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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TEC |
 Gene summary |
| Gene information | Gene symbol | TEC | Gene ID | 7006 |
| Gene name | tec protein tyrosine kinase | |
| Synonyms | PSCTK4 | |
| Cytomap | 4p12-p11 | |
| Type of gene | protein-coding | |
| Description | tyrosine-protein kinase Tec | |
| Modification date | 20180523 | |
| UniProtAcc | P42680 | |
| Context | PubMed: TEC [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TEC | GO:0007229 | integrin-mediated signaling pathway | 9652744 |
| TEC | GO:0010543 | regulation of platelet activation | 9299487|9652744 |
| TEC | GO:0018108 | peptidyl-tyrosine phosphorylation | 10518561 |
| TEC | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 10518561 |
| TEC | GO:0050853 | B cell receptor signaling pathway | 10518561 |
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Exon skipping events across known transcript of Ensembl for TEC from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TEC |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TEC |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_429416 | 4 | 48140932:48141039:48143371:48143436:48147095:48147312 | 48143371:48143436 | ENSG00000135605.8 | ENST00000505452.1,ENST00000381501.3 |
| exon_skip_429418 | 4 | 48143372:48143436:48147095:48147312:48147424:48147596 | 48147095:48147312 | ENSG00000135605.8 | ENST00000511471.2,ENST00000505452.1,ENST00000381501.3 |
| exon_skip_429421 | 4 | 48173384:48173466:48178098:48178203:48230493:48230676 | 48178098:48178203 | ENSG00000135605.8 | ENST00000381501.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TEC |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_429416 | 4 | 48140932:48141039:48143371:48143436:48147095:48147312 | 48143371:48143436 | ENSG00000135605.8 | ENST00000381501.3,ENST00000505452.1 |
| exon_skip_429418 | 4 | 48143372:48143436:48147095:48147312:48147424:48147596 | 48147095:48147312 | ENSG00000135605.8 | ENST00000381501.3,ENST00000505452.1,ENST00000511471.2 |
| exon_skip_429420 | 4 | 48158696:48158751:48165718:48165784:48169794:48169965 | 48165718:48165784 | ENSG00000135605.8 | ENST00000381501.3 |
| exon_skip_429421 | 4 | 48173384:48173466:48178098:48178203:48230493:48230676 | 48178098:48178203 | ENSG00000135605.8 | ENST00000381501.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TEC |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000381501 | 48143371 | 48143436 | Frame-shift |
| ENST00000381501 | 48147095 | 48147312 | Frame-shift |
| ENST00000381501 | 48178098 | 48178203 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000381501 | 48143371 | 48143436 | Frame-shift |
| ENST00000381501 | 48147095 | 48147312 | Frame-shift |
| ENST00000381501 | 48165718 | 48165784 | In-frame |
| ENST00000381501 | 48178098 | 48178203 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TEC |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000381501 | 3704 | 631 | 48178098 | 48178203 | 297 | 401 | 46 | 81 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000381501 | 3704 | 631 | 48178098 | 48178203 | 297 | 401 | 46 | 81 |
| ENST00000381501 | 3704 | 631 | 48165718 | 48165784 | 830 | 895 | 224 | 245 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P42680 | 46 | 81 | 45 | 47 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL |
| P42680 | 46 | 81 | 53 | 55 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL |
| P42680 | 46 | 81 | 61 | 64 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL |
| P42680 | 46 | 81 | 69 | 71 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL |
| P42680 | 46 | 81 | 74 | 76 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL |
| P42680 | 46 | 81 | 78 | 83 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL |
| P42680 | 46 | 81 | 1 | 631 | Chain | ID=PRO_0000088170;Note=Tyrosine-protein kinase Tec |
| P42680 | 46 | 81 | 4 | 111 | Domain | Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145 |
| P42680 | 46 | 81 | 56 | 58 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P42680 | 46 | 81 | 45 | 47 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL |
| P42680 | 46 | 81 | 53 | 55 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL |
