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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for TEK

check button Gene summary
Gene informationGene symbol

TEK

Gene ID

7010

Gene nameTEK receptor tyrosine kinase
SynonymsCD202B|GLC3E|TIE-2|TIE2|VMCM|VMCM1
Cytomap

9p21.2

Type of geneprotein-coding
Descriptionangiopoietin-1 receptorTEK tyrosine kinase, endothelialendothelial tyrosine kinasetunica interna endothelial cell kinasetyrosine kinase with Ig and EGF homology domains-2tyrosine-protein kinase receptor TEKtyrosine-protein kinase receptor TIE-2
Modification date20180525
UniProtAcc

Q02763

ContextPubMed: TEK [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
TEK

GO:0001934

positive regulation of protein phosphorylation

15284220

TEK

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

15284220

TEK

GO:0010595

positive regulation of endothelial cell migration

15284220

TEK

GO:0018108

peptidyl-tyrosine phosphorylation

11513602

TEK

GO:0045766

positive regulation of angiogenesis

15284220

TEK

GO:0046777

protein autophosphorylation

11513602

TEK

GO:0048014

Tie signaling pathway

15284220|19223473

TEK

GO:0051259

protein complex oligomerization

19424712

TEK

GO:0051897

positive regulation of protein kinase B signaling

19615361

TEK

GO:0070374

positive regulation of ERK1 and ERK2 cascade

19615361


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Exon skipping events across known transcript of Ensembl for TEK from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for TEK

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for TEK

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_495314927109138:27109640:27157828:27158140:27168492:2716860327157828:27158140ENSG00000120156.16ENST00000406359.4,ENST00000380036.4
exon_skip_495316927157828:27158140:27168492:27168603:27169474:2716962727168492:27168603ENSG00000120156.16ENST00000406359.4,ENST00000380036.4
exon_skip_495320927173219:27173360:27180237:27180366:27183456:2718360827180237:27180366ENSG00000120156.16ENST00000380036.4
exon_skip_495322927185482:27185627:27190526:27190688:27192486:2719262127190526:27190688ENSG00000120156.16ENST00000406359.4,ENST00000519080.1,ENST00000519097.1,ENST00000380036.4
exon_skip_495326927217685:27217756:27218774:27218815:27220046:2722014327218774:27218815ENSG00000120156.16ENST00000406359.4,ENST00000519097.1,ENST00000380036.4
exon_skip_495330927218774:27218815:27220046:27220143:27228203:2722830327220046:27220143ENSG00000120156.16ENST00000406359.4,ENST00000519097.1,ENST00000380036.4

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for TEK

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_495314927109138:27109640:27157828:27158140:27168492:2716860327157828:27158140ENSG00000120156.16ENST00000380036.4,ENST00000406359.4
exon_skip_495316927157828:27158140:27168492:27168603:27169474:2716962727168492:27168603ENSG00000120156.16ENST00000380036.4,ENST00000406359.4
exon_skip_495320927173219:27173360:27180237:27180366:27183456:2718360827180237:27180366ENSG00000120156.16ENST00000380036.4
exon_skip_495322927185482:27185627:27190526:27190688:27192486:2719262127190526:27190688ENSG00000120156.16ENST00000519097.1,ENST00000380036.4,ENST00000406359.4,ENST00000519080.1
exon_skip_495325927204908:27205063:27206579:27206790:27209118:2720922927206579:27206790ENSG00000120156.16ENST00000380036.4,ENST00000406359.4
exon_skip_495326927217685:27217756:27218774:27218815:27220046:2722014327218774:27218815ENSG00000120156.16ENST00000519097.1,ENST00000380036.4,ENST00000406359.4
exon_skip_495330927218774:27218815:27220046:27220143:27228203:2722830327220046:27220143ENSG00000120156.16ENST00000519097.1,ENST00000380036.4,ENST00000406359.4

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for TEK

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003800362721877427218815Frame-shift
ENST000003800362722004627220143Frame-shift
ENST000003800362715782827158140In-frame
ENST000003800362716849227168603In-frame
ENST000003800362718023727180366In-frame
ENST000003800362719052627190688In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003800362720657927206790Frame-shift
ENST000003800362721877427218815Frame-shift
ENST000003800362722004627220143Frame-shift
ENST000003800362715782827158140In-frame
ENST000003800362716849227168603In-frame
ENST000003800362718023727180366In-frame
ENST000003800362719052627190688In-frame

