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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TFDP2 |
 Gene summary |
| Gene information | Gene symbol | TFDP2 | Gene ID | 7029 |
| Gene name | transcription factor Dp-2 | |
| Synonyms | DP2 | |
| Cytomap | 3q23 | |
| Type of gene | protein-coding | |
| Description | transcription factor Dp-2transcription factor Dp-2 (E2F dimerization partner 2) | |
| Modification date | 20180523 | |
| UniProtAcc | Q14188 | |
| Context | PubMed: TFDP2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TFDP2 | GO:0045892 | negative regulation of transcription, DNA-templated | 20176812 |
| TFDP2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7739537 |
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Exon skipping events across known transcript of Ensembl for TFDP2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TFDP2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TFDP2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_389022 | 3 | 141671344:141671538:141671752:141671858:141678515:141678682 | 141671752:141671858 | ENSG00000114126.13 | ENST00000487734.1,ENST00000499676.2,ENST00000397991.4,ENST00000317104.7,ENST00000489671.1,ENST00000467072.1,ENST00000479040.1,ENST00000486111.1,ENST00000495310.1,ENST00000310282.6,ENST00000477292.1 |
| exon_skip_389023 | 3 | 141678641:141678682:141682653:141682805:141688914:141688983 | 141682653:141682805 | ENSG00000114126.13 | ENST00000487734.1,ENST00000499676.2,ENST00000397991.4,ENST00000317104.7,ENST00000489671.1,ENST00000467072.1,ENST00000479040.1,ENST00000486111.1,ENST00000495310.1,ENST00000310282.6,ENST00000467667.1,ENST00000477292.1 |
| exon_skip_389025 | 3 | 141682693:141682805:141688914:141688983:141692889:141693033 | 141688914:141688983 | ENSG00000114126.13 | ENST00000487734.1,ENST00000499676.2,ENST00000397991.4,ENST00000317104.7,ENST00000489671.1,ENST00000467072.1,ENST00000478006.1,ENST00000479040.1,ENST00000497579.1,ENST00000486111.1,ENST00000495310.1,ENST00000310282.6,ENST00000467667.1,ENST00000477292.1 |
| exon_skip_389026 | 3 | 141697429:141697524:141712379:141712427:141713861:141713983 | 141712379:141712427 | ENSG00000114126.13 | ENST00000487734.1,ENST00000499676.2,ENST00000492919.1,ENST00000397991.4,ENST00000489671.1,ENST00000467072.1,ENST00000478006.1,ENST00000479040.1,ENST00000497579.1,ENST00000486111.1,ENST00000488107.2,ENST00000310282.6,ENST00000467667.1 |
| exon_skip_389027 | 3 | 141697429:141697524:141712379:141712427:141724282:141724311 | 141712379:141712427 | ENSG00000114126.13 | ENST00000495310.1 |
| exon_skip_389030 | 3 | 141697429:141697524:141713861:141713983:141724282:141724311 | 141713861:141713983 | ENSG00000114126.13 | ENST00000317104.7 |
| exon_skip_389039 | 3 | 141712414:141712427:141713861:141713983:141724282:141724311 | 141713861:141713983 | ENSG00000114126.13 | ENST00000499676.2,ENST00000489671.1,ENST00000467072.1,ENST00000479040.1,ENST00000497579.1,ENST00000486111.1,ENST00000488107.2,ENST00000475734.1,ENST00000310282.6,ENST00000467667.1 |
| exon_skip_389040 | 3 | 141712414:141712427:141713861:141713983:141747420:141747439 | 141713861:141713983 | ENSG00000114126.13 | ENST00000478006.1 |
| exon_skip_389042 | 3 | 141712414:141712427:141724282:141724386:141747420:141747439 | 141724282:141724386 | ENSG00000114126.13 | ENST00000495310.1 |
| exon_skip_389044 | 3 | 141713937:141713983:141719093:141719196:141724282:141724311 | 141719093:141719196 | ENSG00000114126.13 | ENST00000487734.1 |
| exon_skip_389046 | 3 | 141713937:141713983:141724282:141724386:141747420:141747439 | 141724282:141724386 | ENSG00000114126.13 | ENST00000471095.1,ENST00000486111.1,ENST00000467667.1 |
| exon_skip_389047 | 3 | 141713937:141713983:141724282:141724386:141772956:141772991 | 141724282:141724386 | ENSG00000114126.13 | ENST00000317104.7,ENST00000467072.1 |
| exon_skip_389048 | 3 | 141713937:141713983:141724282:141724386:141811902:141811969 | 141724282:141724386 | ENSG00000114126.13 | ENST00000489671.1,ENST00000467634.1 |
