202218713606:218713810:218745620:218745737:218747068:218747134218745620:218745737ENSG00000079308.12ENST00000430930.1,ENST00000446903.1,ENST00000413554.1,ENST00000419504.1,ENST00000171887.4
exon_skip_3466232218713606:218713810:218745620:218747134:218749757:218749887218745620:218747134ENSG00000079308.12ENST00000479185.1
exon_skip_3466362218747068:218747134:218749757:218749887:218750466:218750533218749757:218749887ENSG00000079308.12ENST00000430930.1,ENST00000310858.6,ENST00000446903.1,ENST00000413554.1,ENST00000419504.1,ENST00000171887.4,ENST00000453356.1,ENST00000479185.1
exon_skip_3466402218757670:218757735:218758161:218758284:218759728:218759779218758161:218758284ENSG00000079308.12ENST00000430930.1,ENST00000310858.6,ENST00000446903.1,ENST00000413554.1,ENST00000419504.1,ENST00000171887.4,ENST00000492338.2
exon_skip_3466412218762615:218762692:218765185:218765235:218766432:218766546218765185:218765235ENSG00000079308.12ENST00000449814.1,ENST00000439083.1
exon_skip_3466422218762615:218762692:218765185:218765235:218771057:218771108218765185:218765235ENSG00000079308.12ENST00000413280.1,ENST00000423413.1,ENST00000430930.1,ENST00000446903.1,ENST00000419504.1,ENST00000171887.4
exon_skip_3466462218765185:218765235:218766432:218766546:218771057:218771108218766432:218766546ENSG00000079308.12ENST00000449814.1
exon_skip_3466482218771057:218771108:218771932:218771974:218784917:218784932218771932:218771974ENSG00000079308.12ENST00000413280.1,ENST00000449814.1,ENST00000423413.1,ENST00000430930.1,ENST00000446903.1,ENST00000419504.1,ENST00000171887.4
exon_skip_3466492218771932:218771974:218784917:218784959:218808587:218808793218784917:218784959ENSG00000079308.12ENST00000449814.1
exon_skip_3466502218771932:218771974:218784917:218784959:218843487:218843525218784917:218784959ENSG00000079308.12ENST00000413280.1,ENST00000446903.1
exon_skip_3466552218784917:218784959:218843487:218843525:218855664:218855752218843487:218843525ENSG00000079308.12ENST00000446903.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for TNS1