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Infer the effects of exon skipping event on protein functional features for TEK

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000038003647771124271578282715814049580617121
ENST00000380036477711242716849227168603807917121158
ENST0000038003647771124271802372718036613441472300343
ENST0000038003647771124271905262719068817701931442496

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000038003647771124271578282715814049580617121
ENST00000380036477711242716849227168603807917121158
ENST0000038003647771124271802372718036613441472300343
ENST0000038003647771124271905262719068817701931442496

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q027631712118121Alternative sequenceID=VSP_042137;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q02763171212629Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763171213335Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763171214046Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763171215659Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763171216466Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763171217476Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763171218088Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q027631712198106Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q0276317121109119Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q0276317121231124ChainID=PRO_0000024474;Note=Angiopoietin-1 receptor
Q027631712144102Disulfide bondOntology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16732286;Dbxref=PMID:16732286
Q027631712144123DomainNote=Ig-like C2-type 1
Q027631712119210Natural variantID=VAR_078045;Note=In GLC3E%3B formation of protein aggregates. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27270174;Dbxref=PMID:27270174
Q0276317121117117Natural variantID=VAR_035714;Note=In breast cancer samples%3B infiltrating ductal carcinoma%3B somatic mutation. K->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16959974,ECO:0000269|PubMed:17344846;Dbxref=PMID:16959974,PMID:17344846
Q0276317121122Signal peptideOntology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340161;Dbxref=PMID:15340161
Q027631712123748Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q02763171216163TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q0276312115818121Alternative sequenceID=VSP_042137;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q02763121158123125Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763121158127133Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763121158139145Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763121158153157Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763121158231124ChainID=PRO_0000024474;Note=Angiopoietin-1 receptor
Q0276312115844123DomainNote=Ig-like C2-type 1
Q02763121158140140GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16732286;Dbxref=PMID:16732286
Q02763121158158158GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q0276312115819210Natural variantID=VAR_078045;Note=In GLC3E%3B formation of protein aggregates. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27270174;Dbxref=PMID:27270174
Q02763121158148148Natural variantID=VAR_041855;Note=I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35969327,PMID:17344846
Q0276312115823748Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q02763300343300342Alternative sequenceID=VSP_042138;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q02763300343322324Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763300343328330Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763300343231124ChainID=PRO_0000024474;Note=Angiopoietin-1 receptor
Q02763300343302311Disulfide bondOntology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16732286;Dbxref=PMID:16732286
Q02763300343315323Disulfide bondOntology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16732286;Dbxref=PMID:16732286
Q02763300343317329Disulfide bondOntology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16732286;Dbxref=PMID:16732286
Q02763300343331340Disulfide bondOntology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16732286;Dbxref=PMID:16732286
Q02763300343301341DomainNote=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
Q0276330034323748Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q02763300343325327TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763442496446449Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UTK
Q02763442496452456Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UTK
Q02763442496461464Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UTK
Q02763442496469472Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UTK
Q02763442496476485Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UTK
Q02763442496493504Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UTK
Q02763442496231124ChainID=PRO_0000024474;Note=Angiopoietin-1 receptor
Q02763442496447541DomainNote=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
Q02763442496464464GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q02763442496486486Natural variantID=VAR_024578;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1334811,PMID:17344846
Q0276344249623748Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q027631712118121Alternative sequenceID=VSP_042137;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q02763171212629Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763171213335Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763171214046Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763171215659Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763171216466Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763171217476Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763171218088Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q027631712198106Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q0276317121109119Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q0276317121231124ChainID=PRO_0000024474;Note=Angiopoietin-1 receptor
Q027631712144102Disulfide bondOntology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16732286;Dbxref=PMID:16732286
Q027631712144123DomainNote=Ig-like C2-type 1
Q027631712119210Natural variantID=VAR_078045;Note=In GLC3E%3B formation of protein aggregates. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27270174;Dbxref=PMID:27270174
Q0276317121117117Natural variantID=VAR_035714;Note=In breast cancer samples%3B infiltrating ductal carcinoma%3B somatic mutation. K->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16959974,ECO:0000269|PubMed:17344846;Dbxref=PMID:16959974,PMID:17344846
Q0276317121122Signal peptideOntology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15340161;Dbxref=PMID:15340161
Q027631712123748Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q02763171216163TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q0276312115818121Alternative sequenceID=VSP_042137;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q02763121158123125Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763121158127133Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763121158139145Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763121158153157Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763121158231124ChainID=PRO_0000024474;Note=Angiopoietin-1 receptor
Q0276312115844123DomainNote=Ig-like C2-type 1
Q02763121158140140GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16732286;Dbxref=PMID:16732286
Q02763121158158158GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q0276312115819210Natural variantID=VAR_078045;Note=In GLC3E%3B formation of protein aggregates. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27270174;Dbxref=PMID:27270174
Q02763121158148148Natural variantID=VAR_041855;Note=I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35969327,PMID:17344846
Q0276312115823748Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q02763300343300342Alternative sequenceID=VSP_042138;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q02763300343322324Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763300343328330Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763300343231124ChainID=PRO_0000024474;Note=Angiopoietin-1 receptor
Q02763300343302311Disulfide bondOntology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16732286;Dbxref=PMID:16732286
Q02763300343315323Disulfide bondOntology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16732286;Dbxref=PMID:16732286
Q02763300343317329Disulfide bondOntology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16732286;Dbxref=PMID:16732286
Q02763300343331340Disulfide bondOntology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16732286;Dbxref=PMID:16732286
Q02763300343301341DomainNote=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
Q0276330034323748Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q02763300343325327TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GY5
Q02763442496446449Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UTK
Q02763442496452456Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UTK
Q02763442496461464Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UTK
Q02763442496469472Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UTK
Q02763442496476485Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UTK
Q02763442496493504Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UTK
Q02763442496231124ChainID=PRO_0000024474;Note=Angiopoietin-1 receptor
Q02763442496447541DomainNote=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
Q02763442496464464GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q02763442496486486Natural variantID=VAR_024578;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1334811,PMID:17344846
Q0276344249623748Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255