| P42680 | 46 | 81 | 61 | 64 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL |
| P42680 | 46 | 81 | 69 | 71 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL |
| P42680 | 46 | 81 | 74 | 76 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL |
| P42680 | 46 | 81 | 78 | 83 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL |
| P42680 | 46 | 81 | 1 | 631 | Chain | ID=PRO_0000088170;Note=Tyrosine-protein kinase Tec |
| P42680 | 46 | 81 | 4 | 111 | Domain | Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145 |
| P42680 | 46 | 81 | 56 | 58 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LUL |
| P42680 | 224 | 245 | 1 | 631 | Chain | ID=PRO_0000088170;Note=Tyrosine-protein kinase Tec |
| P42680 | 224 | 245 | 179 | 239 | Domain | Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192 |
| P42680 | 224 | 245 | 228 | 228 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195 |
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SNVs in the skipped exons for TEC |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LUAD | TCGA-86-7954-01 | exon_skip_429418 | 48147096 | 48147312 | 48147134 | 48147134 | Nonsense_Mutation | C | A | p.E478* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| MERO25_LUNG | 48143372 | 48143436 | 48143390 | 48143390 | Missense_Mutation | G | A | p.S506F |
| NCIH2342_LUNG | 48147096 | 48147312 | 48147139 | 48147139 | Missense_Mutation | C | A | p.G476V |
| NCIH82_LUNG | 48147096 | 48147312 | 48147155 | 48147155 | Missense_Mutation | G | C | p.Q471E |
| KU812_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 48147096 | 48147312 | 48147173 | 48147173 | Missense_Mutation | C | G | p.V465L |
| CCK81_LARGE_INTESTINE | 48147096 | 48147312 | 48147269 | 48147269 | Missense_Mutation | T | C | p.T433A |
| BT474_BREAST | 48178099 | 48178203 | 48178101 | 48178101 | Missense_Mutation | G | C | p.Q81E |
| SNU719_STOMACH | 48178099 | 48178203 | 48178163 | 48178163 | Missense_Mutation | T | G | p.K60T |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TEC |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_429418 | 4 | 48143372:48143436:48147095:48147312:48147424:48147596 | 48147095:48147312 | ENST00000511471.2,ENST00000505452.1,ENST00000381501.3 | ESCA | rs17574371 | chr4:48147309 | T/C | 1.26e-06 |
| exon_skip_429418 | 4 | 48143372:48143436:48147095:48147312:48147424:48147596 | 48147095:48147312 | ENST00000511471.2,ENST00000505452.1,ENST00000381501.3 | LAML | rs17574371 | chr4:48147309 | T/C | 7.65e-09 |
| exon_skip_429418 | 4 | 48143372:48143436:48147095:48147312:48147424:48147596 | 48147095:48147312 | ENST00000511471.2,ENST00000505452.1,ENST00000381501.3 | KIRP | rs17574371 | chr4:48147309 | T/C | 1.41e-06 |
| exon_skip_429418 | 4 | 48143372:48143436:48147095:48147312:48147424:48147596 | 48147095:48147312 | ENST00000511471.2,ENST00000505452.1,ENST00000381501.3 | KIRC | rs17574371 | chr4:48147309 | T/C | 1.56e-11 |
| exon_skip_429418 | 4 | 48143372:48143436:48147095:48147312:48147424:48147596 | 48147095:48147312 | ENST00000511471.2,ENST00000505452.1,ENST00000381501.3 | LUAD | rs17574371 | chr4:48147309 | T/C | 2.22e-13 |
| exon_skip_429418 | 4 | 48143372:48143436:48147095:48147312:48147424:48147596 | 48147095:48147312 | ENST00000511471.2,ENST00000505452.1,ENST00000381501.3 | PRAD | rs17574371 | chr4:48147309 | T/C | 6.47e-05 |
| exon_skip_429418 | 4 | 48143372:48143436:48147095:48147312:48147424:48147596 | 48147095:48147312 | ENST00000511471.2,ENST00000505452.1,ENST00000381501.3 | TGCT | rs17574371 | chr4:48147309 | T/C | 1.85e-04 |
| exon_skip_429418 | 4 | 48143372:48143436:48147095:48147312:48147424:48147596 | 48147095:48147312 | ENST00000511471.2,ENST00000505452.1,ENST00000381501.3 | THCA | rs17574371 | chr4:48147309 | T/C | 1.34e-33 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TEC |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TEC |
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RelatedDrugs for TEC |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P42680 | DB12010 | Fostamatinib | Tyrosine-protein kinase Tec | small molecule | approved|investigational |
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RelatedDiseases for TEC |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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