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3465932218668588:218669326:218672797:218672830:218673325:218673394218672797:218672830ENSG00000079308.12ENST00000171887.4,ENST00000446688.1,ENST00000490566.1,ENST00000419504.1,ENST00000430930.1
exon_skip_3465942218673325:218673394:218674545:218674714:218674970:218675027218674545:218674714ENSG00000079308.12ENST00000171887.4,ENST00000446688.1,ENST00000490566.1,ENST00000419504.1,ENST00000430930.1
exon_skip_3465952218677090:218677168:218677937:218678027:218678407:218678539218677937:218678027ENSG00000079308.12ENST00000419504.1
exon_skip_3465962218677090:218677168:218677937:218678030:218678407:218678539218677937:218678030ENSG00000079308.12ENST00000171887.4,ENST00000446688.1,ENST00000490566.1,ENST00000430930.1
exon_skip_3465972218686462:218686661:218694566:218694605:218695089:218695113218694566:218694605ENSG00000079308.12ENST00000171887.4
exon_skip_3466022218686462:218686661:218695089:218695113:218696177:218696270218695089:218695113ENSG00000079308.12ENST00000419504.1
exon_skip_3466032218686462:218686661:218696177:218696270:218699813:218699889218696177:218696270ENSG00000079308.12ENST00000446688.1,ENST00000430930.1
exon_skip_3466042218694566:218694605:218695089:218695113:218696177:218696270218695089:218695113ENSG00000079308.12ENST00000171887.4
exon_skip_3466102218700737:218700934:218712232:218713810:218745620:218745737218712232:218713810ENSG00000079308.12ENST00000171887.4,ENST00000419504.1,ENST00000430930.1
exon_skip_3466202218713606:218713810:218745620:218745737:218747068:218747134218745620:218745737ENSG00000079308.12ENST00000171887.4,ENST00000419504.1,ENST00000430930.1,ENST00000446903.1,ENST00000413554.1
exon_skip_3466232218713606:218713810:218745620:218747134:218749757:218749887218745620:218747134ENSG00000079308.12ENST00000479185.1
exon_skip_3466362218747068:218747134:218749757:218749887:218750466:218750533218749757:218749887ENSG00000079308.12ENST00000171887.4,ENST00000419504.1,ENST00000430930.1,ENST00000446903.1,ENST00000479185.1,ENST00000413554.1,ENST00000310858.6,ENST00000453356.1
exon_skip_3466402218757670:218757735:218758161:218758284:218759728:218759779218758161:218758284ENSG00000079308.12ENST00000171887.4,ENST00000419504.1,ENST00000430930.1,ENST00000446903.1,ENST00000413554.1,ENST00000310858.6,ENST00000492338.2
exon_skip_3466412218762615:218762692:218765185:218765235:218766432:218766546218765185:218765235ENSG00000079308.12ENST00000439083.1,ENST00000449814.1
exon_skip_3466422218762615:218762692:218765185:218765235:218771057:218771108218765185:218765235ENSG00000079308.12ENST00000171887.4,ENST00000419504.1,ENST00000430930.1,ENST00000446903.1,ENST00000413280.1,ENST00000423413.1
exon_skip_3466462218765185:218765235:218766432:218766546:218771057:218771108218766432:218766546ENSG00000079308.12ENST00000449814.1
exon_skip_3466482218771057:218771108:218771932:218771974:218784917:218784932218771932:218771974ENSG00000079308.12ENST00000171887.4,ENST00000419504.1,ENST00000430930.1,ENST00000446903.1,ENST00000413280.1,ENST00000423413.1,ENST00000449814.1
exon_skip_3466492218771932:218771974:218784917:218784959:218808587:218808793218784917:218784959ENSG00000079308.12ENST00000449814.1
exon_skip_3466502218771932:218771974:218784917:218784959:218843487:218843525218784917:218784959ENSG00000079308.12ENST00000446903.1,ENST00000413280.1
exon_skip_3466552218784917:218784959:218843487:218843525:218855664:218855752218843487:218843525ENSG00000079308.12ENST00000446903.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for TNS1

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000001718872187651852187652353UTR-3UTR
ENST000001718872187719322187719743UTR-3UTR
ENST00000171887218674545218674714Frame-shift
ENST00000171887218749757218749887Frame-shift
ENST00000171887218672797218672830In-frame
ENST00000171887218677937218678030In-frame
ENST00000171887218694566218694605In-frame
ENST00000171887218695089218695113In-frame
ENST00000171887218712232218713810In-frame
ENST00000171887218745620218745737In-frame
ENST00000171887218758161218758284In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000001718872187651852187652353UTR-3UTR
ENST000001718872187719322187719743UTR-3UTR
ENST00000171887218674545218674714Frame-shift
ENST00000171887218749757218749887Frame-shift
ENST00000171887218672797218672830In-frame
ENST00000171887218677937218678030In-frame
ENST00000171887218694566218694605In-frame
ENST00000171887218695089218695113In-frame
ENST00000171887218712232218713810In-frame
ENST00000171887218745620218745737In-frame
ENST00000171887218758161218758284In-frame

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Infer the effects of exon skipping event on protein functional features for TNS1

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000017188710348173521875816121875828467379573114
ENST0000017188710348173521874562021874573713911507312351
ENST0000017188710348173521871223221871381015083085351877
ENST000001718871034817352186945662186946053476351410071020
ENST000001718871034817352186779372186780305003509515161547
ENST000001718871034817352186727972186728305484551616771687