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SNVs in the skipped exons for TEK

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A3A0-01exon_skip_495314
27157829271581402715792627157926Frame_Shift_DelC-p.R50fs
LIHCTCGA-DD-A3A1-01exon_skip_495314
27157829271581402715799227157992Frame_Shift_DelG-p.L72fs
ESCATCGA-L5-A4OI-01exon_skip_495314
27157829271581402715802627158026Frame_Shift_DelA-p.A83fs
ESCATCGA-L5-A4OI-01exon_skip_495314
27157829271581402715802627158026Frame_Shift_DelA-p.K85fs
ESCATCGA-L5-A4OI-01exon_skip_495314
27157829271581402715802627158026Frame_Shift_DelA-p.V86fs
SARCTCGA-DX-A6BA-01exon_skip_495314
27157829271581402715802627158026Frame_Shift_DelA-p.K85fs
SARCTCGA-DX-A6BA-01exon_skip_495314
27157829271581402715802627158026Frame_Shift_DelA-p.V86fs
LIHCTCGA-DD-A1EG-01exon_skip_495316
27168493271686032716859727168597Frame_Shift_DelA-p.K157fs
LIHCTCGA-DD-A3A0-01exon_skip_495316
27168493271686032716859727168597Frame_Shift_DelA-p.K157fs
LIHCTCGA-DD-A1EG-01exon_skip_495320
27180238271803662718025827180258Frame_Shift_DelG-p.G308fs
LIHCTCGA-G3-A3CJ-01exon_skip_495322
27190527271906882719054827190548Frame_Shift_DelC-p.A450fs
LIHCTCGA-DD-A1EG-01exon_skip_495322
27190527271906882719068327190683Frame_Shift_DelT-p.I495fs
HNSCTCGA-CQ-6227-01exon_skip_495330
27220047272201432722006427220064Frame_Shift_DelG-p.G1041fs
STADTCGA-CD-8536-01exon_skip_495322
27190527271906882719054727190548Frame_Shift_Ins-Cp.A450fs
STADTCGA-CD-8536-01exon_skip_495322
27190527271906882719054827190549Frame_Shift_Ins-Cp.A407fs
SKCMTCGA-D3-A8GK-06exon_skip_495314
27157829271581402715804027158040Nonsense_MutationGAp.W88*
PAADTCGA-3A-A9J0-01exon_skip_495314
27157829271581402715804727158047Nonsense_MutationGTp.E91*
PAADTCGA-3A-A9J0-01exon_skip_495314
27157829271581402715804727158047Nonsense_MutationGTp.E91X
STADTCGA-BR-4255-01exon_skip_495314
27157829271581402715809527158095Nonsense_MutationCTp.R107*
STADTCGA-BR-4255-01exon_skip_495314
27157829271581402715809527158095Nonsense_MutationCTp.R107X
UCECTCGA-B5-A0JY-01exon_skip_495314
27157829271581402715809527158095Nonsense_MutationCTp.R107*
UCECTCGA-D1-A16X-01exon_skip_495314
27157829271581402715809527158095Nonsense_MutationCTp.R107*
READTCGA-F5-6814-01exon_skip_495314
27157829271581402715810127158101Nonsense_MutationGTp.E109X
ESCATCGA-L5-A4OI-01exon_skip_495320
27180238271803662718030527180305Nonsense_MutationTAp.C323*
ESCATCGA-L5-A4OI-01exon_skip_495320
27180238271803662718030527180305Nonsense_MutationTAp.C323X
COADTCGA-A6-2676-01exon_skip_495320
27180238271803662718034127180341Nonsense_MutationGAp.W335X
SKCMTCGA-YG-AA3N-01exon_skip_495326
27218775272188152721879827218798Nonsense_MutationGAp.W1029*
HNSCTCGA-CV-7250-01exon_skip_495326
27218775272188152721881527218815Nonsense_MutationGTp.G1035*
COADTCGA-AZ-4315-01exon_skip_495330
27220047272201432722007927220079Nonsense_MutationGTp.E1046X