| exon_skip_389049 | 3 | 141713937:141713983:141724282:141724386:141868024:141868302 | 141724282:141724386 | ENSG00000114126.13 | ENST00000475734.1 |
| exon_skip_389055 | 3 | 141724282:141724386:141772956:141772991:141811902:141811969 | 141772956:141772991 | ENSG00000114126.13 | ENST00000317104.7,ENST00000467072.1 |
| exon_skip_389057 | 3 | 141724282:141724386:141772956:141772991:141868024:141868379 | 141772956:141772991 | ENSG00000114126.13 | ENST00000464782.1 |
| exon_skip_389058 | 3 | 141724282:141724386:141811867:141811969:141820576:141820599 | 141811867:141811969 | ENSG00000114126.13 | ENST00000499676.2 |
| exon_skip_389060 | 3 | 141724282:141724386:141811902:141811969:141820576:141820599 | 141811902:141811969 | ENSG00000114126.13 | ENST00000487734.1,ENST00000476617.1,ENST00000489671.1,ENST00000467634.1 |
| exon_skip_389062 | 3 | 141724282:141724386:141820576:141820683:141868024:141868302 | 141820576:141820683 | ENSG00000114126.13 | ENST00000494358.1 |
| exon_skip_389064 | 3 | 141772956:141772991:141811902:141811969:141820576:141820599 | 141811902:141811969 | ENSG00000114126.13 | ENST00000317104.7,ENST00000467072.1 |
| exon_skip_389069 | 3 | 141811902:141811969:141820576:141820683:141868024:141868302 | 141820576:141820683 | ENSG00000114126.13 | ENST00000476617.1,ENST00000317104.7,ENST00000489671.1,ENST00000491667.1,ENST00000467072.1,ENST00000495095.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TFDP2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_389022 | 3 | 141671344:141671538:141671752:141671858:141678515:141678682 | 141671752:141671858 | ENSG00000114126.13 | ENST00000499676.2,ENST00000489671.1,ENST00000486111.1,ENST00000477292.1,ENST00000495310.1,ENST00000467072.1,ENST00000317104.7,ENST00000310282.6,ENST00000479040.1,ENST00000487734.1,ENST00000397991.4 |
| exon_skip_389023 | 3 | 141678641:141678682:141682653:141682805:141688914:141688983 | 141682653:141682805 | ENSG00000114126.13 | ENST00000499676.2,ENST00000489671.1,ENST00000486111.1,ENST00000477292.1,ENST00000495310.1,ENST00000467072.1,ENST00000317104.7,ENST00000310282.6,ENST00000479040.1,ENST00000487734.1,ENST00000397991.4,ENST00000467667.1 |
| exon_skip_389025 | 3 | 141682693:141682805:141688914:141688983:141692889:141693033 | 141688914:141688983 | ENSG00000114126.13 | ENST00000499676.2,ENST00000489671.1,ENST00000486111.1,ENST00000477292.1,ENST00000495310.1,ENST00000467072.1,ENST00000317104.7,ENST00000310282.6,ENST00000479040.1,ENST00000487734.1,ENST00000397991.4,ENST00000467667.1,ENST00000478006.1,ENST00000497579.1 |
| exon_skip_389026 | 3 | 141697429:141697524:141712379:141712427:141713861:141713983 | 141712379:141712427 | ENSG00000114126.13 | ENST00000499676.2,ENST00000489671.1,ENST00000486111.1,ENST00000467072.1,ENST00000310282.6,ENST00000479040.1,ENST00000487734.1,ENST00000397991.4,ENST00000467667.1,ENST00000478006.1,ENST00000497579.1,ENST00000492919.1,ENST00000488107.2 |
| exon_skip_389027 | 3 | 141697429:141697524:141712379:141712427:141724282:141724311 | 141712379:141712427 | ENSG00000114126.13 | ENST00000495310.1 |
| exon_skip_389030 | 3 | 141697429:141697524:141713861:141713983:141724282:141724311 | 141713861:141713983 | ENSG00000114126.13 | ENST00000317104.7 |
| exon_skip_389039 | 3 | 141712414:141712427:141713861:141713983:141724282:141724311 | 141713861:141713983 | ENSG00000114126.13 | ENST00000499676.2,ENST00000489671.1,ENST00000486111.1,ENST00000467072.1,ENST00000310282.6,ENST00000479040.1,ENST00000467667.1,ENST00000497579.1,ENST00000488107.2,ENST00000475734.1 |
| exon_skip_389040 | 3 | 141712414:141712427:141713861:141713983:141747420:141747439 | 141713861:141713983 | ENSG00000114126.13 | ENST00000478006.1 |
| exon_skip_389042 | 3 | 141712414:141712427:141724282:141724386:141747420:141747439 | 141724282:141724386 | ENSG00000114126.13 | ENST00000495310.1 |
| exon_skip_389044 | 3 | 141713937:141713983:141719093:141719196:141724282:141724311 | 141719093:141719196 | ENSG00000114126.13 | ENST00000487734.1 |