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000017188710348173521875816121875828467379573114
ENST0000017188710348173521874562021874573713911507312351
ENST0000017188710348173521871223221871381015083085351877
ENST000001718871034817352186945662186946053476351410071020
ENST000001718871034817352186779372186780305003509515161547
ENST000001718871034817352186727972186728305484551616771687

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q9HBL07311411735ChainID=PRO_0000215900;Note=Tensin-1
Q9HBL0731144176DomainNote=Phosphatase tensin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00590
Q9HBL031235111735ChainID=PRO_0000215900;Note=Tensin-1
Q9HBL0312351338338Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
Q9HBL0351877352385Alternative sequenceID=VSP_056336;Note=In isoform 2. EVVGHTQGPLDGSLYAKVKKKDSLHGSTGAVNAT->DGNKQNTNSQSIGSISGGLEDQYTWPDTHWPSQS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q9HBL03518773861735Alternative sequenceID=VSP_056337;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q9HBL035187711735ChainID=PRO_0000215900;Note=Tensin-1
Q9HBL0351877651667Compositional biasNote=Gln-rich
Q9HBL0351877364364Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
Q9HBL0351877366366Modified residueNote=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
Q9HBL0351877378378Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
Q9HBL0351877379379Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
Q9HBL0351877433433Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
Q9HBL0351877621621Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9HBL0351877701701Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
Q9HBL0351877764764Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
Q9HBL0351877769769Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
Q9HBL0351877794794Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
Q9HBL0351877860860Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
Q9HBL0351877466466Natural variantID=VAR_047067;Note=R->C;Dbxref=dbSNP:rs3815849
Q9HBL0351877528528Natural variantID=VAR_047068;Note=T->I;Dbxref=dbSNP:rs3796033
Q9HBL0100710203861735Alternative sequenceID=VSP_056337;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q9HBL01007102011735ChainID=PRO_0000215900;Note=Tensin-1
Q9HBL0151615473861735Alternative sequenceID=VSP_056337;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q9HBL01516154711735ChainID=PRO_0000215900;Note=Tensin-1
Q9HBL01516154714631572DomainNote=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
Q9HBL0167716873861735Alternative sequenceID=VSP_056337;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q9HBL01677168711735ChainID=PRO_0000215900;Note=Tensin-1


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q9HBL07311411735ChainID=PRO_0000215900;Note=Tensin-1
Q9HBL0731144176DomainNote=Phosphatase tensin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00590
Q9HBL031235111735ChainID=PRO_0000215900;Note=Tensin-1
Q9HBL0312351338338Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
Q9HBL0351877352385Alternative sequenceID=VSP_056336;Note=In isoform 2. EVVGHTQGPLDGSLYAKVKKKDSLHGSTGAVNAT->DGNKQNTNSQSIGSISGGLEDQYTWPDTHWPSQS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q9HBL03518773861735Alternative sequenceID=VSP_056337;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q9HBL035187711735ChainID=PRO_0000215900;Note=Tensin-1
Q9HBL0351877651667Compositional biasNote=Gln-rich
Q9HBL0351877364364Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
Q9HBL0351877366366Modified residueNote=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
Q9HBL0351877378378Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
Q9HBL0351877379379Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
Q9HBL0351877433433Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
Q9HBL0351877621621Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9HBL0351877701701Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
Q9HBL0351877764764Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
Q9HBL0351877769769Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
Q9HBL0351877794794Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
Q9HBL0351877860860Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
Q9HBL0351877466466Natural variantID=VAR_047067;Note=R->C;Dbxref=dbSNP:rs3815849
Q9HBL0351877528528Natural variantID=VAR_047068;Note=T->I;Dbxref=dbSNP:rs3796033
Q9HBL0100710203861735Alternative sequenceID=VSP_056337;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q9HBL01007102011735ChainID=PRO_0000215900;Note=Tensin-1
Q9HBL0151615473861735Alternative sequenceID=VSP_056337;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q9HBL01516154711735ChainID=PRO_0000215900;Note=Tensin-1
Q9HBL01516154714631572DomainNote=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
Q9HBL0167716873861735Alternative sequenceID=VSP_056337;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q9HBL01677168711735ChainID=PRO_0000215900;Note=Tensin-1