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE27157829271581402715802627158026Frame_Shift_DelA-p.K85fs
DU145_PROSTATE27157829271581402715802627158026Frame_Shift_DelA-p.K85fs
NCIH650_LUNG27157829271581402715783427157834Missense_MutationGTp.V20L
BICR18_UPPER_AERODIGESTIVE_TRACT27157829271581402715792527157925Missense_MutationGAp.R50H
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE27157829271581402715792527157925Missense_MutationGAp.R50H
OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE27157829271581402715792527157925Missense_MutationGAp.R50H
HEC151_ENDOMETRIUM27157829271581402715806527158065Missense_MutationAGp.N97D
HCC2218_BREAST27157829271581402715812727158127Missense_MutationGCp.K117N
OVCAR8_OVARY27168493271686032716853027168530Missense_MutationCAp.D134E
451LU_SKIN27168493271686032716853427168534Missense_MutationGAp.G136R
CORL88_LUNG27168493271686032716856427168564Missense_MutationGCp.V146L
SUPHD1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE27168493271686032716858227168582Missense_MutationGAp.D152N
CHLA57_BONE27180238271803662718024627180246Missense_MutationCTp.P304S
LU135_LUNG27180238271803662718024727180247Missense_MutationCTp.P304L
GP2D_LARGE_INTESTINE27180238271803662718030727180307Missense_MutationATp.D324V
CW2_LARGE_INTESTINE27190527271906882719055627190556Missense_MutationGAp.V453M
BICR18_UPPER_AERODIGESTIVE_TRACT27190527271906882719058327190583Missense_MutationGAp.V462I
CCK81_LARGE_INTESTINE27190527271906882719058427190584Missense_MutationTCp.V462A
NB5_AUTONOMIC_GANGLIA27190527271906882719060427190604Missense_MutationCGp.P469A
JHUEM7_ENDOMETRIUM27157829271581402715809527158095Nonsense_MutationCTp.R107*

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TEK

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TEK


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TEK


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RelatedDrugs for TEK

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
Q02763DB05294VandetanibAngiopoietin-1 receptorsmall moleculeapproved
Q02763DB08896RegorafenibAngiopoietin-1 receptorsmall moleculeapproved
Q02763DB08901PonatinibAngiopoietin-1 receptorsmall moleculeapproved|investigational
Q02763DB12010FostamatinibAngiopoietin-1 receptorsmall moleculeapproved|investigational
Q02763DB00415AmpicillinAngiopoietin-1 receptorsmall moleculeapproved|vet_approved

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RelatedDiseases for TEK

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
TEKC0014556Epilepsy, Temporal Lobe1CTD_human
TEKC0018923Hemangiosarcoma1CTD_human
TEKC0023904Liver Neoplasms, Experimental1CTD_human
TEKC0027686Pathologic Neovascularization1CTD_human
TEKC1838437VENOUS MALFORMATIONS, MULTIPLE CUTANEOUS AND MUCOSAL1CTD_human;ORPHANET;UNIPROT