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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for TNNT3

check button Gene summary
Gene informationGene symbol

TNNT3

Gene ID

7140

Gene nametroponin T3, fast skeletal type
SynonymsTNTF|beta-TnTF
Cytomap

11p15.5

Type of geneprotein-coding
Descriptiontroponin T, fast skeletal muscletroponin T type 3 (skeletal, fast)
Modification date20180524
UniProtAcc

P45378

ContextPubMed: TNNT3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
TNNT3

GO:0003009

skeletal muscle contraction

17194691

TNNT3

GO:0006942

regulation of striated muscle contraction

17194691

TNNT3

GO:0043462

regulation of ATPase activity

17194691


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Exon skipping events across known transcript of Ensembl for TNNT3 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for TNNT3

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for TNNT3

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_56047111944104:1944121:1944277:1944291:1944784:19448021944277:1944291ENSG00000130595.12ENST00000453458.1,ENST00000381558.1,ENST00000381579.3,ENST00000381561.4,ENST00000278317.6,ENST00000381589.3,ENST00000381548.3,ENST00000381549.3,ENST00000381563.4,ENST00000360603.3,ENST00000397301.1,ENST00000344578.4
exon_skip_56048111944104:1944121:1944277:1944291:1946328:19463461944277:1944291ENSG00000130595.12ENST00000446240.1,ENST00000381557.2,ENST00000397304.2
exon_skip_56059111944277:1944291:1944784:1944802:1946328:19463461944784:1944802ENSG00000130595.12ENST00000381558.1,ENST00000381579.3,ENST00000381561.4,ENST00000278317.6,ENST00000381589.3,ENST00000381548.3,ENST00000381549.3,ENST00000381563.4,ENST00000360603.3,ENST00000397301.1,ENST00000344578.4
exon_skip_56060111944277:1944291:1944784:1944802:1951039:19510581944784:1944802ENSG00000130595.12ENST00000453458.1
exon_skip_56061111944277:1944291:1946328:1946346:1951039:19510581946328:1946346ENSG00000130595.12ENST00000446240.1,ENST00000397304.2
exon_skip_56064111944784:1944802:1946328:1946346:1947924:19479391946328:1946346ENSG00000130595.12ENST00000381558.1,ENST00000381579.3,ENST00000278317.6,ENST00000381549.3
exon_skip_56066111944784:1944802:1946328:1946346:1951039:19510581946328:1946346ENSG00000130595.12ENST00000344578.4
exon_skip_56077111946328:1946346:1946485:1946506:1947699:19477111946485:1946506ENSG00000130595.12ENST00000381589.3,ENST00000492075.1,ENST00000381563.4,ENST00000397301.1
exon_skip_56079111946328:1946346:1946485:1946506:1950349:19503731946485:1946506ENSG00000130595.12ENST00000381548.3
exon_skip_56080111946328:1946346:1946485:1946506:1951039:19510581946485:1946506ENSG00000130595.12ENST00000360603.3
exon_skip_56094111946328:1946346:1947924:1947939:1950349:19503731947924:1947939ENSG00000130595.12ENST00000278317.6
exon_skip_56095111946328:1946346:1947924:1947939:1951039:19510581947924:1947939ENSG00000130595.12ENST00000381558.1,ENST00000381579.3,ENST00000381557.2,ENST00000381549.3
exon_skip_56106111946328:1946346:1951039:1951058:1953698:19537441951039:1951058ENSG00000130595.12ENST00000446240.1,ENST00000344578.4,ENST00000397304.2
exon_skip_56113111946485:1946506:1947699:1947711:1947924:19479391947699:1947711ENSG00000130595.12ENST00000492075.1,ENST00000381563.4,ENST00000397301.1
exon_skip_56115111946485:1946506:1947699:1947711:1951039:19510581947699:1947711ENSG00000130595.12ENST00000381589.3
exon_skip_56120111946485:1946506:1950349:1950373:1951039:19510581950349:1950373ENSG00000130595.12ENST00000381548.3
exon_skip_56121111947699:1947711:1947924:1947939:1950349:19503731947924:1947939ENSG00000130595.12ENST00000397301.1
exon_skip_56122111947699:1947711:1947924:1947939:1951039:19510581947924:1947939ENSG00000130595.12ENST00000381563.4
exon_skip_56133111947699:1947711:1951039:1951058:1953698:19537441951039:1951058ENSG00000130595.12ENST00000381589.3
exon_skip_56136111947924:1947939:1950297:1950373:1951039:19510581950297:1950373ENSG00000130595.12ENST00000492075.1
exon_skip_56139111947924:1947939:1950349:1950373:1951039:19510581950349:1950373ENSG00000130595.12ENST00000278317.6,ENST00000397301.1
exon_skip_56142111947924:1947939:1951039:1951058:1953698:19537441951039:1951058ENSG00000130595.12ENST00000381558.1,ENST00000381579.3,ENST00000381557.2,ENST00000381549.3,ENST00000381563.4
exon_skip_56149111950349:1950373:1951039:1951058:1953698:19537441951039:1951058ENSG00000130595.12ENST00000278317.6,ENST00000381548.3,ENST00000492075.1,ENST00000397301.1
exon_skip_56154111951041:1951058:1953698:1953744:1954950:19550671953698:1953744ENSG00000130595.12ENST00000453458.1,ENST00000381558.1,ENST00000381579.3,ENST00000381561.4,ENST00000446240.1,ENST00000278317.6,ENST00000381557.2,ENST00000381589.3,ENST00000381548.3,ENST00000492075.1,ENST00000381549.3,ENST00000381563.4,ENST00000360603.3,ENST00000397301.1,ENS
exon_skip_56156111956058:1956149:1957443:1957484:1959667:19597221957443:1957484ENSG00000130595.12ENST00000381579.3,ENST00000446240.1,ENST00000360603.3
exon_skip_56158111956058:1956149:1958192:1958233:1959667:19597221958192:1958233ENSG00000130595.12ENST00000381558.1,ENST00000381561.4,ENST00000278317.6,ENST00000381557.2,ENST00000381589.3,ENST00000381548.3,ENST00000381549.3,ENST00000381563.4,ENST00000397301.1,ENST00000344578.4,ENST00000397304.2