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SNVs in the skipped exons for TNS1

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.
TNS1_BRCA_exon_skip_346623_psi_boxplot.png
boxplot
TNS1_COAD_exon_skip_346610_psi_boxplot.png
boxplot
TNS1_LIHC_exon_skip_346610_psi_boxplot.png
boxplot
TNS1_LIHC_exon_skip_346623_psi_boxplot.png
boxplot
TNS1_LUAD_exon_skip_346610_psi_boxplot.png
boxplot
TNS1_STAD_exon_skip_346623_psi_boxplot.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A1EG-01exon_skip_346594
218674546218674714218674617218674617Frame_Shift_DelG-p.P1630fs
LIHCTCGA-DD-A39Y-01exon_skip_346594
218674546218674714218674647218674647Frame_Shift_DelT-p.K1620fs
LIHCTCGA-DD-A3A0-01exon_skip_346595
218677938218678027218677943218677943Frame_Shift_DelT-p.N1546fs
LIHCTCGA-DD-A3A0-01exon_skip_346596
218677938218678030218677943218677943Frame_Shift_DelT-p.N1546fs
LIHCTCGA-DD-A3A0-01exon_skip_346603
218696178218696270218696207218696207Frame_Shift_DelG-p.P990fs
COADTCGA-AU-6004-01exon_skip_346603
218696178218696270218696258218696258Frame_Shift_DelG-p.P973fs
UCECTCGA-BS-A0TJ-01exon_skip_346603
218696178218696270218696258218696258Frame_Shift_DelG-p.P973fs
LIHCTCGA-DD-A1EG-01exon_skip_346610
218712233218713810218712775218712775Frame_Shift_DelG-p.P697fs
LIHCTCGA-G3-A3CJ-01exon_skip_346610
218712233218713810218712792218712792Frame_Shift_DelG-p.P691fs
COADTCGA-AD-5900-01exon_skip_346610
218712233218713810218712955218712955Frame_Shift_DelC-p.G637fs
LIHCTCGA-DD-A39Y-01exon_skip_346610
218712233218713810218713218218713218Frame_Shift_DelG-p.P549fs
COADTCGA-CK-5916-01exon_skip_346610
218712233218713810218713456218713456Frame_Shift_DelC-p.G470fs
LIHCTCGA-G3-A3CJ-01exon_skip_346610
218712233218713810218713484218713484Frame_Shift_DelG-p.Q461fs
UCECTCGA-BG-A0VZ-01exon_skip_346610
218712233218713810218713686218713686Frame_Shift_DelG-p.P393fs
LIHCTCGA-BC-A3KG-01exon_skip_346623
218745621218747134218747075218747075Frame_Shift_DelT-p.I311fs
LUADTCGA-05-4382-01exon_skip_346636
218749758218749887218749786218749786Frame_Shift_DelC-p.G281fs
LIHCTCGA-DD-A1EG-01exon_skip_346640
218758162218758284218758204218758204Frame_Shift_DelC-p.W100fs
HNSCTCGA-F7-A624-01exon_skip_346603
218696178218696270218696257218696258Frame_Shift_Ins-Gp.R973fs
KIRPTCGA-5P-A9K0-01exon_skip_346610
218712233218713810218712606218712607Frame_Shift_Ins-Ap.S753fs
LUADTCGA-64-1680-01exon_skip_346610
218712233218713810218713071218713072Frame_Shift_Ins-Gp.R598fs
LUADTCGA-49-6767-01exon_skip_346610
218712233218713810218713343218713343Nonsense_MutationGAp.Q508*
BRCATCGA-E9-A1RF-01exon_skip_346620
218745621218745737218745658218745658Nonsense_MutationGAp.R115*
BRCATCGA-E9-A1RF-01exon_skip_346623
218745621218747134218745658218745658Nonsense_MutationGAp.R115*
STADTCGA-BR-6565-01exon_skip_346623
218745621218747134218747129218747129Nonsense_MutationGAp.R293*
STADTCGA-BR-6565-01exon_skip_346623
218745621218747134218747129218747129Nonsense_MutationGAp.R293X

