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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for KLF10 |
 Gene summary |
| Gene information | Gene symbol | KLF10 | Gene ID | 7071 |
| Gene name | Kruppel like factor 10 | |
| Synonyms | EGR-alpha|EGRA|TIEG|TIEG1 | |
| Cytomap | 8q22.3 | |
| Type of gene | protein-coding | |
| Description | Krueppel-like factor 10TGFB-inducible early growth response protein 1early growth response-alphatransforming growth factor-beta-inducible early growth response protein 1zinc finger transcription factor TIEG | |
| Modification date | 20180523 | |
| UniProtAcc | Q13118 | |
| Context | PubMed: KLF10 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| KLF10 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15087465 |
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Exon skipping events across known transcript of Ensembl for KLF10 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for KLF10 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for KLF10 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_491709 | 8 | 103661013:103662619:103663376:103664289:103664391:103664625 | 103663376:103664289 | ENSG00000155090.10 | ENST00000395884.3,ENST00000285407.6 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for KLF10 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_491709 | 8 | 103661013:103662619:103663376:103664289:103664391:103664625 | 103663376:103664289 | ENSG00000155090.10 | ENST00000285407.6,ENST00000395884.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for KLF10 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000285407 | 103663376 | 103664289 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000285407 | 103663376 | 103664289 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for KLF10 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for KLF10 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| STAD | TCGA-HU-A4GX-01 | exon_skip_491709 | 103663377 | 103664289 | 103663533 | 103663534 | Frame_Shift_Del | GA | - | p.343_343del |
| STAD | TCGA-HU-A4GX-01 | exon_skip_491709 | 103663377 | 103664289 | 103663533 | 103663534 | Frame_Shift_Del | GA | - | p.P343fs |
| LIHC | TCGA-DD-A3A1-01 | exon_skip_491709 | 103663377 | 103664289 | 103663811 | 103663811 | Frame_Shift_Del | G | - | p.P239fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_491709 | 103663377 | 103664289 | 103663811 | 103663811 | Frame_Shift_Del | G | - | p.P239fs |
| STAD | TCGA-MX-A5UJ-01 | exon_skip_491709 | 103663377 | 103664289 | 103663648 | 103663649 | Frame_Shift_Ins | - | G | p.P304fs |
| STAD | TCGA-MX-A5UJ-01 | exon_skip_491709 | 103663377 | 103664289 | 103663648 | 103663649 | Frame_Shift_Ins | - | G | p.R293fs |
| BLCA | TCGA-ZF-A9R7-01 | exon_skip_491709 | 103663377 | 103664289 | 103663469 | 103663469 | Nonsense_Mutation | G | C | p.S353* |
| ESCA | TCGA-VR-A8EW-01 | exon_skip_491709 | 103663377 | 103664289 | 103663830 | 103663830 | Nonsense_Mutation | G | A | p.Q233* |
| ESCA | TCGA-VR-A8EW-01 | exon_skip_491709 | 103663377 | 103664289 | 103663830 | 103663830 | Nonsense_Mutation | G | A | p.Q244* |
| ESCA | TCGA-VR-A8EW-01 | exon_skip_491709 | 103663377 | 103664289 | 103663830 | 103663830 | Nonsense_Mutation | G | A | p.Q244X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| RKO_LARGE_INTESTINE | 103663377 | 103664289 | 103663649 | 103663649 | Frame_Shift_Del | G | - | p.P304fs |
| 253J_URINARY_TRACT | 103663377 | 103664289 | 103663389 | 103663389 | Missense_Mutation | T | C | p.R391G |
| 253JBV_URINARY_TRACT | 103663377 | 103664289 | 103663389 | 103663389 | Missense_Mutation | T | C | p.R391G |
| BC3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 103663377 | 103664289 | 103663482 | 103663482 | Missense_Mutation | G | C | p.Q360E |
| HS695T_SKIN | 103663377 | 103664289 | 103663619 | 103663619 | Missense_Mutation | T | C | p.K314R |
| BHT101_THYROID | 103663377 | 103664289 | 103663619 | 103663619 | Missense_Mutation | T | C | p.K314R |
| PANC1005_PANCREAS | 103663377 | 103664289 | 103663649 | 103663649 | Missense_Mutation | G | T | p.P304H |
| SISO_CERVIX | 103663377 | 103664289 | 103663655 | 103663655 | Missense_Mutation | C | T | p.C302Y |
| GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 103663377 | 103664289 | 103663655 | 103663655 | Missense_Mutation | C | T | p.C302Y |
| P3HR1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 103663377 | 103664289 | 103663694 | 103663694 | Missense_Mutation | A | T | p.V289D |
| CS1_BONE | 103663377 | 103664289 | 103663746 | 103663746 | Missense_Mutation | C | A | p.V272F |
| RL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 103663377 | 103664289 | 103663746 | 103663746 | Missense_Mutation | C | G | p.V272L |
| SNGM_ENDOMETRIUM | 103663377 | 103664289 | 103663838 | 103663838 | Missense_Mutation | C | T | p.C241Y |
| HEC1A_ENDOMETRIUM | 103663377 | 103664289 | 103663890 | 103663890 | Missense_Mutation | C | T | p.A224T |
| HEC1_ENDOMETRIUM | 103663377 | 103664289 | 103663890 | 103663890 | Missense_Mutation | C | T | p.A224T |
| HEC1B_ENDOMETRIUM | 103663377 | 103664289 | 103663890 | 103663890 | Missense_Mutation | C | T | p.A224T |
| CCLFPEDS0018T_SOFT_TISSUE | 103663377 | 103664289 | 103663911 | 103663911 | Missense_Mutation | C | T | p.V217M |
| COLO824_BREAST | 103663377 | 103664289 | 103663952 | 103663952 | Missense_Mutation | G | A | p.A203V |
| 639V_URINARY_TRACT | 103663377 | 103664289 | 103663964 | 103663964 | Missense_Mutation | T | G | p.N199T |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 103663377 | 103664289 | 103663970 | 103663970 | Missense_Mutation | C | A | p.R197I |
| NCIH2009_LUNG | 103663377 | 103664289 | 103663980 | 103663980 | Missense_Mutation | C | T | p.E194K |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 103663377 | 103664289 | 103664192 | 103664192 | Missense_Mutation | G | A | p.S123L |
| BHY_UPPER_AERODIGESTIVE_TRACT | 103663377 | 103664289 | 103664276 | 103664276 | Missense_Mutation | G | T | p.P95H |
| HEC265_ENDOMETRIUM | 103663377 | 103664289 | 103664282 | 103664282 | Missense_Mutation | G | T | p.T93N |
| MC116_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 103663377 | 103664289 | 103664284 | 103664284 | Missense_Mutation | C | G | p.L92F |
| LC1F_LUNG | 103663377 | 103664289 | 103663482 | 103663482 | Nonsense_Mutation | G | A | p.Q360* |
| CW2_LARGE_INTESTINE | 103663377 | 103664289 | 103663737 | 103663737 | Nonsense_Mutation | G | A | p.Q275* |
| ONS76_CENTRAL_NERVOUS_SYSTEM | 103663377 | 103664289 | 103664247 | 103664247 | Nonsense_Mutation | G | A | p.Q105* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for KLF10 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for KLF10 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for KLF10 |
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RelatedDrugs for KLF10 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KLF10 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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