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for TNNT3

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_56047111944104:1944121:1944277:1944291:1944784:19448021944277:1944291ENSG00000130595.12ENST00000278317.6,ENST00000381561.4,ENST00000381548.3,ENST00000360603.3,ENST00000381549.3,ENST00000453458.1,ENST00000381589.3,ENST00000381579.3,ENST00000381563.4,ENST00000344578.4,ENST00000381558.1,ENST00000397301.1
exon_skip_56048111944104:1944121:1944277:1944291:1946328:19463461944277:1944291ENSG00000130595.12ENST00000381557.2,ENST00000397304.2,ENST00000446240.1
exon_skip_56059111944277:1944291:1944784:1944802:1946328:19463461944784:1944802ENSG00000130595.12ENST00000278317.6,ENST00000381561.4,ENST00000381548.3,ENST00000360603.3,ENST00000381549.3,ENST00000381589.3,ENST00000381579.3,ENST00000381563.4,ENST00000344578.4,ENST00000381558.1,ENST00000397301.1
exon_skip_56060111944277:1944291:1944784:1944802:1951039:19510581944784:1944802ENSG00000130595.12ENST00000453458.1
exon_skip_56061111944277:1944291:1946328:1946346:1951039:19510581946328:1946346ENSG00000130595.12ENST00000397304.2,ENST00000446240.1
exon_skip_56064111944784:1944802:1946328:1946346:1947924:19479391946328:1946346ENSG00000130595.12ENST00000278317.6,ENST00000381549.3,ENST00000381579.3,ENST00000381558.1
exon_skip_56066111944784:1944802:1946328:1946346:1951039:19510581946328:1946346ENSG00000130595.12ENST00000344578.4
exon_skip_56077111946328:1946346:1946485:1946506:1947699:19477111946485:1946506ENSG00000130595.12ENST00000381589.3,ENST00000381563.4,ENST00000397301.1,ENST00000492075.1
exon_skip_56079111946328:1946346:1946485:1946506:1950349:19503731946485:1946506ENSG00000130595.12ENST00000381548.3
exon_skip_56080111946328:1946346:1946485:1946506:1951039:19510581946485:1946506ENSG00000130595.12ENST00000360603.3
exon_skip_56094111946328:1946346:1947924:1947939:1950349:19503731947924:1947939ENSG00000130595.12ENST00000278317.6
exon_skip_56095111946328:1946346:1947924:1947939:1951039:19510581947924:1947939ENSG00000130595.12ENST00000381549.3,ENST00000381557.2,ENST00000381579.3,ENST00000381558.1
exon_skip_56113111946485:1946506:1947699:1947711:1947924:19479391947699:1947711ENSG00000130595.12ENST00000381563.4,ENST00000397301.1,ENST00000492075.1
exon_skip_56115111946485:1946506:1947699:1947711:1951039:19510581947699:1947711ENSG00000130595.12ENST00000381589.3
exon_skip_56120111946485:1946506:1950349:1950373:1951039:19510581950349:1950373ENSG00000130595.12ENST00000381548.3
exon_skip_56121111947699:1947711:1947924:1947939:1950349:19503731947924:1947939ENSG00000130595.12ENST00000397301.1
exon_skip_56122111947699:1947711:1947924:1947939:1951039:19510581947924:1947939ENSG00000130595.12ENST00000381563.4
exon_skip_56133111947699:1947711:1951039:1951058:1953698:19537441951039:1951058ENSG00000130595.12ENST00000381589.3
exon_skip_56136111947924:1947939:1950297:1950373:1951039:19510581950297:1950373ENSG00000130595.12ENST00000492075.1
exon_skip_56139111947924:1947939:1950349:1950373:1951039:19510581950349:1950373ENSG00000130595.12ENST00000278317.6,ENST00000397301.1
exon_skip_56142111947924:1947939:1951039:1951058:1953698:19537441951039:1951058ENSG00000130595.12ENST00000381549.3,ENST00000381557.2,ENST00000381579.3,ENST00000381563.4,ENST00000381558.1
exon_skip_56149111950349:1950373:1951039:1951058:1953698:19537441951039:1951058ENSG00000130595.12ENST00000278317.6,ENST00000381548.3,ENST00000397301.1,ENST00000492075.1
exon_skip_56154111951041:1951058:1953698:1953744:1954950:19550671953698:1953744ENSG00000130595.12ENST00000278317.6,ENST00000381561.4,ENST00000381548.3,ENST00000360603.3,ENST00000381549.3,ENST00000453458.1,ENST00000381557.2,ENST00000381589.3,ENST00000381579.3,ENST00000381563.4,ENST00000344578.4,ENST00000381558.1,ENST00000397301.1,ENST00000397304.2,ENS
exon_skip_56156111956058:1956149:1957443:1957484:1959667:19597221957443:1957484ENSG00000130595.12ENST00000360603.3,ENST00000381579.3,ENST00000446240.1
exon_skip_56158111956058:1956149:1958192:1958233:1959667:19597221958192:1958233ENSG00000130595.12ENST00000278317.6,ENST00000381561.4,ENST00000381548.3,ENST00000381549.3,ENST00000381557.2,ENST00000381589.3,ENST00000381563.4,ENST00000344578.4,ENST00000381558.1,ENST00000397301.1,ENST00000397304.2