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description
TNS1_218713606_218713810_218745620_218747134_218749757_218749887_TCGA-E9-A1RF-01Sample: TCGA-E9-A1RF-01
Cancer type: BRCA
ESID: exon_skip_346623
Skipped exon start: 218745621
Skipped exon end: 218747134
Mutation start: 218745658
Mutation end: 218745658
Mutation type: Nonsense_Mutation
Reference seq: G
Mutation seq: A
AAchange: p.R115*
TNS1_218713606_218713810_218745620_218747134_218749757_218749887_TCGA-E9-A1RF-01Sample: TCGA-E9-A1RF-01
Cancer type: BRCA
ESID: exon_skip_346620
Skipped exon start: 218745621
Skipped exon end: 218745737
Mutation start: 218745658
Mutation end: 218745658
Mutation type: Nonsense_Mutation
Reference seq: G
Mutation seq: A
AAchange: p.R115*
exon_skip_346623_BRCA_TCGA-E9-A1RF-01.png
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exon_skip_356010_BRCA_TCGA-E9-A1RF-01.png
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TNS1_218713606_218713810_218745620_218747134_218749757_218749887_TCGA-BR-6565-01Sample: TCGA-BR-6565-01
Cancer type: STAD
ESID: exon_skip_346623
Skipped exon start: 218745621
Skipped exon end: 218747134
Mutation start: 218747129
Mutation end: 218747129
Mutation type: Nonsense_Mutation
Reference seq: G
Mutation seq: A
AAchange: p.R293X
TNS1_218713606_218713810_218745620_218747134_218749757_218749887_TCGA-BR-6565-01Sample: TCGA-BR-6565-01
Cancer type: STAD
ESID: exon_skip_346623
Skipped exon start: 218745621
Skipped exon end: 218747134
Mutation start: 218747129
Mutation end: 218747129
Mutation type: Nonsense_Mutation
Reference seq: G
Mutation seq: A
AAchange: p.R293*
exon_skip_140664_STAD_TCGA-BR-6565-01.png
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exon_skip_346623_STAD_TCGA-BR-6565-01.png
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TNS1_218713606_218713810_218745620_218747134_218749757_218749887_TCGA-BC-A3KG-01Sample: TCGA-BC-A3KG-01
Cancer type: LIHC
ESID: exon_skip_346623
Skipped exon start: 218745621
Skipped exon end: 218747134
Mutation start: 218747075
Mutation end: 218747075
Mutation type: Frame_Shift_Del
Reference seq: T
Mutation seq: -
AAchange: p.I311fs
exon_skip_107008_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_107009_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_107010_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_10760_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_11532_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_123519_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_17069_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_300924_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_346623_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_374970_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_387350_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_423555_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_441299_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_441300_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_444819_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_450818_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_456987_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_459274_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_494352_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_64409_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_64412_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_69788_LIHC_TCGA-BC-A3KG-01.png
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exon_skip_98384_LIHC_TCGA-BC-A3KG-01.png
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TNS1_218700737_218700934_218712232_218713810_218745620_218745737_TCGA-64-1680-01Sample: TCGA-64-1680-01
Cancer type: LUAD
ESID: exon_skip_346610
Skipped exon start: 218712233
Skipped exon end: 218713810
Mutation start: 218713071
Mutation end: 218713072
Mutation type: Frame_Shift_Ins
Reference seq: -
Mutation seq: G
AAchange: p.R598fs
exon_skip_346610_LUAD_TCGA-64-1680-01.png
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exon_skip_73998_LUAD_TCGA-64-1680-01.png
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check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
DU145_PROSTATE218696178218696270218696258218696258Frame_Shift_DelG-p.P973fs
LIM1215_LARGE_INTESTINE218696178218696270218696258218696258Frame_Shift_DelG-p.P973fs
SISO_CERVIX218712233218713810218713076218713076Frame_Shift_DelG-p.H597fs
GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE218712233218713810218713076218713076Frame_Shift_DelG-p.H597fs
SISO_CERVIX218712233218713810218713270218713270Frame_Shift_DelC-p.G532fs
GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE218712233218713810218713270218713270Frame_Shift_DelC-p.G532fs
SKOV3_OVARY218712233218713810218713456218713456Frame_Shift_DelC-p.G470fs
SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE218696178218696270218696257218696258Frame_Shift_Ins-Gp.P973fs
CW2_LARGE_INTESTINE218712233218713810218712954218712955Frame_Shift_Ins-Cp.G637fs
MKN7_STOMACH218674546218674714218674590218674590Missense_MutationGTp.F1639L
CORL32_LUNG218674546218674714218674693218674693Missense_MutationTCp.N1605S