| exon_skip_389046 | 3 | 141713937:141713983:141724282:141724386:141747420:141747439 | 141724282:141724386 | ENSG00000114126.13 | ENST00000486111.1,ENST00000467667.1,ENST00000471095.1 |
| exon_skip_389047 | 3 | 141713937:141713983:141724282:141724386:141772956:141772991 | 141724282:141724386 | ENSG00000114126.13 | ENST00000467072.1,ENST00000317104.7 |
| exon_skip_389048 | 3 | 141713937:141713983:141724282:141724386:141811902:141811969 | 141724282:141724386 | ENSG00000114126.13 | ENST00000489671.1,ENST00000467634.1 |
| exon_skip_389049 | 3 | 141713937:141713983:141724282:141724386:141868024:141868302 | 141724282:141724386 | ENSG00000114126.13 | ENST00000475734.1 |
| exon_skip_389055 | 3 | 141724282:141724386:141772956:141772991:141811902:141811969 | 141772956:141772991 | ENSG00000114126.13 | ENST00000467072.1,ENST00000317104.7 |
| exon_skip_389057 | 3 | 141724282:141724386:141772956:141772991:141868024:141868379 | 141772956:141772991 | ENSG00000114126.13 | ENST00000464782.1 |
| exon_skip_389058 | 3 | 141724282:141724386:141811867:141811969:141820576:141820599 | 141811867:141811969 | ENSG00000114126.13 | ENST00000499676.2 |
| exon_skip_389060 | 3 | 141724282:141724386:141811902:141811969:141820576:141820599 | 141811902:141811969 | ENSG00000114126.13 | ENST00000489671.1,ENST00000487734.1,ENST00000467634.1,ENST00000476617.1 |
| exon_skip_389062 | 3 | 141724282:141724386:141820576:141820683:141868024:141868302 | 141820576:141820683 | ENSG00000114126.13 | ENST00000494358.1 |
| exon_skip_389064 | 3 | 141772956:141772991:141811902:141811969:141820576:141820599 | 141811902:141811969 | ENSG00000114126.13 | ENST00000467072.1,ENST00000317104.7 |
| exon_skip_389069 | 3 | 141811902:141811969:141820576:141820683:141868024:141868302 | 141820576:141820683 | ENSG00000114126.13 | ENST00000489671.1,ENST00000467072.1,ENST00000317104.7,ENST00000495095.2,ENST00000476617.1,ENST00000491667.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TFDP2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000489671 | 141820576 | 141820683 | 3UTR-3CDS |
| ENST00000489671 | 141671752 | 141671858 | Frame-shift |
| ENST00000489671 | 141682653 | 141682805 | Frame-shift |
| ENST00000489671 | 141713861 | 141713983 | Frame-shift |
| ENST00000489671 | 141724282 | 141724386 | Frame-shift |
| ENST00000489671 | 141811902 | 141811969 | Frame-shift |
| ENST00000489671 | 141688914 | 141688983 | In-frame |
| ENST00000489671 | 141712379 | 141712427 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000489671 | 141820576 | 141820683 | 3UTR-3CDS |
| ENST00000489671 | 141671752 | 141671858 | Frame-shift |
| ENST00000489671 | 141682653 | 141682805 | Frame-shift |
| ENST00000489671 | 141713861 | 141713983 | Frame-shift |
| ENST00000489671 | 141724282 | 141724386 | Frame-shift |
| ENST00000489671 | 141811902 | 141811969 | Frame-shift |
| ENST00000489671 | 141688914 | 141688983 | In-frame |
| ENST00000489671 | 141712379 | 141712427 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TFDP2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000489671 | 3155 | 446 | 141712379 | 141712427 | 740 | 787 | 103 | 118 |
| ENST00000489671 | 3155 | 446 | 141688914 | 141688983 | 1095 | 1163 | 221 | 244 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000489671 | 3155 | 446 | 141712379 | 141712427 | 740 | 787 | 103 | 118 |
| ENST00000489671 | 3155 | 446 | 141688914 | 141688983 | 1095 | 1163 | 221 | 244 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for TFDP2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| KIRC | TCGA-B0-5075-01 | exon_skip_389022 | 141671753 | 141671858 | 141671843 | 141671843 | Frame_Shift_Del | G | - | p.P296fs |
| KIRC | TCGA-B0-5075-01 | exon_skip_389022 | 141671753 | 141671858 | 141671843 | 141671843 | Frame_Shift_Del | G | - | p.P356fs |
| HNSC | TCGA-CR-7370-01 | exon_skip_389023 | 141682654 | 141682805 | 141682777 | 141682777 | Frame_Shift_Del | C | - | p.R194fs |