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for TNNT3

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000039730119442771944291Frame-shift
ENST0000039730119510391951058Frame-shift
ENST0000039730119536981953744Frame-shift
ENST0000039730119581921958233Frame-shift
ENST0000039730119447841944802In-frame
ENST0000039730119464851946506In-frame
ENST0000039730119476991947711In-frame
ENST0000039730119479241947939In-frame
ENST0000039730119503491950373In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000039730119442771944291Frame-shift
ENST0000039730119510391951058Frame-shift
ENST0000039730119536981953744Frame-shift
ENST0000039730119581921958233Frame-shift
ENST0000039730119447841944802In-frame
ENST0000039730119464851946506In-frame
ENST0000039730119476991947711In-frame
ENST0000039730119479241947939In-frame
ENST0000039730119503491950373In-frame

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Infer the effects of exon skipping event on protein functional features for TNNT3

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


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SNVs in the skipped exons for TNNT3

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A3A0-01exon_skip_56154
1953699195374419537241953724Frame_Shift_DelG-p.G43fs
LUADTCGA-44-3918-01exon_skip_56154
1953699195374419537271953727Nonsense_MutationGTp.E44*
BRCATCGA-BH-A0WA-01exon_skip_56120
exon_skip_56139
1950350195037319503491950349Splice_SiteGAe6-1

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
NCIH1155_LUNG1953699195374419537421953742Missense_MutationGTp.D68Y
MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE1944785194480219447861944786Splice_SiteGTp.E11D
DIFI_LARGE_INTESTINE1946486194650619465061946506Splice_SiteGTp.V30F

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TNNT3

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TNNT3


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TNNT3


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RelatedDrugs for TNNT3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TNNT3

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
TNNT3C1834523ARTHROGRYPOSIS, DISTAL, TYPE 2B1CTD_human;ORPHANET;UNIPROT