NCIH2073_LUNG218696178218696270218696216218696216Missense_MutationGAp.P987L
NCIH2347_LUNG218696178218696270218696256218696256Missense_MutationCAp.G974C
OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE218696178218696270218696264218696264Missense_MutationGCp.S971C
MM415_SKIN218712233218713810218712292218712292Missense_MutationGAp.S858F
SKOV3_OVARY218712233218713810218712338218712338Missense_MutationTCp.T843A
NCIH1770_LUNG218712233218713810218712377218712377Missense_MutationGAp.P830S
NCIH2106_LUNG218712233218713810218712377218712377Missense_MutationGAp.P830S
SW620_LARGE_INTESTINE218712233218713810218712407218712407Missense_MutationGAp.P820S
EOL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE218712233218713810218712436218712436Missense_MutationTCp.H810R
NCIH1573_LUNG218712233218713810218712500218712500Missense_MutationGAp.P789S
IPC298_SKIN218712233218713810218712503218712503Missense_MutationGAp.P788S
EJM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE218712233218713810218712524218712524Missense_MutationGAp.R781W
PK59_PANCREAS218712233218713810218712524218712524Missense_MutationGAp.R781W
NCIH1734_LUNG218712233218713810218712572218712572Missense_MutationCAp.G765C
IALM_LUNG218712233218713810218712586218712586Missense_MutationGAp.T760I
SNU719_STOMACH218712233218713810218712721218712721Missense_MutationAGp.L715P
NCIH650_LUNG218712233218713810218712742218712742Missense_MutationGCp.S708C
WM35_SKIN218712233218713810218712776218712776Missense_MutationGAp.P697S
IGROV1_OVARY218712233218713810218712802218712802Missense_MutationGTp.T688N
KYSE150_OESOPHAGUS218712233218713810218712815218712815Missense_MutationGAp.P684S
NCIH1436_LUNG218712233218713810218712848218712848Missense_MutationCGp.E673Q
KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE218712233218713810218712946218712946Missense_MutationCTp.R640Q
MTA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE218712233218713810218712947218712947Missense_MutationGAp.R640W
M980513_SKIN218712233218713810218712959218712959Missense_MutationCTp.G636R
NCIH522_LUNG218712233218713810218713012218713012Missense_MutationCTp.R618H
KP3_PANCREAS218712233218713810218713022218713022Missense_MutationCTp.G615S
NCIH2291_LUNG218712233218713810218713031218713031Missense_MutationCTp.D612N
MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE218712233218713810218713139218713139Missense_MutationCTp.A576T
GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE218712233218713810218713157218713157Missense_MutationCTp.A570T
MIAPACA2_PANCREAS218712233218713810218713237218713237Missense_MutationCAp.G543V
MZ7MEL_SKIN218712233218713810218713274218713274Missense_MutationCTp.G531R
KMM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE218712233218713810218713277218713277Missense_MutationCTp.E530K
SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE218712233218713810218713378218713378Missense_MutationCTp.R496Q
SNU478_BILIARY_TRACT218712233218713810218713453218713453Missense_MutationGAp.S471L
KM12_LARGE_INTESTINE218712233218713810218713465218713465Missense_MutationGAp.P467L
NKM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE218712233218713810218713530218713530Missense_MutationATp.S445R
TE15_OESOPHAGUS218712233218713810218713532218713532Missense_MutationTGp.S445R
SNU81_LARGE_INTESTINE218712233218713810218713610218713610Missense_MutationCTp.D419N
KNS62_LUNG218712233218713810218713651218713651Missense_MutationTCp.D405G
HEC151_ENDOMETRIUM218712233218713810218713654218713654Missense_MutationCTp.S404N
SEKI_SKIN218712233218713810218713708218713708Missense_MutationCTp.R386H
HUNS1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE218745621218747134218745672218745672Missense_MutationGAp.R335C
HUNS1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE218745621218745737218745672218745672Missense_MutationGAp.R335C
KNS42_CENTRAL_NERVOUS_SYSTEM218745621218747134218745698218745698Missense_MutationTGp.D326A
KNS42_CENTRAL_NERVOUS_SYSTEM218745621218745737218745698218745698Missense_MutationTGp.D326A
SW579_THYROID218745621218747134218747086218747086Missense_MutationCTp.G307E
CGTHW1_THYROID218745621218747134218747086218747086Missense_MutationCTp.G307E
BICR18_UPPER_AERODIGESTIVE_TRACT218745621218747134218747118218747118Missense_MutationCGp.E296D
LS411N_LARGE_INTESTINE218749758218749887218749854218749854Missense_MutationCTp.A259T
SARC9371_BONE218758162218758284218758178218758178Missense_MutationACp.V109G
JHUEM2_ENDOMETRIUM218677938218678027218677977218677977Nonsense_MutationCAp.G1535*
JHUEM2_ENDOMETRIUM218677938218678030218677977218677977Nonsense_MutationCAp.G1535*
MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE218712233218713810218713390218713390Nonsense_MutationATp.L492*
ES2_OVARY218712233218713810218713453218713453Nonsense_MutationGTp.S471*
HCT15_LARGE_INTESTINE218758162218758284218758204218758204Nonsense_MutationCTp.W100*
MDST8_LARGE_INTESTINE218758162218758284218758205218758205Nonsense_MutationCTp.W100*
BICR18_UPPER_AERODIGESTIVE_TRACT218674546218674714218674713218674713Splice_SiteGAp.A1598A
BICR18_UPPER_AERODIGESTIVE_TRACT218696178218696270218696179218696179Splice_SiteTAp.G999G