| HNSC | TCGA-CR-7370-01 | exon_skip_389023 | 141682654 | 141682805 | 141682777 | 141682777 | Frame_Shift_Del | C | - | p.R254fs |
| LUAD | TCGA-17-Z022-01 | exon_skip_389027 exon_skip_389026 | 141712380 | 141712427 | 141712394 | 141712395 | Frame_Shift_Del | AG | - | p.S53fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_389042 exon_skip_389048 exon_skip_389047 exon_skip_389046 exon_skip_389049 | 141724283 | 141724386 | 141724285 | 141724285 | Frame_Shift_Del | T | - | p.M62fs |
| STAD | TCGA-F1-6874-01 | exon_skip_389042 exon_skip_389048 exon_skip_389047 exon_skip_389046 exon_skip_389049 | 141724283 | 141724386 | 141724321 | 141724321 | Frame_Shift_Del | T | - | p.T50fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_389042 exon_skip_389048 exon_skip_389047 exon_skip_389046 exon_skip_389049 | 141724283 | 141724386 | 141724328 | 141724328 | Frame_Shift_Del | T | - | p.L47fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_389042 exon_skip_389048 exon_skip_389047 exon_skip_389046 exon_skip_389049 | 141724283 | 141724386 | 141724329 | 141724329 | Frame_Shift_Del | A | - | p.L47fs |
| LUSC | TCGA-18-3421-01 | exon_skip_389023 | 141682654 | 141682805 | 141682763 | 141682763 | Nonsense_Mutation | C | A | p.E259* |
| STAD | TCGA-FP-A4BE-01 | exon_skip_389023 | 141682654 | 141682805 | 141682772 | 141682772 | Nonsense_Mutation | G | A | p.R256* |
| STAD | TCGA-FP-A4BE-01 | exon_skip_389023 | 141682654 | 141682805 | 141682772 | 141682772 | Nonsense_Mutation | G | A | p.R256X |
| BRCA | TCGA-BH-A0HP-01 | exon_skip_389022 | 141671753 | 141671858 | 141671859 | 141671859 | Splice_Site | C | G | e9-1 |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| GP2D_LARGE_INTESTINE | 141671753 | 141671858 | 141671769 | 141671769 | Missense_Mutation | T | C | p.T381A |
| GP5D_LARGE_INTESTINE | 141671753 | 141671858 | 141671769 | 141671769 | Missense_Mutation | T | C | p.T381A |
| SNU8_OVARY | 141682654 | 141682805 | 141682663 | 141682663 | Missense_Mutation | G | C | p.S292C |
| L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 141682654 | 141682805 | 141682702 | 141682702 | Missense_Mutation | A | G | p.I279T |
| OELE_OVARY | 141682654 | 141682805 | 141682727 | 141682727 | Missense_Mutation | T | C | p.T271A |
| SNU175_LARGE_INTESTINE | 141682654 | 141682805 | 141682799 | 141682799 | Missense_Mutation | C | T | p.A247T |
| SNU175_LARGE_INTESTINE | 141688915 | 141688983 | 141688920 | 141688920 | Missense_Mutation | G | T | p.L243I |
| EWS834_BONE | 141688915 | 141688983 | 141688956 | 141688956 | Missense_Mutation | T | A | p.I231L |
| HEC108_ENDOMETRIUM | 141688915 | 141688983 | 141688979 | 141688979 | Missense_Mutation | T | C | p.E223G |
| KP1N_PANCREAS | 141713862 | 141713983 | 141713976 | 141713976 | Missense_Mutation | C | A | p.S65I |
| SNGM_ENDOMETRIUM | 141724283 | 141724386 | 141724323 | 141724323 | Missense_Mutation | T | C | p.K49R |
| HPBALL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 141724283 | 141724386 | 141724383 | 141724383 | Missense_Mutation | T | C | p.N29S |
| GP2D_LARGE_INTESTINE | 141820577 | 141820683 | 141820587 | 141820587 | Missense_Mutation | G | A | p.T2M |
| TT_THYROID | 141682654 | 141682805 | 141682772 | 141682772 | Nonsense_Mutation | G | A | p.R256* |
| T3M10_LUNG | 141671753 | 141671858 | 141671858 | 141671858 | Splice_Site | T | C | p.D351G |
| SBC3_LUNG | 141811868 | 141811969 | 141811969 | 141811969 | Splice_Site | C | A | p.V6F |
| SBC3_LUNG | 141811903 | 141811969 | 141811969 | 141811969 | Splice_Site | C | A | p.V6F |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TFDP2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TFDP2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TFDP2 |
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RelatedDrugs for TFDP2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TFDP2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TFDP2 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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