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TNS1

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value
exon_skip_3466102218700737:218700934:218712232:218713810:218745620:218745737218712232:218713810ENST00000430930.1,ENST00000419504.1,ENST00000171887.4BRCArs1364641chr2:218712606G/A1.56e-05
exon_skip_3466102218700737:218700934:218712232:218713810:218745620:218745737218712232:218713810ENST00000430930.1,ENST00000419504.1,ENST00000171887.4BRCArs1364641chr2:218712606G/A1.57e-05
exon_skip_3466102218700737:218700934:218712232:218713810:218745620:218745737218712232:218713810ENST00000430930.1,ENST00000419504.1,ENST00000171887.4BRCArs1364642chr2:218712726A/G2.24e-05
exon_skip_3466102218700737:218700934:218712232:218713810:218745620:218745737218712232:218713810ENST00000430930.1,ENST00000419504.1,ENST00000171887.4BRCArs1364642chr2:218712726A/G2.26e-05
exon_skip_3466102218700737:218700934:218712232:218713810:218745620:218745737218712232:218713810ENST00000430930.1,ENST00000419504.1,ENST00000171887.4BRCArs1004814chr2:218712306C/T3.03e-05
exon_skip_3466102218700737:218700934:218712232:218713810:218745620:218745737218712232:218713810ENST00000430930.1,ENST00000419504.1,ENST00000171887.4BRCArs1004814chr2:218712306C/T3.05e-05

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TNS1


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TNS1


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RelatedDrugs for TNS1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TNS1

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource